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    METHOD FOR PREPARING BIODEGRADABLE POLYMER MATERIALS, BIODEGRADABLE POLYMER MATERIALS AND PRODUCT FOR FIXING BONE
    1.
    发明申请
    METHOD FOR PREPARING BIODEGRADABLE POLYMER MATERIALS, BIODEGRADABLE POLYMER MATERIALS AND PRODUCT FOR FIXING BONE 审中-公开
    制备生物可降解聚合物材料的方法，可生物降解的聚合物材料和固定骨的产品

    公开(公告)号：US20130035449A1

    公开(公告)日：2013-02-07

    申请号：US13566483

    申请日：2012-08-03

    申请人： Young Mee JUNG ,  Soo Hyun Kim ,  Sang Heon Kim ,  Young Ha Kim

    发明人： Young Mee JUNG ,  Soo Hyun Kim ,  Sang Heon Kim ,  Young Ha Kim

    IPC分类号： B29C47/00 ,  C08L67/04

    CPC分类号： C08G63/08 ,  B29C48/0011 ,  B29C48/0018 ,  B29C48/022 ,  B29C48/03 ,  B29C48/79 ,  B29C48/92 ,  B29C2948/92514 ,  B29C2948/9258 ,  B29C2948/92704 ,  B29K2067/043 ,  B29K2067/046 ,  B29K2867/043 ,  B29K2867/046 ,  B29K2995/0056 ,  B29K2995/006

    摘要： Disclosed are a method for preparing biodegradable polymer materials, biodegradable polymer materials, and a product for fixing bone. The method includes a complex preparing step of preparing polylactide stereoisomeric complex by using a polymer having weight-average molecular weight more than 100,000 g/mol; a molding step of compression-molding the complex; a cooling step of cooling the compression-molded complex; and an extruding step of solid state extruding the cooled complex. Biodegradable polymer materials prepared by the method may be applied to a product for fixing bone or spine requiring high strength. Biodegradable polymer materials may have no corrosion in the body, may require no additional operation for removal after healing bones and tissues, and may prevent stress shielding.

    摘要翻译： 公开了一种制备可生物降解的聚合物材料，可生物降解的聚合物材料和用于固定骨的产品的方法。 该方法包括通过使用重均分子量大于100,000g / mol的聚合物制备聚丙交酯立体异构体络合物的复合制备步骤; 压缩成型复合体的成型步骤; 冷却压缩成形体的冷却工序; 以及固态挤出冷却的复合物的挤出步骤。 通过该方法制备的可生物降解的聚合物材料可以应用于需要高强度的用于固定骨或脊柱的产品。 可生物降解的聚合物材料在体内可能没有腐蚀，在骨骼和组织愈合后不需要额外的去除手术，并且可以防止应力屏蔽。

    METHOD FOR DIFFERENTIATION OF STEM CELLS INTO VASCULAR CELLS AND THE INDUCTION OF ANGIOGENESIS USING THE SAME
    3.
    发明申请
    METHOD FOR DIFFERENTIATION OF STEM CELLS INTO VASCULAR CELLS AND THE INDUCTION OF ANGIOGENESIS USING THE SAME 有权
    将干细胞分化成血管细胞的方法和使用其的血管生成的诱导

    公开(公告)号：US20120134965A1

    公开(公告)日：2012-05-31

    申请号：US13259767

    申请日：2010-03-24

    申请人： Sang-Heon Kim ,  Soo Hyun Kim ,  In Su Park ,  Young Mee Jung

    发明人： Sang-Heon Kim ,  Soo Hyun Kim ,  In Su Park ,  Young Mee Jung

    IPC分类号： A61K35/12 ,  C12N5/077 ,  C12N5/0775 ,  C12N5/0797 ,  A61P25/00 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P9/04 ,  C12N5/071 ,  C12N5/0789

    CPC分类号： C12N5/069 ,  A61K35/28 ,  A61K35/30 ,  A61K35/44 ,  A61K35/51 ,  A61K35/545 ,  C12N2501/115 ,  C12N2506/1384 ,  C12N2513/00 ,  C12N2533/52 ,  C12N2533/54 ,  C12N2533/70

    摘要： The present invention relates to a method for differentiating stem cells into vascular cells by culturing them in the form of a three-dimensional cell cluster and the use of the three-dimensional cell cluster for angiogenesis. Specifically, the present invention teaches a method for differentiating stem cells into vascular cells comprising culturing stem cells by adhering them onto a culture plate with a surface having a hydrophobic property or a culture plate onto which a growth factor is immobilized, wherein the cultured stem cells are later detached from the culture plate as their density increases to form a three-dimensional cell cluster and grown in the form of a three-dimensional cell cluster while differentiating into vascular cells. Also disclosed is the use of a three-dimensional cell cluster composed of the vascular cells differentiated from stem cells by the above method as a cell therapy agent for angiogenesis.

