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    Method Of Producing Vascular Endothelial Cells From Primate Embryonic Stem Cells
    1.
    发明申请
    Method Of Producing Vascular Endothelial Cells From Primate Embryonic Stem Cells 审中-公开
    从灵长类胚胎干细胞产生血管内皮细胞的方法

    公开(公告)号：US20080025955A1

    公开(公告)日：2008-01-31

    申请号：US11630208

    申请日：2005-06-15

    申请人： Kazuwa Nakao ,  Hiroshi Itoh ,  Jun Yamashita ,  Masakatsu Sone ,  Kenichi Yamahara ,  Yasushi Kondo ,  Yutaka Suzuki

    发明人： Kazuwa Nakao ,  Hiroshi Itoh ,  Jun Yamashita ,  Masakatsu Sone ,  Kenichi Yamahara ,  Yasushi Kondo ,  Yutaka Suzuki

    IPC分类号： A61K35/12 ,  A61P9/00 ,  C12N5/06

    CPC分类号： C12N5/0691 ,  A61K35/12 ,  C12N5/069 ,  C12N2506/02

    摘要： To provide a method for differentiating primate embryonic stem cells into vascular endothelial cells, and a technique using the method. A method for differentiating primate embryonic stem cells into early developmental vascular endothelial cells comprising differentiating primate embryonic stem cells into vascular endothelial cell parker-positive cell population; the early developmental vascular endothelial cells; a method for producing the vascular endothelial cells; a method for amplifying the vascular endothelial cells; a vascular lesion-therapeutic agent containing the early developmental vascular endothelial cells as an active ingredient; a method for revascularization comprising supplying the early developmental vascular endothelial cells; a method for transplantation comprising transplanting the early developmental vascular endothelial cells; and a method for treatment comprising administering the early developmental vascular endothelial cells in a therapeutically effective dose.

    摘要翻译： 提供一种将灵长动物胚胎干细胞分化成血管内皮细胞的方法，以及使用该方法的技术。 将灵长类动物胚胎干细胞分化成早期发育性血管内皮细胞的方法，包括将灵长类动物胚胎干细胞分化成血管内皮细胞停滞阳性细胞群; 早期发育性血管内皮细胞; 一种生产血管内皮细胞的方法; 扩增血管内皮细胞的方法; 含有早期发育性血管内皮细胞作为活性成分的血管病变治疗剂; 一种血运重建方法，包括供应早期发育性血管内皮细胞; 一种移植方法，包括移植早期发育性血管内皮细胞; 和一种治疗方法，包括以治疗有效剂量施用早期发育性血管内皮细胞。

    Method for differentiating primate embryonic stem cell into vascular cell
    2.
    发明申请
    Method for differentiating primate embryonic stem cell into vascular cell 有权
    将灵长类动物胚胎干细胞分化成血管细胞的方法

    公开(公告)号：US20050191744A1

    公开(公告)日：2005-09-01

    申请号：US11063584

    申请日：2005-02-24

    申请人： Kazuwa Nakao ,  Hiroshi Itoh ,  Jun Yamashita ,  Masakatsu Sone ,  Yasushi Kondo ,  Yutaka Suzuki

    发明人： Kazuwa Nakao ,  Hiroshi Itoh ,  Jun Yamashita ,  Masakatsu Sone ,  Yasushi Kondo ,  Yutaka Suzuki

    IPC分类号： C12N5/071 ,  C12N5/08

    CPC分类号： C12N5/069 ,  C12N2501/165 ,  C12N2506/03

    摘要： To provide a technique of the differentiation from a primate embryonic stem cell into a vascular cell, and techniques using the same. A method for differentiating a primate embryonic stem cell into a vascular cell, comprising differentiating a primate embryonic stem cell into a VEGFR-2-positive and undifferentiated primate embryonic stem cell marker-negative cell, and if need, further differentiating the resulting cell, a method of the differentiation into a vascular cell, and a vascular cell obtained by the method.

    摘要翻译： 提供从灵长类动物胚胎干细胞分化成血管细胞的技术以及使用其的技术。 一种将灵长动物胚胎干细胞分化为血管细胞的方法，其包括将灵长类动物胚胎干细胞分化为VEGFR-2阳性和未分化的灵长类动物胚胎干细胞标记物阴性细胞，如果需要，进一步分化所得细胞， 分化成血管细胞的方法和通过该方法获得的血管细胞。

    LOW-VISCOSITY LIQUID CRYSTAL COMPOUND
    5.
    发明申请
    LOW-VISCOSITY LIQUID CRYSTAL COMPOUND 有权
    低粘度液晶化合物

    公开(公告)号：US20120264923A1

    公开(公告)日：2012-10-18

    申请号：US13518932

    申请日：2010-12-27

    申请人： Yutaka Ikeda ,  Jun Yamashita ,  Ichiro Hijikuro ,  Satoshi Imuta ,  Yasuhiro HIroki ,  Takashi Takahashi

