公开(公告)号：US20240415775A1

公开(公告)日：2024-12-19

申请号：US18686557

申请日：2022-10-12

Applicant: Fertin Pharma A/S

Inventor： Helle Wittorff

IPC: A61K9/24 ,  A61K9/20 ,  A61K31/137 ,  A61K31/167 ,  A61K31/198 ,  A61K31/375 ,  A61K31/485 ,  A61K31/522 ,  A61K36/258

Abstract: An oral chewable tablet contains dextrose in an amount from 50 to 95% by weight of the tablet; and one or more active ingredients in an amount from 0.1 to 50% by weight of the tablet. The oral chewable tablet includes at least two compressed layers containing the dextrose and the one or more active ingredients, the first of the compressed layers being cohered to and adjacent to the second layer.

公开(公告)号：US11911375B2

公开(公告)日：2024-02-27

申请号：US17098550

申请日：2020-11-16

Applicant: Fertin Pharma A/S

Inventor： Kent Albin Nielsen ,  Jessie Poulsen

IPC: A61K31/465 ,  A61K9/68 ,  A61K9/20 ,  A61K47/02 ,  A61K47/14 ,  A61K47/26 ,  A61K47/32 ,  A61K47/44

CPC classification number: A61K31/465 ,  A61K9/0058 ,  A61K9/2009 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/2068 ,  A61K47/02 ,  A61K47/14 ,  A61K47/26 ,  A61K47/32 ,  A61K47/44

Abstract: A solid oral nicotine formulation is disclosed, the formulation comprises a nicotine-ion exchange resin combination, and a salt comprising inorganic divalent cations, wherein the salt has a water-solubility of at least 5 grams per 100 mL of water measured at 25 degrees Celsius, atmospheric pressure and pH 7.0.

公开(公告)号：US20240008514A1

公开(公告)日：2024-01-11

申请号：US17857937

申请日：2022-07-05

Applicant: Fertin Pharma A/S

Inventor： Dorthe Schackinger Boesen ,  Simon Lykke Roest Laursen ,  Sanne Skov Jensen

IPC: A23L29/00 ,  A61K36/185 ,  A23L29/30 ,  A23L33/105 ,  A23L27/30

CPC classification number: A23L29/035 ,  A61K36/185 ,  A23L29/37 ,  A23L33/105 ,  A23L27/34

Abstract: The invention relates to a powder premixture for oral administration of cannabinoids, comprising a cannabinoid powder composition comprising one or more isolated cannabinoids in an amount of at least 2% by weight of the powder premixture; a lipid composition comprising one or more triglycerides in an amount of at least 1.0% by weight of the powder premixture; and a sweetener powder composition comprising one or more sweeteners, wherein the weight ratio between the one or more triglycerides and the one or more sweeteners is in the range of 1:50 to 1:4.

公开(公告)号：US20240000706A1

公开(公告)日：2024-01-04

申请号：US18364862

申请日：2023-08-03

Applicant: Fertin Pharma A/S

Inventor： Dorthe Schackinger Boesen ,  Heidi Ziegler Bruun ,  Bruno Provstgaard Nielsen ,  Kent Albin Nielsen ,  Rikke Pranger-Rasmussen

IPC: A61K9/00 ,  A61K31/465 ,  A61K47/26 ,  A61K47/32

CPC classification number: A61K9/0056 ,  A61K47/32 ,  A61K47/26 ,  A61K31/465

Abstract: A water-dissolvable compressed oral nicotine lozenge is disclosed, the oral nicotine lozenge comprising a first module and a second module, the first and the second modules being fused by compression, the first module being a lozenge module comprising at least one sugar alcohol and the second module being an FDT-module comprising at least one sugar alcohol and nicotine. Also, a method of manufacturing a water-dissolvable compressed oral nicotine lozenge is disclosed.

公开(公告)号：US20230181478A1

公开(公告)日：2023-06-15

申请号：US17644182

申请日：2021-12-14

Applicant: Fertin Pharma A/S

Inventor： Kent Albin Nielsen ,  Rikke Pranger-Rasmussen ,  Dorthe Schackinger Boesen ,  Heidi Ziegler Bruun ,  Bruno Provstgaard Nielsen

IPC: A61K9/20 ,  A61K31/4439

CPC classification number: A61K9/2086 ,  A61K31/4439 ,  A61K9/2018 ,  A61K9/2009 ,  A61K9/2013

Abstract: A water-dissolvable nicotine tablet is disclosed, the nicotine tablet comprising at least a first compressed module and a second compressed module, wherein the first compressed module is an FDT-module and comprises nicotine, alkaline pH regulating agent, and disintegrant, and, wherein the second compressed module is a lozenge-module and comprises acidic pH regulating agent. Also, a method of manufacturing a nicotine tablet is disclosed.

