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16 条记录 (耗时 0.026 秒)

    Hemoglobin combined with a poly(alkylene oxide)
    3.
    发明授权
    Hemoglobin combined with a poly(alkylene oxide) 失效
    血红蛋白与聚（环氧烷）

    公开(公告)号：US4670417A

    公开(公告)日：1987-06-02

    申请号：US831500

    申请日：1986-02-21

    申请人： Keiji Iwasaki ,  Yuji Iwashita ,  Taketoshi Okami

    发明人： Keiji Iwasaki ,  Yuji Iwashita ,  Taketoshi Okami

    IPC分类号： A61K38/16 ,  A61K38/00 ,  A61P7/08 ,  C07K14/805 ,  C07K13/00 ,  A61K31/74 ,  A61K35/14

    CPC分类号： C07K14/805 ,  A61K38/00 ,  Y10S514/832

    摘要： There is disclosed hemoglobin modified in that a poly(alkylene oxide) is bonded thereto by a bond between a terminal group of said poly(alkylene oxide) and an amino group of said hemoglobin, said bond having the structure:--CH.sub.2 --O--(CH.sub.2)--CONH--Hbwherein Hb represents said hemoglobin and n represents a positive integer, preferably 1 to 7. The modified hemoglobin is an effective oxygen carrier and can therefore be used as a blood substitute.

    摘要翻译： 公开了血红蛋白的修饰，其中聚（环氧烷）通过所述聚（环氧烷）的末端基团和所述血红蛋白的氨基之间的键键合，所述键具有以下结构：-CH 2 -O-（ CH2）-CONH-Hb，其中Hb表示所述血红蛋白，n表示正整数，优选为1〜7.修饰的血红蛋白为有效的氧载体，因此可用作血液替代品。

    Cysteine derivatives
    6.
    发明授权
    Cysteine derivatives 失效
    半胱氨酸衍生物

    公开(公告)号：US06703031B1

    公开(公告)日：2004-03-09

    申请号：US09806937

    申请日：2001-06-14

    申请人： Keiji Iwasaki ,  Manabu Kitazawa ,  Eiji Shiojiri ,  Kazutami Sakamoto

    发明人： Keiji Iwasaki ,  Manabu Kitazawa ,  Eiji Shiojiri ,  Kazutami Sakamoto

    IPC分类号： A61K700

    CPC分类号： C07C323/60 ,  A61K8/02 ,  A61K8/0212 ,  A61K8/35 ,  A61K8/368 ,  A61K8/37 ,  A61K8/411 ,  A61K8/447 ,  A61K8/45 ,  A61K8/46 ,  A61K8/494 ,  A61K8/60 ,  A61K8/63 ,  A61K8/676 ,  A61K8/678 ,  A61K8/86 ,  A61Q1/02 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/004 ,  A61Q19/02 ,  A61Q19/08 ,  A61Q19/10 ,  Y10S514/844 ,  Y10S514/847

    摘要： Objects of the present invention are to provide an oxidative stress inhibitor which is capable of suppressing the expression of a cytotoxic protein and the activation of a gene transcriptional regulatory factor taking part such expression of a cytotoxic protein and exhibits good feeling upon use and safety; to provide a method for preventing, retarding, alleviating or treating a skin change due to aging or an undesirable aesthetic skin change, both caused or promoted by an oxidative stress; and to provide a cosmetic composition or dermatologic preparation for external use comprising the oxidative stress inhibitor as an effective ingredient, and for those purposes are employed an oxidative stress inhibiting agent which comprises, as an effective ingredient, at least one selected from cysteine or cystine derivatives and the salts thereof.

