公开(公告)号：US06770717B2

公开(公告)日：2004-08-03

申请号：US10298111

申请日：2002-11-14

申请人： Young Ha Kim ,  Soo Hyun Kim ,  Soo-Hong Lee ,  Oju Jeon

发明人： Young Ha Kim ,  Soo Hyun Kim ,  Soo-Hong Lee ,  Oju Jeon

IPC分类号： C08G6308

CPC分类号： C08G63/08

摘要： Disclosed is a sequentially ordered biodegradable lactide (or glycolide or lactide/glycolide)/&egr;-caprolactone multi-block copolymers having proper degradation properties and enhanced mechanical properties such as flexibility and elasticity and a process for the preparation thereof.

摘要翻译： 公开了具有适当降解性能和增强的机械性能如柔韧性和弹性的依次有序的可生物降解丙交酯（或乙交酯或丙交酯/乙交酯）/ε-己内酯多嵌段共聚物及其制备方法。

公开(公告)号：US06476156B1

公开(公告)日：2002-11-05

申请号：US09778081

申请日：2001-02-07

申请人： Young Ha Kim ,  Soo Hyun Kim ,  Ki Dong Park ,  Soo-Hong Lee

发明人： Young Ha Kim ,  Soo Hyun Kim ,  Ki Dong Park ,  Soo-Hong Lee

IPC分类号： C08G6308

CPC分类号： C08G65/3324 ,  C08G63/664 ,  C08L71/02 ,  C08L2666/18

摘要： The present invention relates to polyethyleneglycol/polylactide(or polyglycolide or polycaprolactone)/polyethyleneglycol triblock copolymers with an enhanced reactivity, and process for their preparation. More specifically, the present invention is directed to triblock copolymers that are obtained by the process comprising the step of synthesizing a polylactide(or polyglycolide or polycaprolactone) having hydroxy groups at both ends and the step of coupling said polylactide with polyethyleneglycol having an acylhalide group of a high reactivity at one of its ends, and the process for preparing the same Since the triblock copolymer according to the present invention has an ester structure with good biocompatibility, it can be applied extensively for biomaterials used in tissue engineering, in a matrix that slowly releases drugs, etc.

摘要翻译： 本发明涉及具有增强反应性的聚乙二醇/聚丙交酯（或聚乙交酯或聚己内酯）/聚乙二醇三嵌段共聚物及其制备方法。 更具体地说，本发明涉及三嵌段共聚物，该三嵌段共聚物通过包括以下步骤获得的方法：合成在两端具有羟基的聚丙交酯（或聚乙交酯或聚己内酯）和将所述聚交酯与具有酰卤基团的聚乙二醇 在其一端的高反应性及其制备方法由于本发明的三嵌段共聚物具有良好的生物相容性的酯结构，因此可广泛用于组织工程中使用的生物材料 释放药物等

公开(公告)号：US20130035449A1

公开(公告)日：2013-02-07

申请号：US13566483

申请日：2012-08-03

申请人： Young Mee JUNG ,  Soo Hyun Kim ,  Sang Heon Kim ,  Young Ha Kim

发明人： Young Mee JUNG ,  Soo Hyun Kim ,  Sang Heon Kim ,  Young Ha Kim

IPC分类号： B29C47/00 ,  C08L67/04

CPC分类号： C08G63/08 ,  B29C48/0011 ,  B29C48/0018 ,  B29C48/022 ,  B29C48/03 ,  B29C48/79 ,  B29C48/92 ,  B29C2948/92514 ,  B29C2948/9258 ,  B29C2948/92704 ,  B29K2067/043 ,  B29K2067/046 ,  B29K2867/043 ,  B29K2867/046 ,  B29K2995/0056 ,  B29K2995/006

摘要： Disclosed are a method for preparing biodegradable polymer materials, biodegradable polymer materials, and a product for fixing bone. The method includes a complex preparing step of preparing polylactide stereoisomeric complex by using a polymer having weight-average molecular weight more than 100,000 g/mol; a molding step of compression-molding the complex; a cooling step of cooling the compression-molded complex; and an extruding step of solid state extruding the cooled complex. Biodegradable polymer materials prepared by the method may be applied to a product for fixing bone or spine requiring high strength. Biodegradable polymer materials may have no corrosion in the body, may require no additional operation for removal after healing bones and tissues, and may prevent stress shielding.

