公开(公告)号：US08952357B2

公开(公告)日：2015-02-10

申请号：US13148548

申请日：2010-02-08

申请人： Seiji Yamada ,  Yuichi Tokita ,  Yoshio Goto ,  Wei Luo ,  Daisuke Yamaguchi ,  Daisuke Ito ,  Jusuke Shimura

发明人： Seiji Yamada ,  Yuichi Tokita ,  Yoshio Goto ,  Wei Luo ,  Daisuke Yamaguchi ,  Daisuke Ito ,  Jusuke Shimura

IPC分类号： H01L29/08 ,  H01L51/00 ,  B82Y10/00 ,  G01J1/58 ,  H01L27/30 ,  H01L51/42

CPC分类号： H01L51/0093 ,  B82Y10/00 ,  G01J1/58 ,  H01L27/307 ,  H01L51/0012 ,  H01L51/0051 ,  H01L51/0083 ,  H01L51/0092 ,  H01L51/0098 ,  H01L51/42 ,  Y10T428/31685 ,  Y10T428/31768

摘要： A color imaging element, a photosensor and a photoelectric transducer which use a protein and are capable of being stably used for a long time, and methods of manufacturing them are provided. A zinc-substituted cytochrome c552 is immobilized on a gold electrode with a self-assembled monolayer in between to form a blue-light photoelectric transducer. Alternatively, a cytochrome c552 is immobilized on a gold electrode with a self-assembled monolayer in between, and a fluorescent protein absorbing blue light is bonded to the cytochrome c552, thereby forming a blue-light photoelectric transducer. These photoelectric transducers each are used as a color imaging element or a blue-light photoelectric transducer of a photosensor.

摘要翻译： 提供使用蛋白质并能够长期稳定使用的彩色成像元件，光传感器和光电传感器及其制造方法。 将锌取代的细胞色素c552固定在具有自组装单层的金电极之间，形成蓝光光电传感器。 或者，细胞色素c552固定在金电极上，其间具有自组装单层，吸收蓝光的荧光蛋白质结合到细胞色素c552上，从而形成蓝光光电变换器。 这些光电传感器各自用作光电传感器的彩色成像元件或蓝光光电传感器。

公开(公告)号：US08178872B2

公开(公告)日：2012-05-15

申请号：US12756555

申请日：2010-04-08

申请人： Yuichi Tokita ,  Yoshio Goto ,  Jusuke Shimura ,  Seiji Yamada ,  Wei Luo ,  Daisuke Yamaguchi ,  Daisuke Ito

发明人： Yuichi Tokita ,  Yoshio Goto ,  Jusuke Shimura ,  Seiji Yamada ,  Wei Luo ,  Daisuke Yamaguchi ,  Daisuke Ito

IPC分类号： H01L29/08 ,  H01L35/24 ,  H01L51/00

CPC分类号： H01L51/0595 ,  B82Y10/00 ,  H01L51/0093 ,  H01L51/4206

摘要： A molecular device includes a gold electrode, cytochrome c552 or a derivative or variant thereof immobilized on the gold electrode, and an electron transfer protein coupled to the cytochrome c552 or the derivative or variant thereof. Electrons or holes, or both, are transferred through the electron transfer protein by transition of electrons between molecular orbitals of the electron transfer protein.

摘要翻译： 分子装置包括固定在金电极上的金电极，细胞色素c552或其衍生物或变体，以及与细胞色素c552或其衍生物或变体偶联的电子转移蛋白。 通过电子在电子转移蛋白的分子轨道之间的转变，电子或空穴或两者通过电子转移蛋白转移。

公开(公告)号：US20100264409A1

公开(公告)日：2010-10-21

申请号：US12756555

申请日：2010-04-08

申请人： Yuichi Tokita ,  Yoshio Goto ,  Jusuke Shimura ,  Seiji Yamada ,  Wei Luo ,  Daisuke Yamaguchi ,  Daisuke Ito

发明人： Yuichi Tokita ,  Yoshio Goto ,  Jusuke Shimura ,  Seiji Yamada ,  Wei Luo ,  Daisuke Yamaguchi ,  Daisuke Ito

IPC分类号： H01L51/54

CPC分类号： H01L51/0595 ,  B82Y10/00 ,  H01L51/0093 ,  H01L51/4206

摘要： A molecular device includes a gold electrode, cytochrome c552 or a derivative or variant thereof immobilized on the gold electrode, and an electron transfer protein coupled to the cytochrome c552 or the derivative or variant thereof. Electrons or holes, or both, are transferred through the electron transfer protein by transition of electrons between molecular orbitals of the electron transfer protein.

