公开(公告)号：US20250163180A1

公开(公告)日：2025-05-22

申请号：US19034755

申请日：2025-01-23

Applicant: ABL Bio Inc. ,  YUHAN CORPORATION

Inventor： Hyejin CHUNG ,  Yeryoung YONG ,  Kyeongsu PARK ,  Eunyoung PARK ,  Ui-Jung JUNG ,  Yangsoon LEE ,  Eunjung KIM ,  Yong-Gyu SON ,  Wonjun SON ,  Seawon AHN ,  Donghoon YEOM ,  Chanmoo LEE ,  Junghyeon HONG ,  Moo Young SONG ,  Eun-Jung LEE ,  Na Rae LEE ,  Young Bong PARK ,  Eun-Jung LEE ,  Taewang KIM

IPC: C07K16/32 ,  A61K39/00 ,  A61P35/00 ,  C07K16/28

Abstract: Provided are an anti-4-1BB/anti-HER2 bispecific antibody, and a pharmaceutical composition and a method for treating and/or preventing a cancer using the same.

公开(公告)号：US12049493B2

公开(公告)日：2024-07-30

申请号：US16475853

申请日：2018-01-05

Applicant: ABL Bio Inc.

Inventor： Jinhyung Ahn ,  Sungwon An ,  Dongin Kim ,  Eunsil Sung ,  Jaehyun Eom ,  Sang Hoon Lee ,  Seung-Jae Lee ,  Tae Kyung Kim ,  Min Sun Choi ,  Weonkyoo You ,  Jaeho Jung ,  Juhee Kim ,  Jinwon Jung ,  Yeunju Kim ,  Yonggyu Son ,  Byungje Sung

IPC: C07K16/18 ,  A61K39/00 ,  A61P25/14 ,  G01N33/68

CPC classification number: C07K16/18 ,  A61P25/14 ,  G01N33/6896 ,  A61K2039/505 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/92 ,  G01N2800/2835

Abstract: The disclosure discloses anti α-Syn antibodies preferentially recognizing α-Syn aggregates. The antibodies of the present invention bind to α-Syn aggregates with high affinity and specificity and inhibit accumulation or intercellular transfer of α-Syn aggregates, and thus can be used for detection, diagnosis and/or treatment or prevention of various diseases caused by the accumulation of α-Syn aggregates.

公开(公告)号：US20240101687A1

公开(公告)日：2024-03-28

申请号：US18480071

申请日：2023-10-03

Applicant: ABL Bio Inc.

Inventor： Jinhyung AHN ,  Sungwon AN ,  Dongin KIM ,  Eunsil SUNG ,  Jaehyun EOM ,  Sang Hoon Lee ,  Weonkyoo YOU ,  Juhee KIM ,  Kyungjin PARK ,  Hyejin CHUNG ,  Jinwon JUNG ,  Bora LEE ,  Byungje SUNG ,  Yeunju KIM ,  Yong-Gyu SON ,  Seawon AHN ,  Daehae SONG ,  Jiseon YOO ,  Youngdon PAK ,  Donghoon YEOM ,  Yoseob LEE ,  Jaeho JUNG

IPC: C07K16/28 ,  A61K47/68 ,  C07K16/18

CPC classification number: C07K16/2863 ,  A61K47/6845 ,  C07K16/18 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/567

Abstract: The present invention relates to a bi-specific antibody that specifically binds to alpha-synuclein and IGF1R, and an use of the bi-specific antibody for the prevention, treatment and/or diagnosis of synucleinopathies associated with alpha-synuclein or alpha-synuclein aggregates, and can allow the alpha-synuclein antibody or an antigen-binding fragment thereof to penetrate the blood brain barrier to exert its action in the brain, and extend the half-life to maintain the efficacy for a long time.

公开(公告)号：US20220363763A1

公开(公告)日：2022-11-17

申请号：US17269784

申请日：2019-08-21

Applicant: ABL BIO INC.

Inventor： Eunyoung PARK ,  Yangsoon LEE ,  Uijung JUNG ,  YoungKwang KIM ,  Yeun Ju KIM ,  Youngdon PAK ,  Sang Hoon LEE ,  Weon-Kyoo YOU ,  Jaeho JUNG ,  Lei FANG ,  Wenqing JIANG

IPC: C07K16/28 ,  A61P35/00

Abstract: The present disclosure provides an anti-PD-L1/anti-LAG3 bispecific antibody capable to effectively block the interactions between PD-L1 and its receptor PD-1 and between LAG3 and its ligand (e.g., a MHC class II molecule and FGL1). The bispecific antibody may have high binding affinity to both of a PD-L1 protein (e.g., a human PD-L1 protein) and a LAG3 protein (e.g., a human LAG3 protein). Also provided are antibodies and fragments that have specificity to the PD-L1 or LAG3 protein alone, or antibodies and fragments having additional specificity to one or more other antigens.

公开(公告)号：US20220242961A1

公开(公告)日：2022-08-04

申请号：US17296752

申请日：2019-12-02

Applicant: ABL Bio Inc.

Inventor： Eunyoung PARK ,  Yangsoon LEE ,  Hyejin CHUNG ,  Uijung JUNG ,  Youngdon PAK ,  Jun Hyun JEONG ,  Yeunju KIM ,  Seawon AHN ,  Byungje SUNG

IPC: C07K16/28 ,  A61P35/00

Abstract: Provided is an anti-4-1 BB antibody or an antigen-binding fragment thereof, and uses thereof.

