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1.发明申请Novel CD40:CD154 binding interruptor compounds and use thereof to treat immunological complications 审中-公开新型CD40：CD154结合阻断剂及其用于治疗免疫并发症的药物公开(公告)号：US20070249682A1
公开(公告)日：2007-10-25
申请号：US11701983
申请日：2007-02-02
申请人： Zhongli Zheng , Mary Carter , YuSheng Liao , Lihong Sun , Leonid Kirkovsky , Susan Mrose , Yen-Ming Hsu , David Thomas , Gerald Shipps , Satish Jindal , George Lenz , Huw Nash
发明人： Zhongli Zheng , Mary Carter , YuSheng Liao , Lihong Sun , Leonid Kirkovsky , Susan Mrose , Yen-Ming Hsu , David Thomas , Gerald Shipps , Satish Jindal , George Lenz , Huw Nash
IPC分类号： A61K31/44 , A61P37/08 , C07C303/00 , C07D213/44
CPC分类号： A61K31/444 , C07C311/47 , C07D401/14 , F25B9/10 , F25B9/145 , F25B2309/1408 , F25B2309/1411 , F25B2309/1418 , F25B2309/1424 , F25B2309/14241
摘要： The present invention relates to novel CD40:CD154 binding interrupter compounds and use of these compounds and pharmaceutical compositions comprising them, to treat conditions associated with inappropriate CD154 activation in a subject. Specifically, this invention provides compounds which are identified by screening a library of small molecules for those that are capable of specifically binding CD154 and interrupting CD40:CD154 interaction.
摘要翻译： 本发明涉及新的CD40：CD154结合中断剂化合物，以及这些化合物和包含它们的药物组合物的用途，以治疗与受试者中不适当的CD154活化相关的病症。 具体地，本发明提供了通过筛选能够特异性结合CD154并中断CD40：CD154相互作用的那些的小分子文库来鉴定的化合物。
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2.发明授权CD40:CD154 binding interrupter compounds and use thereof to treat immunological complications 失效CD40：CD154结合中断剂化合物及其用于治疗免疫并发症的用途公开(公告)号：US07173046B2
公开(公告)日：2007-02-06
申请号：US10377928
申请日：2003-02-28
申请人： Zhongli Zheng , Mary-Beth Carter , YuSheng Liao , Lihong Sun , Leonid Kirkovsky , Susan Mrose , Yen-Ming Hsu , David Thomas , Gerald W. Shipps, Jr. , Satish Jindal , George R. Lenz , Huw M. Nash
发明人： Zhongli Zheng , Mary-Beth Carter , YuSheng Liao , Lihong Sun , Leonid Kirkovsky , Susan Mrose , Yen-Ming Hsu , David Thomas , Gerald W. Shipps, Jr. , Satish Jindal , George R. Lenz , Huw M. Nash
IPC分类号： A61K31/4439 , C07D401/14
CPC分类号： A61K31/444 , C07C311/47 , C07D401/14 , F25B9/10 , F25B9/145 , F25B2309/1408 , F25B2309/1411 , F25B2309/1418 , F25B2309/1424 , F25B2309/14241
摘要： The present invention relates to novel CD40:CD154 binding interrupter compounds and use of these compounds and pharmaceutical compositions comprising them, to treat conditions associated with inappropriate CD154 activation in a subject. Specifically, this invention provides compounds which are identified by screening a library of small molecules for those that are capable of specifically binding CD154 and interrupting CD40:CD154 interaction.
