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    Method Of Producing Vascular Endothelial Cells From Primate Embryonic Stem Cells
    2.
    发明申请
    Method Of Producing Vascular Endothelial Cells From Primate Embryonic Stem Cells 审中-公开
    从灵长类胚胎干细胞产生血管内皮细胞的方法

    公开(公告)号：US20080025955A1

    公开(公告)日：2008-01-31

    申请号：US11630208

    申请日：2005-06-15

    申请人： Kazuwa Nakao ,  Hiroshi Itoh ,  Jun Yamashita ,  Masakatsu Sone ,  Kenichi Yamahara ,  Yasushi Kondo ,  Yutaka Suzuki

    发明人： Kazuwa Nakao ,  Hiroshi Itoh ,  Jun Yamashita ,  Masakatsu Sone ,  Kenichi Yamahara ,  Yasushi Kondo ,  Yutaka Suzuki

    IPC分类号： A61K35/12 ,  A61P9/00 ,  C12N5/06

    CPC分类号： C12N5/0691 ,  A61K35/12 ,  C12N5/069 ,  C12N2506/02

    摘要： To provide a method for differentiating primate embryonic stem cells into vascular endothelial cells, and a technique using the method. A method for differentiating primate embryonic stem cells into early developmental vascular endothelial cells comprising differentiating primate embryonic stem cells into vascular endothelial cell parker-positive cell population; the early developmental vascular endothelial cells; a method for producing the vascular endothelial cells; a method for amplifying the vascular endothelial cells; a vascular lesion-therapeutic agent containing the early developmental vascular endothelial cells as an active ingredient; a method for revascularization comprising supplying the early developmental vascular endothelial cells; a method for transplantation comprising transplanting the early developmental vascular endothelial cells; and a method for treatment comprising administering the early developmental vascular endothelial cells in a therapeutically effective dose.

    摘要翻译： 提供一种将灵长动物胚胎干细胞分化成血管内皮细胞的方法，以及使用该方法的技术。 将灵长类动物胚胎干细胞分化成早期发育性血管内皮细胞的方法，包括将灵长类动物胚胎干细胞分化成血管内皮细胞停滞阳性细胞群; 早期发育性血管内皮细胞; 一种生产血管内皮细胞的方法; 扩增血管内皮细胞的方法; 含有早期发育性血管内皮细胞作为活性成分的血管病变治疗剂; 一种血运重建方法，包括供应早期发育性血管内皮细胞; 一种移植方法，包括移植早期发育性血管内皮细胞; 和一种治疗方法，包括以治疗有效剂量施用早期发育性血管内皮细胞。

    Process for producing nerve cells
    5.
    发明授权
    Process for producing nerve cells 失效
    产生神经细胞的方法

    公开(公告)号：US08492145B2

    公开(公告)日：2013-07-23

    申请号：US10518749

    申请日：2003-06-23

    申请人： Takashi Nakayama ,  Nobuo Inoue ,  Yasushi Kondo ,  Yutaka Suzuki

    发明人： Takashi Nakayama ,  Nobuo Inoue ,  Yasushi Kondo ,  Yutaka Suzuki

    IPC分类号： C12N5/071 ,  C12N5/00 ,  C12N5/02

    CPC分类号： C12N5/0619 ,  C12N5/0618 ,  C12N5/0623 ,  C12N2500/44 ,  C12N2501/06 ,  C12N2501/115 ,  C12N2501/235 ,  C12N2502/13 ,  C12N2506/02

    摘要： To supply substantially isolated neural cells in a large amount, and to provide an application means for a neuroregenerative medicine or the like for a neurodegenerative disease, a nervous damage or the like. A method for producing a substantially isolated neural cell, comprising the step of carrying out the suspension culture of embryonic stem cells in the presence of an astrocyte conditioned medium or ingredients substantially equivalent to the conditioned medium; and a neural cell obtained thereby; a cell pharmaceutical composition comprising, as an active ingredient, the isolated neural stem cell; and a method for treating a neurodegenerative disease or nervous damage, comprising the step of introducing the neural cell into a neurodegenerative site or a nervous damage site.

    摘要翻译： 提供大量分离的神经细胞，并提供用于神经退行性疾病，神经损伤等的神经再生药物等的应用手段。 一种生产基本上分离的神经细胞的方法，包括在星形细胞条件培养基或与条件培养基基本上相当的成分的存在下进行胚胎干细胞的悬浮培养的步骤; 和由此获得的神经细胞; 一种细胞药物组合物，其包含分离的神经干细胞作为活性成分; 以及治疗神经变性疾病或神经损伤的方法，包括将神经细胞引入神经变性部位或神经损伤部位的步骤。

    Process for producing nerve cells
    6.
    发明申请
    Process for producing nerve cells 失效
    产生神经细胞的方法