公开(公告)号：US11311623B2

公开(公告)日：2022-04-26

申请号：US16095145

申请日：2016-04-21

Applicant: Fertin Pharma A/S

Inventor： Jesper Thorsen ,  Bjarne Vestbö ,  Birgitte Kringelum Breindal ,  Jesper Neergaard

IPC: A61K9/14 ,  A61K47/58 ,  A61K9/00 ,  A61K9/68 ,  A61K31/465 ,  A61K9/16

Abstract: The present invention relates to a nicotine delivery product comprising, or even consisting essentially of, a population of nicotine-loaded cation exchange resin particles, said population comprises at least 50% (w/w) particles having a size in the range of 90-300 micron which provides an improved nicotine stability to oral dosage forms comprising the nicotine delivery product. The invention furthermore relates to methods of producing the nicotine delivery product and the oral dosage forms and to the use of the nicotine delivery product.

公开(公告)号：US11135156B2

公开(公告)日：2021-10-05

申请号：US15602968

申请日：2017-05-23

Applicant: FERTIN PHARMA A/S

Inventor： Martin Topsoe ,  Kirsten Lund

IPC: A61K9/00 ,  A23G3/36 ,  A23G4/20 ,  A23G4/08 ,  A23G4/18 ,  A24B13/00 ,  A61K9/68 ,  A61K9/20 ,  A23L33/10 ,  A23G3/42 ,  A24B15/10 ,  A23G4/10 ,  A61K31/465

Abstract: A pharmaceutical tablet for use in administering one or more pharmaceutically active ingredients, comprising a polymer system, the one or more pharmaceutically active ingredients, a flavor, and a sweetener, wherein at least 20% by weight of the pharmaceutical tablet comprises substantially non-elastomeric polymer and less than 5% by weight of the pharmaceutical tablet comprises one or a combination of elastomeric polymers, and wherein the pharmaceutical tablet comprises at least 70% by weight of said polymer system comprising polyvinyl acetate (PVA) and less than 10% by weight of said polymer system comprising polymer having a molecular weight (Mw) greater than 50,000 g/mol.

公开(公告)号：US20210205355A1

公开(公告)日：2021-07-08

申请号：US17206226

申请日：2021-03-19

Applicant: FERTIN PHARMA A/S

Inventor： Jesper NEERGAARD

IPC: A61K33/10 ,  A61K9/00 ,  A61K9/20 ,  A61K31/192 ,  A61K9/68 ,  A61K31/167

Abstract: The invention relates to a solid pharmaceutical tablet for oral delivery, the tablet comprising calcium carbonate in an amount of more than 30% by weight of the tablet and organic water-insoluble components in an amount of more than 20% by weight of the tablet, wherein the tablet is designed to be masticated into a coherent residual containing the organic water-insoluble components, and wherein the tablet is adapted to release more than 80% of the calcium carbonate within 5 minutes of mastication.

公开(公告)号：US20210106516A1

公开(公告)日：2021-04-15

申请号：US16599991

申请日：2019-10-11

Applicant: Fertin Pharma A/S

Inventor： Kent Albin Nielsen

IPC: A61K9/00 ,  A61K9/20 ,  A61K31/465

Abstract: The present invention relates to an oral tablet for oromucosal delivery of biologically active compounds, the tablet comprising a sugar alcohol composition comprising one or more sugar alcohol particles in an amount of at least 20% by weight of the tablet, an ion-exchange composition comprising a plurality of particles of at least one water-soluble anionic mucoadhesive polymer loaded with a cationic biologically active compound.

公开(公告)号：US10391054B2

公开(公告)日：2019-08-27

申请号：US15411205

申请日：2017-01-20

Applicant: Fertin Pharma A/S

Inventor： Helle Wittorff ,  Kirsten Lund

IPC: A61K31/465 ,  A61K9/20 ,  A61K9/68 ,  A61K9/00 ,  A23G3/36 ,  A23G4/20 ,  A23G4/08 ,  A23G4/18 ,  A24B13/00 ,  A24B15/10 ,  A23L33/10 ,  A23G3/42 ,  A23G4/10

Abstract: The invention relates to a chewable tablet including a polymer system, tobacco powder, flavor and sweetener, at least about 70% by weight of the polymer system being polyvinyl acetate (PVAc) and less than 10% by weight of the polymer system being polymer having a molecular weight (Mw) of greater than about 50000 g/mol.