摘要翻译： 公开了一种制备可生物降解的聚合物材料，可生物降解的聚合物材料和用于固定骨的产品的方法。 该方法包括通过使用重均分子量大于100,000g / mol的聚合物制备聚丙交酯立体异构体络合物的复合制备步骤; 压缩成型复合体的成型步骤; 冷却压缩成形体的冷却工序; 以及固态挤出冷却的复合物的挤出步骤。 通过该方法制备的可生物降解的聚合物材料可以应用于需要高强度的用于固定骨或脊柱的产品。 可生物降解的聚合物材料在体内可能没有腐蚀，在骨骼和组织愈合后不需要额外的去除手术，并且可以防止应力屏蔽。

公开(公告)号：US20070009570A1

公开(公告)日：2007-01-11

申请号：US11482393

申请日：2006-07-06

申请人： Sang Heon Kim ,  Soo Hyun Kim ,  Young Ha Kim ,  Jae Hyun Kwon ,  Min Sub Chung

发明人： Sang Heon Kim ,  Soo Hyun Kim ,  Young Ha Kim ,  Jae Hyun Kwon ,  Min Sub Chung

IPC分类号： A61F2/00 ,  B28B1/08

CPC分类号： A61L27/507 ,  A61L27/18 ,  A61L27/20 ,  A61L27/56 ,  C08L67/04 ,  C08L5/00

摘要： The present invention relates to a method of preparing a porous polymer scaffold for tissue engineering using a gel spinning molding technique. The method of the present invention can prepare a porous polymer scaffold having a uniform pore size, high interconnectivity between pores and mechanical strength, as well as high cell seeding and proliferation efficiencies, which can be effectively used in tissue engineering applications. Further, the method of the present invention can easily mold a porous polymer scaffold in various types such as a tube type favorable for regeneration of blood vessels, esophagus, nerves and the like, as well as a sheet type favorable for regeneration of skins, muscles and the like, by regulating the shape and size of a template shaft.

摘要翻译： 本发明涉及使用凝胶纺丝成型技术制备用于组织工程的多孔聚合物支架的方法。 本发明的方法可以制备具有均匀的孔径，孔之间的高互连性和机械强度的多孔聚合物支架，以及可以有效地用于组织工程应用中的高细胞接种和增殖效率。 此外，本发明的方法可以容易地模制多种类型的多孔聚合物支架，例如有利于血管，食管，神经等的再生的管型，以及有利于皮肤，肌肉再生的片状 通过调节模板轴的形状和尺寸。

公开(公告)号：US06617027B2

公开(公告)日：2003-09-09

申请号：US09816446

申请日：2001-03-26

申请人： Young Ha Kim ,  Ki Dong Park ,  Soo Hyun Kim ,  Won Kyu Lee ,  Hyun Chul Goo

发明人： Young Ha Kim ,  Ki Dong Park ,  Soo Hyun Kim ,  Won Kyu Lee ,  Hyun Chul Goo

IPC分类号： B32B2736

CPC分类号： B82Y30/00 ,  A61L31/088 ,  A61L33/0011 ,  A61L33/0076 ,  A61L33/0082 ,  Y10T428/31504

摘要： Disclosed are surface-modified medical metallic materials and preparation thereof. The medical metallic material is prepared by coating a gold or silver thin layer onto a base metal, adsorbing a polyfunctional sulfur compound onto the gold or silver thin layer, and chemically bonding a biologically active material such as heparin or estradiol to the functional group of the sulfur compound. The biologically active material is firmly bonded to the base metal via the sulfur compound. Being significantly improved in antithrombogenicity and biocompatibility, the metallic materials are suitable for use in various implants, including stents, artificial cardiac valves and catheters.

摘要翻译： 公开了表面改性的医用金属材料及其制备方法。 通过将金或银薄层涂覆在母体金属上，将多官能硫化合物吸附到金或银薄层上，并将生物活性物质如肝素或雌二醇化学键合到所述金属或金属的官能团上来制备医用金属材料 硫化合物。 生物活性物质通过硫化合物牢固地结合到贱金属。 抗凝血性和生物相容性显着提高，金属材料适用于各种植入物，包括支架，人造心脏瓣膜和导管。

公开(公告)号：US06913826B2

公开(公告)日：2005-07-05

申请号：US10682760

申请日：2003-10-08

申请人： Youn-Woo Lee ,  Soo Hyun Kim ,  Young Ha Kim ,  Jong Sung Lim ,  Jong Min Park ,  Ji Won Pack

发明人： Youn-Woo Lee ,  Soo Hyun Kim ,  Young Ha Kim ,  Jong Sung Lim ,  Jong Min Park ,  Ji Won Pack

IPC分类号： C08L101/16 ,  C08G63/08 ,  C08G63/64 ,  C08G63/688 ,  C08G63/78 ,  C08G63/81 ,  C08G63/82 ,  C08G63/88 ,  B32B21/02

CPC分类号： C08G63/64 ,  C08G63/08 ,  C08G63/6882 ,  C08G63/81 ,  C08G63/823 ,  Y02P20/544 ,  Y10T428/2982

摘要： In polymerizing biodegradable polymer material, a compressed gas is used as a reaction solvent for a solution-polymerization, in order to prepare biodegradable polyester homopolymer and copolymer with a high molecular weight in a fine powder form with a particle size of 0.01˜1000 μm.

