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    Cysteine derivatives
    5.
    发明授权
    Cysteine derivatives 失效
    半胱氨酸衍生物

    公开(公告)号：US06703031B1

    公开(公告)日：2004-03-09

    申请号：US09806937

    申请日：2001-06-14

    申请人： Keiji Iwasaki ,  Manabu Kitazawa ,  Eiji Shiojiri ,  Kazutami Sakamoto

    发明人： Keiji Iwasaki ,  Manabu Kitazawa ,  Eiji Shiojiri ,  Kazutami Sakamoto

    IPC分类号： A61K700

    CPC分类号： C07C323/60 ,  A61K8/02 ,  A61K8/0212 ,  A61K8/35 ,  A61K8/368 ,  A61K8/37 ,  A61K8/411 ,  A61K8/447 ,  A61K8/45 ,  A61K8/46 ,  A61K8/494 ,  A61K8/60 ,  A61K8/63 ,  A61K8/676 ,  A61K8/678 ,  A61K8/86 ,  A61Q1/02 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/004 ,  A61Q19/02 ,  A61Q19/08 ,  A61Q19/10 ,  Y10S514/844 ,  Y10S514/847

    摘要： Objects of the present invention are to provide an oxidative stress inhibitor which is capable of suppressing the expression of a cytotoxic protein and the activation of a gene transcriptional regulatory factor taking part such expression of a cytotoxic protein and exhibits good feeling upon use and safety; to provide a method for preventing, retarding, alleviating or treating a skin change due to aging or an undesirable aesthetic skin change, both caused or promoted by an oxidative stress; and to provide a cosmetic composition or dermatologic preparation for external use comprising the oxidative stress inhibitor as an effective ingredient, and for those purposes are employed an oxidative stress inhibiting agent which comprises, as an effective ingredient, at least one selected from cysteine or cystine derivatives and the salts thereof.

    摘要翻译： 本发明的目的是提供能够抑制细胞毒性蛋白质的表达和基因转录调节因子的活化的氧化应激抑制剂，其采用这种细胞毒性蛋白质的这种表达，并且在使用和安全性方面表现出良好的感觉; 提供一种预防，延缓，减轻或治疗由于老化引起的皮肤变化或由氧化应激引起或促进的不期望的美容皮肤变化的方法; 并且提供包含氧化应激抑制剂作为有效成分的外用化妆品组合物或皮肤病学制剂，并且为了这些目的，使用氧化应激抑制剂，其包含作为有效成分的至少一种选自半胱氨酸或胱氨酸衍生物 及其盐。

    Melanocyte-stimulating hormone inhibitors
    6.
    发明授权
    Melanocyte-stimulating hormone inhibitors 有权
    促黑细胞激素抑制剂

    公开(公告)号：US07375085B1

    公开(公告)日：2008-05-20

    申请号：US09926391

    申请日：2000-04-25

    申请人： Eiji Shiojiri ,  Yoshinobu Takino ,  Hiromi Chujou ,  Kazutami Sakamoto ,  Chiori Ijichi ,  Yuzuru Eto ,  Keiji Iwasaki

    发明人： Eiji Shiojiri ,  Yoshinobu Takino ,  Hiromi Chujou ,  Kazutami Sakamoto ,  Chiori Ijichi ,  Yuzuru Eto ,  Keiji Iwasaki

    IPC分类号： C07K5/08 ,  A61K38/00

    CPC分类号： C07K5/0812 ,  A61K38/00

    摘要： In the present specification is disclosed a melanocyte-stimulating hormone inhibitory composition which comprises, as the active ingredient, a di- or tripeptide derivative having a certain naphthyl group or the salts thereof, or a melanocyte-stimulating hormone inhibitory compound having a 50% inhibitory concentration of cAMP production (IC50) of 100 nM or less, which composition can prevent pigmentation, or can prevent, improve or recover from immune abnormality or immunodeficiency, or regulate body weight by appetite control, and also can be used as cosmetics or external preparations for the skin, and in addition, can be produced easily, and are excellent in the stability during storage.

    摘要翻译： 在本说明书中公开了一种黑素细胞刺激激素抑制组合物，其包含作为活性成分的具有某个萘基的二肽或三肽衍生物或其盐，或具有50％抑制性的黑素细胞刺激激素抑制化合物 cAMP产生浓度（IC 50）为100nM以下，该组合物可以防止色素沉积，或者可以防止，改善或恢复免疫异常或免疫缺陷，或通过食欲控制来调节体重，并且还可以用作化妆品或外用制剂 并且另外可以容易地制造，并且在保存期间的稳定性优异。

    Mesoporous silica and process for producing the same
    7.
    发明授权
    Mesoporous silica and process for producing the same 失效
    介孔二氧化硅及其制备方法

    公开(公告)号：US07405315B2

    公开(公告)日：2008-07-29

    申请号：US10716427

    申请日：2003-11-20

    申请人： Takashi Tatsumi ,  Hideaki Yoshitake ,  Toshiyuki Yokoi ,  Shunai Che ,  Kazutami Sakamoto