摘要翻译： 本发明涉及新的CD40：CD154结合中断剂化合物，以及这些化合物和包含它们的药物组合物的用途，以治疗与受试者中不适当的CD154活化相关的病症。 具体地，本发明提供了通过筛选能够特异性结合CD154并中断CD40：CD154相互作用的那些的小分子文库来鉴定的化合物。
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公开(公告)号：US20060106033A1
公开(公告)日：2006-05-18
申请号：US10526839
申请日：2003-09-05
申请人： Wen-Cherng Lee , Mary Carter , Lihong Sun , Claudio Chuaqui , Zhongli Zheng , Juswinder Singh , Paula Boriack-Sjodin , Paul Lyne
发明人： Wen-Cherng Lee , Mary Carter , Lihong Sun , Claudio Chuaqui , Zhongli Zheng , Juswinder Singh , Paula Boriack-Sjodin , Paul Lyne
IPC分类号： C07D471/02 , A61K31/519 , C07D487/04
CPC分类号： C07D487/04 , C07D471/04
摘要： Compounds of formula I possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. In one embodiment, the invention features a compound of formula I:
摘要翻译： 式I的化合物对Alk 5和/或Alk 4具有出人意料的高亲和力，并且可用作其拮抗剂，用于预防和/或治疗包括纤维化疾病在内的许多疾病。 在一个实施方案中，本发明的特征在于式I的化合物：
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公开(公告)号：US07691865B2
公开(公告)日：2010-04-06
申请号：US10526839
申请日：2003-09-05
申请人： Wen-Cherng Lee , Mary Beth Carter , Lihong Sun , Paul Lyne , Claudio Chuaqui , Zhongli Zheng , Juswinder Singh , Paula Boriack-Sjodin
发明人： Wen-Cherng Lee , Mary Beth Carter , Lihong Sun , Paul Lyne , Claudio Chuaqui , Zhongli Zheng , Juswinder Singh , Paula Boriack-Sjodin
IPC分类号： A61K31/519 , C07D471/02 , C07D487/04
CPC分类号： C07D487/04 , C07D471/04
摘要： Compounds of formula I possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. In one embodiment, the invention features a compound of formula I:
摘要翻译： 式I的化合物对Alk 5和/或Alk 4具有出人意料的高亲和力，并且可用作其拮抗剂，用于预防和/或治疗包括纤维化疾病在内的许多疾病。 在一个实施方案中，本发明的特征在于式I的化合物：
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公开(公告)号：US07612094B2
公开(公告)日：2009-11-03
申请号：US10510459
申请日：2003-04-04
申请人： Wen-Cherng Lee , Lihong Sun , Feng Shan , Claudio Chuaqui , Zhongli Zheng , Russell C. Petter
发明人： Wen-Cherng Lee , Lihong Sun , Feng Shan , Claudio Chuaqui , Zhongli Zheng , Russell C. Petter
IPC分类号： A61K31/4545 , C07D401/14
CPC分类号： C07D471/04 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/00 , C07D487/08
摘要： Compounds of formula (I) possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders.In one embodiment, the invention features a compound of the general formula (I).
摘要翻译： 式（I）化合物对Alk 5和/或Alk 4具有出人意料的高亲和力，并且可用作其拮抗剂，用于预防和/或治疗包括纤维化疾病在内的许多疾病。 在一个实施方案中，本发明的特征在于通式（I）的化合物。
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公开(公告)号：US20060063809A1
公开(公告)日：2006-03-23
申请号：US10510459
申请日：2003-04-04
申请人： Wen-Cherng Lee , Lihong Sun , Feng Shan , Claudio Chuaqui , Zhongli Zheng , Russell Petter
发明人： Wen-Cherng Lee , Lihong Sun , Feng Shan , Claudio Chuaqui , Zhongli Zheng , Russell Petter
IPC分类号： A61K31/4545 , A61K31/4439 , C07D403/14
CPC分类号： C07D471/04 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/00 , C07D487/08
摘要： Compounds of formula (I) possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. In one embodiment, the invention features a compound of the general formula (I).
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公开(公告)号：US20060264440A1
公开(公告)日：2006-11-23
申请号：US10545179
申请日：2004-02-12
申请人： Wen-Cherng Lee , Lihong Sun , Feng Shan , Claudio Chuaqui , Mark Cornebise , Timothy Pontz , Mary Carter , Juswinder Singh , Paula Boriack-Sjodin , Leona Ling , Russell Petter
发明人： Wen-Cherng Lee , Lihong Sun , Feng Shan , Claudio Chuaqui , Mark Cornebise , Timothy Pontz , Mary Carter , Juswinder Singh , Paula Boriack-Sjodin , Leona Ling , Russell Petter
IPC分类号： A61K31/522 , A61K31/52 , A61K31/519 , A61K31/517 , C07D473/02 , C07D487/04
CPC分类号： C07D401/14 , C07D401/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The invention is based on the discovery that compounds of formula I possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. In one embodiment, the invention features a compound of formula I (I).