    摘要翻译： 本发明涉及一种通过以三维细胞簇的形式培养它们并使用三维细胞簇进行血管发生来将干细胞分化为血管细胞的方法。 具体而言，本发明教导了将干细胞分化成血管细胞的方法，包括通过将干细胞粘附在具有疏水性的表面的培养板上或培养板上固定有生长因子培养干细胞，其中培养的干细胞 随着其密度增加而随培养板分离，形成三维细胞簇，并以三维细胞簇的形式生长，同时分化为血管细胞。 还公开了通过上述方法将由干细胞分化的血管细胞组成的三维细胞簇用作血管发生的细胞治疗剂。

    METHOD FOR PREPARING BIODEGRADABLE POLYMER STEREOCOMPLEXES USING A SUPERCRITICAL FLUID-ORGANIC SOLVENT SYSTEM AND STEREOCOMPLEXES PREPARED BY THE SAME
    7.
    发明申请
    METHOD FOR PREPARING BIODEGRADABLE POLYMER STEREOCOMPLEXES USING A SUPERCRITICAL FLUID-ORGANIC SOLVENT SYSTEM AND STEREOCOMPLEXES PREPARED BY THE SAME 有权
    使用超临界流体有机溶剂系统制备可生物降解的聚合物立体异构体的方法及其制备的立体异构体

    公开(公告)号：US20110201710A1

    公开(公告)日：2011-08-18

    申请号：US12948621

    申请日：2010-11-17

    申请人： Soo Hyun Kim ,  Young Mee Jung ,  Sang-Heon Kim ,  Purnama Purba

    发明人： Soo Hyun Kim ,  Young Mee Jung ,  Sang-Heon Kim ,  Purnama Purba

    IPC分类号： C08J9/00 ,  C08G63/08

    CPC分类号： C08J3/005 ,  C08J9/0061 ,  C08J2203/08 ,  C08J2300/12 ,  C08J2300/16 ,  C08J2367/04 ,  C08J2369/00 ,  C08J2373/02 ,  C08J2400/14 ,  C08J2467/00 ,  C08J2469/00 ,  C08J2473/00

    摘要： The present invention relates to methods for preparing biodegradable polymer stereocomplexes using a supercritical fluid-organic solvent system and polymer stereocomplexes prepared by such methods. The method of the present invention involves introducing two types of homopolymers having different stereostructures and a small amount of organic solvent into a reactor, adding a supercritical fluid thereto, followed by applying a specific temperature and pressure to form a polymer stereocomplex having a crystalline structure. According to the method of the present invention, biodegradable polymer stereocomplexes in the form of powder or porous foam having excellent thermal and mechanical stabilities can be prepared in a simple, economical and environmentally-friendly manner in a single process.

    摘要翻译： 本发明涉及使用超临界流体 - 有机溶剂体系制备可生物降解的聚合物立体络合物的方法和通过这些方法制备的聚合物立体络合物。 本发明的方法包括将具有不同立体结构和少量有机溶剂的两种均聚物引入反应器中，向其中加入超临界流体，然后施加特定的温度和压力以形成具有结晶结构的聚合物立体络合物。 根据本发明的方法，可以在单一方法中以简单，经济和环保的方式制备具有优异热稳定性和机械稳定性的粉末或多孔泡沫形式的可生物降解的聚合物立体络合物。

    Method for preparing porous polymer scaffold for tissue engineering using gel spinning molding technique
    8.
    发明申请
    Method for preparing porous polymer scaffold for tissue engineering using gel spinning molding technique 审中-公开
    使用凝胶纺丝成型技术制备组织工程多孔聚合物支架的方法

    公开(公告)号：US20070009570A1

    公开(公告)日：2007-01-11

    申请号：US11482393

    申请日：2006-07-06

    申请人： Sang Heon Kim ,  Soo Hyun Kim ,  Young Ha Kim ,  Jae Hyun Kwon ,  Min Sub Chung

    发明人： Sang Heon Kim ,  Soo Hyun Kim ,  Young Ha Kim ,  Jae Hyun Kwon ,  Min Sub Chung

    IPC分类号： A61F2/00 ,  B28B1/08

    CPC分类号： A61L27/507 ,  A61L27/18 ,  A61L27/20 ,  A61L27/56 ,  C08L67/04 ,  C08L5/00

    摘要： The present invention relates to a method of preparing a porous polymer scaffold for tissue engineering using a gel spinning molding technique. The method of the present invention can prepare a porous polymer scaffold having a uniform pore size, high interconnectivity between pores and mechanical strength, as well as high cell seeding and proliferation efficiencies, which can be effectively used in tissue engineering applications. Further, the method of the present invention can easily mold a porous polymer scaffold in various types such as a tube type favorable for regeneration of blood vessels, esophagus, nerves and the like, as well as a sheet type favorable for regeneration of skins, muscles and the like, by regulating the shape and size of a template shaft.

