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公开(公告)号：US20230114205A1
公开(公告)日：2023-04-13
申请号：US17962149
申请日：2022-10-07
摘要： The present disclosure generally relates to compositions and method for delivery, e.g., sustained delivery of active agents, and their use for the treatment of diseases or disorders.
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公开(公告)号：US10953107B2
公开(公告)日：2021-03-23
申请号：US16441208
申请日：2019-06-14
摘要： Described herein are methods and compositions related to compositions comprising combinations of V/K-type and V/E-type docking peptides and uses thereof, e.g., to deliver therapeutic agents to treat certain conditions such as cancer, infection, or trauma.
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公开(公告)号：US10646614B2
公开(公告)日：2020-05-12
申请号：US15975132
申请日：2018-05-09
IPC分类号： A61L26/00 , A61L27/52 , A61L27/54 , A61L27/58 , A61L15/44 , A61L15/60 , A61L15/64 , A61L24/00
摘要： The inventions provided herein relate to dissolvable hydrogel compositions and methods of uses, e.g., but not limited to, in wound management. Accordingly, methods for wound management involving the dissolvable hydrogel compositions are also provided herein. In some embodiments, the dissolvable hydrogel composition comprises an adhesive thioester hydrogel, which can facilitate adherence of the dissolvable hydrogen composition to a surface (e.g., a wound) and can be controllably dissolved later upon addition of a thiolate compound to release the dissolvable hydrogel composition from the surface (e.g., the wound).
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公开(公告)号：US10400064B2
公开(公告)日：2019-09-03
申请号：US15529462
申请日：2015-11-25
IPC分类号： C08G64/34 , C08G64/42 , A61K47/59 , A61K31/337 , C08G64/02
摘要： The invention provides polymer compositions, compounds, processes, and methods of use of the polymers for drug delivery, biodegradable consumer plastics, or solvents for Li-based batteries or supercapacitors.
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公开(公告)号：US09993577B2
公开(公告)日：2018-06-12
申请号：US14901858
申请日：2014-06-30
IPC分类号： C12N5/02 , A61L26/00 , A61L27/52 , A61L27/54 , A61L27/58 , A61L15/44 , A61L15/60 , A61L15/64 , A61L24/00
CPC分类号： A61L26/008 , A61L15/44 , A61L15/60 , A61L15/64 , A61L24/0015 , A61L24/0031 , A61L24/0042 , A61L26/0028 , A61L26/0066 , A61L26/009 , A61L27/52 , A61L27/54 , A61L27/58
摘要： The inventions provided herein relate to dissolvable hydrogel compositions and methods of uses, e.g., but not limited to, in wound management. Accordingly, methods for wound management involving the dissolvable hydrogel compositions are also provided herein. In some embodiments, the dissolvable hydrogel composition comprises an adhesive thioester hydrogel, which can facilitate adherence of the dissolvable hydrogen composition to a surface (e.g., a wound) and can be controllably dissolved later upon addition of a thiolate compound to release the dissolvable hydrogel composition from the surface (e.g., the wound).
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公开(公告)号：US20180043066A1
公开(公告)日：2018-02-15
申请号：US15552875
申请日：2016-02-22
发明人： Mark W. Grinstaff , Stacy L. Chin , Ruiqing Xiao , Benjamin Goldman Cooper , Karen Buch , Ducksoo Kim
IPC分类号： A61L31/10 , A61L31/14 , C08F220/06 , C08J7/04 , C08J7/18 , C08F220/28 , A61L31/04 , A61L31/16
CPC分类号： A61L31/10 , A61L27/16 , A61L27/34 , A61L29/041 , A61L29/085 , A61L31/048 , A61L31/049 , A61L31/14 , A61L31/16 , A61L2400/10 , A61L2420/02 , A61L2420/06 , C08F220/06 , C08F220/28 , C08J7/047 , C08J7/18 , C08J2321/02 , C08J2433/02 , C08J2433/06 , C08L2205/04 , C09D133/066 , C08F220/20 , C08F2220/1891 , C09D133/06 , C08L39/06 , C08L7/02 , C08L33/08
摘要： Provided herein are methods comprising the use of a macroinitiator and application protocols to apply a hydrophilic coating to latex, or natural rubber, and compositions resulting from such methods. This coating results in e.g., an increased sense of lubrication when in contact with water or an aqueous solution.