    公开(公告)号：US20050221479A1

    公开(公告)日：2005-10-06

    申请号：US10518749

    申请日：2003-06-23

    申请人： Takashi Nakayama ,  Nobuo Inoue ,  Yasushi Kondo ,  Yutaka Suzuki

    发明人： Takashi Nakayama ,  Nobuo Inoue ,  Yasushi Kondo ,  Yutaka Suzuki

    IPC分类号： A61P25/00 ,  C12N5/0793 ,  C12N5/0797 ,  C12N5/08 ,  C12N5/06

    CPC分类号： C12N5/0619 ,  C12N5/0618 ,  C12N5/0623 ,  C12N2500/44 ,  C12N2501/06 ,  C12N2501/115 ,  C12N2501/235 ,  C12N2502/13 ,  C12N2506/02

    摘要： To supply substantially isolated neural cells in a large amount, and to provide an application means for a neuroregenerative medicine or the like for a neurodegenerative disease, a nervous damage or the like. A method for producing a substantially isolated neural cell, comprising the step of carrying out the suspension culture of embryonic stem cells in the presence of an astrocyte conditioned medium or ingredients substantially equivalent to the conditioned medium; and a neural cell obtained thereby; a cell pharmaceutical composition comprising, as an active ingredient, the isolated neural stem cell; and a method for treating a neurodegenerative disease or nervous damage, comprising the step of introducing the neural cell into a neurodegenerative site or a nervous damage site.

    摘要翻译： 提供大量分离的神经细胞，并提供用于神经退行性疾病，神经损伤等的神经再生药物等的应用手段。 一种生产基本上分离的神经细胞的方法，包括在星形细胞条件培养基或与条件培养基基本上相当的成分的存在下进行胚胎干细胞的悬浮培养的步骤; 和由此获得的神经细胞; 一种细胞药物组合物，其包含分离的神经干细胞作为活性成分; 以及治疗神经变性疾病或神经损伤的方法，包括将神经细胞引入神经变性部位或神经损伤部位的步骤。

    Method for differentiating primate embryonic stem cell into vascular cell
    7.
    发明申请
    Method for differentiating primate embryonic stem cell into vascular cell 有权
    将灵长类动物胚胎干细胞分化成血管细胞的方法

    公开(公告)号：US20050191744A1

    公开(公告)日：2005-09-01

    申请号：US11063584

    申请日：2005-02-24

    申请人： Kazuwa Nakao ,  Hiroshi Itoh ,  Jun Yamashita ,  Masakatsu Sone ,  Yasushi Kondo ,  Yutaka Suzuki

    发明人： Kazuwa Nakao ,  Hiroshi Itoh ,  Jun Yamashita ,  Masakatsu Sone ,  Yasushi Kondo ,  Yutaka Suzuki

    IPC分类号： C12N5/071 ,  C12N5/08

    CPC分类号： C12N5/069 ,  C12N2501/165 ,  C12N2506/03

    摘要： To provide a technique of the differentiation from a primate embryonic stem cell into a vascular cell, and techniques using the same. A method for differentiating a primate embryonic stem cell into a vascular cell, comprising differentiating a primate embryonic stem cell into a VEGFR-2-positive and undifferentiated primate embryonic stem cell marker-negative cell, and if need, further differentiating the resulting cell, a method of the differentiation into a vascular cell, and a vascular cell obtained by the method.

    摘要翻译： 提供从灵长类动物胚胎干细胞分化成血管细胞的技术以及使用其的技术。 一种将灵长动物胚胎干细胞分化为血管细胞的方法，其包括将灵长类动物胚胎干细胞分化为VEGFR-2阳性和未分化的灵长类动物胚胎干细胞标记物阴性细胞，如果需要，进一步分化所得细胞， 分化成血管细胞的方法和通过该方法获得的血管细胞。

    Solid-state image sensor
    8.
    发明授权
    Solid-state image sensor 有权
    固态图像传感器

    公开(公告)号：US08988571B2

    公开(公告)日：2015-03-24

    申请号：US12676562

    申请日：2008-09-04

    申请人： Shigetoshi Sugawa ,  Yasushi Kondo ,  Hideki Tominaga

    发明人： Shigetoshi Sugawa ,  Yasushi Kondo ,  Hideki Tominaga

    IPC分类号： H04N5/335 ,  H04N5/355 ,  H04N5/3745 ,  H04N5/378

    CPC分类号： H04N5/35527 ,  H04N5/37452 ,  H04N5/378

    摘要： A pixel area with a two-dimensional array of pixels (10) each including a photodiode and a memory area (3a) on which memory sections for holding signals produced by the pixels for continuously recordable frames are separately provided on a semiconductor substrate. All the pixels simultaneously perform a photocharge storage operation, and the signals produced by the photocharge storage are extracted in parallel through mutually independent pixel output lines (14). In a plurality of memory sections connected to one pixel output line, a sample-and-hold transistor of a different memory section is turned on for each exposure cycle so as to sequentially hold signals in a capacitor of each memory section. After the continuous imaging is completed, all the pixel are sequentially read. Unlike CCD cameras, the present sensor does not simultaneously drive all the gate loads. Therefore, the sensor consumes less power yet can be driven at high speeds. The separation between the memory area and pixel area prevents signals from deterioration due to an intrusion of excessive photocharges. As a result, the sensor can perform imaging operations at higher speeds than ever before and yet capture images with higher qualities.