摘要翻译： 本发明基于以下发现：式I化合物对Alk 5和/或Alk 4具有出人意料的高亲和力，并且可用作其拮抗剂，用于预防和/或治疗包括纤维化病症在内的许多疾病。 在一个实施方案中，本发明的特征在于式I（I）的化合物。
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公开(公告)号：US20060135517A1
公开(公告)日：2006-06-22
申请号：US10526653
申请日：2003-09-05
申请人： Wen-Cherng Lee , Mary Carter , Lihong Sun , Claudio Chuaqui , Juswinder Singh , Paula Boriack-Sjodin , Michael Choi
发明人： Wen-Cherng Lee , Mary Carter , Lihong Sun , Claudio Chuaqui , Juswinder Singh , Paula Boriack-Sjodin , Michael Choi
IPC分类号： A61K31/5377 , C07D471/02 , A61K31/506
CPC分类号： C07D471/04 , C07D471/02 , C07D487/04
摘要： Compounds of formula I possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. In one embodiment, the invention features a compound of formula I:
摘要翻译： 式I的化合物对Alk 5和/或Alk 4具有出人意料的高亲和力，并且可用作其拮抗剂，用于预防和/或治疗包括纤维化疾病在内的许多疾病。 在一个实施方案中，本发明的特征在于式I的化合物：
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公开(公告)号：US20080171755A1
公开(公告)日：2008-07-17
申请号：US11661531
申请日：2005-08-24
申请人： Wen-Cherng Lee , Lihong Sun , Claudio Chuaqui , Mark Comebise , Juswinder Singh , Feng Shan
发明人： Wen-Cherng Lee , Lihong Sun , Claudio Chuaqui , Mark Comebise , Juswinder Singh , Feng Shan
IPC分类号： A61K31/506 , C07D405/14 , C12N5/06 , A61P35/00 , A61P35/02 , A61P25/28
CPC分类号： C07D471/04 , C07D401/14 , C07D403/14 , C07D405/14
摘要： The invention is based on the discovery that compounds of formula (I) possess high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. The invention features a compound of formula (I) and uses thereof: formula (I).
摘要翻译： 本发明基于以下发现：式（I）化合物对Alk 5和/或Alk 4具有高亲和力，并且可用作其拮抗剂，用于预防和/或治疗包括纤维化疾病在内的许多疾病。 本发明的特征在于式（I）化合物及其用途：式（I）。
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公开(公告)号：US09546165B2
公开(公告)日：2017-01-17
申请号：US13499835
申请日：2010-10-05
申请人： Joseph Arndt , Timothy Chan , Kevin Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Daniel Scott , Lihong Sun , Jermaine Thomas , Kurt van Vloten , Deping Wang , Lei Zhang , Daniel Erlanson
发明人： Joseph Arndt , Timothy Chan , Kevin Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Daniel Scott , Lihong Sun , Jermaine Thomas , Kurt van Vloten , Deping Wang , Lei Zhang , Daniel Erlanson
IPC分类号： C07D471/04 , C07D487/04 , C07D239/94 , C07D241/26 , C07D213/82 , C07D213/85 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/14 , C07D473/34 , C07D491/052 , C07D519/00 , C07D241/28 , C07D498/04
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/452 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/4985 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/5383 , C07D213/82 , C07D213/85 , C07D241/26 , C07D241/28 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/14 , C07D473/34 , C07D487/04 , C07D491/052 , C07D498/04 , C07D519/00
摘要： The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.
摘要翻译： 本发明提供了可用作PDK1抑制剂的化合物。 本发明还提供了其组合物，以及治疗PDK1介导的疾病的方法。
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