    发明人： Takashi Tatsumi ,  Hideaki Yoshitake ,  Toshiyuki Yokoi ,  Shunai Che ,  Kazutami Sakamoto

    IPC分类号： C07F7/04

    CPC分类号： C01B37/02 ,  C07B2200/11 ,  C07F7/1804

    摘要： (A) An anionic surfactant, (B) a silicate monomer and (C) a basic silane are mixed in water or a mixed solvent of a water-miscible organic solvent and water to obtain a mesoporous silica complex having mesopores with a uniform size, the anionic surfactant Component (A) is removed by washing the resultant mesoporous silica complex with an acidic aqueous solution, a water-miscible organic solvent or an aqueous solution thereof to obtain a mesoporous silica outer shell utilizing the structure of the mesoporous silica complex as a template, and the mesoporous silica complex or the mesoporous silica outer shell is calcined to obtain a mesoporous silica. The mesoporous silica can be synthesized in this manner utilizing the anionic surfactant micelle with a remarkably low affinity to the silicate monomer.

    摘要翻译： （A）阴离子表面活性剂，（B）硅酸盐单体和（C）碱性硅烷在水或水混溶性有机溶剂与水的混合溶剂中混合，得到具有均匀尺寸的介孔的介孔二氧化硅配合物， 通过用酸性水溶液，水溶性有机溶剂或其水溶液洗涤所得介孔二氧化硅配合物来除去阴离子表面活性剂组分（A），以获得使用介孔二氧化硅络合物的结构的介孔二氧化硅外壳作为 模板和介孔二氧化硅配合物或介孔二氧化硅外壳进行煅烧，得到介孔二氧化硅。 可以以这种方式利用对硅酸盐单体的亲和力非常低的阴离子表面活性剂胶束来合成介孔二氧化硅。

    Silica Composite Capsules Obtained By Blending Water-Soluble Silane Derivative, Composition Containg The Same, And Transparent Gel-Form Composition
    8.
    发明申请
    Silica Composite Capsules Obtained By Blending Water-Soluble Silane Derivative, Composition Containg The Same, And Transparent Gel-Form Composition 失效
    通过混合水溶性硅烷衍生物获得的二氧化硅复合胶囊，含有它的组合物和透明的凝胶形式组合物

    公开(公告)号：US20100016200A1

    公开(公告)日：2010-01-21

    申请号：US12440614

    申请日：2007-09-11

    申请人： Yuko Nagare ,  Kei Watanabe ,  Kazutami Sakamoto ,  Shun Takahashi ,  Teruhiko Hineno

    发明人： Yuko Nagare ,  Kei Watanabe ,  Kazutami Sakamoto ,  Shun Takahashi ,  Teruhiko Hineno

    IPC分类号： A61K8/06

    CPC分类号： A61Q19/10 ,  A61K8/0291 ,  A61K8/0295 ,  A61K8/042 ,  A61K8/11 ,  A61K8/25 ,  A61K8/585 ,  A61K2800/262 ,  A61K2800/412 ,  A61Q1/02

    摘要： The present invention provides new silica composite capsules that can be easily prepared, a composition containing the silica composite capsules, and a transparent gel-form composition excellent in appearance transparency and texture in use, and in particular, a transparent gel-form composition with improved cleansing properties when used as a cleanser. Micelle/silica composite capsules can easily be obtained, in an aqueous system, by mixing a material capable of forming micelles in water and a water-soluble silane derivative having a specific structure in aqueous solution. In addition, emulsion/silica composite capsules wherein the periphery of emulsion particles in the inner phase is coated with silica, can easily be obtained by mixing a surfactant, water, an oil, and a water-soluble silane derivative having a specific structure. Moreover, a transparent gel-form composition showing excellent appearance transparency, the texture in use and cleansing properties, can be obtained by blending a water-soluble silane derivative having a specific structure into the formulation that contains a surfactant, an oil and water, and capable of taking a surfactant association structure with aqueous continuous phase or both of aqueous continuous phase and oil continuous phase in the formulation.

    摘要翻译： 本发明提供了可以容易地制备的新的二氧化硅复合胶囊，含有二氧化硅复合胶囊的组合物，以及外观透明性和使用质地优异的透明凝胶状组合物，特别是具有改进的透明凝胶状组合物 用作清洁剂时的清洁性能。 通过将能够在水中形成胶束的材料和在水溶液中具有特定结构的水溶性硅烷衍生物混合，可以在水性体系中容易地获得胶束/二氧化硅复合胶囊。 此外，通过混合表面活性剂，水，油和具有特定结构的水溶性硅烷衍生物，可以容易地得到内层的乳液粒子的周围用二氧化硅涂布的乳液/二氧化硅复合胶囊。 此外，通过将具有特定结构的水溶性硅烷衍生物掺入含有表面活性剂，油和水的配方中，可以获得表现出优异的外观透明度，使用质地和清洁性能的透明凝胶状组合物，以及 能够在制剂中具有含水连续相或水相连续相和油连续相的表面活性剂缔合结构。

