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    Paramyxoviruses comprising modified transcription start sequence
    1.
    发明授权
    Paramyxoviruses comprising modified transcription start sequence 失效
    副粘病毒包括修饰的转录起始序列

    公开(公告)号：US07144579B2

    公开(公告)日：2006-12-05

    申请号：US09979908

    申请日：2001-11-28

    申请人： Yoshiyuki Nagai ,  Atsushi Kato ,  Mamoru Hasegawa ,  Makoto Inoue

    发明人： Yoshiyuki Nagai ,  Atsushi Kato ,  Mamoru Hasegawa ,  Makoto Inoue

    IPC分类号： C07H19/00 ,  C12N15/63 ,  C12N15/66 ,  A61K39/12 ,  A61K39/155

    CPC分类号： C07K14/005 ,  A61K48/00 ,  C12N15/86 ,  C12N2760/18822 ,  C12N2760/18843

    摘要： The present invention provides virus vectors of the family Paramyxoviridae in which the transcription start (S) sequence has been modified so as to modify the expression of genes located downstream thereof, a method for producing the vectors, and uses thereof. By measuring the transcription initiation efficiency of the S sequence of each gene carried by Sendai viruses (SeV), it was clarified that the S sequence of F gene has a significantly lower ability to promote transcription than the other three S sequences. When the S sequence of the F gene of wild type Sendai virus was substituted by the S sequence of the P/M/HN gene-type showing a high transcription initiation efficiency, the F gene of the resultant Sendai virus mutant and genes located downstream thereof show elevated expression levels. It was also revealed that this mutant proliferates more quickly than the wild type. The vectors of this invention are useful in elevating the expression of foreign genes and producing pharmaceutical compositions and vaccines. Furthermore, by lowering virus gene expression from virus vectors, it is possible to suppress transcription and/or replication and reduce cytotoxicity of the vector genome.

    摘要翻译： 本发明提供了副粘病毒科的病毒载体，其中已经修饰了转录起始（S）序列，以便修饰其下游的基因的表达，生成载体的方法及其用途。 通过测量仙台病毒（SeV）携带的每个基因的S序列的转录起始效率，阐明了F基因的S序列比其他三个S序列具有显着较低的促进转录能力。 当野生型仙台病毒的F基因的S序列被显示高转录起始效率的P / M / HN基因型的S序列取代时，得到的仙台病毒突变体的F基因和位于其下游的基因 显示升高的表达水平。 还显示，该突变体比野生型增殖更快。 本发明的载体可用于提高外源基因的表达并产生药物组合物和疫苗。 此外，通过降低来自病毒载体的病毒基因表达，可以抑制转录和/或复制并降低载体基因组的细胞毒性。

    AIDS virus vaccines using Sendai virus vector
    2.
    发明授权
    AIDS virus vaccines using Sendai virus vector 有权
    艾滋病病毒疫苗使用仙台病毒载体

    公开(公告)号：US08217019B2

    公开(公告)日：2012-07-10

    申请号：US12701303

    申请日：2010-02-05

    申请人： Munehide Kano ,  Tetsuro Matano ,  Atsushi Kato ,  Yoshiyuki Nagai ,  Mamoru Hasegawa

    发明人： Munehide Kano ,  Tetsuro Matano ,  Atsushi Kato ,  Yoshiyuki Nagai ,  Mamoru Hasegawa

    IPC分类号： A61K48/00 ,  C12N15/74 ,  A01N63/00

    CPC分类号： C12N15/86 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/53 ,  A61K2039/543 ,  A61K2039/545 ,  A61K2039/57 ,  C12N2740/15034 ,  C12N2760/18843 ,  C12N2760/18871 ,  C12N2800/30

    摘要： The present invention provides a vaccine containing a Sendai virus vector encoding a virus protein of an immunodeficiency virus. By intranasally administering a Sendai virus encoding a virus protein of an immunodeficiency virus to a macaque monkey, the present inventors have succeeded in efficiently inducing protective immunity against an immunodeficiency virus. As a result of intranasal inoculation of vaccine, expression of an antigen protein mediated by Sendai virus vector was detected in intranasal mucous membrane and local lymph nodes and antigen-specific cellular immune response was induced at a significant level. No pathological symptom by vaccination was observed. After vaccination, exposure of simian immunodeficiency virus was performed and the effect was examined. As a result, the amount of virus in plasma significantly decreased, compared with that of the control animal. The present invention provides a promising vaccine as an AIDS vaccine.