摘要翻译： 在聚合可生物降解的聚合物材料中，使用压缩气体作为溶液聚合的反应溶剂，以制备具有0.01〜1000μm的粒度的细粉末状的高分子量的可生物降解的聚酯均聚物和共聚物。

公开(公告)号：US08765672B2

公开(公告)日：2014-07-01

申请号：US13550136

申请日：2012-07-16

申请人： Giyoong Tae ,  Bo-young Kim ,  Kihak Gwon ,  Young Ha Kim ,  Myung-Han Yoon

发明人： Giyoong Tae ,  Bo-young Kim ,  Kihak Gwon ,  Young Ha Kim ,  Myung-Han Yoon

IPC分类号： C07K14/50 ,  C07K17/06 ,  C07K17/14

CPC分类号： C08B37/0075 ,  A61K31/727 ,  B01J2219/00612 ,  B01J2219/0063 ,  C08B37/0081

摘要： The present invention relates to a method of modulating a release of biomolecules having heparin-binding affinity, and more specifically, to a method of modulating a release of biomolecules having heparin-binding affinity, using thiolated heparin adsorbed on metal surface. According to the present invention, it is possible to modulate various biomolecules having heparin-binding affinity such as growth factors spatiotemporally by external electrical stimulations, without causing cytotoxicity and having deteriorating effects on cell activity. Thus, the present invention can be applied for various biomedical and biotechnical fields including drug delivery, biosensor, and cell culture.

摘要翻译： 本发明涉及一种调节具有肝素结合亲和力的生物分子的释放方法，更具体地说，涉及使用吸附在金属表面上的硫醇化肝素来调节具有肝素结合亲和力的生物分子释放的方法。 根据本发明，可以通过外部电刺激来时空调制具有肝素结合亲和力的各种生物分子，如生长因子，而不引起细胞毒性并对细胞活性具有恶化作用。 因此，本发明可以应用于各种生物医药和生物技术领域，包括药物递送，生物传感器和细胞培养。

公开(公告)号：US20120087859A1

公开(公告)日：2012-04-12

申请号：US13378330

申请日：2011-01-21

申请人： Gi Yoong Tae ,  Won II Choi ,  Young Ha Kim ,  Ja-Young Kim ,  Jong Hyun Lee

发明人： Gi Yoong Tae ,  Won II Choi ,  Young Ha Kim ,  Ja-Young Kim ,  Jong Hyun Lee

IPC分类号： A61K47/36 ,  A61K38/43 ,  A61K49/00 ,  A61K51/06 ,  A61K49/12 ,  A61K38/02 ,  A61P35/00 ,  A61K31/70 ,  A61K31/7088 ,  A61K39/395 ,  A61K38/22 ,  A61K39/00 ,  A61K38/28 ,  A61K38/19 ,  A61K38/21 ,  A61K38/20 ,  A61K38/18 ,  A61K38/25 ,  A61K38/13 ,  A61K31/713 ,  A61K33/24 ,  A61K31/704 ,  A61K31/337 ,  C08G65/333 ,  C08J3/28 ,  C08F16/06 ,  C08J9/00 ,  C08B37/08 ,  B82Y99/00 ,  B82B3/00

CPC分类号： A61K49/0093 ,  A61K9/0014 ,  A61K9/5161 ,  A61K41/0052

摘要： The present invention relates to a biopolymer-modified nanocarrier in which chitosan is bound to a water-soluble biocompatible polymer that has been crosslinked via a photo-crosslinkable functional group; wherein the chitosan-modified nanocarrier has a diameter which changes in accordance with changes in temperature, has enhanced skin permeability or cellular uptake and selective delivery to cancer tissue as compared with a bare nanocarrier to which chitosan has not been bound, and exhibits characteristics that are advantageous in photothermal therapy. The chitosan-modified nanocarrier of the present invention exhibits highly superior efficacy as a transdermal carrier, since the skin permeability is enhanced to a significant level as compared with a bare nanocarrier that has no chitosan. The chitosan-modified nanocarrier of the present invention can be advantageous in the imaging and photothermal therapy of tumour cells and cancer cells, since the cellular uptake by tumour cells and cancer cells is substantially improved.

