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    Method for biomolecule immobilization
    1.
    发明申请
    Method for biomolecule immobilization 审中-公开
    生物分子固定方法

    公开(公告)号：US20090111713A1

    公开(公告)日：2009-04-30

    申请号：US12153911

    申请日：2008-05-28

    申请人： Yu-Chia Tsao ,  Yi-Wen Yang ,  Ko-Shao Chen ,  Tsui-Shan Hung ,  Shu-Juan Liao

    发明人： Yu-Chia Tsao ,  Yi-Wen Yang ,  Ko-Shao Chen ,  Tsui-Shan Hung ,  Shu-Juan Liao

    IPC分类号： C40B50/18

    CPC分类号： C40B50/18 ,  C08F291/00 ,  C08F292/00 ,  C40B40/04

    摘要： The present invention relates to a method for biomolecule immobilization, comprising: providing a substrate; forming a surface modification layer of carboxy groups on one surface of the substrate, wherein the process for forming the surface modification layer comprises plasma surface modification; and providing pluralities of biomolecules and bonding the biomolecules with the surface modification layer. Accordingly, the method for biomolecule immobilization of the present invention can reduce manufacturing time and enhance the stability of manufacture. In addition, the method can be employed in a biosensor to efficiently enhance sensitivity of the biosensor.

    摘要翻译： 本发明涉及一种生物分子固定方法，包括：提供底物; 在基板的一个表面上形成羧基的表面改性层，其中形成表面改性层的方法包括等离子体表面改性; 并提供多个生物分子并将生物分子与表面改性层结合。 因此，本发明的生物分子固定方法可以缩短制造时间，提高制造稳定性。 此外，该方法可以用于生物传感器中以有效地提高生物传感器的灵敏度。

    Method for real-time monitoring thickness chance of coating film
    2.
    发明授权
    Method for real-time monitoring thickness chance of coating film 有权
    实时监测涂膜厚度变化的方法

    公开(公告)号：US08377503B2

    公开(公告)日：2013-02-19

    申请号：US12662546

    申请日：2010-04-22

    申请人： Yu-Chia Tsao ,  Chung-Pei Lee ,  Ko-Shao Chen ,  Jia-Huey Tsao ,  Chun-Chih Lin ,  Ren-Kun Liang

    发明人： Yu-Chia Tsao ,  Chung-Pei Lee ,  Ko-Shao Chen ,  Jia-Huey Tsao ,  Chun-Chih Lin ,  Ren-Kun Liang

    IPC分类号： C23C14/54

    CPC分类号： C23C16/44 ,  G01N21/553

    摘要： A method for real-timely monitoring thickness change of a coating film is disclosed. In the method, a coating module having a chamber and a film thickness-monitoring module containing an SPR optical fiber sensor, a light source, a light-receiving detector, and optical fibers are first provided. The optical fibers are used to connect the SPR optical fiber sensor with the light source and the light-receiving detector. The SPR optical fiber sensor has a sensing area and is arranged in the chamber. The light source provides the SPR optical fiber sensor with light. Then, a substrate is put into the chamber. While coating process is performed on the substrate, a film is also formed on the sensing area of the SPR optical fiber sensor. The light-receiving detector receives signals output from the sensing area of the SPR optical fiber sensor and then outputs signals of light-intensity change.

    摘要翻译： 公开了一种用于实时监测涂膜厚度变化的方法。 在该方法中，首先提供具有室的涂布模块和包含SPR光纤传感器，光源，光接收检测器和光纤的膜厚监测模块。 光纤用于将SPR光纤传感器与光源和光接收检测器连接。 SPR光纤传感器具有感测区域，并且布置在腔室中。 光源为SPR光纤传感器提供光源。 然后，将基板放入室中。 虽然在基板上进行涂布处理，但是也在SPR光纤传感器的感测区域上形成膜。 光接收检测器接收从SPR光纤传感器的感测区域输出的信号，然后输出光强变化的信号。

    Coating apparatus and method for real-timely monitoring thickness change of coating film
    3.
    发明申请
    Coating apparatus and method for real-timely monitoring thickness change of coating film 有权
    涂膜设备及实时监测涂膜厚度变化的方法

    公开(公告)号：US20110151107A1

    公开(公告)日：2011-06-23

    申请号：US12662546

    申请日：2010-04-22

    申请人： Yu-Chia Tsao ,  Chung-Pei Lee ,  Ko-Shao Chen ,  Jia-Huey Tsao ,  Chun-Chih Lin ,  Ren-Kun Liang

    发明人： Yu-Chia Tsao ,  Chung-Pei Lee ,  Ko-Shao Chen ,  Jia-Huey Tsao ,  Chun-Chih Lin ,  Ren-Kun Liang

    IPC分类号： C23C16/44 ,  C23C16/00

    CPC分类号： C23C16/44 ,  G01N21/553

    摘要： A method for real-timely monitoring thickness change of a coating film is disclosed. In the method, a coating module having a chamber and a film thickness-monitoring module containing an SPR optical fiber sensor, a light source, a light-receiving detector, and optical fibers are first provided. The optical fibers are used to connect the SPR optical fiber sensor with the light source and the light-receiving detector. The SPR optical fiber sensor has a sensing area and is arranged in the chamber. The light source provides the SPR optical fiber sensor with light. Then, a substrate is put into the chamber. While coating process is performed on the substrate, a film is also formed on the sensing area of the SPR optical fiber sensor. The light-receiving detector receives signals output from the sensing area of the SPR optical fiber sensor and then outputs signals of light-intensity change.