    摘要翻译： 本发明提供含有编码免疫缺陷病毒病毒蛋白质的仙台病毒载体的疫苗。 通过将编码免疫缺陷病毒的病毒蛋白的仙台病毒鼻内施用于猕猴，本发明人成功地有效地诱导针对免疫缺陷病毒的保护性免疫。 鼻内接种疫苗后，在鼻内粘膜中检测到仙台病毒载体介导的抗原蛋白的表达，局部淋巴结的表达明显升高，抗原特异性细胞免疫应答水平明显升高。 未观察到接种疫苗的病理症状。 接种疫苗后，进行猿猴免疫缺陷病毒的暴露，并检查其效果。 结果，与对照动物相比，血浆中的病毒量显着降低。 本发明提供了作为AIDS疫苗的有希望的疫苗。

    AIDS VIRUS VACCINES USING SENDAI VIRUS VECTOR
    3.
    发明申请
    AIDS VIRUS VACCINES USING SENDAI VIRUS VECTOR 有权
    艾滋病病毒疫苗使用SENDAI病毒载体

    公开(公告)号：US20100266633A1

    公开(公告)日：2010-10-21

    申请号：US12701303

    申请日：2010-02-05

    申请人： Munehide KANO ,  Tetsuro Matano ,  Atsushi Kato ,  Yoshiyuki Nagai ,  Mamoru Hasegawa

    发明人： Munehide KANO ,  Tetsuro Matano ,  Atsushi Kato ,  Yoshiyuki Nagai ,  Mamoru Hasegawa

    IPC分类号： A61K39/21

    CPC分类号： C12N15/86 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/53 ,  A61K2039/543 ,  A61K2039/545 ,  A61K2039/57 ,  C12N2740/15034 ,  C12N2760/18843 ,  C12N2760/18871 ,  C12N2800/30

    摘要： The present invention provides a vaccine containing a Sendai virus vector encoding a virus protein of an immunodeficiency virus. By intranasally administering a Sendai virus encoding a virus protein of an immunodeficiency virus to a macaque monkey, the present inventors have succeeded in efficiently inducing protective immunity against an immunodeficiency virus. As a result of intranasal inoculation of vaccine, expression of an antigen protein mediated by Sendai virus vector was detected in intranasal mucous membrane and local lymph nodes and antigen-specific cellular immune response was induced at a significant level. No pathological symptom by vaccination was observed. After vaccination, exposure of simian immunodeficiency virus was performed and the effect was examined. As a result, the amount of virus in plasma significantly decreased, compared with that of the control animal. The present invention provides a promising vaccine as an AIDS vaccine.

    摘要翻译： 本发明提供含有编码免疫缺陷病毒病毒蛋白质的仙台病毒载体的疫苗。 通过将编码免疫缺陷病毒的病毒蛋白的仙台病毒鼻内施用于猕猴，本发明人成功地有效地诱导针对免疫缺陷病毒的保护性免疫。 鼻内接种疫苗后，在鼻内粘膜中检测到仙台病毒载体介导的抗原蛋白的表达，局部淋巴结的表达明显升高，抗原特异性细胞免疫应答水平明显升高。 未观察到接种疫苗的病理症状。 接种疫苗后，进行猿猴免疫缺陷病毒的暴露，并检查其效果。 结果，与对照动物相比，血浆中的病毒量显着降低。 本发明提供了作为AIDS疫苗的有希望的疫苗。

    Projector and controlling method of the same
    9.
    发明授权
    Projector and controlling method of the same 有权
    投影机及其控制方法相同

