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    Method of hemoglobin correction due to temperature variation
    1.
    发明申请
    Method of hemoglobin correction due to temperature variation 审中-公开
    由于温度变化引起的血红蛋白校正方法

    公开(公告)号：US20070054404A1

    公开(公告)日：2007-03-08

    申请号：US11222457

    申请日：2005-09-08

    申请人： Ziling Huo ,  William Li ,  Cheng Qian

    发明人： Ziling Huo ,  William Li ,  Cheng Qian

    IPC分类号： G01N33/72

    CPC分类号： G01N33/721 ,  G01N33/726

    摘要： A method of measuring a hemoglobin parameter of a test sample of blood comprises diluting and lysing a test sample. Then, a temperature corresponding to the test sample is obtained. The diluted and lysed test sample is then delivered to a cuvette, and a spectrophotometer determines the absorbance and/or transmittance of the sample in the cuvette. With the absorbance and/or transmittance of the test sample, a first measurement of the hemoglobin parameter of the test sample is obtained. After a first measurement of the hemoglobin parameter is obtained, a processor determines a corrected measurement of the hemoglobin parameter of the test sample. The corrected measurement is a function of the measured temperature that corresponds to the test sample and the first measurement of the hemoglobin parameter. The method of measuring a hemoglobin parameter is valid over a range of test sample temperatures.

    摘要翻译： 测量血液的测试样品的血红蛋白参数的方法包括稀释和裂解测试样品。 然后，获得与测试样品相对应的温度。 稀释并裂解的测试样品然后输送到比色皿，分光光度计确定样品在比色杯中的吸光度和/或透射率。 利用测试样品的吸光度和/或透射率，获得测试样品的血红蛋白参数的第一次测量。 在获得血红蛋白参数的第一次测量之后，处理器确定测试样品的血红蛋白参数的校正测量值。 校正的测量值是对应于测试样品的测量温度和血红蛋白参数的第一次测量的函数。 测量血红蛋白参数的方法在测试样品温度范围内有效。

    Embedded bio-sensor system
    2.
    发明授权
    Embedded bio-sensor system 失效

    公开(公告)号：US07297112B2

    公开(公告)日：2007-11-20

    申请号：US11582790

    申请日：2006-10-18

    申请人： Peter Zhou ,  Dexing Pang ,  William Li

    发明人： Peter Zhou ,  Dexing Pang ,  William Li

    IPC分类号： A61B5/00 ,  A61B5/05

    CPC分类号： A61B5/14865 ,  A61B5/0031 ,  A61B5/14532 ,  A61B2562/08 ,  G06F19/00 ,  G06F19/3418

    摘要： Provided is a bio-sensor system which utilizes radio frequency identification technology and which includes a remote transponder in wireless communication with an implantable passively-powered on-chip transponder. The bio-sensor system is specifically adapted to provide a substantially stable and precise sensor reference voltage to a sensor assembly that is included with the on-chip transponder. The remote transponder is also configured to remotely receive data representative of a physiological parameter of the patient as well as identification data and may enable readout of one or more of the physiological parameters that are measured, processed and transmitted by the on-chip transponder upon request by the remote transponder. The precision and stability of the sensor reference voltage is enhanced by the specific circuit architecture of the glucose sensor to allow for relatively accurate measurement of the physiological parameter such as measurement of glucose concentration by a glucose sensor without the use of a microprocessor.

    Method and apparatus for controlling reaction temperature in bio-chemical instruments
    3.
    发明申请
    Method and apparatus for controlling reaction temperature in bio-chemical instruments 有权
    用于控制生物化学仪器中反应温度的方法和装置