    摘要翻译： 公开了一种用于实时监测涂膜厚度变化的方法。 在该方法中，首先提供具有室的涂布模块和包含SPR光纤传感器，光源，光接收检测器和光纤的膜厚监视模块。 光纤用于将SPR光纤传感器与光源和光接收检测器连接。 SPR光纤传感器具有感测区域，并且布置在腔室中。 光源为SPR光纤传感器提供光源。 然后，将基板放入室中。 虽然在基板上进行涂布处理，但是也在SPR光纤传感器的感测区域上形成膜。 光接收检测器接收从SPR光纤传感器的感测区域输出的信号，然后输出光强变化的信号。

    Phototherapy patch
    5.
    发明申请
    Phototherapy patch 审中-公开
    光疗补丁

    公开(公告)号：US20110306918A1

    公开(公告)日：2011-12-15

    申请号：US12805739

    申请日：2010-08-18

    申请人： Yu-Chia Tsao ,  Yi-Wen Yang ,  Jung-Chien Chang

    发明人： Yu-Chia Tsao ,  Yi-Wen Yang ,  Jung-Chien Chang

    IPC分类号： A61N5/06 ,  A61M35/00

    CPC分类号： A61K9/0097 ,  A61K9/7084 ,  A61N5/0616 ,  A61N2005/0645 ,  A61N2005/0656 ,  A61N2005/0659 ,  A61N2005/0662

    摘要： A phototherapy patch is disclosed, which includes: an adhesive layer, having a first surface and an opposite second surface; a pharmaceutical drug layer, disposed on the first surface of the adhesive layer; and a spontaneous emission layer, disposed over the pharmaceutical drug layer and capable of emitting therapeutic light by light illumination or a chemical reaction. Accordingly, the phototherapy patch according to the present invention has no power supply disposed therein, and thereby is suitable to be manufactured as a particularly thin and thus inconspicuous device.

    摘要翻译： 公开了一种光疗贴片，其包括：具有第一表面和相对的第二表面的粘合剂层; 药物层，设置在粘合剂层的第一表面上; 以及设置在药物药物层上并能够通过光照射或化学反应发射治疗光的自发发射层。 因此，根据本发明的光疗贴片没有设置在其中的电源，因此适合制造为特别薄且因此不显眼的装置。

    Phototherapy patch
    6.
    发明授权
    Phototherapy patch 失效
    光疗补丁

    公开(公告)号：US08478396B2

    公开(公告)日：2013-07-02

    申请号：US13552921

    申请日：2012-07-19

    申请人： Yu-Chia Tsao ,  Yi-Wen Yang ,  Jung-Chien Chang

    发明人： Yu-Chia Tsao ,  Yi-Wen Yang ,  Jung-Chien Chang

    IPC分类号： A61N1/30

    CPC分类号： A61K9/0097 ,  A61K9/7084 ,  A61N5/0616 ,  A61N2005/0645 ,  A61N2005/0656 ,  A61N2005/0659 ,  A61N2005/0662

    摘要： A phototherapy patch is disclosed, which includes: an adhesive layer, having a first surface and an opposite second surface; a pharmaceutical drug layer, disposed on the first surface of the adhesive layer; and a spontaneous emission layer, disposed over the pharmaceutical drug layer and capable of emitting therapeutic light by light illumination or a chemical reaction. Accordingly, the phototherapy patch according to the present invention has no power supply disposed therein, and thereby is suitable to be manufactured as a particularly thin and thus inconspicuous device.

    摘要翻译： 公开了一种光疗贴片，其包括：具有第一表面和相对的第二表面的粘合剂层; 药物层，设置在粘合剂层的第一表面上; 以及设置在药物药物层上并能够通过光照射或化学反应发射治疗光的自发发射层。 因此，根据本发明的光疗贴片没有设置在其中的电源，因此适合制造为特别薄且因此不显眼的装置。

    PHOTOTHERAPY DEVICE
    7.
    发明申请
    PHOTOTHERAPY DEVICE 审中-公开
    照相装置

    公开(公告)号：US20130096657A1

    公开(公告)日：2013-04-18

    申请号：US13484307

    申请日：2012-05-31

    申请人： Yi-Wen YANG ,  Jung-Chien Chang ,  Ming-Da Yang ,  Chen-Ho Cheng ,  Yu-Chia Tsao

    发明人： Yi-Wen YANG ,  Jung-Chien Chang ,  Ming-Da Yang ,  Chen-Ho Cheng ,  Yu-Chia Tsao

    IPC分类号： A61N5/06

    CPC分类号： A61N5/0616 ,  A61B2017/00115 ,  A61B2090/049 ,  A61N2005/0628 ,  A61N2005/063 ,  A61N2005/0644 ,  A61N2005/0652

    摘要： The present invention relates to a phototherapy device, which is driven by a power supply and includes: a housing, having a top portion, a bottom portion and a handheld portion, where the top portion has a light outlet, the handheld portion connects the top portion and the bottom portion, and the handheld portion has at least one protruding part; a light-transmitting plate, which covers the light outlet; a light-blocking part, formed into a protruding rim along the circumferential direction of the light outlet; an LED module, disposed in the housing and corresponding to the light outlet; and a control module, electrically connected to the power supply and the LED module. Accordingly, the phototherapy device according to the present invention is suitable for handheld use.

