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51 条记录 (耗时 0.023 秒)

    Device and method for realizing prefix code construction
    7.
    发明授权
    Device and method for realizing prefix code construction 有权
    实现前缀码构造的装置和方法

    公开(公告)号：US08665988B2

    公开(公告)日：2014-03-04

    申请号：US13202189

    申请日：2009-12-21

    申请人： Lei Yu ,  Zheng Wei ,  Laiguo Zhai ,  Zhixin Tong ,  Hongfeng Sun

    发明人： Lei Yu ,  Zheng Wei ,  Laiguo Zhai ,  Zhixin Tong ,  Hongfeng Sun

    IPC分类号： H04L27/00

    CPC分类号： H03M7/40

    摘要： The present invention provides a device and method for realizing prefix code construction. The device includes a sort indexer, a generator and a sequence regulator. The sort indexer is used to sort a group of received code lengths to obtain a group of sorted code lengths, and record the position correspondence relationship. The generator receives the sorted code lengths and orderly generates the prefix codes. Except that the first prefix code is preconfigured, the generator generates a current prefix code by adding one to the adjacently previous prefix code and then shifting left by a certain number of bits. The sequence regulator is used to receive the prefix codes corresponding to the sorted code lengths, and regulates the sequence of the prefix codes corresponding to the sorted code lengths according to the position correspondence relationship recorded by the sort indexer to obtain the prefix codes corresponding to the code lengths.

    摘要翻译： 本发明提供一种实现前缀码构造的装置和方法。 该设备包括分类索引器，发生器和序列调节器。 分类索引器用于对一组接收到的代码长度进行排序以获得一组排序的代码长度，并记录位置对应关系。 生成器接收排序的代码长度，并有序地生成前缀代码。 除了第一个前缀代码被预先配置之外，生成器通过将相加的前一个前缀代码相加，然后向左移动一定数量的位来生成当前前缀代码。 序列调节器用于接收与分类码长相对应的前缀码，并且根据由分类索引器记录的位置对应关系来调节与分类码长相对应的前缀码序列，以获得对应于 代码长度

    Compositions useful as ligands for the formyl peptide receptor like 1 receptor and methods of use thereof
    9.
    发明授权
    Compositions useful as ligands for the formyl peptide receptor like 1 receptor and methods of use thereof 有权
    可用作甲酰肽受体如1受体的配体的组合物及其使用方法

    公开(公告)号：US08637043B2

    公开(公告)日：2014-01-28

    申请号：US11175003

    申请日：2005-07-05

    申请人： Thomas J. Schall ,  Zhenhua Miao ,  Robert Berahovich ,  Zheng Wei ,  Maureen Howard ,  Brett Premack

    发明人： Thomas J. Schall ,  Zhenhua Miao ,  Robert Berahovich ,  Zheng Wei ,  Maureen Howard ,  Brett Premack

    IPC分类号： A61K39/02

    CPC分类号： C07K14/523 ,  A61K38/00 ,  A61K39/39 ,  A61K2039/55522 ,  Y02A50/39 ,  Y02A50/401 ,  Y02A50/466 ,  Y02A50/484

    摘要： The inventors have discovered that a CKβ8-1 truncation variant, CKβ8-1 (25-116), is a bifunctional ligand for two distinct GPCRs, chemokine receptor CCR1 and formyl peptide receptor like 1 (FPRL1). Hence, the inventors have discovered that, in addition to its functional activity on CCR1, CKβ8-1(25-116) is also a functional ligand for the GPCR receptor FPRL1 that is involved in inflammatory reactions and innate immunity by recruiting monocytes and neutrophils. In addition, the inventors have discovered an alternatively spliced exon of CKβ8-1, named SHAAGtide. SHAAGtide, along with its parent chemokine CKβ8-1 (25-116), is fully functional on both monocytes and neutrophils that are known to express FPRL1.This application relates generally to enhancing immune responses. Such immune responses may be elicited by vaccine administration. Compositions and methods for inducing or enhancing an immune response to an antigen are provided. The compositions and methods are useful for vaccine formulations for therapeutic and prophylactic use (immunization) and for production of antibodies.

    摘要翻译： 本发明人已经发现CKbeta8-1截短变体CKbeta8-1（25-116）是两种不同GPCR，趋化因子受体CCR1和甲酰肽受体1（FPRL1）的双功能配体。 因此，本发明人发现除了CCR1的功能活性外，CKbeta8-1（25-116）也是通过募集单核细胞和嗜中性粒细胞参与炎症反应和先天免疫的GPCR受体FPRL1的功能性配体。 此外，本发明人已经发现了称为SHAAGTIDE的CKbeta8-1的可变剪接外显子。 SHAAGTIDE与其母体趋化因子CKbeta8-1（25-116）一起在已知表达FPRL1的单核细胞和嗜中性粒细胞上完全起作用。 本申请一般涉及增强免疫应答。 这种免疫应答可以通过疫苗施用引起。 提供了诱导或增强对抗原的免疫应答的组合物和方法。 组合物和方法可用于治疗和预防用途（免疫）和产生抗体的疫苗制剂。