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公开(公告)号：US20240307628A1
公开(公告)日：2024-09-19
申请号：US18594627
申请日：2024-03-04
IPC分类号： A61M5/315 , A61K31/7048
CPC分类号： A61M5/31513 , A61K31/7048
摘要： Systems and methods are described for treatment and/or prevention of a metabolic disorder and/or another medical condition in a patient (e.g., a feline) by administering to the patient a liquid pharmaceutical composition, preferably including one or more SGLT-2 inhibitor compound(s), via a delivery system that includes a syringe. The syringe includes features that facilitate easy, safe and effective doses of small volumetric amounts of the liquid pharmaceutical composition to the patient during administration.
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2.发明公开公开(公告)号：US20240307426A1
公开(公告)日：2024-09-19
申请号：US18578207
申请日：2022-07-26
发明人： Carla KROH , Ingo Ulrich LANG , José MATALLO
IPC分类号： A61K31/7056 , A61K31/382 , A61K31/7034 , A61K31/7048 , A61P13/12
CPC分类号： A61K31/7056 , A61K31/382 , A61K31/7034 , A61K31/7048 , A61P13/12
摘要： The present invention is directed to the use of one or more SGLT-2 inhibitors or pharmaceutically acceptable forms thereof for the prophylaxis and/or treatment of one or more renal diseases in a non-human mammal, such as a carnivore, in particular a cat or a dog.
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公开(公告)号：US20240226264A1
公开(公告)日：2024-07-11
申请号：US18396787
申请日：2023-12-27
发明人： Arun IYER , Luis Alejandro Hernandez , Abby Patterson , Bailey Arruda , Luis Gabriel Gimenez-Lirola , Dave Michael Anstrom , Eric M. Vaughn , Pablo E Pineyro Pineiro , Troy James Kaiser , Joseph Ralph Hermann
CPC分类号： A61K39/12 , A61K39/23 , A61P31/20 , A61P37/04 , A61K2039/545 , A61K2039/552 , A61K2039/70 , C12N2750/10034 , C12N2750/10071 , C12N2750/14034
摘要： The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 3 (PCV3) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV3 infection.
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公开(公告)号：US11992522B2
公开(公告)日：2024-05-28
申请号：US18316499
申请日：2023-05-12
IPC分类号： A61K39/02 , A61K39/09 , C07K14/315 , A61K39/00
CPC分类号： A61K39/092 , C07K14/315 , A61K2039/522 , A61K2039/542 , A61K2039/552
摘要： The invention relates to bacterial infections, vaccines directed against those infections and bacterial vaccines. More particularly, the invention relates to vaccines directed against Streptococcus infections in pigs. The invention provides a ΔFolT mutant of a bacterium having reduced capacity to transport folate, wherein said capacity has been reduced by functionally deleting folate transporter (FolT) function. The invention also provides a method to reduce virulence of a bacterium comprising reducing the capacity of said bacterium to transport folate.
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公开(公告)号：US20240108544A1
公开(公告)日：2024-04-04
申请号：US18473915
申请日：2023-09-25
发明人： Marie-Amélie CLERC
IPC分类号： A61J1/06 , A61J1/14 , B32B7/02 , B32B27/08 , B32B27/30 , B32B27/32 , B65B3/00 , B65B3/02 , B65D75/32 , B65D75/58
CPC分类号： A61J1/067 , A61J1/1468 , B32B7/02 , B32B27/08 , B32B27/306 , B32B27/325 , B65B3/006 , B65B3/022 , B65D75/322 , B65D75/5811 , B32B2250/05 , B32B2250/246 , B32B2307/31 , B32B2307/7244 , B32B2307/7246 , B32B2307/7376 , B32B2307/738 , B32B2439/80
摘要： An administration packaging and method for its production. The administration packaging having a bottom part and a cover which are formed of multi-layer films.
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公开(公告)号：US11858962B2
公开(公告)日：2024-01-02
申请号：US17168439
申请日：2021-02-05
IPC分类号： C07K14/005 , C12N7/00 , G01N33/569
CPC分类号： C07K14/005 , C12N7/00 , G01N33/56983 , C07K2319/30 , C12N2760/20022 , G01N2333/145 , G01N2469/20
摘要： The present invention relates to recombinantly constructed proteins useful for analytical assays, in particular for determining in a biological sample obtained from an individual the presence of antibodies specific for a rhabdovirus. More particular, the present invention relates to a polypeptide comprising an ectodomain of a rhabdovirus glycoprotein and a heterologous multimerization domain linked to said ectodomain. In one example, a fusion protein of the formula x-y-z is provided, wherein x consists of or comprises such an ectodomain being optionally free of a furin cleavage site, y is a linker moiety, and z is a heterologous multimerization domain optionally selected from the group consisting of immunoglobulin sequence, coiled coil sequence, streptavidin sequence, fibritin sequence, and avidin sequence.