    摘要翻译： 本发明涉及一种由电源驱动的光疗装置，包括：具有顶部，底部和手持部分的壳体，其中顶部具有光出口，手持部分连接顶部 部分和底部，并且手持部分具有至少一个突出部分; 透光板，其覆盖光出口; 遮光部，沿着光出口的圆周方向形成为突出的边缘; LED模块，设置在所述壳体中并对应于所述灯出口; 以及电连接到电源和LED模块的控制模块。 因此，根据本发明的光疗装置适用于手持式使用。

    Surface plasmon resonance sensing device
    9.
    发明申请
    Surface plasmon resonance sensing device 失效
    表面等离子体共振检测装置

    公开(公告)号：US20110157590A1

    公开(公告)日：2011-06-30

    申请号：US12662545

    申请日：2010-04-22

    申请人： Chung-Pei Lee ,  Yu-Chia Tsao ,  Woo-Hu Tsai ,  Hsiang-Chih Hsu

    发明人： Chung-Pei Lee ,  Yu-Chia Tsao ,  Woo-Hu Tsai ,  Hsiang-Chih Hsu

    IPC分类号： G01N21/55

    CPC分类号： G01N21/553 ,  G01N2201/0221

    摘要： A surface plasmon resonance sensing device that is portable, and having the fiber sensing unit whose resonant wavelength being within the transmission range of a single-mode fiber or a multi-mode fiber, is disclosed. The disclosed sensing device comprises: a light source unit, a fiber sensing unit, an optical sensor, a plurality of fibers, and a computing and displaying unit. The fiber sensing unit includes a trench, a cladding layer, a core layer, a first metallic layer, and a plurality of dielectric thin film layers, wherein the first metallic layer covers the trench, and the plurality of dielectric thin film layers forms on the first metallic layer. The light source provided by the light source unit will become a light signal, after the light passes through the fiber sensing unit. The optical sensor transforms the light signal into a corresponding electric signal, for the usage of the computing and displaying unit.

    摘要翻译： 公开了一种便携式的表面等离子体共振感测装置，其具有谐振波长在单模光纤或多模光纤的传输范围内的光纤传感单元。 所公开的感测装置包括：光源单元，光纤感测单元，光学传感器，多个光纤以及计算和显示单元。 光纤感测单元包括沟槽，包覆层，芯层，第一金属层和多个电介质薄膜层，其中第一金属层覆盖沟槽，并且多个电介质薄膜层形成在 第一金属层。 在光通过光纤感测单元之后，由光源单元提供的光源将成为光信号。 光学传感器将光信号转换成相应的电信号，以用于计算和显示单元的使用。

    Method of improving optical sensor
    10.
    发明申请
    Method of improving optical sensor 审中-公开
    改善光学传感器的方法

    公开(公告)号：US20110064886A1

    公开(公告)日：2011-03-17

    申请号：US12656855

    申请日：2010-02-18

    申请人： Yu-Chia Tsao ,  Min-Tzu Chao ,  Woo-Hu Tsai ,  Shu-Ting Chang ,  Hsiao-Ling Yeh

    发明人： Yu-Chia Tsao ,  Min-Tzu Chao ,  Woo-Hu Tsai ,  Shu-Ting Chang ,  Hsiao-Ling Yeh

    IPC分类号： B05D3/04

    CPC分类号： G01N21/7703 ,  G01N21/553

    摘要： A method for improving an optical sensor is disclosed, which includes the following steps: providing an optical sensor; acid-treating the surface of the optical sensor; forming a thin metal film on the acid-treated surface of the optical sensor; and plasma-modifying the thin metal film on the optical sensor. The aforesaid method is to clean the surface of the optical sensor and then to improve the hydrophilicity thereof by acid treatment. The thin metal film subsequently formed has good flatness and improved adhesion to the optical sensor. Once the optical sensor has the improved hydrophilicity, the plasma modification is performed to further improve optical performance of the optical sensor.

    摘要翻译： 公开了一种改进光学传感器的方法，包括以下步骤：提供光学传感器; 对光学传感器的表面进行酸处理; 在光学传感器的酸处理表面上形成薄金属膜; 并对光学传感器上的薄金属膜进行等离子体修饰。 上述方法是清洁光学传感器的表面，然后通过酸处理改善其亲水性。 随后形成的薄金属膜具有良好的平整度和对光学传感器的改善的粘合性。 一旦光学传感器具有改善的亲水性，则进行等离子体修饰以进一步改善光学传感器的光学性能。