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公开(公告)号：US07176455B1
公开(公告)日：2007-02-13
申请号：US11135926
申请日：2005-05-23
申请人： Craig M. Whitehouse , Erol Gulcicek
发明人： Craig M. Whitehouse , Erol Gulcicek
IPC分类号： H01J49/00
CPC分类号： H01J49/063 , H01J49/0481
摘要： A multipole ion guide which begins in one pumping stage and extends continuously into one or more subsequent pumping stages has been incorporated into an atmospheric pressure ion source mass spectrometer system. Ions delivered into vacuum from an Electrospray, Atmospheric Pressure Chemical Ionization or Inductively Coupled Plasma ion source are guided and focused into a mass analyzer with high efficiency using the multipole ion guide. The background pressure over a portion of the multipole ion guide length is high enough to cause kinetic energy cooling of ions traversing the ion guide length due to ion collisions with neutral background gas molecules. This ion kinetic energy cooling lowers energy spread of ions traversing the multipole ion guide length. The multipole ion guide DC offset potential can be used to adjust the mean ion energy and the ion guide an and qn values can be set to reduce or expand the range of ion mass to charge which will be transmitted through the ion guide. These features of multipole ion guides and multiple pumping stage multipole ion guides are used to improve performance and lower the cost of Atmospheric Pressure Ion source mass spectrometer instruments.
摘要翻译： 在一个泵送阶段开始并连续延伸到一个或多个后续泵送阶段的多极离子导向器已经被并入到大气压离子源质谱仪系统中。 从电喷雾，大气压化学电离或电感耦合等离子体离子源进入真空的离子被引导并且使用多极离子导向器以高效率聚焦到质量分析器中。 多极离子导向器长度的一部分上的背景压力足够高，由于与中性背景气体分子的离子碰撞而导致横过离子导向器长度的离子的动能冷却。 这种离子动能冷却降低了穿过多极离子导向器长度的离子的能量扩散。 可以使用多极离子导向DC偏移电位来调整平均离子能量，并且可以设置离子导向器以减小或扩大范围 将通过离子导向器传输的离子质量。 多极离子导向器和多泵级多极离子导向器的这些特性用于提高大气压离子源质谱仪器的性能和降低成本。
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公开(公告)号：US07019285B2
公开(公告)日：2006-03-28
申请号：US09808468
申请日：2001-03-14
IPC分类号： H01J49/40
CPC分类号： H01J49/401
摘要： A method and an apparatus which combines at least one linear two dimensional ion guide or a two dimensional ion storage device in tandem with a time-of-flight mass analyzer to analyze ionic chemical species generated by an ion source. The method improves the duty cycle, and therefore, the overall instrument sensitivity with respect to the analyzed chemical species.
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公开(公告)号：US06060705A
公开(公告)日：2000-05-09
申请号：US988491
申请日：1997-12-10
CPC分类号： H01J49/165
摘要： Improvements have been made to the Electrospray and Atmospheric Pressure Chemical Ionization source chambers interfaced to mass spectrometers to simplify source performance optimization and source operation and to improve system sensitivity. The atmospheric pressure ion source procedure for optimizing performance has been simplified by adding windows along the sides of the atmospheric pressure ionization chamber allowing direct viewing of the Electrospray and Atmospheric pressure ion sources during operation. A cylindrical lens which extends along the side walls of the atmospheric pressure chamber has been configured to be semitransparent for viewing into the chamber. This cylindrical shaped side lens is electrically isolated from the Electrospray liquid introduction needle and Electrospray chamber endplate. Improved Electrospray mass spectrometer system sensitivity can be achieved when operating the cylindrical lens with a higher potential difference between it and the Electrospray liquid introduction needle than is set between the needle and the endplate.
