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    2-benzoylimidazopyridine derivatives, preparation and therapeutic use thereof
    2.
    发明授权
    2-benzoylimidazopyridine derivatives, preparation and therapeutic use thereof 失效
    2-苯甲酰基咪唑并吡啶衍生物，其制备和治疗用途

    公开(公告)号：US07902219B2

    公开(公告)日：2011-03-08

    申请号：US12336989

    申请日：2008-12-17

    申请人： Jean-Francois Peyronel ,  Youssef El-Ahmad

    发明人： Jean-Francois Peyronel ,  Youssef El-Ahmad

    IPC分类号： A61K31/437 ,  C07D471/04

    CPC分类号： C07D471/04

    摘要： The present invention is related to a compound of formula (I) wherein R1, R2, R3, R4 and X are as defined herein, or an acid-addition salt thereof, its preparation and therapeutic use in the treatment or prevention of diseases involving the Nurr-1 nuclear receptors, also known as NR4A2, NOT, TINUR, RNR-1 and HZF3.

    摘要翻译： 本发明涉及其中R 1，R 2，R 3，R 4和X如本文所定义的式（I）化合物或其酸加成盐，其在治疗或预防涉及 Nurr-1核受体，也称为NR4A2，NOT，TINUR，RNR-1和HZF3。

    Process for preparing 3-fluoroquinolines
    5.
    发明授权
    Process for preparing 3-fluoroquinolines 失效
    制备3-氟喹啉的方法

    公开(公告)号：US07396934B2

    公开(公告)日：2008-07-08

    申请号：US10985533

    申请日：2004-11-10

    申请人： Youssef El-Ahmad ,  Jean-Pierre Leconte ,  Joël Malpart ,  Serge Mignani ,  Stéphane Mutti ,  Michel Tabart

    发明人： Youssef El-Ahmad ,  Jean-Pierre Leconte ,  Joël Malpart ,  Serge Mignani ,  Stéphane Mutti ,  Michel Tabart

    IPC分类号： C07D215/38 ,  C07D215/18

    CPC分类号： C07D215/38 ,  C07D215/18 ,  Y02P20/55

    摘要： The invention relates to a novel preparation of 3-fluoroquinolines of formula (I) in which R1, R2, R3 and R4 represent: a) a fluorine; b) an alkyl optionally substituted with one to three fluorines, with OR5 in which R5 is an alkyl, a hydrogen or a hydroxyl-protecting group, or with NR′R″ in which R′ and R″ represent an alkyl, a hydrogen or an amino-protecting group; c) OR6 in which R6 represents a hydrogen, a phenol-protecting group or an alkyl, optionally substituted with a fluorine, with OR5 or with NR′R″ as defined above; d) NR′1R″1 in which R′1 and R″1 have the values of R′ et R″ or represent an alkyl substituted with a fluorine, with OR5 or NR′R″ as defined above; e) CO2Ra, in which Ra represents hydrogen, alkyl or a carboxyl-protecting group, and also novel intermediate compounds. The quinolines of formula (I) are intermediates useful in the preparation of compounds having antibacterial activity, described in particular in applications WO 02/40474 or WO 02/72572.

    摘要翻译： 本发明涉及式（I）的3-氟喹啉的新型制备方法，其中R 1，R 2，R 3和R 3， 代表：a）氟; b）任选被一至三个氟取代的烷基，其中R 5是烷基，氢或羟基保护基或NR' 其中R'和R“表示烷基，氢或氨基保护基的”R“ c）OR 6其中R 6表示氢，苯酚保护基或任选被氟取代的烷基，OR 5或N >或如上定义的NR'R“ d）NR'1 R“1其中R'1和R”1 <1的数值为 或者代表被氟取代的烷基，其具有如上定义的OR 5或NR'R“; e）其中R aa代表氢，烷基或羧基保护基，以及新的中间体化合物的CO 2 CO 2。 式（I）的喹啉是可用于制备具有抗菌活性的化合物的中间体，特别在申请WO 02/40474或WO 02/72572中有所描述。