    摘要翻译： 本发明涉及使用凝胶纺丝成型技术制备用于组织工程的多孔聚合物支架的方法。 本发明的方法可以制备具有均匀的孔径，孔之间的高互连性和机械强度的多孔聚合物支架，以及可以有效地用于组织工程应用中的高细胞接种和增殖效率。 此外，本发明的方法可以容易地模制多种类型的多孔聚合物支架，例如有利于血管，食管，神经等的再生的管型，以及有利于皮肤，肌肉再生的片状 通过调节模板轴的形状和尺寸。

    PREPARATION METHOD OF FLEXIBLE POLYLACTIDE STEREOCOMPLEX AND THE COMPOUND THEREOF
    9.
    发明申请
    PREPARATION METHOD OF FLEXIBLE POLYLACTIDE STEREOCOMPLEX AND THE COMPOUND THEREOF 有权

    公开(公告)号：US20130053464A1

    公开(公告)日：2013-02-28

    申请号：US13285322

    申请日：2011-10-31

    申请人： Chae Hwan Hong ,  Do Suck Han ,  Soo Hyun Kim ,  Young Mee Jung

    发明人： Chae Hwan Hong ,  Do Suck Han ,  Soo Hyun Kim ,  Young Mee Jung

    IPC分类号： C08G81/00

    CPC分类号： C08G63/08 ,  C08G63/81 ,  C08J9/28 ,  C08J2367/04 ,  Y02P20/544

    摘要： Disclosed are a polylactide stereocomplex with improved thermal stability and thus improved processability and a method for preparing the same. In order to confer flexibility to polymer chains, D-type polylactide polymer containing a small amount of caprolactone (poly D-lactide-caprolactone copolymer) is synthesized and it is uniformly mixed with L-type single-phase polylactide to prepare a flexible polylactide stereocomplex. Since the polylactide stereocomplex having flexible polymer chains has superior heat resistance and mechanical stability and experiences little decrease of the degree of stereocomplex formation even after thermal processing, the polylactide stereocomplex having improved thermal stability can be advantageously used for engineering plastics requiring high strength and good thermal stability, alternative materials for general-use plastics, high-performance medical materials, or the like because of its remarkably improved processability.

    Preparation method of flexible polylactide stereocomplex and the compound thereof
    10.
    发明授权
    Preparation method of flexible polylactide stereocomplex and the compound thereof 有权
    柔性聚交酯立体络合物的制备方法及其化合物

    公开(公告)号：US08889797B2

    公开(公告)日：2014-11-18

    申请号：US13285322

    申请日：2011-10-31

    申请人： Chae Hwan Hong ,  Do Suck Han ,  Soo Hyun Kim ,  Young Mee Jung

    发明人： Chae Hwan Hong ,  Do Suck Han ,  Soo Hyun Kim ,  Young Mee Jung

    IPC分类号： C08G63/08 ,  C08J9/00 ,  C08J9/12 ,  C08G63/81

    CPC分类号： C08G63/08 ,  C08G63/81 ,  C08J9/28 ,  C08J2367/04 ,  Y02P20/544

    摘要： Disclosed are a polylactide stereocomplex with improved thermal stability and thus improved processability and a method for preparing the same. In order to confer flexibility to polymer chains, D-type polylactide polymer containing a small amount of caprolactone (poly D-lactide-caprolactone copolymer) is synthesized and it is uniformly mixed with L-type single-phase polylactide to prepare a flexible polylactide stereocomplex. Since the polylactide stereocomplex having flexible polymer chains has superior heat resistance and mechanical stability and experiences little decrease of the degree of stereocomplex formation even after thermal processing, the polylactide stereocomplex having improved thermal stability can be advantageously used for engineering plastics requiring high strength and good thermal stability, alternative materials for general-use plastics, high-performance medical materials, or the like because of its remarkably improved processability.

    摘要翻译： 公开了具有改进的热稳定性和因此改善的加工性的聚交酯立体络合物及其制备方法。 为了赋予聚合物链柔性，合成含有少量己内酯（聚D-丙交酯 - 己内酯共聚物）的D型聚丙交酯聚合物，并与L型单相聚丙烯酸酯均匀混合以制备柔性聚交酯立体络合物 。 由于具有柔性聚合物链的聚交酯立体络合物具有优异的耐热性和机械稳定性，并且即使在热加工后也几乎不降低立体复合物形成程度，所以具有改善的热稳定性的聚交酯立体络合物可有利地用于需要高强度和良好热的工程塑料 稳定性，一般用途塑料的替代材料，高性能医疗材料等，因为其显着改进的加工性能。