摘要翻译： 已经对与质谱仪连接的电喷雾和大气压化学电离源室进行了改进，以简化源性能优化和源操作，并提高系统灵敏度。 通过在大气压电离室的侧面添加窗口可简化用于优化性能的大气压离子源程序，从而可以在运行期间直接观察电喷雾和大气压离子源。 沿着大气压力室的侧壁延伸的圆柱形透镜已经被配置为半透明的，用于观察室。 该圆柱形侧透镜与电喷雾液引入针和电喷雾室终板电隔离。 当操作具有比电针与终板之间设置的电喷雾引入针之间更高的电位差的柱面透镜时，可以实现改进的电喷雾质谱系统灵敏度。
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公开(公告)号：US6040575A
公开(公告)日：2000-03-21
申请号：US235945
申请日：1999-01-22
CPC分类号： H01J49/40 , B82Y15/00 , B82Y30/00 , H01J49/0068
摘要： A Time-Of-Flight mass spectrometer is configured with a pulsing region and electronic controls to cause the directing of ions to a surface in the Time-Of-Flight pulsing region. The population of ions resulting from the collecting of said ions on or near said surface is subsequently accelerated into the Time-Of-Flight tube for mass to charge analysis. Ions produced away from said surface located in the pulsing region of a Time-Of-Flight mass spectrometer can be directed to the surface with high or low surface collisional energies. Higher energy ion collisions with the surface can result in Surface Induced Dissociation fragmentation and the resulting ion fragment population can be accelerated into Time-Of-Flight tube where the ions are mass to charge analyzed. Ion mass to charge selection can occur prior to directing ions to the pulsing region surface allowing MS/MS Time-Of-Flight mass analysis with SID. Ion to surface low energy collisions or soft landings resulting in little or no ion fragmentation provide a means for spatially focusing ions on or near the surface prior to accelerating the surface collected ions into the Time-Of-Flight tube. The apparatus and methods described in the invention result in refined control of ion fragmentation energy and improved Time-Of-Flight mass to charge analysis performance.
摘要翻译： 飞行时间质谱仪配置有脉冲区域和电子控制器，以将离子引导到飞行时间脉动区域中的表面。 随后在所述表面上或附近收集所述离子产生的离子群随后被加速到飞行时间管中用于质量进行电荷分析。 离开位于飞行时间质谱仪的脉冲区域的所述表面的离子可以被引导到具有高或低表面碰撞能量的表面。 与表面的高能离子碰撞可导致表面诱导解离破碎，并且所得到的离子片段群体可以加速到飞行时间管中，其中离子被质量分析。 在将离子引导到脉冲区域表面之前可以进行离子质量以进行电荷选择，从而允许使用SID的MS / MS飞行时间质量分析。 离子到表面的低能量碰撞或软着陆导致很少或没有离子碎裂提供了在将表面收集的离子加速到飞行时间管之前将离子空间聚焦在表面上或附近的手段。 本发明中描述的装置和方法导致离子断裂能量的精细控制和改进的飞行时间质量以进行电荷分析性能。
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公开(公告)号：US6020586A
公开(公告)日：2000-02-01
申请号：US971521
申请日：1997-11-17
CPC分类号： H01J49/401 , H01J49/004 , H01J49/063
摘要： A method and an apparatus which combines at least one linear two dimensional ion guide or a two dimensional ion storage device in tandem with a time-of-flight mass analyzer to analyze ionic chemical species generated by an ion source. The method improves the duty cycle, and therefore, the overall instrument sensitivity with respect to the analyzed chemical species.
摘要翻译： 将至少一个线性二维离子导向器或二维离子存储装置与飞行时间质量分析器串联组合以分析由离子源产生的离子化学物质的方法和装置。 该方法提高了相对于分析的化学物质的占空比，因此提高了仪器的整体灵敏度。
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公开(公告)号：US5869829A
公开(公告)日：1999-02-09
申请号：US887615
申请日：1997-07-03
申请人： Thomas Dresch
发明人： Thomas Dresch
CPC分类号： H01J49/405 , H01J49/40 , H01J49/403
摘要： A Time-of-Flight Mass Spectrometer (TOF-MS) is configured to improve resolution and sensitivity performance. The TOF-MS includes an arrangement of electrodes comprising an ion accelerator with two stages of homogeneous electric fields, an ion reflector with a single stage of a homogeneous electric field, accelerator and reflector being separated by a first drift space, and an ion detector which is separated from the reflector by a second drift space. Contrary to known TOF-MS of similar configuration, the set of electric potentials which must be applied to said electrodes is predetermined for a given geometry in such a way that a spatial distribution of ions initially at rest in the first gap of the said accelerator is compressed at the location of the detector in the longitudinal direction to a focus of first and second order in the initial axial coordinate. Therefore, mass resolution is enhanced over a TOF-MS that provides only for longitudinal focusing of first order, while the number of passages through grid electrodes along the flight path is reduced, and hence ion transmission and instrument sensitivity are improved.
