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公开(公告)号:US20100227902A1
公开(公告)日:2010-09-09
申请号:US12780390
申请日:2010-05-14
申请人: Solomon Ungashe , Zheng Wei , J. J. Wright , Andrew Pennell , Brett Permack , Thomas Schall
发明人: Solomon Ungashe , Zheng Wei , J. J. Wright , Andrew Pennell , Brett Permack , Thomas Schall
IPC分类号: A61K31/421 , C07C311/21 , A61K31/18 , C07D307/77 , A61K31/343 , C07D231/12 , C07D263/32 , A61K31/415 , A61P29/00 , C12N5/07
CPC分类号: C07D213/26 , A61K31/4245 , A61K31/433 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D213/50 , C07D213/70 , C07D213/74 , C07D213/84 , C07D213/89 , C07D241/12 , C07D413/12
摘要: Compounds are provided that act as potent antagonists of chemokine receptors. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of chemokine receptor-mediated diseases, and as controls in assays for the identification of chemokine antagonists.
摘要翻译: 提供了作为趋化因子受体的有效拮抗剂的化合物。 化合物通常为芳基磺酰胺衍生物,可用于药物组合物,治疗趋化因子受体介导的疾病的方法,以及用于鉴定趋化因子拮抗剂的测定中的对照。
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公开(公告)号:US07678891B2
公开(公告)日:2010-03-16
申请号:US11407729
申请日:2006-04-19
申请人: Maureen Howard , Thomas Schall
发明人: Maureen Howard , Thomas Schall
IPC分类号: C07K16/00 , C07K16/28 , A61K39/395 , G01N33/53
CPC分类号: C07K16/2866 , G01N33/6863 , G01N2333/715 , G01N2500/10
摘要: Antibodies that bind to CCX-CKR2 and methods of their use are provided.
摘要翻译: 提供了结合CCX-CKR2的抗体及其使用方法。
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公开(公告)号:US07335653B2
公开(公告)日:2008-02-26
申请号:US11789304
申请日:2007-04-23
申请人: Solomon Ungashe , Zheng Wei , John J. Wright , Andrew Pennell , Brett Permack , Thomas Schall
发明人: Solomon Ungashe , Zheng Wei , John J. Wright , Andrew Pennell , Brett Permack , Thomas Schall
IPC分类号: A61K31/54
CPC分类号: C07D213/26 , A61K31/18 , A61K31/195 , A61K31/397 , A61K31/4245 , A61K31/433 , A61K31/445 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , C07D213/50 , C07D213/70 , C07D213/74 , C07D213/84 , C07D213/89 , C07D241/12 , C07D413/12
摘要: Compounds are provided that act as potent antagonists of chemokine receptors. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of chemokine receptor-mediated diseases, and as controls in assays for the identification of chemokine antagonists.
摘要翻译: 提供了作为趋化因子受体的有效拮抗剂的化合物。 化合物通常为芳基磺酰胺衍生物,可用于药物组合物,治疗趋化因子受体介导的疾病的方法,以及用于鉴定趋化因子拮抗剂的测定中的对照。
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公开(公告)号:US20080044835A1
公开(公告)日:2008-02-21
申请号:US11847872
申请日:2007-08-30
申请人: Wei Wang , Kurt Gish , Thomas Schall , Alain Vicari , Albert Zlotnik
发明人: Wei Wang , Kurt Gish , Thomas Schall , Alain Vicari , Albert Zlotnik
CPC分类号: C07K16/24 , C07K14/523 , C07K14/7158
摘要: Novel chemokines from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said chemokines. Chemokine receptors are also provided. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译: 来自哺乳动物的新型趋化因子,与其相关的试剂,包括纯化的蛋白质,特异性抗体和编码所述趋化因子的核酸。 还提供趋化因子受体。 还提供了使用所述试剂和诊断试剂盒的方法。
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公开(公告)号:US07227035B2
公开(公告)日:2007-06-05
申请号:US10848836
申请日:2004-05-19
申请人: Solomon Ungashe , Zheng Wei , J. J. Wright , Andrew Pennell , Brett Permack , Thomas Schall
发明人: Solomon Ungashe , Zheng Wei , J. J. Wright , Andrew Pennell , Brett Permack , Thomas Schall
IPC分类号: C07C303/00 , A61K31/33 , A61K31/397 , A61K31/55
CPC分类号: C07D213/26 , A61K31/18 , A61K31/195 , A61K31/397 , A61K31/4245 , A61K31/433 , A61K31/445 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , C07D213/50 , C07D213/70 , C07D213/74 , C07D213/84 , C07D213/89 , C07D241/12 , C07D413/12
摘要: Compounds are provided that act as potent antagonists of chemokine receptors. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of chemokine receptor-mediated diseases, and as controls in assays for the identification of chemokine antagonists.