    公开(公告)号：US20070183945A1

    公开(公告)日：2007-08-09

    申请号：US11349445

    申请日：2006-02-07

    申请人： William Li ,  Rongchang Xin ,  Wing Pang ,  Dobson Okawa

    发明人： William Li ,  Rongchang Xin ,  Wing Pang ,  Dobson Okawa

    IPC分类号： B01J19/00

    CPC分类号： G01N1/38 ,  B01F13/0222 ,  B01F13/0233 ,  B01J2219/00495 ,  B01L7/00 ,  G01N2035/00425

    摘要： Method and apparatus for controlling the temperature of one or more reaction vessels in a bio-chemical analyzer comprises a heat-exchange block, preferably made of cast aluminum or the like, and a thermoelectric device for heating or cooling the block to within a desired temperature range. The heat-transfer block cradles one or more reaction vessels in a thermal energy-transferring relationship, and further supports, in a thermal energy-transferring relationship, one or more fluid conduits serving to transmit a liquid or gas to the interior of the reaction vessels. Preferably, the heat-transfer block is cast from aluminum, and the fluid conduits are disposed inside the casting. By supporting the reaction vessel(s) and fluid conduit(s) in a common block, a single thermoelectric device and controller can be used to simultaneously control the respective temperatures of multiple fluid reagents and/or gases, as well as one or more reaction vessels, thereby reducing the power requirements of the thermal control system.

    摘要翻译： 用于控制生物化学分析仪中一个或多个反应容器的温度的方法和装置包括优选由铸铝等制成的热交换块和用于将块加热或冷却至所需温度的热电装置 范围。 热传递块以热能传递关系支撑一个或多个反应容器，并且在热能传递关系中进一步支撑用于将液体或气体传输到反应容器内部的一个或多个流体导管 。 优选地，传热块从铝铸造，并且流体导管设置在铸件内部。 通过将反应容器和流体导管支撑在共同的块中，可以使用单个热电装置和控制器来同时控制多个流体试剂和/或气体的相应温度，以及一个或多个反应 容器，从而降低了热控制系统的功率要求。

    Embedded bio-sensor system
    4.
    发明授权
    Embedded bio-sensor system 失效
    嵌入式生物传感器系统

    公开(公告)号：US07125382B2

    公开(公告)日：2006-10-24

    申请号：US10849614

    申请日：2004-05-20

    申请人： Peter Zhou ,  Dexing Pang ,  William Li

    发明人： Peter Zhou ,  Dexing Pang ,  William Li

    IPC分类号： A61B5/00 ,  A61B5/05

    CPC分类号： A61B5/14865 ,  A61B5/0031 ,  A61B5/14532 ,  A61B2562/08 ,  G06F19/00 ,  G06F19/3418

    摘要： Provided is a bio-sensor system which utilizes radio frequency identification technology and which includes a remote transponder in wireless communication with an implantable passively-powered on-chip transponder. The bio-sensor system is specifically adapted to provide a substantially stable and precise sensor reference voltage to a sensor assembly that is included with the on-chip transponder. The remote transponder is also configured to remotely receive data representative of a physiological parameter of the patient as well as identification data and may enable readout of one or more of the physiological parameters that are measured, processed and transmitted by the on-chip transponder upon request by the remote transponder. The precision and stability of the sensor reference voltage is enhanced by the specific circuit architecture of the glucose sensor to allow for relatively accurate measurement of the physiological parameter such as measurement of glucose concentration by a glucose sensor without the use of a microprocessor.

    摘要翻译： 提供了一种利用射频识别技术的生物传感器系统，其包括与可植入式被动供电的片上转发器进行无线通信的远程转发器。 生物传感器系统特别地适于向片上转发器附带的传感器组件提供基本上稳定和精确的传感器参考电压。 远程转发器还被配置为远程接收表示患者的生理参数的数据以及识别数据，并且可以使得能够读出由片上应答器根据请求测量，处理和传输的一个或多个生理参数 由远程转发器。 传感器参考电压的精度和稳定性通过葡萄糖传感器的具体电路结构得到增强，以允许相对精确地测量生理参数，例如葡萄糖传感器测量葡萄糖浓度而不使用微处理器。

    Light refraction illumination device
    5.
    发明授权
    Light refraction illumination device 有权
    光折射照明装置

    公开(公告)号：US08029157B2

    公开(公告)日：2011-10-04

    申请号：US12336352

    申请日：2008-12-16

    申请人： William Li ,  Jack Li

    发明人： William Li ,  Jack Li

    IPC分类号： F21S4/00 ,  F21V21/00

    CPC分类号： F21V5/048 ,  F21V13/04 ,  F21Y2115/10 ,  G02B19/0028 ,  G02B19/0066 ,  Y10S362/80

    摘要： In an embodiment, a light refraction illumination device is disclosed. The light refraction illumination device may comprise or include a support member, and a plurality of lenses associated with the support member, wherein each lens from among the plurality of lenses may comprise or include a plurality of concave surfaces. The light refraction illumination device may further comprise or include at least one light source associated with the support member, wherein the at least one light source is configured to emit light, and wherein the at least one light source is positioned relative to the plurality of lenses such that the light is configured to travel through the plurality of concave surfaces.