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公开(公告)号：US07601951B1
公开(公告)日：2009-10-13
申请号：US09423471
申请日：1997-05-17
IPC分类号： B01D59/44
CPC分类号： H01J49/145 , H01J49/06
摘要： An API source for mass spectrometry which is configured such that all or a portion of its vacuum assembly, including ion focusing and transport electrostatic lenses and ion guides, and two or more vacuum stages can be removed from the source or system vacuum housing as a complete assembly. The API source may be an ES, APCI or ICP source, or any other ion source which operates at substantially atmospheric pressure. The insert assembly can be electrically isolated from the grounded vacuum housing to enable the delivery of kilovolt potential ions into a magnetic sector mass analyzer from the API source. The insert assemblies can be configured to interface to quadrupole, Time-Of-Flight, ion trap, Fourier Transform, and magnetic sector mass analyzers. Electrical connections can be configured internally to make and break automatically when said insert assembly is inserted or removed from the surrounding vacuum housing. The insert assembly is configured to be removed from the vacuum housing without the need to disconnect vacuum pumps, vacuum pumping lines, vacuum gauges, or external electrical connectors. The invention simplifies the cleaning and maintenance of API mass analyzer systems, can reduce the cost and complexity of said systems and can reduce instrument down time. The API insert assembly removal allows for the insertion of alternative ion sources, for example, Laser Desorption, Electron Bombardment, Chemical Ionization, Thermospray, and Particle Beam hardware which can utilize the same vacuum pumps and electrical contacts as are used by the API source.
摘要翻译： 用于质谱的API来源，其被配置为使得其真空组件的全部或一部分（包括离子聚焦和输送静电透镜和离子导向器）以及两个或更多个真空级可以从源或系统真空壳体中移除，作为完整的 部件。 API源可以是ES，APCI或ICP源，或者在基本上大气压下工作的任何其他离子源。 插入组件可以与接地的真空壳体电隔离，以使得能够从API源将千伏电位离子输送到磁性扇区质量分析器中。 插入组件可以配置为与四极杆，飞行时间，离子阱，傅立叶变换和磁性扇区质量分析仪接口。 当所述插入组件从周围的真空壳体插入或移除时，可以在内部配置电气连接以自动制动和断开。 插入组件被配置为从真空壳体移除，而不需要断开真空泵，真空泵送管线，真空计或外部电连接器。 本发明简化了API质量分析仪系统的清洁和维护，可以降低所述系统的成本和复杂性，并可以减少仪器停机时间。 API插入组件移除允许插入替代离子源，例如激光解吸，电子轰击，化学离子化，热气体和粒子束硬件，其可以利用与API源使用的相同的真空泵和电触点。
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公开(公告)号：US07528369B2
公开(公告)日：2009-05-05
申请号：US11965448
申请日：2007-12-27
IPC分类号： H01J49/00
CPC分类号： H01J49/167
摘要： An improved sample introduction probe is disclosed for the production of ions from liquid sample solutions in an electrospray ion source. Nebulization of a liquid sample emerging from the end of an inner flow tube is pneumatically assisted by gas flowing from the end of an outer gas flow tube essentially coaxial with the inner sample flow tube. The disclosed probe provides for adjustment of the relative axial positions of the ends of the liquid and gas flow tubes without degrading the precise concentricity between the inner and outer tubes. Additionally, the terminal portion of the outer gas flow tube may be fabricated either from a conductive or dielectric material, thereby allowing the pneumatic nebulization and electrospray processes to be optimized separately and independently. Hence, the disclosed invention provides a pneumatically-assisted electrospray probe with improved mechanical and operational stability, reliability, reproducibility, and ease of use compared to prior art probes.