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公开(公告)号:US20050137179A1
公开(公告)日:2005-06-23
申请号:US10848836
申请日:2004-05-19
申请人: Solomon Ungashe , Zheng Wei , J. J. Wright , Andrew Pennell , Brett Premack , Thomas Schall
发明人: Solomon Ungashe , Zheng Wei , J. J. Wright , Andrew Pennell , Brett Premack , Thomas Schall
IPC分类号: A61K31/18 , A61K31/195 , A61K31/397 , A61K31/445 , A61K31/55 , C07D213/26 , C07D213/50 , C07D213/70 , C07D213/74 , C07D213/84 , C07D213/89 , C07D241/12 , C07D413/12
CPC分类号: C07D213/26 , A61K31/18 , A61K31/195 , A61K31/397 , A61K31/4245 , A61K31/433 , A61K31/445 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , C07D213/50 , C07D213/70 , C07D213/74 , C07D213/84 , C07D213/89 , C07D241/12 , C07D413/12
摘要: Compounds are provided that act as potent antagonists of chemokine receptors. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of chemokine receptor-mediated diseases, and as controls in assays for the identification of chemokine antagonists.
摘要翻译: 提供了作为趋化因子受体的有效拮抗剂的化合物。 化合物通常为芳基磺酰胺衍生物,可用于药物组合物,治疗趋化因子受体介导的疾病的方法,以及用于鉴定趋化因子拮抗剂的测定中的对照。
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公开(公告)号:US20100278820A1
公开(公告)日:2010-11-04
申请号:US12691576
申请日:2010-01-21
申请人: Maureen Howard , Thomas Schall
发明人: Maureen Howard , Thomas Schall
CPC分类号: C07K16/2866 , G01N33/6863 , G01N2333/715 , G01N2500/10
摘要: Antibodies that bind to CCX-CKR2 and methods of their use are provided.
摘要翻译: 提供了结合CCX-CKR2的抗体及其使用方法。
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公开(公告)号:US07741519B2
公开(公告)日:2010-06-22
申请号:US12024860
申请日:2008-02-01
申请人: Solomon Ungashe , Zheng Wei , John J. Wright , Andrew Pennell , Brett Permack , Thomas Schall
发明人: Solomon Ungashe , Zheng Wei , John J. Wright , Andrew Pennell , Brett Permack , Thomas Schall
IPC分类号: C07C303/00 , A61K31/33 , A61K31/55 , A61K31/397
CPC分类号: C07D213/26 , A61K31/4245 , A61K31/433 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D213/50 , C07D213/70 , C07D213/74 , C07D213/84 , C07D213/89 , C07D241/12 , C07D413/12
摘要: Compounds are provided that act as potent antagonists of chemokine receptors. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of chemokine receptor-mediated diseases, and as controls in assays for the identification of chemokine antagonists.
摘要翻译: 提供了作为趋化因子受体的有效拮抗剂的化合物。 化合物通常为芳基磺酰胺衍生物,可用于药物组合物,治疗趋化因子受体介导的疾病的方法,以及用于鉴定趋化因子拮抗剂的测定中的对照。
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公开(公告)号:US07649011B2
公开(公告)日:2010-01-19
申请号:US10743281
申请日:2003-12-22
IPC分类号: A61K31/541 , A61K31/496 , C07D417/02
CPC分类号: C07D241/04 , C07C235/48 , C07C235/50 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/14 , C07D211/42 , C07D211/56 , C07D241/42 , C07D295/13 , C07D401/04 , C07D401/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14
摘要: Pharmaceutical compositions containing organic compounds or salts thereof that serve as modulators for the SDF-1 or I-TAC chemokines are disclosed. The compounds and compositions are useful in the treatment of cancer, especially in the inhibition of cancer proliferation, growth, and metastasis. Methods of interfering with SDF-1 and/or I-TAC binding to the CCXCKR2 receptor and treating cancer using the compounds and pharmaceutical compositions of the present invention are also disclosed.
摘要翻译: 公开了含有作为SDF-1或I-TAC趋化因子调节剂的有机化合物或其盐的药物组合物。 化合物和组合物可用于治疗癌症,特别是抑制癌细胞增殖,生长和转移。 还公开了使用本发明的化合物和药物组合物干扰SDF-1和/或I-TAC与CCXCKR2受体结合并治疗癌症的方法。
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公开(公告)号:US20080261966A1
公开(公告)日:2008-10-23
申请号:US12024860
申请日:2008-02-01
申请人: Solomon Ungashe , Zheng Wei , J.J. Wright , Andrew Pennell , Brett Permack , Thomas Schall
发明人: Solomon Ungashe , Zheng Wei , J.J. Wright , Andrew Pennell , Brett Permack , Thomas Schall
IPC分类号: A61K31/5375 , C07D231/10 , A61K31/415 , A61K31/18 , A61K31/421 , A61P37/00 , A61P29/00 , C12N5/00 , C07D263/30 , C07C311/00 , C07D295/00
CPC分类号: C07D213/26 , A61K31/4245 , A61K31/433 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D213/50 , C07D213/70 , C07D213/74 , C07D213/84 , C07D213/89 , C07D241/12 , C07D413/12
摘要: Compounds are provided that act as potent antagonists of chemokine receptors. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of chemokine receptor-mediated diseases, and as controls in assays for the identification of chemokine antagonists.
摘要翻译: 提供了作为趋化因子受体的有效拮抗剂的化合物。 化合物通常为芳基磺酰胺衍生物,可用于药物组合物,治疗趋化因子受体介导的疾病的方法,以及用于鉴定趋化因子拮抗剂的测定中的对照。
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