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公开(公告)号：US20120022118A1
公开(公告)日：2012-01-26
申请号：US13252423
申请日：2011-10-04
申请人： Zachary Demko , Christopher Borella , Shoujun Chen , Lijun Sun
发明人： Zachary Demko , Christopher Borella , Shoujun Chen , Lijun Sun
IPC分类号： A61K31/4192 , A61P35/00 , C07D249/06
CPC分类号： C07F9/6518 , A61K31/4192 , A61K31/422 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/501 , A61K31/506 , A61K31/675 , C07D249/06 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/10
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
摘要翻译： 本发明涉及结构式（I）的化合物或其药学上可接受的盐，溶剂化物，包合物和前药，其中R a，R b和R 2在本文中定义。 这些化合物抑制微管蛋白聚合和/或靶向脉管系统，并且可用于治疗增殖性疾病如癌症。
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公开(公告)号：US20100279410A1
公开(公告)日：2010-11-04
申请号：US12768164
申请日：2010-04-27
申请人： Zachary Demko , Christopher Borella , Shoujun Chen , Lijun Sun
发明人： Zachary Demko , Christopher Borella , Shoujun Chen , Lijun Sun
IPC分类号： C12N5/09
CPC分类号： C07F9/6518 , A61K31/4192 , A61K31/422 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/501 , A61K31/506 , A61K31/675 , C07D249/06 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/10
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
摘要翻译： 本发明涉及结构式（I）的化合物或其药学上可接受的盐，溶剂化物，包合物和前药，其中R a，R b和R 2在本文中定义。 这些化合物抑制微管蛋白聚合和/或靶向脉管系统，并且可用于治疗增殖性疾病如癌症。
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公开(公告)号：US20070238699A1
公开(公告)日：2007-10-11
申请号：US11492692
申请日：2006-07-24
申请人： Zachary Demko , Christopher Borella , Shoujun Chen , Lijun Sun
发明人： Zachary Demko , Christopher Borella , Shoujun Chen , Lijun Sun
IPC分类号： A61K31/724 , A61K31/506 , A61K31/501 , A61K31/4439 , A61K31/4192 , C07D403/04
CPC分类号： C07F9/6518 , A61K31/4192 , A61K31/422 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/501 , A61K31/506 , A61K31/675 , C07D249/06 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/10
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
摘要翻译： 本发明涉及结构式（I）的化合物或其药学上可接受的盐，溶剂化物，包合物和前药，其中R a，R b，R b， SUB> 2 在本文中定义。 这些化合物抑制微管蛋白聚合和/或靶向脉管系统，并且可用于治疗增殖性疾病如癌症。
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公开(公告)号：US08501790B2
公开(公告)日：2013-08-06
申请号：US13252423
申请日：2011-10-04
申请人： Zachary Demko , Christopher Borella , Shoujun Chen , Lijun Sun
发明人： Zachary Demko , Christopher Borella , Shoujun Chen , Lijun Sun
IPC分类号： A61K31/41 , C07D249/00
CPC分类号： C07F9/6518 , A61K31/4192 , A61K31/422 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/501 , A61K31/506 , A61K31/675 , C07D249/06 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/10
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
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公开(公告)号：US07781462B2
公开(公告)日：2010-08-24
申请号：US11492692
申请日：2006-07-24
申请人： Zachary Demko , Christopher Borella , Shoujun Chen , Lijun Sun
发明人： Zachary Demko , Christopher Borella , Shoujun Chen , Lijun Sun
IPC分类号： A61K31/41 , C07D249/00
CPC分类号： C07F9/6518 , A61K31/4192 , A61K31/422 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/501 , A61K31/506 , A61K31/675 , C07D249/06 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/10
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
摘要翻译： 本发明涉及结构式（I）的化合物或其药学上可接受的盐，溶剂化物，包合物和前药，其中R a，R b和R 2在本文中定义。 这些化合物抑制微管蛋白聚合和/或靶向脉管系统，并且可用于治疗增殖性疾病如癌症。
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公开(公告)号：US20130338162A1
公开(公告)日：2013-12-19
申请号：US13953558
申请日：2013-07-29
申请人： Lijun Sun , Keizo Koya , Shoujun Chen , Zachary Demko , Zhi-Qiang Xia
发明人： Lijun Sun , Keizo Koya , Shoujun Chen , Zachary Demko , Zhi-Qiang Xia
IPC分类号： C07C327/56 , C07D277/50 , C07D213/81 , C07D231/08 , C07D237/04
CPC分类号： C07C327/56 , C07C243/24 , C07C255/56 , C07C255/58 , C07C337/02 , C07C337/06 , C07C2601/02 , C07C2601/14 , C07D207/34 , C07D213/81 , C07D213/86 , C07D231/08 , C07D237/04 , C07D277/50 , C07D303/48 , C07D307/66 , C07D307/68 , C07D309/38 , C07D333/36 , C07D333/38
摘要： Disclosed are compounds and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer induction. Also, disclosed are pharmaceutical compositions comprising compounds of the invention and a pharmaceutically acceptable carrier.
