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公开(公告)号:US4645862A
公开(公告)日:1987-02-24
申请号:US723082
申请日:1985-04-15
申请人: Yoshiyuki Tahara , Yasuhiro Komatsu , Hiroyasu Koyama , Reiko Kubota , Teruhito Yamaguchi , Toshihiro Takahashi
发明人: Yoshiyuki Tahara , Yasuhiro Komatsu , Hiroyasu Koyama , Reiko Kubota , Teruhito Yamaguchi , Toshihiro Takahashi
IPC分类号: C07D295/12 , A61K31/13 , A61K31/135 , A61P31/12 , C07C67/00 , C07C209/00 , C07C211/09 , C07C211/21 , C07C211/27 , C07C211/44 , C07C213/00 , C07C215/02 , C07C215/10 , C07C215/14 , C07C215/30 , C07C217/56 , C07C217/58 , C07C217/60 , C07C217/62 , C07D273/08 , C07D295/13 , C07C87/28 , C07C87/48
CPC分类号: C07D295/13
摘要: Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.3 each is benzyl or substituted with up to 3 methoxy groups, R.sub.2 is a hydrogen atom and (alkylene) is lower alkyl and the compounds are useful for controlling viral infections.
摘要翻译: 其中R 1和R 3各自为苄基或被至多3个甲氧基取代的式的化合物,R 2为氢原子,(亚烷基)为低级烷基,并且该化合物可用于控制病毒感染。
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公开(公告)号:US4380668A
公开(公告)日:1983-04-19
申请号:US208324
申请日:1980-11-19
IPC分类号: C07D213/38 , C07D213/74 , C07C87/28 , A61K31/13 , A61K31/44 , C07D213/06
CPC分类号: C07D213/74 , C07D213/38 , Y10S514/889
摘要: This invention relates to new decaprenylamines and the acid addition salts thereof, which are useful for controlling virus infection of vertebrate animals.
摘要翻译: 本发明涉及用于控制脊椎动物病毒感染的新癸酰胺及其酸加成盐。
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公开(公告)号:US4265910A
公开(公告)日:1981-05-05
申请号:US145754
申请日:1980-05-01
CPC分类号: A61K31/13
摘要: This invention relates to new isoprenylamines and the acid addition salts thereof. Further, the invention is concerned with antiviral agents for vertebrate animal, said agents containing as their active ingredients isoprenylamine or physiologically acceptable acid addition salt thereof.
摘要翻译: 本发明涉及新的异戊二烯胺及其酸加成盐。 此外,本发明涉及用于脊椎动物的抗病毒剂,所述药物含有作为其活性成分的异戊二胺或其生理上可接受的酸加成盐。
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公开(公告)号:US4857529A
公开(公告)日:1989-08-15
申请号:US178510
申请日:1988-04-07
IPC分类号: C07D295/02 , A61K31/415 , A61K31/425 , A61K31/426 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/5375 , A61P31/12 , A61P43/00 , C07D233/54 , C07D233/58 , C07D277/04 , C07D295/03 , C07D295/08 , C07D295/088 , C07D521/00
CPC分类号: C07D295/03 , C07D231/12 , C07D233/56 , C07D249/08 , C07D277/04 , C07D295/088
摘要: New antiviral nonaprenylamine derivatives represented by the following formula ##STR1## wherein R is 4 or 5 atoms selected from the group consisting of C and N so as to complete, with the non-R nitrogen, a 5- or 6-membered heterocyclic ring, and X is selected from the group consisting of H and hydroxy-lower alkyl and non-toxic, pharmaceutically acceptable acid addition salts thereof and a pharmaceutically acceptable carrier.
摘要翻译: 由下式(IMAGE)表示的新的抗病毒非戊烯胺衍生物,其中R是选自C和N的4或5个原子,以便与非R氮完全一个5-或6-元杂环, 并且X选自H和羟基 - 低级烷基和无毒的药学上可接受的酸加成盐和药学上可接受的载体。
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公开(公告)号:US4723008A
公开(公告)日:1988-02-02
申请号:US899073
申请日:1986-08-21
申请人: Yoshiyuki Tahara , Yasuhiro Komatsu , Hiroyasu Koyama , Reiko Kubota , Teruhito Yamaguchi , Toshihiro Takahashi
发明人: Yoshiyuki Tahara , Yasuhiro Komatsu , Hiroyasu Koyama , Reiko Kubota , Teruhito Yamaguchi , Toshihiro Takahashi
IPC分类号: C07D295/12 , A61K31/13 , A61K31/135 , A61P31/12 , C07C67/00 , C07C209/00 , C07C211/09 , C07C211/21 , C07C211/27 , C07C211/44 , C07C213/00 , C07C215/02 , C07C215/10 , C07C215/14 , C07C215/30 , C07C217/56 , C07C217/58 , C07C217/60 , C07C217/62 , C07D273/08 , C07D295/13 , C07D241/04 , C07D295/00
CPC分类号: C07D295/13
摘要: A compound of the formula ##STR1## wherein R.sub.1 is a phenethyl group, R.sub.2 and R.sub.3, taken together with the nitrogen atom to which they are bonded, form an N' hydroxylalkyl substituted piperazine, and (aklylene) is a lower alkylene chain substituted with a hydroxyl group; or an acid addition salt thereof is described.