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公开(公告)号：US20230381101A1
公开(公告)日：2023-11-30
申请号：US18321117
申请日：2023-05-22
发明人： Claudius WEILER , Thomas Adam DUCH
IPC分类号： A61K9/08 , A61K31/7004 , A61K31/7042 , A61K31/7048 , A61K31/7056 , A61K47/32 , A61K47/10 , A61K47/12 , A61K47/02 , A61K47/26 , A61K47/46 , A61K47/20 , A61K31/7034
CPC分类号： A61K9/08 , A61K31/7004 , A61K31/7042 , A61K31/7048 , A61K31/7056 , A61K47/32 , A61K47/10 , A61K47/12 , A61K47/02 , A61K47/26 , A61K47/46 , A61K47/20 , A61K31/7034
摘要： The invention relates to novel aqueous pharmaceutical compositions comprising at least one SGLT-2 inhibitor and one or more solubilizing agents as well as corresponding processes of manufacturing such aqueous pharmaceutical compositions and their medical uses.
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公开(公告)号：US20230338406A1
公开(公告)日：2023-10-26
申请号：US18346935
申请日：2023-07-05
发明人： Dania Birte REICHE
IPC分类号： A61K31/7048 , A23K20/24 , A23K20/121 , A61P15/14 , A61K31/351 , A61K31/381 , A61K31/7056 , A61K31/382 , A61K31/7028 , A61K31/7034 , A61K31/7042
CPC分类号： A61K31/7048 , A23K20/24 , A23K20/121 , A61P15/14 , A61K31/351 , A61K31/381 , A61K31/7056 , A61K31/382 , A61K31/7028 , A61K31/7034 , A61K31/7042
摘要： The present invention is directed to the use of at least one SGLT-2 inhibitor in a non-human mammal, preferably ruminant, preferably for drying-off of a non-human mammal, preferably ruminant, as well as corresponding methods, such as improving and/or facilitating the drying-off of a non-human mammal, preferably ruminant, comprising administering to such non-human mammal, preferably ruminant, at least one SGLT-2 inhibitor.
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公开(公告)号：US11744888B2
公开(公告)日：2023-09-05
申请号：US17643293
申请日：2021-12-08
IPC分类号： A61K39/215 , A61P31/14 , C12N7/00 , A61K39/00
CPC分类号： A61K39/215 , A61P31/14 , C12N7/00 , A61K2039/5256 , A61K2039/552 , C12N2770/20021 , C12N2770/20022 , C12N2770/20034 , C12N2770/20071
摘要： The present invention relates i.a. to a 4/91 IBV (infectious bronchitis virus) encoding for a heterologous S (spike) protein or fragment thereof. Further, the present invention relates to an immunogenic composition comprising said 4/91 IBV encoding for a heterologous S (spike) protein or fragment thereof. Furthermore, the present invention relates to methods for immunizing a subject comprising administering to such subject the immunogenic composition of the present invention. Moreover, the present invention relates to methods of treating or preventing clinical signs caused by IBV in a subject of need, the method comprising administering to the subject a therapeutically effective amount of an immunogenic composition according to the present invention.
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公开(公告)号：US11730806B2
公开(公告)日：2023-08-22
申请号：US16879471
申请日：2020-05-20
发明人： Andrea J. Headrick Starks , Fuad Tawfiq Haddadin , Gregory Brian Haiwick , Merrill Lynn Schaeffer , Curtis Robert Edwards
CPC分类号： A61K39/23 , A61K39/12 , A61P31/14 , A61P31/20 , A61K2039/5252 , A61K2039/5254 , A61K2039/552 , A61K2039/70 , C12N2750/14322 , C12N2770/10034
摘要： The present invention relates to a porcine parvovirus and porcine reproductive and respiratory syndrome virus vaccine for protecting a subject, preferably swine, against diseases associated with porcine parvovirus and porcine reproductive and respiratory syndrome virus. The present invention further relates to methods of producing immunogenic compositions as well as such immunogenic compositions exhibiting reduced virucidal activity.
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