    Methods for controlling membrane permeability of a membrane permeable substance and screening methods for a membrane permeable substance
    9.
    发明申请
    Methods for controlling membrane permeability of a membrane permeable substance and screening methods for a membrane permeable substance 审中-公开
    用于控制膜渗透性的膜渗透性的方法和膜可渗透物质的筛选方法

    公开(公告)号：US20050118204A1

    公开(公告)日：2005-06-02

    申请号：US10948755

    申请日：2004-09-24

    申请人： Kazutami Sakamoto ,  Yoshinobu Takino ,  Kazuko Ogasahara

    发明人： Kazutami Sakamoto ,  Yoshinobu Takino ,  Kazuko Ogasahara

    IPC分类号： A61K9/00 ,  A61K38/00 ,  C12N5/074 ,  C12N5/078 ,  C12Q1/00 ,  G01N33/50

    CPC分类号： G01N33/5008 ,  C12N5/0641 ,  C12N5/0672

    摘要： The present invention relates to a method for controlling membrane permeability of a membrane permeable substance, and more particularly it relates to a method for controlling membrane permeability of a membrane permeable substance by changing the curvature of the membrane. The invention also relates to a screening method for a membrane permeable substance, and more particularly, it relates to a screening method for a membrane permeable substance, in which the change of curvature of the membrane and/or the phase change of the membrane, which occurs upon adding a test substance, is detected to evaluate the membrane permeability of the test substance.

    摘要翻译： 本发明涉及一种用于控制膜渗透性的膜渗透性的方法，更具体地，涉及通过改变膜的曲率来控制膜渗透性的膜渗透性的方法。 本发明还涉及膜可渗透物质的筛选方法，更具体地说，涉及膜渗透性物质的筛选方法，其中膜的曲率变化和/或膜的相变，其中 在检测物质的添加时发生检测，以评价检测物质的膜渗透性。

    Silica composite capsules obtained by blending water-soluble silane derivative, composition containing the same, and transparent gel-form composition
    10.
    发明授权
    Silica composite capsules obtained by blending water-soluble silane derivative, composition containing the same, and transparent gel-form composition 失效
    通过混合水溶性硅烷衍生物，含有它们的组合物和透明凝胶状组合物获得的二氧化硅复合胶囊

    公开(公告)号：US08030267B2

    公开(公告)日：2011-10-04

    申请号：US12440614

    申请日：2007-09-11

    申请人： Yuko Nagare ,  Kei Watanabe ,  Kazutami Sakamoto ,  Shun Takahashi ,  Teruhiko Hineno

    发明人： Yuko Nagare ,  Kei Watanabe ,  Kazutami Sakamoto ,  Shun Takahashi ,  Teruhiko Hineno

    IPC分类号： C11D9/36 ,  C11D3/44

    CPC分类号： A61Q19/10 ,  A61K8/0291 ,  A61K8/0295 ,  A61K8/042 ,  A61K8/11 ,  A61K8/25 ,  A61K8/585 ,  A61K2800/262 ,  A61K2800/412 ,  A61Q1/02

    摘要： The present invention provides new silica composite capsules that can be easily prepared, a composition containing the silica composite capsules, and a transparent gel-form composition excellent in appearance transparency and texture in use, and in particular, a transparent gel-form composition with improved cleansing properties when used as a cleanser. Micelle/silica composite capsules can easily be obtained, in an aqueous system, by mixing a material capable of forming micelles in water and a water-soluble silane derivative having a specific structure in aqueous solution. In addition, emulsion/silica composite capsules wherein the periphery of emulsion particles in the inner phase is coated with silica, can easily be obtained by mixing a surfactant, water, an oil, and a water-soluble silane derivative having a specific structure. Moreover, a transparent gel-form composition showing excellent appearance transparency, the texture in use and cleansing properties, can be obtained by blending a water-soluble silane derivative having a specific structure into the formulation that contains a surfactant, an oil and water, and capable of taking a surfactant association structure with aqueous continuous phase or both of aqueous continuous phase and oil continuous phase in the formulation.

    摘要翻译： 本发明提供了可以容易地制备的新的二氧化硅复合胶囊，含有二氧化硅复合胶囊的组合物，以及外观透明性和使用质地优异的透明凝胶状组合物，特别是具有改进的透明凝胶状组合物 用作清洁剂时的清洁性能。 通过将能够在水中形成胶束的材料和在水溶液中具有特定结构的水溶性硅烷衍生物混合，可以在水性体系中容易地获得胶束/二氧化硅复合胶囊。 此外，通过混合表面活性剂，水，油和具有特定结构的水溶性硅烷衍生物，可以容易地得到内层的乳液粒子的周围用二氧化硅涂布的乳液/二氧化硅复合胶囊。 此外，通过将具有特定结构的水溶性硅烷衍生物掺入含有表面活性剂，油和水的配方中，可以获得表现出优异的外观透明度，使用质地和清洁性能的透明凝胶状组合物，以及 能够在制剂中具有含水连续相或水相连续相和油连续相的表面活性剂缔合结构。