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    Antibody therapies and methods for treating coronavirus infection
    3.
    发明授权
    Antibody therapies and methods for treating coronavirus infection 有权

    公开(公告)号：US11584792B2

    公开(公告)日：2023-02-21

    申请号：US17501050

    申请日：2021-10-14

    申请人： TRUSTEES OF BOSTON UNIVERSITY

    发明人： Nelson Ruiz-Opazo ,  Victoria Herrera

    IPC分类号： C07K16/24 ,  C07K16/30 ,  A61K39/395 ,  A61K45/06 ,  A61P31/14

    摘要： Described herein are methods of treating COVID19 from a coronavirus infection, methods of treating a subject having a coronavirus infection, methods of improving a survival rate of a subject having a coronavirus infection, methods of determining prognosis of a subject having a coronavirus infection, methods of preventing or treating organ-dysfunction or multi-organ dysfunction or failure associated with a coronavirus infection, methods of combinational therapy for a subject having a coronavirus infection, methods of reducing microthrombi formation or low flow organ-ischemia associated with a coronavirus infection by administering a DEspR inhibitor.

    Inducible control of gene expression
    4.
    发明授权
    Inducible control of gene expression 有权

    公开(公告)号：US11572565B2

    公开(公告)日：2023-02-07

    申请号：US17381780

    申请日：2021-07-21

    申请人： TRUSTEES OF BOSTON UNIVERSITY

    发明人： Wilson Wai Chun Wong ,  Yage Ding

    IPC分类号： C12N15/63 ,  C12N9/12 ,  C12N9/22

    摘要： The technology described herein is directed to inducible and repressible polypeptides and polypeptide systems. In particular, described herein are split sequence-specific nucleases and split recombinases that are linked to drug-inducible or drug-repressible dimerization domains. In some embodiments, the polypeptides comprise sequestering domains and/or have their expression controlled by an inducible promoter. In multiple aspects described herein are polynucleotides, vectors, cells, and pharmaceutical compositions comprising said polypeptides or polypeptide systems. Also described herein are methods of using said polypeptide systems to modulate the expression of a target polypeptide or to treat a subject in need of a cell therapy.

    MOSCAP RING RESONATOR OPTICAL MODULATOR
    5.
    发明申请
    MOSCAP RING RESONATOR OPTICAL MODULATOR 有权

    公开(公告)号：US20230017023A1

    公开(公告)日：2023-01-19

    申请号：US17952732

    申请日：2022-09-26

    申请人： Trustees of Boston University

    发明人： Hayk Gevorgyan ,  Milos Popovic

    IPC分类号： G02F1/015 ,  G02F1/025

    摘要： A ring resonator optical modulator comprises: an optical region in which optical radiation can propagate in a circular path having an inner radius and an outer radius coincident with an outer perimeter of the ring resonator optical modulator; a MOS capacitor structure having an upper gate device layer and a lower body device layer, and an insulating material being disposed between the upper gate device layer and the lower body device layer; and a cladding region. The optical radiation is confined within the optical region. The insulating material has a first region disposed in the optical region having a first thickness and a second region having a second thickness greater than the first thickness, the second region being disposed radially inwardly from the inner radius of the optical region, such that the optical radiation is radially confined toward the outer side of the inner radius of the optical region.

    HORMONE ELECTROCHEMICAL BIOSENSOR
    8.
    发明申请
    HORMONE ELECTROCHEMICAL BIOSENSOR 有权

    公开(公告)号：US20220361782A1

    公开(公告)日：2022-11-17

    申请号：US17734042

    申请日：2022-04-30

    申请人： Trustees of Boston University

    发明人： James Galagan ,  Uros Kuzmanovic

    IPC分类号： A61B5/145 ,  A61B5/1477 ,  A61B5/1486

    摘要： Disclosed is a hormone electrochemical biosensor, e.g. an amperometric biosensor, for the detection of a hormone and measurement of the concentration of a hormone. The disclosed hormone biosensor comprises a hormone-catalyzing enzyme, such as KSDH1. Also described herein are systems comprising an amperometric biosensor, e.g., chronoamperometric biosensor and methods of using the chronoamperometric biosensor.

    NOTCH RECEPTORS WITH ZINC FINGER-CONTAINING TRANSCRIPTIONAL EFFECTOR
    9.
    发明申请
    NOTCH RECEPTORS WITH ZINC FINGER-CONTAINING TRANSCRIPTIONAL EFFECTOR 有权

    公开(公告)号：US20220356225A1

    公开(公告)日：2022-11-10

    申请号：US17763122

    申请日：2020-09-23

    申请人： The Regents of the University of California ,  Trustees of Boston University

    发明人： Kole T. ROYBAL ,  Iowis ZHU ,  Raymond LIU ,  Ahmad S. KHALIL ,  Divya ISRANI

    IPC分类号： C07K14/705 ,  C07K16/28 ,  C07K14/725 ,  A61K35/17 ,  C12N5/0783

    摘要： The present disclosure generally relates to, inter alia, a new class of chimeric Notch receptors containing a synthetic zinc finger transcriptional effector (synZTE) module, engineered to modulate gene expression and cellular activities in a ligand-dependent manner. The new Notch receptors surprisingly retain the ability to transduce signals in response to ligand binding despite that the Notch extracellular subunit, which includes the negative regulatory region previously believed to be essential for the functioning of Notch receptors, is partly or completely deleted. In addition, the synZTE is designed to bind orthogonal DNA target sequences in target organisms which in turn facilitates precise regulation of therapeutic gene expression with minimal off-target activity. Also provided are compositions and methods useful for producing such receptors, nucleic acids encoding same, host cells genetically modified with the nucleic acids, as well as methods for modulating an activity of a cell and/or for treatment of various health conditions.