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    Tri-substituted phenyl derivatives and processes for their preparation
    1.
    发明授权
    Tri-substituted phenyl derivatives and processes for their preparation 失效
    三取代苯基衍生物及其制备方法

    公开(公告)号：US6077854A

    公开(公告)日：2000-06-20

    申请号：US48592

    申请日：1998-03-26

    申请人： Graham John Warrellow ,  Rikki Peter Alexander

    发明人： Graham John Warrellow ,  Rikki Peter Alexander

    IPC分类号： A61K31/44 ,  A61P11/06 ,  A61P43/00 ,  C07C1/26 ,  C07C1/32 ,  C07C15/02 ,  C07C15/12 ,  C07C17/263 ,  C07C25/02 ,  C07C25/18 ,  C07C43/20 ,  C07C57/30 ,  C07C59/64 ,  C07C237/04 ,  C07C307/04 ,  C07C311/00 ,  C07C323/00 ,  C07C327/00 ,  C07C327/48 ,  C07C335/04 ,  C07D213/30 ,  C07D521/00 ,  C07D213/02

    CPC分类号： C07D213/30

    摘要： Tri-substituted phenyl derivatives and processes for their preparation. In a preferred embodiment, the compounds have the general formula (1) ##STR1## wherein L may be --OR; Z may be --C(R.sup.3)(R.sup.4)--C(R.sup.5)(R.sup.6)(R.sup.7); R may be an optionally substituted cycloalkyl group; R.sup.3, R.sup.6 and R.sup.7 may be hydrogen; R.sup.4 may be --(CH.sub.2).sub.t --Ar--(L.sup.1).sub.n --Ar'; R.sup.5 may be --(CH.sub.2).sub.t Ar; Ar may be a monocyclic or bicyclic aryl or heteroaryl group; L.sup.1 may be a divalent linking group; and Ar' is Ar or an Ar containing group. Compounds of the invention may be potent and selective phosphodiesterase type IV inhibitors and are useful in the prophylaxis and treatment of various diseases, such as asthma, which are associated with an unwanted inflammatory response or muscular spasm.

    摘要翻译： 三取代苯基衍生物及其制备方法。 在优选的实施方案中，化合物具有通式（1），其中L可以是-OR; Z可以是-C（R 3）（R 4）-C（R 5）（R 6）（R 7）; R可以是任选取代的环烷基; R3，R6和R7可以是氢; R4可以是 - （CH2）t-Ar-（L1）n-Ar'; R5可以是 - （CH2）tAr; Ar可以是单环或双环芳基或杂芳基; L1可以是二价连接基团; Ar'为Ar或含Ar基团。 本发明的化合物可以是有效的选择性磷酸二酯酶IV型抑制剂，并且可用于预防和治疗与不想要的炎性反应或肌肉痉挛相关的各种疾病，例如哮喘。

    Tri-substituted phenyl derivatives and processes for their preparation
    2.
    发明授权
    Tri-substituted phenyl derivatives and processes for their preparation 失效
    三取代苯基衍生物及其制备方法

    公开(公告)号：US5786354A

    公开(公告)日：1998-07-28

    申请号：US492639

    申请日：1995-06-20

    申请人： Graham John Warrellow ,  Rikki Peter Alexander

    发明人： Graham John Warrellow ,  Rikki Peter Alexander

    IPC分类号： A61K31/44 ,  A61P11/06 ,  A61P43/00 ,  C07C1/26 ,  C07C1/32 ,  C07C15/02 ,  C07C15/12 ,  C07C17/263 ,  C07C25/02 ,  C07C25/18 ,  C07C43/20 ,  C07C57/30 ,  C07C59/64 ,  C07C237/04 ,  C07C307/04 ,  C07C311/00 ,  C07C323/00 ,  C07C327/00 ,  C07C327/48 ,  C07C335/04 ,  C07D213/30 ,  C07D521/00 ,  A61K31/435

    CPC分类号： C07D213/30

    摘要： Tri-substituted phenyl derivatives and processes for their preparation. In a preferred embodiment, the compounds have the general formula (2) ##STR1## wherein L is preferably --OR; Z is preferably --C(R.sup.3)(R.sup.4)--C(R.sup.5)(R.sup.6)(R.sup.7); R is preferably an optionally substituted cycloalkyl group: R.sup.3 is preferably hydrogen; R.sup.4 is hydrogen, --(CH.sub.2).sub.t Ar or --(CH.sub.2).sub.t --Ar--(L.sup.1).sub.n --Ar'; R.sup.5 is --(CH.sub.2).sub.t Ar or --(CH.sub.2).sub.t --Ar--(L.sup.1).sub.n --Ar'; R.sup.6 and R.sup.7 are preferably hydrogen or methyl; Ar is a monocyclic or bicyclic aryl or heteroaryl group; L.sup.1 is a divalent linking group; and Ar' is Ar or an Ar containing group. Compounds of the invention are potent and selective phosphodiesterase type IV inhibitors and are useful in the prophylaxis and treatment of various diseases, such as asthma, which are associated with an unwanted inflammatory response or muscular spasm.

