摘要:
The present invention provides the compounds represented by formula (I): or pharmaceutical salts thereof, wherein: X1 represents oxygen atoms and the like, X2 represents nitrogen atoms and the like, X3 represents nitrogen atoms and the like, X4 represents nitrogen atoms and the like, R1 represents formula (II-1): wherein X5 represents sulfur atoms and the like, A1 represents carbon atoms and the like, A2 represents nitrogen atoms and the like and A ring represents phenyl group and the like, having mGluR1 inhibiting effect, and being useful for preventing or treating convulsion, acute pain, inflammatory pain, chronic pain, brain disorder such as cerebral infarction or transient ischemick attack, psychotic disorder such as schizophrenia, anxiety, drug dependence, Parkinson's disease, or gastrointestinal disorder.
摘要翻译:本发明提供由式(I)表示的化合物或其药用盐,其中:X1表示氧原子等,X2表示氮原子等,X3表示氮原子等,X4表示氮原子, R 1表示式(II-1):其中X 5表示硫原子等,A 1表示碳原子等,A 2表示氮原子等,A表示具有mGluR1抑制作用的苯基等, 并且可用于预防或治疗惊厥,急性疼痛,炎性疼痛,慢性疼痛,脑梗塞如脑梗塞或短暂性脑缺血发作,精神病如精神分裂症,焦虑症,药物依赖性,帕金森病或胃肠道疾病。
摘要:
The present invention provides the compounds represented by formula (I):(I) or pharmaceutical salts thereof, wherein: X1 represents oxygen atoms and the like, X2 represents nitrogen atoms and the like, X3 represents nitrogen atoms and the like, X4 represents nitrogen atoms and the like, R1 represents formula (II-1): wherein X5 represents sulfur atoms and the like, A1 represents carbon atoms and the like, A2 represents nitrogen atoms and the like and A ring represents phenyl group and the like, having mGluR1 inhibiting effect, and being usefull for preventing or treating convulsion, acute pain, inflammatory pain, chronic pain, brain disorder such as cerebral infarction or transient ischemick attack, psychotic disorder such as schizophrenia, anxiety, drug dependence, Parkinson's disease, or gastrointestinal disorder.
摘要:
The present invention relates to a compound represented by the formula (I): or a pharmaceutically acceptable salt thereof, wherein: R1 is a linear or branched alkoxy group, a cycloalkoxy group, a linear or branched lower alkyl group, etc.; R2 is halogen atom, a lower alkyl group, etc.; Q1 is carbon atom or nitrogen atom; Q2 is carbon atom which may be substituted with oxo group; the formula (III): (II) is a single bond or a double bond; A is a group selected from the group consisting of the substitutent group α; and R5 is hydrogen atom, a lower alkyl group, cyano group, an alkoxy group or a trialkylsilyl group; having an mGluR1 inhibiting action and being useful as treatment and/or prevention of convulsion, acute pain, cerebral disturbance such as cerebral infarction or transient cerebral ischemia onset, anxiety, chemical dependency or Parkinson's disease.
摘要:
The present invention relates to a compound represented by the formula (I): or a pharmaceutically acceptable salt thereof, wherein: R1 is a linear or branched alkoxy group, a cycloalkoxy group, a linear or branched lower alkyl group, etc.; R2 is halogen atom, a lower alkyl group, etc.; Q1 is carbon atom or nitrogen atom; Q2 is carbon atom which may be substituted with oxo group; the formula (III): (II) is a single bond or a double bond; A is a group selected from the group consisting of the substitutent group α; and R5 is hydrogen atom, a lower alkyl group, cyano group, an alkoxy group or a trialkylsilyl group; having an mGluR1 inhibiting action and being useful as treatment and/or prevention of convulsion, acute pain, cerebral disturbance such as cerebral infarction or transient cerebral ischemia onset, anxiety, chemical dependency or Parkinson's disease.
摘要:
A nonvolatile memory element including: a first electrode; a second electrode; a variable resistance layer that is between the first electrode and the second electrode and includes, as stacked layers, a first variable resistance layer connected to the first electrode and a second variable resistance layer connected to the second electrode; and a side wall protecting layer that has oxygen barrier properties and covers a side surface of the variable resistance layer. The first variable resistance layer includes a first metal oxide and a third metal oxide formed around the first metal oxide and having an oxygen deficiency lower than that of the first metal oxide, and the second variable resistance layer includes a second metal oxide having an oxygen deficiency lower than that of the first metal oxide.
摘要:
A terminal device mounted on a movable body, includes: an image capturing unit; a determining unit which determines whether to preferentially display an actually captured guide image using a captured image captured by the image capturing unit or a map guide image using map information, based on a relationship between an image capturing direction of the image capturing unit and a traveling direction of the movable body; and a display controlling unit which displays either the actually captured guide image or the map guide image based on a determination by the determining unit. Therefore, it is possible to appropriately determine whether to preferentially display the actually captured guide image or the map guide image.
摘要:
The present invention relates to pyrazolopyridines and imidazopyridines which are inhibitors of the kinase PDK1 and are thus useful for the treatment of myeloproliferative disorders or cancer. The compounds are also useful as inhibitors of other kinases such as FGFR3, NTRK3, RP-S6K and WEE1. Furthermore, the present compounds also selectively inhibit microtubule affinity regulating kinase (MARK) and are therefore useful for the treatment or prevention of Alzheimer's disease.
摘要:
An integrated circuit device includes first and second transistors NTr1 and PTr1 push-pull connected between first and second power supply lines and outputting a voltage of one of the first and second power supply lines to a connection node ND by a charge-pump operation, and a pad PD electrically connected with the connection node ND and electrically connected with a flying capacitor, to which a given voltage is applied at one end, at the other end of the flying capacitor. The pad PD is disposed in an upper layer of at least one of the first and second transistors NTr1 and PTr1 so that the pad PD overlaps part or the entirety of at least one of the first and second transistors NTr1 and PTr1.
摘要:
An integrated circuit device includes a pad PDx and an electrostatic discharge protection element ESDx formed in a rectangular region and electrically connected with the pad PDx. The pad PDx is disposed in an upper layer of the electrostatic discharge protection element ESDx so that an arrangement direction of the pads is parallel to a long side direction of the region in which the electrostatic discharge protection element ESDx is formed, and the pad PDx overlaps part or the entirety of the electrostatic discharge protection element ESDx.
摘要:
An integrated circuit device includes an amplifier circuit that receives an input signal and performs an offset adjustment corresponding to a DC offset of the input signal and a gain adjustment corresponding to an amplitude of the input signal, a filter that is provided in a subsequent stage of the amplifier circuit, a cut-off frequency of the filter being variably set corresponding to a frequency band of the input signal, an A/D converter that is provided in a subsequent stage of the filter and performs an A/D conversion process on a signal amplified by the amplifier circuit, and a control circuit that sets an offset adjustment of the amplifier circuit, a gain adjustment of the amplifier circuit, and the cut-off frequency of the filter.
摘要翻译:集成电路装置包括:放大器电路,其接收输入信号并执行与输入信号的DC偏移相对应的偏移调整和对应于输入信号的幅度的增益调整;滤波器,其被设置在 所述放大器电路,对应于所述输入信号的频带可变地设置所述滤波器的截止频率; A / D转换器,其设置在所述滤波器的后续级中,并对所述滤波器进行A / D转换处理 由放大器电路放大的信号,以及设置放大器电路的偏移调整,放大器电路的增益调整和滤波器的截止频率的控制电路。