    发明人： Yutaka Ikeda ,  Jun Yamashita ,  Ichiro Hijikuro ,  Satoshi Imuta ,  Yasuhiro HIroki ,  Takashi Takahashi

    IPC分类号： C07C57/03 ,  C07H15/10

    CPC分类号： A61K47/14 ,  A61K9/0019 ,  A61K9/0024 ,  A61K47/08 ,  A61K47/10 ,  A61K47/22 ,  A61K47/26 ,  C07H15/10 ,  C09K19/06

    摘要： The present invention relates to a liquid crystal compound that can be used as a base for injection formulations. The present invention provides an amphipathic compound having the following general formula (I): wherein X and Y each denotes a hydrogen atom or together denote an oxygen atom, n denotes an integer from 0 to 2, m denotes the integer 1 or 2, and R denotes a hydrophilic group generated by removal of one hydroxyl group from any one selected from the group consisting of glycerol, erythritol, pentaerythritol, diglycerol, triglycerol, xylose, sorbitol, ascorbic acid, glucose, galactose, mannose, dipentaerythritol, maltose, mannitol, and xylitol; as well as a base for injection formulations and depot formulation comprising the same.

    摘要翻译： 本发明涉及可用作注射制剂的基质的液晶化合物。 本发明提供具有以下通式（I）的两亲化合物：其中X和Y各自表示氢原子或一起表示氧原子，n表示0至2的整数，m表示整数1或2，并且 R表示通过从选自甘油，赤藓糖醇，季戊四醇，双甘油，三甘油，木糖，山梨醇，抗坏血酸，葡萄糖，半乳糖，甘露糖，二季戊四醇，麦芽糖，甘露糖醇，甘露糖醇， 和木糖醇; 以及用于注射制剂的基料和包含其的包含药剂的制剂。

    Plunger pump
    8.
    发明申请
    Plunger pump 失效
    柱塞泵

    公开(公告)号：US20050002809A1

    公开(公告)日：2005-01-06

    申请号：US10858476

    申请日：2004-06-02

    申请人： Jun Yamashita ,  Tomohide Tanaka ,  Atsushi Shimizu ,  Naotoshi Tamai ,  Motoyasu Nakamura

    发明人： Jun Yamashita ,  Tomohide Tanaka ,  Atsushi Shimizu ,  Naotoshi Tamai ,  Motoyasu Nakamura

    IPC分类号： B60T8/40 ,  F04B1/04 ,  F04B1/047 ,  F04B1/053 ,  F04B9/04 ,  F02M47/02

    CPC分类号： B60T8/4031 ,  F04B1/0413 ,  F04B9/042

    摘要： A plunger pump, includes: a plunger pump unit including a pump chamber and a plunger for pressing a hydraulic fluid in the pump chamber to perform a discharging operation of the hydraulic fluid; a motor; and a cam portion driven by the motor to rotate and press the plunger. The cam portion has at least two discharge regions for pressing the plunger and a suction region formed between the discharge region. The plunger performs the discharging operation two times or more by one rotation of the cam portion.

    摘要翻译： 一种柱塞泵，包括：柱塞泵单元，其包括泵室和用于对泵室中的液压流体进行按压以执行液压流体的排放操作的柱塞; 电机 以及由马达驱动以旋转并按压柱塞的凸轮部分。 凸轮部具有用于按压柱塞的至少两个排出区域和形成在排出区域之间的吸入区域。 柱塞通过凸轮部分的一次旋转执行两次或更多次的排出操作。

    Catalyst for producing conjugated diene polymer
    9.
    发明授权
    Catalyst for producing conjugated diene polymer 失效
    用于制备共轭二烯聚合物的催化剂

    公开(公告)号：US6071845A

    公开(公告)日：2000-06-06

    申请号：US761697

    申请日：1996-12-06

    申请人： Nobuhiro Tsujimoto ,  Michinori Suzuki ,  Kei Tsukahara ,  Shigeru Ikai ,  Koji Imaoka ,  Yoshiyuki Kai ,  Jun Yamashita

    发明人： Nobuhiro Tsujimoto ,  Michinori Suzuki ,  Kei Tsukahara ,  Shigeru Ikai ,  Koji Imaoka ,  Yoshiyuki Kai ,  Jun Yamashita

