摘要:
[Problem] An object of the present invention is to provide a novel anticancer drug which is useful for treating prostate cancer accompanying androgen receptor mutation[Means for Solution] The present inventors conducted thorough research on mutant androgen-related diseases for which the traditional anti-androgen drugs become ineffective. As a result, they found that the compound, which is an active ingredient of the pharmaceutical composition of the present invention, exhibits an inhibitory action against transcriptional activation in a human mutant androgen receptor (AR), and has an excellent antitumor action in a human prostate cancer-bearing mouse, thereby completing the present invention. Accordingly, the compound, which is an active ingredient of the pharmaceutical composition of the present invention, is useful for a series of androgen receptor-related diseases including prostate cancer.
摘要:
As a result of studies on compounds having a selective inhibitory activity against 17βHSD type 5, the present inventors have confirmed that a {1-[(indol-2-yl)carbonyl]piperidyl}alkanol derivative has a potent selective inhibitory activity against 17βHSD type 5. The invention has been completed based on these findings. The compound of the present invention can be used as an agent for treating and/or an agent for preventing diseases associated with 17βHSD type 5, such as benign prostatic hyperplasia and prostate cancer, without accompanying adverse effects due to a decrease in testosterone.
摘要:
There is provided a digital controller which can generate no oscillation even if sensing a load side and enables control of supplying a desired voltage to the load. In an power amplifier which supplies an output voltage vo to the load connected via a load connecting line, a load voltage vL and the output voltage vo are periodically sampled to calculate a manipulating variable ξ1 from the output voltage vo, the load voltage vL and an arbitrary target value r. Based on the manipulating variable ξ1 calculated, a control signal is output to the power amplifier. As a result, when connecting an LC filter with a load device 9 of the power amplifier intended for a control target and besides the load connecting line is long, a robust digital controller without generating oscillation even if sensing the load side is performed can be realized.
摘要:
There is provided a digital controller which can generate no oscillation even if sensing a load side and enables control of supplying a desired voltage to the load. In an power amplifier which supplies an output voltage vo to the load connected via a load connecting line, a load voltage vL and the output voltage vo are periodically sampled to calculate a manipulating variable ξ1 from the output voltage vo, the load voltage vL and an arbitrary target value r. Based on the manipulating variable ξ1 calculated, a control signal is output to the power amplifier. As a result, when connecting an LC filter with a load device 9 of the power amplifier intended for a control target and besides the load connecting line is long, a robust digital controller without generating oscillation even if sensing the load side is performed can be realized.
摘要:
A process cartridge detachably mountable to a main assembly of an electrophotographic image forming apparatus, wherein the main assembly includes a motor, a main assembly side gear for receiving driving force from the motor, a hole defined by twisted surfaces, the hole being substantially coaxial with the gear, and a main assembly side grounding contact provided in the hole, the process cartridge includes an electrophotographic photosensitive drum; process mechanisms actable on the photosensitive drum; and a projection engageable with the twisted surfaces, the projection being provided at a longitudinal end of the photosensitive drum, wherein when the main assembly side gear rotates with the hole and projection engaged with each other, rotational driving force is transmitted from the gear to the photosensitive drum through engagement between the hole and the projection; and a cartridge side grounding contact electrically connected with the electrophotographic photosensitive drum for electrically grounding the electrophotographic photosensitive drum when the process cartridge is mounted to the main assembly of the apparatus, the cartridge side grounding contact being provided on the projection so as to be electrically connectable with the main assembly side grounding contact.
摘要:
A developing apparatus includes a container containing a developing agent and having an opening; a developer bearing member provided at the opening of the container; a magnetic sealing member magnetically restricting leakage of the developing agent out of an end of the developer bearing member in a longitudinal direction of the developer bearing member the magnetic sealing member being formed at the end in the longitudinal direction of the developer bearing member as extending along a circumferential direction of the developer bearing member; a sheet member preventing the developing agent from leaking out of the opening of the container, the sheet member being attached along the longitudinal direction of the container forming the opening, the end in the longitudinal direction of a free end of the sheet member entering in a space between the developer bearing member and the magnetic sealing member; and an auxiliary member holding a free end side of the sheet member around the magnetic sealing member. The container is formed with, at a portion attaching to the sheet member, a recess into which the auxiliary member enters.
摘要:
A process cartridge detachably mountable to a main assembly of an electrophotographic image forming apparatus, wherein the main assembly includes a motor, a main assembly side gear for receiving driving force from the motor, a hole defined by twisted surfaces, the hole being substantially coaxial with the gear, and a main assembly side grounding contact provided in the hole, the process cartridge includes an electrophotographic photosensitive drum; process mechanisms actable on the photosensitive drum; and a projection engageable with the twisted surfaces, the projection being provided at a longitudinal end of the photosensitive drum, wherein when the main assembly side gear rotates with the hole and projection engaged with each other, rotational driving force is transmitted from the gear to the photosensitive drum through engagement between the hole and the projection; and a cartridge side grounding contact electrically connected with the electrophotographic photosensitive drum for electrically grounding the electrophotographic photosensitive drum when the process cartridge is mounted to the main assembly of the apparatus, the cartridge side grounding contact being provided on the projection so as to be electrically connectable with the main assembly side grounding contact
摘要:
The process cartridge includes an electrophotographic photosensitive drum, a first unit frame body supporting the drum, a second unit frame body having a developing device and a developer containing portion, a first connection frame body for connecting one end of the first and second unit frame bodies with respect to the axial direction of the drum, a second connection frame body for connecting the other end of the first and second unit frame bodies with respect to the axial direction, first, second, and third fixation devices for fixing the first and second connection frame bodies to the first and second unit frame bodies through abutment, and a fourth fixation device for fixing the second connection frame body and the second unit frame body to each other by filling a gap between the second connection frame body and the second unit frame body.
摘要:
A memory member usable with an electrophotographic image forming apparatus, includes a base; a storing element, provided in the base, for storing information; a memory antenna, provided in the base, for sending the information stored in the storing element to a main assembly antenna provided in a main assembly of the apparatus, when the memory member is mounted to the main assembly of the electrophotographic image forming apparatus; a sending member, provided in the base, for sending the information stored in the storing element to the memory antenna; and an outer casing member covering the base provided with the storing element, the sending member and the memory antenna.
摘要:
A process cartridge detachably mountable to an electrophotographic image forming apparatus main body, includes: an electrophotographic photosensitive drum; a process member for acting on the electrophotographic photosensitive drum; a frame for holding the electrophotographic photosensitive drum; convex portions, which are provided coaxially with an axis of the electrophotographic photosensitive drum and protrude from one side and from the other side of the frame, for positioning the process cartridge in the apparatus main body when the process cartridge is mounted to the apparatus main body, and a concave portion provided in the upper part of the frame and recessed in the one side, in which the concave portion allows the process cartridge to be inserted into the apparatus main body without abutting against a protrusion provided in the apparatus main body in an inserting process of the process cartridge.