摘要翻译： 分子装置包括固定在金电极上的金电极，细胞色素c552或其衍生物或变体，以及与细胞色素c552或其衍生物或变体偶联的电子转移蛋白。 通过电子在电子转移蛋白的分子轨道之间的转变，电子或空穴或两者通过电子转移蛋白转移。

公开(公告)号：US20120012823A1

公开(公告)日：2012-01-19

申请号：US13148548

申请日：2010-02-08

申请人： Seiji Yamada ,  Yuichi Tokita ,  Yoshio Goto ,  Wei Luo ,  Daisuke Yamaguchi ,  Daisuke Ito ,  Jusuke Shimura

发明人： Seiji Yamada ,  Yuichi Tokita ,  Yoshio Goto ,  Wei Luo ,  Daisuke Yamaguchi ,  Daisuke Ito ,  Jusuke Shimura

IPC分类号： H01L51/48 ,  H01L51/46 ,  C07K19/00 ,  B32B15/04 ,  C07K14/80 ,  C07K1/107

CPC分类号： H01L51/0093 ,  B82Y10/00 ,  G01J1/58 ,  H01L27/307 ,  H01L51/0012 ,  H01L51/0051 ,  H01L51/0083 ,  H01L51/0092 ,  H01L51/0098 ,  H01L51/42 ,  Y10T428/31685 ,  Y10T428/31768

摘要： A color imaging element, a photosensor and a photoelectric transducer which use a protein and are capable of being stably used for a long time, and methods of manufacturing them are provided. A zinc-substituted cytochrome c552 is immobilized on a gold electrode with a self-assembled monolayer in between to form a blue-light photoelectric transducer. Alternatively, a cytochrome c552 is immobilized on a gold electrode with a self-assembled monolayer in between, and a fluorescent protein absorbing blue light is bonded to the cytochrome c552, thereby forming a blue-light photoelectric transducer. These photoelectric transducers each are used as a color imaging element or a blue-light photoelectric transducer of a photosensor.

摘要翻译： 提供使用蛋白质并能够长期稳定使用的彩色成像元件，光传感器和光电传感器及其制造方法。 将锌取代的细胞色素c552固定在具有自组装单层的金电极之间，形成蓝光光电传感器。 或者，细胞色素c552固定在金电极上，其间具有自组装单层，吸收蓝光的荧光蛋白质结合到细胞色素c552上，从而形成蓝光光电变换器。 这些光电传感器各自用作光电传感器的彩色成像元件或蓝光光电传感器。

公开(公告)号：US08603822B2

公开(公告)日：2013-12-10

申请号：US13013239

申请日：2011-01-25

申请人： Daisuke Yamaguchi ,  Seiji Yamada ,  Yoshio Goto ,  Yuichi Tokita

发明人： Daisuke Yamaguchi ,  Seiji Yamada ,  Yoshio Goto ,  Yuichi Tokita

IPC分类号： C12N15/00 ,  C12N9/04 ,  C12N1/20 ,  C12P21/06 ,  C12P21/04 ,  C12Q1/68 ,  C07H21/04

CPC分类号： C12N9/0006 ,  H01M8/16 ,  Y02E60/527

摘要： A method for designing a heat-resistant mutant enzyme, the method including the step of reducing a distance between the α4 helix and the α6 helix in a protein three-dimensional structure to become smaller than that of a wild type enzyme through deletion, replacement, addition, or insertion of one or several amino acids in the amino acid sequence of the wild type enzyme with respect to tyrosine-dependent short-chain dehydrogenase/reductase.