    IPC分类号： C07F17/00 ,  C08F4/625 ,  C08F4/639 ,  C08F4/6392 ,  C08F4/68 ,  C08F10/00 ,  C08F36/04

    CPC分类号： C08F10/00 ,  C07F17/00 ,  C08F36/04 ,  C08F4/68 ,  C08F4/63908 ,  C08F4/63912 ,  C08F4/6392 ,  Y10S526/943

    摘要： A catalyst obtained by contacting (A) a compound of a transition metal of the group V of the Periodic Table represented by formula (I):R.sub.n M(O).sub.m X.sub.p .cndot.L.sub.a (I)wherein M represents a transition metal of the group V of the Periodic Table; R represents a cyclopentadienyl group, a substituted cyclopentadienyl group, an indenyl group, a substituted indenyl group, a fluorenyl group or a substituted fluorenyl group; O represents an oxygen atom; X represents a hydrogen atom, a halogen atom, a hydrocarbon group having 1 to 20 carbon atoms, an alkoxy group, an aryloxy group or an amido group; L represents a Lewis basic compound; n, m, and p each represent an integer selected to make a combination of (n=1, m=1, p=2), (n=1, m=0, p=3), (n=2, m=0, p=1) or (n=1, m=0, p=2); and a represents 0, 1 or 2, and (B) at least one of (B1) an ionic compound comprising a non-coordinating anion and a cation and (B2) an aluminoxane, provided that the component (B) is an ionic compound comprising a non-coordinating anion and a cation (B1) when the combination of n, m, and p of the component (A) is (n=2, m=0, p=1) or (n=1, m=0, p=2).

    摘要翻译： 通过使（A）由式（I）表示的周期表的第V族的过渡金属的化合物：RnM（O）m X pLa（I）与M表示第V族的过渡金属 周期表; R表示环戊二烯基，取代的环戊二烯基，茚基，取代的茚基，芴基或取代的芴基; O表示氧原子; X表示氢原子，卤素原子，碳原子数1〜20的烃基，烷氧基，芳氧基或酰胺基; L代表路易斯碱性化合物; n，m和p各自表示选择以使（n = 1，m = 1，p = 2），（n = 1，m = 0，p = 3），（n = = 0，p = 1）或（n = 1，m = 0，p = 2）; 和（B）包含非配位阴离子和阳离子的离子化合物和（B2）铝氧烷中的至少一种，（B）组分（B）是离子化合物 当组分（A）的n，m和p的组合为（n = 2，m = 0，p = 1）或（n = 1，m = 1）时，包含非配位阴离子和阳离子（B1） 0，p = 2）。

    Low-viscosity liquid crystal compound
    10.
    发明授权
    Low-viscosity liquid crystal compound 有权
    低粘度液晶复合物

    公开(公告)号：US08703922B2

    公开(公告)日：2014-04-22

    申请号：US13518932

    申请日：2010-12-27

    申请人： Yutaka Ikeda ,  Jun Yamashita ,  Ichiro Hijikuro ,  Satoshi Imuta ,  Yasuhiro Hiroki ,  Takashi Takahashi

    发明人： Yutaka Ikeda ,  Jun Yamashita ,  Ichiro Hijikuro ,  Satoshi Imuta ,  Yasuhiro Hiroki ,  Takashi Takahashi

    IPC分类号： C07H15/00 ,  C07H15/04 ,  A61K31/70 ,  A61K31/7028 ,  C07C57/03

    CPC分类号： A61K47/14 ,  A61K9/0019 ,  A61K9/0024 ,  A61K47/08 ,  A61K47/10 ,  A61K47/22 ,  A61K47/26 ,  C07H15/10 ,  C09K19/06

    摘要： The present invention relates to a liquid crystal compound that can be used as a base for injection formulations. The present invention provides an amphipathic compound having the following general formula (I): wherein X and Y each denotes a hydrogen atom or together denote an oxygen atom, n denotes an integer from 0 to 2, m denotes the integer 1 or 2, and R denotes a hydrophilic group generated by removal of one hydroxyl group from any one selected from the group consisting of glycerol, erythritol, pentaerythritol, diglycerol, triglycerol, xylose, sorbitol, ascorbic acid, glucose, galactose, mannose, dipentaerythritol, maltose, mannitol, and xylitol; as well as a base for injection formulations and depot formulation comprising the same.

    摘要翻译： 本发明涉及可用作注射制剂的基质的液晶化合物。 本发明提供具有以下通式（I）的两亲化合物：其中X和Y各自表示氢原子或一起表示氧原子，n表示0至2的整数，m表示整数1或2，并且 R表示通过从选自甘油，赤藓糖醇，季戊四醇，双甘油，三甘油，木糖，山梨醇，抗坏血酸，葡萄糖，半乳糖，甘露糖，二季戊四醇，麦芽糖，甘露糖醇，甘露糖醇， 和木糖醇; 以及用于注射制剂的基料和包含其的包含药剂的制剂。