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    Method of treating ciliated tissue using CSA micelles
    2.
    发明授权
    Method of treating ciliated tissue using CSA micelles 有权

    公开(公告)号：US12070467B2

    公开(公告)日：2024-08-27

    申请号：US16979487

    申请日：2019-03-07

    Applicant: Carl Genberg ,  Paul B. Savage

    Inventor： Carl Genberg ,  Paul B. Savage

    IPC: A61K31/56 ,  A61K47/10

    CPC classification number: A61K31/56 ,  A61K47/10

    Abstract: The present disclosure describes treatment compositions and methods for preventing and/or treating microbial infections of ciliated tissues, such as tissues of the trachea, lungs, and sinuses. The method utilizes a treatment composition that includes a cationic steroidal antimicrobial (CSA) compound, a poloxamer, and a carrier, which is administered to ciliated tissue, such as lung tissue, in order to prevent or treat a microbial infection by killing microbes associated with the ciliated tissue. The poloxamer forms micelles that encapsulate the CSA compound, the poloxamer being included in the treatment composition in an amount, by weight, that is about 100 to 1000 times the amount of the CSA compound.

    Cationic steroidal antimicrobial compounds with urethane linkages
    4.
    发明授权
    Cationic steroidal antimicrobial compounds with urethane linkages 有权

    公开(公告)号：US12030912B2

    公开(公告)日：2024-07-09

    申请号：US17318206

    申请日：2021-05-12

    Applicant: Paul B. Savage

    Inventor： Paul B. Savage

    IPC: C07J9/00 ,  A61P31/04

    CPC classification number: C07J9/005 ,  A61P31/04

    Abstract: Cationic steroidal antimicrobial (CSA) compounds having a structure of Formula I, II or III, or salt thereof, wherein at least one of at least one of R1-R18, (e.g., R3, R7 and R12) is linked to the steroidal backbone by a urethane group:




    At least one of R1-R18, (e.g., R3, R7 and R12) has the following urethanyl structure:

    —O—(C═O)—NR19R20

    where R19 and R20 are independently hydrogen, alkyl, alkenyl, alkynyl, aryl, aminoalkyl, aminoalkenyl, aminoalkynyl, or aminoaryl, provided that at least one of R19 or R20 includes an amino group (e.g., R19 is hydrogen and R20 is (C2-C6)aminoalkyl).

    R18 can have the following structure:

    —R21—(C═O)—NR22R23

    where R21 is omitted or alkyl, alkenyl, alkynyl, or aryl, and R22 and R23 are hydrogen, alkyl, alkenyl, alkynyl, or aryl, provided that at least one of R22 or R23 is not hydrogen.

    Multi-stage stent devices and associated methods
    6.
    发明授权
    Multi-stage stent devices and associated methods 有权

    公开(公告)号：US11903852B2

    公开(公告)日：2024-02-20

    申请号：US15999254

    申请日：2017-02-17

    Applicant: Brigham Young University

    Inventor： Darrell Skousen ,  Anton E. Bowden

    IPC: A61F2/915

    CPC classification number: A61F2/915 ,  A61F2210/0014 ,  A61F2240/001 ,  A61F2250/0031

    Abstract: A multi-stage stent including a stent body and a bio-erodible material is provided. The stent body can be compressed in an initial state and the bio-erodible material can be coupled to the stent body in a configuration that holds the stent body in an expanded first state, following a first stage expansion from the initial state upon deployment of the stent body. Upon erosion of the bio-erodible material the stent body is released from the first state to expand further in a second stage expansion to a second state.

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