    摘要翻译： 本发明的目的是提供能够抑制细胞毒性蛋白质的表达和基因转录调节因子的活化的氧化应激抑制剂，其采用这种细胞毒性蛋白质的这种表达，并且在使用和安全性方面表现出良好的感觉; 提供一种预防，延缓，减轻或治疗由于老化引起的皮肤变化或由氧化应激引起或促进的不期望的美容皮肤变化的方法; 并且提供包含氧化应激抑制剂作为有效成分的外用化妆品组合物或皮肤病学制剂，并且为了这些目的，使用氧化应激抑制剂，其包含作为有效成分的至少一种选自半胱氨酸或胱氨酸衍生物 及其盐。

    Homokinetic tripod joint
    8.
    发明授权
    Homokinetic tripod joint 失效
    人体动物三脚架关节

    公开(公告)号：US4786270A

    公开(公告)日：1988-11-22

    申请号：US46322

    申请日：1987-05-06

    申请人： Keiji Iwasaki

    发明人： Keiji Iwasaki

    IPC分类号： B60K17/30 ,  F16D3/205 ,  F16D3/20

    CPC分类号： F16D3/2055 ,  F16D2003/2026 ,  Y10S464/905

    摘要： A homokinetic tripod type universal joint including a tripod member having three trunnions, with a roller rotatably mounted on each trunnion is mounted in an outer member. The roller consists of an inside ring and an outside ring wherein contact is established between a spherical outer periphery of the inside ring and a cylindrical inner periphery of the outside ring. The outside ring is guided in a direction parallel with the axis of the outer member by guide surfaces provided internally of grooves formed on the outer member. This arrangement helps to reduce sliding resistance, temperature rise and vibrations due to induced thrust.

    摘要翻译： 包括具有三个耳轴的三脚架构件和可旋转地安装在每个耳轴上的滚子的同轴三脚架型万向接头安装在外部构件中。 辊由内圈和外圈构成，其中在内圈的球形外周和外圈的圆柱形内周之间建立接触。 通过设置在外部构件上形成的槽内部的引导表面，外环在与外部构件的轴线平行的方向上被引导。 这种布置有助于减少滑动阻力，温度上升和由于诱导推力引起的振动。

    Melanocyte-stimulating hormone inhibitors
    9.
    发明授权
    Melanocyte-stimulating hormone inhibitors 有权
    促黑细胞激素抑制剂

    公开(公告)号：US07375085B1

    公开(公告)日：2008-05-20

    申请号：US09926391

    申请日：2000-04-25

    申请人： Eiji Shiojiri ,  Yoshinobu Takino ,  Hiromi Chujou ,  Kazutami Sakamoto ,  Chiori Ijichi ,  Yuzuru Eto ,  Keiji Iwasaki

    发明人： Eiji Shiojiri ,  Yoshinobu Takino ,  Hiromi Chujou ,  Kazutami Sakamoto ,  Chiori Ijichi ,  Yuzuru Eto ,  Keiji Iwasaki

    IPC分类号： C07K5/08 ,  A61K38/00

    CPC分类号： C07K5/0812 ,  A61K38/00

    摘要： In the present specification is disclosed a melanocyte-stimulating hormone inhibitory composition which comprises, as the active ingredient, a di- or tripeptide derivative having a certain naphthyl group or the salts thereof, or a melanocyte-stimulating hormone inhibitory compound having a 50% inhibitory concentration of cAMP production (IC50) of 100 nM or less, which composition can prevent pigmentation, or can prevent, improve or recover from immune abnormality or immunodeficiency, or regulate body weight by appetite control, and also can be used as cosmetics or external preparations for the skin, and in addition, can be produced easily, and are excellent in the stability during storage.

    摘要翻译： 在本说明书中公开了一种黑素细胞刺激激素抑制组合物，其包含作为活性成分的具有某个萘基的二肽或三肽衍生物或其盐，或具有50％抑制性的黑素细胞刺激激素抑制化合物 cAMP产生浓度（IC 50）为100nM以下，该组合物可以防止色素沉积，或者可以防止，改善或恢复免疫异常或免疫缺陷，或通过食欲控制来调节体重，并且还可以用作化妆品或外用制剂 并且另外可以容易地制造，并且在保存期间的稳定性优异。