公开(公告)号：US20210317224A1

公开(公告)日：2021-10-14

申请号：US17286437

申请日：2020-08-12

Applicant: I-Mab Biopharma US Limited ,  ABL Bio Inc.

Inventor： Wenqing Jiang ,  Lei Fang ,  Zhengyi Wang ,  Bingshi Guo ,  Eunyoung Park ,  Eunsil Sung ,  Byungje Sung

IPC: C07K16/28 ,  A61P35/00

Abstract: Provided are bispecific and multi-specific antibodies that target both claudin 18.2 (CLDN18.2) and 4-1BB. These antibodies, in the absence of CLDN18.2-expressing cells, can bind to 4-1BB but are unable to activate 4-1BB signaling. In the presence of CLDN18.2-expressing cells, however, these antibodies can trigger CLDN18.2-dependent 4-1BB signaling, leading to potent immune response to the CLDN18.2-expressing tumor cells.

公开(公告)号：US20210024650A1

公开(公告)日：2021-01-28

申请号：US16939536

申请日：2020-07-27

Applicant: ABL Bio Inc. ,  YUHAN CORPORATION

Inventor： Hyejin CHUNG ,  Yeryoung Yong ,  Kyeongsu Park ,  Eunyoung Park ,  Ui-Jung Jung ,  Yangsoon Lee ,  Eunjung Kim ,  Yong-Gyu Son ,  Wonjun Son ,  Seawon Ahn ,  Donghoon Yeom ,  Chanmoo Lee ,  Junghyeon Hong ,  Moo Young Song ,  Eun-Jung Lee ,  Na Rae Lee ,  Young Bong Park ,  Eun-Jung Lee ,  Taewang Kim

IPC: C07K16/32 ,  C07K16/28 ,  A61P35/00

Abstract: Provided are an anti-4-1BB/anti-HER2 bispecific antibody, and a pharmaceutical composition and a method for treating and/or preventing a cancer using the same.

公开(公告)号：US20250145718A1

公开(公告)日：2025-05-08

申请号：US19012836

申请日：2025-01-07

Applicant: ABL BIO INC. ,  I-MAB BIOPHARMA US LIMITED

Inventor： Eunyoung PARK ,  Yangsoon LEE ,  Hyejin CHUNG ,  Eunsil SUNG ,  Jiseon YOO ,  Minji PARK ,  Yong-Gyu SON ,  Hyoju CHOI ,  Eunjung KIM ,  Jaeho JUNG ,  Weon-Kyoo YOU ,  Sang Hoon LEE ,  Lei FANG ,  Wenqing JIANG

IPC: C07K16/28 ,  A61P35/00 ,  C07K16/46

Abstract: The present disclosure provides a polynucleotide encoding the anti-PD-L1/anti-4-1BB bispecific antibody capable to effectively block the interactions between PD-L1 and its receptor PD-1 and between 4-1BB and its ligand. The bispecific antibody may have high binding affinity to both of a PD-L1 protein and a 4-1BB protein.

公开(公告)号：US20250115670A1

公开(公告)日：2025-04-10

申请号：US18830263

申请日：2024-09-10

Applicant: ABL BIO INC.

Inventor： Sungwon AN ,  Jinhyung AHN ,  Byungje SUNG ,  Dongin KIM ,  Daehae SONG ,  Jaehyun EOM ,  Yong-Gyu SON ,  Kyungjin PARK ,  Juhee KIM ,  Jinwon JUNG ,  Bora LEE ,  Hyesu YUN

IPC: C07K16/28 ,  A61K39/00 ,  A61P25/28 ,  C07K16/18

Abstract: The present disclosure relates to a bispecific antibody that specifically binds to alpha-synuclein and IGF1R, and an use of the bispecific antibody for the prevention, treatment and/or diagnosis of synucleinopathies associated with alpha-synuclein or alpha-synuclein aggregates, and can allow the alpha-synuclein antibody or an antigen-binding fragment thereof to penetrate the blood brain barrier to exert its action in the brain, and extend the half-life to maintain the efficacy for a long time.

公开(公告)号：US12240913B2

公开(公告)日：2025-03-04

申请号：US16939536

申请日：2020-07-27

Applicant: ABL Bio Inc. ,  YUHAN CORPORATION

Inventor： Hyejin Chung ,  Yeryoung Yong ,  Kyeongsu Park ,  Eunyoung Park ,  Ui-Jung Jung ,  Yangsoon Lee ,  Eunjung Kim ,  Yong-Gyu Son ,  Wonjun Son ,  Seawon Ahn ,  Donghoon Yeom ,  Chanmoo Lee ,  Junghyeon Hong ,  Moo Young Song ,  Eun-Jung Lee ,  Na Rae Lee ,  Young Bong Park ,  Eun-Jung Lee ,  Taewang Kim

IPC: C07K16/00 ,  A61P35/00 ,  C07K16/28 ,  C07K16/32 ,  A61K39/00

Abstract: Provided are an anti-4-1BB/anti-HER2 bispecific antibody, and a pharmaceutical composition and a method for treating and/or preventing a cancer using the same.