摘要翻译： 公开了用于在电喷雾离子源中从液体样品溶液中产生离子的改进的样品引入探针。 从内流管端部出现的液体样品的雾化由气体从与内部样品流管同轴的外部气体流管的端部流动的气体辅助。 所公开的探针提供了调节液体和气体流管的端部的相对轴向位置，而不会降低内管和外管之间的精确同心度。 此外，外部气体流动管的端子部分可以由导电材料或介电材料制成，从而允许气动雾化和电喷雾工艺被独立地和独立地优化。 因此，与现有技术的探针相比，所公开的发明提供了具有改进的机械和操作稳定性，可靠性，再现性和易用性的气动辅助电喷雾探针。
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9.发明授权Method and apparatus for multiplexing plural ion beams to a mass spectrometer 有权将多个离子束多路复用于质谱仪的方法和装置公开(公告)号：US07528366B1
公开(公告)日：2009-05-05
申请号：US12107539
申请日：2008-04-22
申请人： James G. Boyle , Robert A. Valley
发明人： James G. Boyle , Robert A. Valley
IPC分类号： H01J49/40
CPC分类号： H01J49/107
摘要： A method and apparatus for multiplexing plural ion beams to a mass spectrometer. At least two ion sources are provided with means of transporting the ions from the ion sources to separate two-dimensional ion traps. Each ion trap is used for storage and transmission of the ions and operates between the ion sources and the mass analyzer. Each ion trap has a set of equally spaced, parallel multipole rods, as well as entrance and exit sections into which and from which ions enter and exit the trap, respectively. For each ion trap, the entrance section is placed in a region where background gas pressure is at viscous flow. The pressure at the exit section drops to molecular flow pressure regimes without a break in the structure of the ion trap. Each trap alternately stores and transmits ions by way of a fast voltage switch applied to the ion trap exit lens.
摘要翻译： 一种用于将多个离子束复制到质谱仪的方法和装置。 至少两个离子源具有将离子从离子源输送到分离的二维离子阱的装置。 每个离子阱用于离子的存储和传输，并在离子源和质量分析仪之间运行。 每个离子阱具有一组等间隔的平行多极杆，以及离子分别进入和离开的入口和出口部分。 对于每个离子阱，入口部分被放置在背景气体压力处于粘性流动的区域中。 出口部分的压力下降到分子流压力方案，而离子阱的结构没有中断。 每个陷阱通过施加到离子阱出口透镜的快速电压开关交替地存储和传输离子。
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公开(公告)号：US07365317B2
公开(公告)日：2008-04-29
申请号：US11133724
申请日：2005-05-20
IPC分类号： H01J49/42
CPC分类号： H01J49/42 , H01J49/062
摘要： Apparatus and methods are provided for trapping, manipulation and transferring ions along RF and DC potential surfaces and through RF ion guides. Potential wells are formed near RF-field generating surfaces due to the overlap of the radio-frequency (RF) fields and electrostatic fields created by static potentials applied to surrounding electrodes. Ions can be constrained and accumulated over time in such wells. During confinement, ions may be subjected to various processes, such as accumulation, fragmentation, collisional cooling, focusing, mass-to-charge filtering, spatial separation ion mobility and chemical interactions, leading to improved performance in subsequent processing and analysis steps, such as mass analysis. Alternatively, the motion of ions may be better manipulated during confinement to improve the efficiency of their transport to specific locations, such as an entrance aperture into vacuum from atmospheric pressure or into a subsequent vacuum stage.
摘要翻译： 提供了设备和方法，用于沿着RF和DC电势表面以及通过RF离子导向器捕获，操纵和转移离子。 由于射频（RF）场和施加到周围电极的静电势产生的静电场的重叠，在RF场产生表面附近形成潜在的阱。 这些井中的离子可以随着时间的推移而受到约束和积累。 在限制期间，离子可以经历各种过程，例如累积，碎裂，碰撞冷却，聚焦，质量 - 电荷过滤，空间分离离子迁移和化学相互作用，导致后续处理和分析步骤中的改进的性能，例如 质量分析。 或者，可以在限制期间更好地操作离子的运动，以提高其运送到特定位置的效率，例如从大气压进入真空的入口孔或进入随后的真空级。
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