摘要翻译： 公开了使用本发明化合物治疗患有增殖性疾病如癌症的受试者的化合物和方法，以及用于治疗响应于Hsp70诱导和/或自然杀伤诱导的病症的方法。 此外，公开了包含本发明化合物和药学上可接受的载体的药物组合物。
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公开(公告)号：US08497272B2
公开(公告)日：2013-07-30
申请号：US12310299
申请日：2007-08-20
申请人： Lijun Sun , Keizo Koya , Shoujun Chen , Zachary Demko , Zhi-Qiang Xia
发明人： Lijun Sun , Keizo Koya , Shoujun Chen , Zachary Demko , Zhi-Qiang Xia
IPC分类号： A61K31/497
CPC分类号： C07C327/56 , C07C243/24 , C07C255/56 , C07C255/58 , C07C337/02 , C07C337/06 , C07C2601/02 , C07C2601/14 , C07D207/34 , C07D213/81 , C07D213/86 , C07D231/08 , C07D237/04 , C07D277/50 , C07D303/48 , C07D307/66 , C07D307/68 , C07D309/38 , C07D333/36 , C07D333/38
摘要： Disclosed are compounds and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer induction. Also, disclosed are pharmaceutical compositions comprising compounds of the invention and a pharmaceutically acceptable carrier.
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公开(公告)号：US09156783B2
公开(公告)日：2015-10-13
申请号：US14108162
申请日：2013-12-16
申请人： Shoujun Chen , Keizo Koya , Zachary Demko , Lijun Sun
发明人： Shoujun Chen , Keizo Koya , Zachary Demko , Lijun Sun
IPC分类号： A61K31/15 , C07C243/14 , C07C243/42 , C07C327/56 , C07C243/28 , C07C255/66 , C07C257/22 , C07C261/04 , C07C281/06 , C07C307/04 , C07C311/49 , C07C311/51 , C07C337/06 , C07D207/34 , C07D207/36 , C07D233/74 , C07D263/48 , C07D271/10 , C07D271/113 , C07D307/66 , C07F9/44 , A61K31/16 , A61K31/166 , A61K31/18 , A61K31/277 , A61K31/341 , A61K31/40 , A61K31/4245 , A61K31/664 , C07C243/34 , C07C311/55 , C07F9/22 , C07F9/46
CPC分类号： C07C327/56 , A61K31/16 , A61K31/166 , A61K31/18 , A61K31/277 , A61K31/341 , A61K31/40 , A61K31/4245 , A61K31/664 , C07C243/28 , C07C243/34 , C07C255/66 , C07C257/22 , C07C261/04 , C07C281/06 , C07C307/04 , C07C311/49 , C07C311/51 , C07C311/55 , C07C337/06 , C07C2601/02 , C07D207/34 , C07D207/36 , C07D233/74 , C07D263/48 , C07D271/10 , C07D271/113 , C07D307/66 , C07F9/228 , C07F9/4423 , C07F9/4496 , C07F9/46
摘要： Disclosed are compounds of formulae (I), (III), (IV), (VII), (X), (XI), (XII), (XIII) and (XIV), wherein the variables are as defined in the claims, and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer induction. Also disclosed are pharmaceutical compositions comprising compounds of the invention and a pharmaceutically acceptable carrier.