    公开(公告)号：US09584780B2

    公开(公告)日：2017-02-28

    申请号：US14655695

    申请日：2012-12-27

    申请人： Atsushi Kato

    发明人： Atsushi Kato

    IPC分类号： G03B35/26 ,  H04N13/04 ,  H04N9/31 ,  G03B21/20 ,  G03B33/12 ,  G03B35/16 ,  G02B26/08 ,  G02B27/10 ,  G02B27/22 ,  G02B27/26 ,  G02B27/09

    CPC分类号： H04N9/3164 ,  G02B26/0883 ,  G02B27/0927 ,  G02B27/0994 ,  G02B27/1026 ,  G02B27/2264 ,  G02B27/26 ,  G03B21/2066 ,  G03B33/12 ,  G03B35/16 ,  G03B35/26 ,  H04N9/3108 ,  H04N9/3111 ,  H04N9/312 ,  H04N9/3152 ,  H04N9/3182 ,  H04N13/324 ,  H04N13/334 ,  H04N13/346 ,  H04N13/363 ,  H04N13/365

    摘要： The projector comprises: at least one light source; a light separation unit separating light emitted from the light source into a first and second lights in different wavelength bands; a TIR prism through which the first and second lights pass; an optical modulating element irradiated with and modulating the first and second lights to emit the modulated first and second lights toward the TIR prism; a projection lens expanding and projecting the light which is modulated by the optical modulating element and passes the TIR prism; a rotating prism which is rotatably arranged in the light path between the light separation unit and the TIR prism and emits, from different positions in accordance with rotation, the first and second lights emitted from the light separation unit; and a control unit which, when the image signals representing a first and second images are supplied, causes the optical modulating element to perform modulation according to the image signal of the first image with regard to the area irradiated by the first light and to perform modulation according to the image signal of the second image with regard to the area irradiated by the second light.

    摘要翻译： 该投影仪包括：至少一个光源; 光分离单元，将从所述光源发射的光分离成不同波长带的第一和第二光; 第一和第二个光通过的TIR棱镜; 照射并调制第一和第二光的光调制元件，以朝向TIR棱镜发射调制的第一和第二光; 投影透镜，使由光调制元件调制的光通过TIR棱镜， 可旋转地布置在光分离单元和TIR棱镜之间的光路中的旋转棱镜，并且从光分离单元发射的第一和第二光从旋转的不同位置发射; 以及控制单元，当提供表示第一和第二图像的图像信号时，光调制元件根据第一图像的图像信号相对于由第一光照射的面积进行调制，并且执行调制 根据第二图像的图像信号相对于由第二光照射的面积。

    Image forming apparatus
    10.
    发明授权
    Image forming apparatus 有权
    图像形成装置

    公开(公告)号：US09377746B2

    公开(公告)日：2016-06-28

    申请号：US13851332

    申请日：2013-03-27

    申请人： Shuichi Kato ,  Seiichi Senda ,  Atsushi Kato ,  Masanari Yoshikawa

    发明人： Shuichi Kato ,  Seiichi Senda ,  Atsushi Kato ,  Masanari Yoshikawa

    IPC分类号： G03G21/16

    CPC分类号： G03G21/1619 ,  G03G21/1623 ,  G03G2221/1684 ,  G03G2221/1869

    摘要： An image forming apparatus comprises: a casing including a side wall having an opening; a drawer member configured to support a plurality of cartridges in such a manner as to allow the cartridges to be detachably attached thereto, and to be movable through the opening from an inside position in which the drawer member is located inside the casing to an outside position in which the drawer member is located outside the casing in a moving direction; and a leg portion configured to support the casing. In this image forming apparatus, the leg portion includes a portion located downstream from the opening in the moving direction of the drawer member.

    摘要翻译： 图像形成装置包括：壳体，其包括具有开口的侧壁; 抽屉构件，其构造成以允许所述盒可拆卸地附接到其上的方式支撑多个盒，并且能够通过所述开口从所述抽屉构件位于所述壳体内部的内部位置移动到外部位置 其中所述抽屉构件沿着移动方向位于所述壳体外部; 以及腿部，其构造成支撑所述壳体。 在该图像形成装置中，腿部包括沿着抽屉构件的移动方向位于开口下游的部分。