摘要翻译： 一种耐热突变酶的设计方法，其特征在于，将蛋白质三维结构中的α4螺旋和α6螺旋之间的距离减小到比野生型酶的缺失，置换， 相对于酪氨酸依赖性短链脱氢酶/还原酶，在野生型酶的氨基酸序列中添加或插入一个或几个氨基酸。

公开(公告)号：US20110236771A1

公开(公告)日：2011-09-29

申请号：US13132257

申请日：2009-11-30

申请人： Daisuke Yamaguchi ,  Yoshio Goto ,  Seiji Yamada ,  Yuichi Tokita

发明人： Daisuke Yamaguchi ,  Yoshio Goto ,  Seiji Yamada ,  Yuichi Tokita

IPC分类号： C12N9/04 ,  H01M8/16

CPC分类号： H01M14/00 ,  C12N9/0006

摘要： The present disclosure provides a mutant gluconate dehydrogenase whose enzyme activity and/or heat resistance is a predetermined level or higher. The mutant gluconate dehydrogenase is made by an amino acid sequence obtained by deleting, substituting, adding or inserting one or plural amino acids in an amino acid sequence represented by sequence number 1. The mutant gluconate dehydrogenase displays enzyme activity which is equal to or higher than 120% of a wild-type gluconate dehydrogenase made by an amino acid sequence represented by sequence number 1, and/or displays residual enzyme activity after heat treatment under predetermined conditions, which is equal to or higher than 20% of the enzyme activity before the heat treatment.

摘要翻译： 本公开内容提供其酶活性和/或耐热性为预定水平或更高水平的突变体葡萄糖酸脱氢酶。 突变型葡萄糖酸脱氢酶由通过在序列号1所示的氨基酸序列中缺失，取代，添加或插入一个或多个氨基酸而获得的氨基酸序列制成。突变型葡萄糖酸脱氢酶显示等于或高于 120％由序列号1表示的氨基酸序列制备的野生型葡萄糖酸脱氢酶，和/或在预定条件下热处理后显示残留酶活性，其等于或高于前述酶活性的20％ 热处理。

公开(公告)号：US20120313867A1

公开(公告)日：2012-12-13

申请号：US13474197

申请日：2012-05-17

申请人： Wei Luo ,  Yuichi Tokita ,  Yoshio Goto ,  Seiji Yamada ,  Satoshi Nakamaru

发明人： Wei Luo ,  Yuichi Tokita ,  Yoshio Goto ,  Seiji Yamada ,  Satoshi Nakamaru

IPC分类号： G06F3/041

CPC分类号： G02B27/0093 ,  G02B27/22 ,  G06F3/0412 ,  G06F3/042 ,  G06F3/0425

摘要： Provided is a thin three-dimensional interactive display which enables multi-touch sensing and three-dimensional gesture recognition. The three-dimensional interactive display includes a light source for irradiating an object to be detected with a light, a light modulation layer, into which a scattered light generated by irradiating the object with the light from the light source enters, at least for modulating an intensity of the scattered light, a transparent light-receiving layer for receiving the light transmitted through the light modulation layer, and a display panel or a back light panel disposed on the opposite side of the transparent light-receiving layer from the light modulation layer. The transparent light-receiving layer has a two-dimensional array of light-receiving elements.

摘要翻译： 提供了一种薄的三维交互式显示器，其实现多点触摸感测和三维手势识别。 三维交互式显示器包括用于用光照射待检测物体的光源，光调制层，其中通过用来自光源的光进入的物体照射物体而产生的散射光至少用于调制 散射光的强度，用于接收透过光调制层的光的透明光接收层和从光调制层设置在透明光接收层的相反侧的显示面板或背光面板。 透明光接收层具有受光元件的二维阵列。

公开(公告)号：US20120181517A1

公开(公告)日：2012-07-19

申请号：US13339064

申请日：2011-12-28

申请人： Seiji Yamada ,  Yuichi Tokita ,  Yoshio Goto ,  Wei Luo ,  Satoshi Nakamaru

发明人： Seiji Yamada ,  Yuichi Tokita ,  Yoshio Goto ,  Wei Luo ,  Satoshi Nakamaru

IPC分类号： H01L51/46 ,  H01L51/48

CPC分类号： H01L51/0093 ,  B82Y10/00 ,  H01L27/307 ,  H01L51/424 ,  Y02E10/542 ,  Y02E10/549 ,  Y02P70/521

摘要： A protein photoelectric conversion device including a gold electrode; and a substance selected from the group consisting of a metal-substituted cytochrome b562, a zinc chlorin cytochrome b562, a derivative thereof, and a variant thereof immobilized on the gold electrode.