摘要翻译： 本发明涉及生物聚合物改性的纳米载体，其中壳聚糖与已经通过光交联官能团交联的水溶性生物相容性聚合物结合; 其中壳聚糖修饰的纳米载体具有根据温度变化而变化的直径，与未结合壳聚糖的裸纳米载体相比具有增强的皮肤渗透性或细胞摄取和选择性递送至癌组织，并且具有以下特征： 有利于光热治疗。 本发明的脱乙酰壳多糖修饰的纳米载体作为透皮载体表现出非常优异的功效，因为与不具有壳聚糖的裸纳米载体相比，皮肤渗透性提高到显着水平。 本发明的壳聚糖修饰的纳米载体可以有利于肿瘤细胞和癌细胞的成像和光热治疗，因为肿瘤细胞和癌细胞的细胞摄取得到显着改善。

公开(公告)号：US20130117950A1

公开(公告)日：2013-05-16

申请号：US13812031

申请日：2011-07-29

申请人： Young Ha Kim

发明人： Young Ha Kim

IPC分类号： A61C17/22

CPC分类号： A46B15/0034 ,  A61C17/22 ,  A61C17/221 ,  A61C17/222 ,  A61C17/32 ,  A61C19/06 ,  A61C19/066 ,  A61N5/06 ,  A61N5/0603 ,  A61N5/0624 ,  A61N2005/0606 ,  A61N2005/0651

摘要： One aspect of the present invention relates to an electric toothbrush in which an LED unit is mounted to perform oral sterilization and tooth whitening treatment during the brushing of the teeth, and further relates to a toothbrush bristle assembly for the electric toothbrush. The electric toothbrush according to one embodiment of the present invention comprises: a toothbrush bristle assembly including a handle having a vibrator, and a coupling space into which the vibrator is coupled. The toothbrush bristle assembly comprises: a toothbrush bristle body having a brush; an LED unit mounted on the toothbrush bristle body to perform oral sterilization and tooth whitening treatment; and a connector module having a first connector arranged in the toothbrush bristle body to interconnect the LED unit and a driving power source, as well as a second connector arranged in the vibrator.

摘要翻译： 本发明的一个方面涉及一种电动牙刷，其中安装LED单元以在刷牙期间进行口腔灭菌和牙齿增白处理，并且还涉及一种用于电动牙刷的牙刷刷毛组件。 根据本发明的一个实施例的电动牙刷包括：牙刷刷毛组件，其包括具有振动器的手柄和耦合空间，振动器耦合到该耦合空间中。 牙刷刷毛组件包括：具有刷子的牙刷刷毛体; 安装在牙刷刷毛体上的LED单元进行口腔灭菌和牙齿美白处理; 以及连接器模块，其具有布置在所述牙刷刷毛体中的第一连接器，以连接所述LED单元和驱动电源，以及布置在所述振动器中的第二连接器。

公开(公告)号：US5697972A

公开(公告)日：1997-12-16

申请号：US480318

申请日：1995-06-07

申请人： Young Ha Kim ,  Ki Dong Park ,  Dong Keun Han ,  Hack Joo Kim

发明人： Young Ha Kim ,  Ki Dong Park ,  Dong Keun Han ,  Hack Joo Kim

IPC分类号： A61L27/00 ,  A61F2/24 ,  A61L27/34 ,  A61L27/36

CPC分类号： A61L27/3687 ,  A61L27/34 ,  A61L27/3604 ,  A61L27/3625 ,  A61L27/3645 ,  A61L27/507 ,  A61F2/24 ,  A61L2400/02 ,  Y10S623/901 ,  Y10S623/918

摘要： The specification describes an invention of calcification resistant bioprosthetic heart valves which can be used for a long term, and have good blood compatibility and in vivo stability, and have high calcification resistance. The bioprosthetic heart valves of the invention can be prepared by binding sulfonated polyethylene oxide (PEO) derivatives covalently to the tissue. The valves have an anionic effect equal to that of chondroitin sulfate, space filling effect, and blocking effect of the carboxyl group of collagen which has been known as one factor of the calcium deposition,. In particular, the present method has better advantages in view of calcification resistance than any other conventional methods, because it suppresses thrombosis and embolism and decreases incidence of infection.

摘要翻译： 该说明书是能够长期使用且具有良好的血液相容性和体内稳定性，耐钙化性高的生物假体心脏瓣膜的发明。 本发明的生物假体心脏瓣膜可以通过将磺化聚环氧乙烷（PEO）衍生物共价结合到组织来制备。 这些阀具有与硫酸软骨素相当的阴离子效应，空间填充效应和被称为钙沉积的一个因素的胶原羧基的阻断作用。 特别地，本方法考虑到耐钙化性优于任何其它常规方法，因为其抑制血栓形成和栓塞并降低感染发生率。