摘要翻译: 其中R 1是苯乙基,R 2和R 3与它们所键合的氮原子一起形成N'羟基烷基取代的哌嗪,和(a-亚甲基)是被下列基团取代的低级亚烷基链: 羟基; 或其酸加成盐。
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公开(公告)号:US4658063A
公开(公告)日:1987-04-14
申请号:US723084
申请日:1985-04-15
申请人: Yoshiyuki Tahara , Yasuhiro Komatsu , Hiroyasu Koyama , Reiko Kubota , Teruhito Yamaguchi , Toshihiro Takahashi
发明人: Yoshiyuki Tahara , Yasuhiro Komatsu , Hiroyasu Koyama , Reiko Kubota , Teruhito Yamaguchi , Toshihiro Takahashi
IPC分类号: C07D295/12 , A61K31/13 , A61K31/135 , A61P31/12 , C07C67/00 , C07C209/00 , C07C211/09 , C07C211/21 , C07C211/27 , C07C211/44 , C07C213/00 , C07C215/02 , C07C215/10 , C07C215/14 , C07C215/30 , C07C217/56 , C07C217/58 , C07C217/60 , C07C217/62 , C07D273/08 , C07D295/13 , C07C87/28
CPC分类号: C07D295/13
摘要: A compound of the formula ##STR1## wherein R.sub.1 is a phenethyl group, R.sub.2 is a hydrogen atom, R.sub.3 is a lower alkyl group, and (alkylene) is a lower alkylene chain substituted with a hydroxyl group; or an acid addition salt thereof is described.
摘要翻译: 其中R 1是苯乙基,R 2是氢原子,R 3是低级烷基,和(亚烷基)是被羟基取代的低级亚烷基链; 或其酸加成盐。
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公开(公告)号:US4393209A
公开(公告)日:1983-07-12
申请号:US208326
申请日:1980-11-19
IPC分类号: C07D295/02 , A61K31/415 , A61K31/445 , A61K31/495 , A61P31/12 , A61P35/00 , A61P43/00 , C07D231/12 , C07D233/58 , C07D277/04 , C07D295/03 , C07D521/00 , C07D211/06 , C07D239/20 , C07D277/22
CPC分类号: C07D295/03 , C07D231/12 , C07D233/56 , C07D249/08 , C07D277/04
摘要: Decaprenylamines and the acid addition salts thereof, which are useful for controlling virus infection.
摘要翻译: 癸酰胺及其酸加成盐,可用于控制病毒感染。
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公开(公告)号:US4568765A
公开(公告)日:1986-02-04
申请号:US377577
申请日:1982-05-12
申请人: Yoshiyuki Tahara , Yasuhiro Komatsu , Hiroyasu Koyama , Reiko Kubota , Teruhito Yamaguchi , Toshihiro Takahashi
发明人: Yoshiyuki Tahara , Yasuhiro Komatsu , Hiroyasu Koyama , Reiko Kubota , Teruhito Yamaguchi , Toshihiro Takahashi
IPC分类号: A61K31/13 , A61K31/135 , A61K31/16 , A61K31/165 , A61K31/195 , A61P31/12 , A61P43/00 , C07C67/00 , C07C209/00 , C07C211/09 , C07C211/13 , C07C211/14 , C07C211/20 , C07C211/21 , C07C211/22 , C07C211/26 , C07C211/27 , C07C231/00 , C07C231/02 , C07C233/36 , C07C233/78 , C07C87/24 , C07C87/48
CPC分类号: A61K31/13 , A61K31/16 , C07C211/14 , C07C211/22 , C07C211/27
摘要: This invention relates to new isoprenylamine derivatives and acid addition salts thereof, which are useful as medicines for controlling virus infection of vertebrate animals, or the intermediates therefor.
摘要翻译: 本发明涉及新的异戊烯胺衍生物及其酸加成盐,其可用作控制脊椎动物病毒感染的药物或其中间体。
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公开(公告)号:US4514573A
公开(公告)日:1985-04-30
申请号:US377579
申请日:1982-05-12
申请人: Yoshiyuki Tahara , Yasuhiro Komatsu , Hiroyasu Koyama , Reiko Kubota , Teruhito Yamaguchi , Toshihiro Takahashi
发明人: Yoshiyuki Tahara , Yasuhiro Komatsu , Hiroyasu Koyama , Reiko Kubota , Teruhito Yamaguchi , Toshihiro Takahashi
IPC分类号: A61K31/13 , A61K31/135 , A61K31/19 , A61K31/195 , A61P31/12 , A61P43/00 , C07C67/00 , C07C209/00 , C07C211/27 , C07C211/30 , C07C211/43 , C07C213/00 , C07C215/28 , C07C215/46 , C07C215/76 , C07C217/54 , C07C217/56 , C07C217/58 , C07C217/84 , C07C229/38 , C07C229/54 , C07C229/62 , C07C229/64 , C07C229/68 , C07C229/70 , C07C87/28 , C07C101/48
CPC分类号: C07C211/48 , C07C211/29 , C07C211/45 , C07C217/58 , C07C229/60 , C07C229/64
摘要: This invention relates to new isoprenylamine derivatives and acid addition salts thereof, which are useful for controlling virus infection of vertebrate animals.
摘要翻译: 本发明涉及新的异戊烯胺衍生物及其酸加成盐,其可用于控制脊椎动物的病毒感染。
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公开(公告)号:US4431811A
公开(公告)日:1984-02-14
申请号:US362674
申请日:1982-03-29
IPC分类号: A61K31/13 , A61K31/44 , C07D213/38 , C07D213/74 , C07D213/53
CPC分类号: C07D213/74 , A61K31/13 , A61K31/44 , C07D213/38
摘要: New decaprenylamines and the acid addition salts thereof, useful for controlling virus infections in animals, are described.
摘要翻译: 描述了可用于控制动物中的病毒感染的新癸酰胺及其酸加成盐。
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