    摘要翻译： 在一个实施例中，公开了一种光折射照明装置。 光折射照明装置可以包括或包括支撑构件和与支撑构件相关联的多个透镜，其中来自多个透镜中的每个透镜可以包括或包括多个凹面。 光折射照明装置还可以包括或包括与支撑构件相关联的至少一个光源，其中所述至少一个光源被配置为发射光，并且其中所述至少一个光源相对于所述多个透镜定位 使得所述光被配置成行进通过所述多个凹面。

    System and method for continuously transferring and processing liquids
    6.
    发明申请
    System and method for continuously transferring and processing liquids 有权
    用于连续转移和处理液体的系统和方法

    公开(公告)号：US20070086923A1

    公开(公告)日：2007-04-19

    申请号：US11249192

    申请日：2005-10-13

    申请人： William Li ,  Rongchang Xin ,  Elgardo Echevarria ,  John Mitchell

    发明人： William Li ,  Rongchang Xin ,  Elgardo Echevarria ,  John Mitchell

    IPC分类号： B01L3/02

    CPC分类号： B01L3/0203 ,  B01L2200/0684 ,  B01L2200/16 ,  B01L2400/0487 ,  G01N35/1002 ,  Y10T436/2575

    摘要： A liquid transfer system for transferring liquid from a plurality of containers to a plurality of destinations comprises a plurality of inlet valves. Each inlet valve is operable between an open position allowing liquid from a container to be drawn into the system and a closed position blocking liquid from a container from being drawn into the system. Liquid drawn from each of the liquid containers is delivered to a buffer chamber designed to degas the liquid in the buffer chamber. The buffer chamber leads to a vented feeder chamber that is also adapted to retain a volume of liquid. A chamber connection valve is provided between the buffer chamber and the feeder chamber to allow or block the flow of liquid between the buffer chamber and the feeder chamber. The feeder chamber is connected to a plurality of distribution valves operable to deliver liquid to a plurality of destinations.

    摘要翻译： 用于将液体从多个容器传送到多个目的地的液体传送系统包括多个入口阀。 每个入口阀可以在允许来自容器的液体被吸入系统的打开位置和封闭位置之间操作，该封闭位置阻止液体从容器被吸入系统。 从每个液体容器抽出的液体被输送到设计成使缓冲室中的液体脱气的缓冲室。 缓冲室通向通风的进料室，其也适于保持一定体积的液体。 腔室连接阀设置在缓冲室和进料室之间，以允许或阻止液体在缓冲室和给料室之间的流动。 进料室连接到可操作以将液体输送到多个目的地的多个分配阀。

    Apparatus for aspirating liquids from sealed containers
    7.
    发明申请
    Apparatus for aspirating liquids from sealed containers 有权

    公开(公告)号：US20060216208A1

    公开(公告)日：2006-09-28

    申请号：US11088157

    申请日：2005-03-23

    申请人： William Li ,  Craig Veiner ,  Sergio Cabrera

    发明人： William Li ,  Craig Veiner ,  Sergio Cabrera

    IPC分类号： B01L3/02

    CPC分类号： G01N35/1079 ,  B01L3/0293 ,  B01L9/52 ,  G01N2035/0405

    摘要： Apparatus for aspirating liquid from a container, e.g., a test tube, having a puncturable stopper includes a pair of stepper motors that share a common linear actuator or drive member. One motor operates to axially advance the linear drive member (preferably a lead screw) to a position in which it serves to position a rigidly connected tube-detector/stripper member in engagement with the top of a stopper on a tube. Thereafter, the second motor operates to move along the surface of the same drive member to advance an aspiration probe through the engaged stopper and into a liquid aspirating position within the tube. Preferably, a linear guide rail, slidably-mounted on a frame that supports the liquid-aspirating apparatus, serves to guide both the movement of the aspiration probe and the linear drive member. As a result of the shared components, the apparatus is highly precise and reliable.