    摘要翻译： 具有二维像素阵列（10）的像素区域，每个像素（10）包括光电二极管和存储区域（3a），在半导体衬底上分别设置有用于保持用于连续可记录帧的像素产生的信号的存储部分。 所有像素同时进行光电荷存储操作，并且通过相互独立的像素输出线（14）并行提取由光电荷存储产生的信号。 在连接到一个像素输出线的多个存储器部分中，对于每个曝光周期，不同存储器部分的采样和保持晶体管导通，以便顺序地保持每个存储器部分的电容器中的信号。 连续成像完成后，依次读取所有像素。 与CCD相机不同，本传感器不会同时驱动所有的栅极负载。 因此，传感器消耗较少的功率，但可以高速驱动。 存储区域和像素区域之间的分离可以防止信号由于过多的光电荷的入侵而恶化。 因此，传感器可以以比以往更高的速度进行成像操作，并且捕获具有更高质量的图像。

    Solid-state image sensor
    9.
    发明授权
    Solid-state image sensor 有权
    固态图像传感器

    公开(公告)号：US08530947B2

    公开(公告)日：2013-09-10

    申请号：US13382878

    申请日：2010-06-23

    申请人： Yasushi Kondo ,  Hideki Tominaga ,  Kenji Takubo ,  Ryuta Hirose ,  Shigetoshi Sugawa ,  Hideki Mutoh

    发明人： Yasushi Kondo ,  Hideki Tominaga ,  Kenji Takubo ,  Ryuta Hirose ,  Shigetoshi Sugawa ,  Hideki Mutoh

    IPC分类号： H01L27/148

    CPC分类号： H01L27/14603 ,  H01L27/14607 ,  H01L27/14609 ,  H01L27/1461

    摘要： A floating diffusion region is formed at an edge of a light-receiving surface of an embedded photodiode, with a transfer gate electrode located therebetween. A first region, with radially extending portions centered on the FD region, and a second region, located to the outside of the first region, are created in the substantially sector-shaped light-receiving surface. A dopant whose conductivity type is the same as the signal charges to be collected in the first region are introduced, whereby an electric field for moving the signal charges from the radially extending sections towards the center is created due to a three-dimensional field effect. As a result, the charge-transfer time is reduced. Additionally, since a circuit element in the subsequent stage can be placed adjacent to the floating diffusion region, the parasitic capacitance of the floating diffusion region can be reduced and a highly sensitive element can be obtained.

    摘要翻译： 在嵌入式光电二极管的光接收表面的边缘处形成浮动扩散区，其中位于其间的传输栅电极。 在大致扇形的光接收表面上形成有以FD区域为中心的径向延伸部分的第一区域和位于第一区域外部的第二区域。 引入导电类型与要在第一区域中收集的信号电荷相同的掺杂剂，由此由于三维场效应，产生用于使信号从径向延伸部分向中心移动的电场。 结果，电荷转移时间减少。 此外，由于随后阶段的电路元件可以放置在与浮动扩散区域相邻的位置，所以可以减小浮动扩散区域的寄生电容，并且可以获得高灵敏度的元件。

    IMAGE PICKUP APPARATUS
    10.
    发明申请
    IMAGE PICKUP APPARATUS 有权
    图像拾取装置

    公开(公告)号：US20090256943A1

    公开(公告)日：2009-10-15

    申请号：US12303248

    申请日：2007-05-23

    申请人： Yasushi Kondo

    发明人： Yasushi Kondo

    IPC分类号： H04N5/335

    CPC分类号： H04N5/2253 ,  H04N5/2254 ,  H04N5/2258 ,  H04N5/238 ,  H04N5/335 ,  H04N5/372 ,  H04N5/37206

    摘要： An image converter tube 2c and a plurality of image sensors CCDs 1 (eight CCDs 1 here) are provided, and the respective CCDs 1 and image positions in the image converter tube 2c are in one-to-one correspondence. By carrying out at least one of a control to make a shift to a different image position after image formation in one and the same image position for a predetermined number of frames, and a control to make a shift to a different image position in an imaging cycle with a predetermined time interval, various image pickup situations can be accommodated without changing the structure of CCDs 1 per se.

    摘要翻译： 图像转换管2c和多个图像传感器CCD 1（这里为八个CCD1），并且各个CCD1和图像转换管2c中的图像位置一一对应。 通过执行控制中的至少一个，以在预定数量的帧的同一图像位置中的图像形成之后转换到不同的图像位置，以及控制以在成像中进行向不同图像位置的移位 以预定的时间间隔循环，可以适应各种图像拾取情况而不改变CCD1本身的结构。