摘要翻译： 公开了式（I），（III），（IV），（VII），（X），（XI），（XII），（XIII）和（XIV）的化合物，其中变量如权利要求 以及使用本发明化合物治疗患有增殖性疾病（例如癌症）的受试者的方法，以及用于治疗对Hsp70诱导和/或自然杀伤诱导反应的病症的方法。 还公开了包含本发明化合物和药学上可接受的载体的药物组合物。
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公开(公告)号：US08609720B2
公开(公告)日：2013-12-17
申请号：US12310304
申请日：2007-08-20
申请人： Shoujun Chen , Keizo Koya , Zachary Demko , Lijun Sun
发明人： Shoujun Chen , Keizo Koya , Zachary Demko , Lijun Sun
IPC分类号： A61K31/15 , C07C243/14 , C07C243/42
CPC分类号： C07C327/56 , A61K31/16 , A61K31/166 , A61K31/18 , A61K31/277 , A61K31/341 , A61K31/40 , A61K31/4245 , A61K31/664 , C07C243/28 , C07C243/34 , C07C255/66 , C07C257/22 , C07C261/04 , C07C281/06 , C07C307/04 , C07C311/49 , C07C311/51 , C07C311/55 , C07C337/06 , C07C2601/02 , C07D207/34 , C07D207/36 , C07D233/74 , C07D263/48 , C07D271/10 , C07D271/113 , C07D307/66 , C07F9/228 , C07F9/4423 , C07F9/4496 , C07F9/46
摘要： Disclosed are compounds of formulae (I), (III), (IV), (VII), (X), (XI), (XII), (XIII) and (XIV), wherein the variables are as defined in the claims, and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer induction. Also disclosed are pharmaceutical compositions comprising compounds of the invention and a pharmaceutically acceptable carrier.
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公开(公告)号：US20100081635A1
公开(公告)日：2010-04-01
申请号：US12310304
申请日：2007-08-20
申请人： Shoujun Chen , Keizo Koya , Zachary Demko , Lijun Sun
发明人： Shoujun Chen , Keizo Koya , Zachary Demko , Lijun Sun
IPC分类号： A61K31/66 , C07C281/06 , A61K31/175 , C07C327/00 , A61K31/16 , C07F9/547
CPC分类号： C07C327/56 , A61K31/16 , A61K31/166 , A61K31/18 , A61K31/277 , A61K31/341 , A61K31/40 , A61K31/4245 , A61K31/664 , C07C243/28 , C07C243/34 , C07C255/66 , C07C257/22 , C07C261/04 , C07C281/06 , C07C307/04 , C07C311/49 , C07C311/51 , C07C311/55 , C07C337/06 , C07C2601/02 , C07D207/34 , C07D207/36 , C07D233/74 , C07D263/48 , C07D271/10 , C07D271/113 , C07D307/66 , C07F9/228 , C07F9/4423 , C07F9/4496 , C07F9/46
摘要： Disclosed are compounds of formulae (I), (III), (IV), (VII), (X), (XI), (XII), (XIII) and (XIV), wherein the variabables are as defined in the claims, and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer induction. Also disclosed are pharmaceutical compositions comprising compounds of the invention and a pharmaceutically acceptable carrier.
摘要翻译： 公开了式（I），（III），（IV），（VII），（X），（XI），（XII），（XIII）和（XIV）的化合物，其中可变量如权利要求 以及使用本发明化合物治疗患有增殖性疾病（例如癌症）的受试者的方法，以及用于治疗对Hsp70诱导和/或自然杀伤诱导反应的病症的方法。 还公开了包含本发明化合物和药学上可接受的载体的药物组合物。
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