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7.发明申请公开(公告)号：US20160287745A1
公开(公告)日：2016-10-06
申请号：US14901858
申请日：2014-06-30
IPC分类号： A61L26/00
CPC分类号： A61L26/008 , A61L15/44 , A61L15/60 , A61L15/64 , A61L24/0015 , A61L24/0031 , A61L24/0042 , A61L26/0028 , A61L26/0066 , A61L26/009 , A61L27/52 , A61L27/54 , A61L27/58
摘要： The inventions provided herein relate to dissolvable hydrogel compositions and methods of uses, e.g., but not limited to, in wound management. Accordingly, methods for wound management involving the dissolvable hydrogel compositions are also provided herein. In some embodiments, the dissolvable hydrogel composition comprises an adhesive thioester hydrogel, which can facilitate adherence of the dissolvable hydrogen composition to a surface (e.g., a wound) and can be controllably dissolved later upon addition of a thiolate compound to release the dissolvable hydrogel composition from the surface (e.g., the wound).
摘要翻译： 本文提供的发明涉及可溶解的水凝胶组合物和使用方法，例如但不限于伤口管理。 因此，本文还提供涉及可溶性水凝胶组合物的伤口处理方法。 在一些实施方案中，可溶解的水凝胶组合物包含粘合剂硫酯水凝胶，其可以促进可溶性氢组合物粘附到表面（例如伤口）上，并且在加入硫醇盐化合物以释放可溶解水凝胶组合物后可以可控地溶解 从表面（例如，伤口）。
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公开(公告)号：US20140271489A1
公开(公告)日：2014-09-18
申请号：US14351972
申请日：2012-10-17
IPC分类号： A61K9/16 , A61K31/519 , A61K31/352 , A61K31/337 , A61K49/00
CPC分类号： A61K9/1641 , A61K9/5138 , A61K31/337 , A61K31/352 , A61K31/519 , A61K47/555 , A61K49/0054
摘要： Provided herein are polymeric particles and compounds and processes that can be used to prepare polymer-based particles and methods of using those particles to localize or concentrate a subsequently delivered agent to an in vivo site.
摘要翻译： 本文提供了可用于制备基于聚合物的颗粒的聚合物颗粒和化合物和方法，以及使用这些颗粒将随后递送的试剂定位或浓缩到体内位点的方法。
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公开(公告)号：US20130204010A1
公开(公告)日：2013-08-08
申请号：US13759496
申请日：2013-02-05
发明人： Mark W. Grinstaff , Michel Wathier
IPC分类号： C07C211/09 , C07C59/305 , C07F9/28 , C07D403/12
CPC分类号： C07C229/24 , C07C59/305 , C07C211/09 , C07C211/14 , C07D403/12 , C07F9/28 , C07F9/5407 , C08F120/06 , C08F236/12 , C08G65/00 , C08L33/08 , C08L33/14 , C08L35/06 , C08L43/02 , C10N2220/04 , C08L2666/04 , C08L2666/02
摘要： One embodiment of the present invention relates to ionic liquids and ionic viscoelastics formed between [1] a small molecule or macromolecule containing two or more cations; and [2] a small molecule or macromolecule containing two or more anions. Another embodiment of the invention is the use of the inventive ionic liquids and ionic viscoelastics, formed between a small molecule or macromolecule containing two or more cations and a small molecule or macromolecule containing two or more anions, to form a crosslinked network. In certain embodiments, the ionic liquids formed can be viscous liquids, viscous liquid formed networks, or viscoelastic networks/gels. In certain embodiments, the ionic material of the invention may be used for a variety of applications including, but not limited to, lubricants, additives, gas separation, liquid separation, membranes, fuel cells, sensors, batteries, coatings, heat storage, liquid crystals, biocompatible fluids, solvents, and electronic materials.
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公开(公告)号：US10098967B2
公开(公告)日：2018-10-16
申请号：US14095816
申请日：2013-12-03
摘要： Disclosed are conjugates of hydrophobic drugs linked to protected or unprotected amino acids or peptides. The disclosed conjugates are amphiphilic and can self assemble into nantubes. Nanotubes comprising the conjugates are also described and can have high loading of the drug and protect it from degradation or elimination. The nanotubes are well suited to deliver hydrophobic and unstable drugs to individuals.
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