摘要翻译： 一种包含金电极的蛋白质光电转换装置; 以及选自金属取代的细胞色素b562，二氯卟酚细胞色素b562，其衍生物和固定在金电极上的变体的物质。

公开(公告)号：US20120138770A1

公开(公告)日：2012-06-07

申请号：US13389759

申请日：2010-08-09

申请人： Wei Luo ,  Seiji Yamada ,  Yoshio Goto ,  Yuichi Tokita

发明人： Wei Luo ,  Seiji Yamada ,  Yoshio Goto ,  Yuichi Tokita

IPC分类号： G01J1/42 ,  B05D5/12

CPC分类号： H01L51/0093 ,  B82Y10/00 ,  H01L51/4206 ,  H01L51/4253 ,  Y02E10/542 ,  Y02P70/521

摘要： A non-wetted all solid protein photoelectric conversion device that is able to be operated without existence of a liquid such as water inside and outside of the device and a method of manufacturing the same are provided. The non-wetted all solid protein photoelectric conversion device has a structure in which a solid protein layer composed of an electron transfer protein is sandwiched between an electrode and an electrode. The solid protein layer is immobilized onto the electrodes and. The solid protein layer does not contain a liquid such as water. The solid protein layer is composed of a monomolecular film or a multimolecular film of the electron transfer protein.

摘要翻译： 提供能够在不存在装置内部和外部的水等液体的情况下操作的非湿润全固态蛋白质光电转换装置及其制造方法。 非湿润全固体蛋白质光电转换装置具有将由电子转移蛋白构成的固体蛋白质层夹在电极和电极之间的结构。 将固体蛋白质层固定在电极上。 固体蛋白质层不含液体如水。 固体蛋白质层由单分子膜或电子转移蛋白质的多分子膜组成。

公开(公告)号：US08884899B2

公开(公告)日：2014-11-11

申请号：US13474197

申请日：2012-05-17

申请人： Wei Luo ,  Yuichi Tokita ,  Yoshio Goto ,  Seiji Yamada ,  Satoshi Nakamaru

发明人： Wei Luo ,  Yuichi Tokita ,  Yoshio Goto ,  Seiji Yamada ,  Satoshi Nakamaru

IPC分类号： G06F3/041 ,  G06F3/042 ,  G02B27/00 ,  G02B27/22

CPC分类号： G02B27/0093 ,  G02B27/22 ,  G06F3/0412 ,  G06F3/042 ,  G06F3/0425

摘要： Provided is a thin three-dimensional interactive display which enables multi-touch sensing and three-dimensional gesture recognition. The three-dimensional interactive display includes a light source for irradiating an object to be detected with a light, a light modulation layer, into which a scattered light generated by irradiating the object with the light from the light source enters, at least for modulating an intensity of the scattered light, a transparent light-receiving layer for receiving the light transmitted through the light modulation layer, and a display panel or a back light panel disposed on the opposite side of the transparent light-receiving layer from the light modulation layer. The transparent light-receiving layer has a two-dimensional array of light-receiving elements.

摘要翻译： 提供了一种薄的三维交互式显示器，其实现多点触摸感测和三维手势识别。 三维交互式显示器包括用于用光照射待检测物体的光源，光调制层，其中通过用来自光源的光进入的物体照射物体而产生的散射光至少用于调制 散射光的强度，用于接收透过光调制层的光的透明光接收层和从光调制层设置在透明光接收层的相反侧的显示面板或背光面板。 透明光接收层具有受光元件的二维阵列。