    摘要翻译： 三取代苯基衍生物及其制备方法。 在优选的实施方案中，化合物具有通式（2）其中L优选为-OR; Z优选为-C（R 3）（R 4）-C（R 5）（R 6）（R 7）; R优选为任选取代的环烷基：R 3优选为氢; R4是氢， - （CH2）tAr或 - （CH2）t-Ar-（L1）n-Ar'; R5是 - （CH2）tAr或 - （CH2）t-Ar-（L1）n-Ar'; R6和R7优选为氢或甲基; Ar是单环或双环芳基或杂芳基; L1是二价连接基团; Ar'是Ar或含Ar的基团。 本发明的化合物是有效和选择性的磷酸二酯酶IV型抑制剂，并且可用于预防和治疗与不想要的炎症反应或肌肉痉挛相关的各种疾病，例如哮喘。

    Adhesive composition
    7.
    发明授权
    Adhesive composition 失效
    粘合剂组合物

    公开(公告)号：US5480720A

    公开(公告)日：1996-01-02

    申请号：US204929

    申请日：1994-03-01

    申请人： Eric K. Eisenhart ,  Louis C. Graziano ,  Jose P. Lalas

    发明人： Eric K. Eisenhart ,  Louis C. Graziano ,  Jose P. Lalas

    IPC分类号： C07C307/04 ,  C07D207/26 ,  C07D207/273 ,  C07D477/02 ,  C07D477/14 ,  C07D477/20 ,  C07D501/00 ,  C08L63/00 ,  C09J133/06 ,  B32B27/38

    CPC分类号： C07D207/273 ,  C07C307/04 ,  C07D477/02 ,  C07D477/14 ,  C07D477/20 ,  C07D501/00 ,  C09J133/064 ,  C08L63/00 ,  Y10T428/31515 ,  Y10T428/31895 ,  Y10T428/31928

    摘要： An adhesive composition includes from about 30 weight percent to about 70 weight percent solids dispersed in an aqueous medium. The solids include from about 60 weight percent to about 97.9 weight percent of a polymer having a glass transition temperature of about -40.degree. C. to about 10.degree. C. and including first repeating units derived from an alkyl (meth)acrylate monomer, a vinyl ester monomer, a styrenic monomer or a mixture thereof and second repeating units derived from a hydroxyalkyl (meth)acrylate monomer, a monoethylenically unsaturated nitrogenous monomer or a mixture thereof; from about 2 weight percent to about 30 weight percent of a polyfunctional epoxy resin including two or more epoxide groups per molecule; from about 0.1 weight percent to about 10 weight percent of a polyfunctional curing agent including two or more amino groups or amido groups per molecule; and from about 0.01 weight percent to about 30 weight percent of a metal salt. A method for making a laminate includes applying a layer of the aqueous adhesive composition to a first substrate layer and covering the layer of adhesive composition with a second substrate layer to form the laminated article. A laminate includes two substrate layers bonded together by an interposed layer of the solids of the adhesive composition.

    摘要翻译： 粘合剂组合物包含分散在水性介质中的约30重量％至约70重量％的固体。 固体包括约60重量％至约97.9重量％的玻璃化转变温度为约-40℃至约10℃的聚合物，并且包括衍生自（甲基）丙烯酸烷基酯单体的第一重复单元， 乙烯基酯单体，苯乙烯单体或其混合物，以及衍生自（甲基）丙烯酸羟烷基酯单体，单烯属不饱和含氮单体或其混合物的第二重复单元; 约2重量％至约30重量％的每分子包含两个或更多个环氧基团的多官能环氧树脂; 约0.1重量％至约10重量％的每分子含有两个或多个氨基或酰氨基的多官能固化剂; 和约0.01重量％至约30重量％的金属盐。 制造层压体的方法包括将水性粘合剂组合物层施加到第一基材层并用第二基材层覆盖粘合剂组合物层以形成层压制品。 层压体包括通过粘合剂组合物的固体的插入层粘合在一起的两个基底层。