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公开(公告)号：US09858389B2
公开(公告)日：2018-01-02
申请号：US12462041
申请日：2009-07-27
申请人： Michael Donovan , Faisal Khan , Gerardo Fernandez , Ali Tabesh , Ricardo Mesa-Tejada , Carlos Cordon-Cardo , Jose Costa , Stephen Fogarasi , Yevgen Vengrenyuk
发明人： Michael Donovan , Faisal Khan , Gerardo Fernandez , Ali Tabesh , Ricardo Mesa-Tejada , Carlos Cordon-Cardo , Jose Costa , Stephen Fogarasi , Yevgen Vengrenyuk
摘要： Clinical information, molecular information and/or computer-generated morphometric information is used in a predictive model for predicting the occurrence of a medical condition. In an embodiment, a model predicts risk of prostate cancer progression in a patient, where the model is based on features including one or more (e.g., all) of preoperative PSA, dominant Gleason Grade, Gleason Score, at least one of a measurement of expression of AR in epithelial and stromal nuclei and a measurement of expression of Ki67-positive epithelial nuclei, a morphometric measurement of average edge length in the minimum spanning tree (MST) of epithelial nuclei, and a morphometric measurement of area of non-lumen associated epithelial cells relative to total tumor area. In some embodiments, the morphometric information is based on image analysis of tissue subject to multiplex immunofluorescence and may include characteristic(s) of a minimum spanning tree (MST) and/or a fractal dimension observed in the images.
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公开(公告)号：US20240270855A1
公开(公告)日：2024-08-15
申请号：US18565581
申请日：2022-06-02
IPC分类号： C07K16/28 , A61K31/137 , A61K31/27 , A61K31/44 , A61K31/4704 , A61K31/4706 , A61K31/538 , A61K31/55 , A61K38/17 , A61K38/18 , A61K39/395 , A61P3/04
CPC分类号： C07K16/2863 , A61K31/137 , A61K31/27 , A61K31/44 , A61K31/4704 , A61K31/4706 , A61K31/538 , A61K31/55 , A61K38/179 , A61K38/185 , A61K39/3955 , A61P3/04
摘要： The present disclosure provides a neuro-mesenchyme signaling axis that controls group 2 innate lymphoid cells (ILC2s), adipose tissue physiology, metabolism, and obesity. This signaling axis includes ILC2s with rearranged during transfection (RET) receptor, mesenchymal stromal cells (MSCs) with beta-2 adrenergic receptor (ADRB2), and high-order brain areas including the paraventricular nucleus of the hypothalamus (PVH).
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公开(公告)号：US20180025212A1
公开(公告)日：2018-01-25
申请号：US15660727
申请日：2017-07-26
发明人： Peter Ajemba , Richard Scott , Janakiramanan Ramachandran , Jack Zeineh , Michael Donovan , Gerardo Fernandez , Qiuhua Liu , Faisal Khan
CPC分类号： G06K9/00147 , G06T5/008 , G06T7/0012 , G06T7/11 , G06T7/155 , G06T7/45 , G06T2207/10056 , G06T2207/20041 , G06T2207/20212 , G06T2207/30024
摘要： Apparatus, methods, and computer-readable media are provided for segmentation, processing (e.g., preprocessing and/or postprocessing), and/or feature extraction from tissue images such as, for example, images of nuclei and/or cytoplasm. Tissue images processed by various embodiments described herein may be generated by Hematoxylin and Eosin (H&E) staining, immunofluorescence (IF) detection, immunohistochemistry (IHC), similar and/or related staining processes, and/or other processes. Predictive features described herein may be provided for use in, for example, one or more predictive models for treating, diagnosing, and/or predicting the occurrence (e.g., recurrence) of one or more medical conditions such as, for example, cancer or other types of disease.
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公开(公告)号：US09888976B2
公开(公告)日：2018-02-13
申请号：US15377933
申请日：2016-12-13
IPC分类号： A61B50/13 , A61B50/18 , A61J7/04 , A61J7/00 , A61B5/1172 , A61B5/1171 , A61B5/0205 , A61B5/00 , A61B5/021 , A61B5/024 , A61B5/08 , A61B5/1455 , A61G12/00 , G06F19/22 , G06F19/00
CPC分类号： A61B50/13 , A61B5/002 , A61B5/02055 , A61B5/021 , A61B5/02438 , A61B5/0816 , A61B5/1172 , A61B5/1176 , A61B5/14551 , A61B5/742 , A61B5/746 , A61B50/18 , A61G12/001 , A61J7/0076 , A61J7/0445 , A61J7/0481 , G06F19/00 , G06F19/3418 , G06F19/3456 , G06F19/3462 , G16H10/60 , G16H20/10 , G16H40/67
摘要： The present invention relates to systems and methods for remotely monitoring the health of a patient in a real-time, continuous manner, remotely deliver therapeutic medications to the patient, and facilitating communication between the patient and a remotely located patient care provider.
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公开(公告)号：US20220296926A1
公开(公告)日：2022-09-22
申请号：US17631152
申请日：2020-07-30
申请人： MEMORIAL SLOAN KETTERING CANCER CENTER , FUNDAÇÃO D. ANNA DE SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD
发明人： Richard KOLESNICK , Zvi FUKS , Carlo GRECO
摘要： The present disclosure provides methods and systems for treating tumors with radiotherapy, wherein a first dose of radiation is administered to a first sub-volume of the tumor and a second dose of radiation is administered to a second sub-volume of the tumor.
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6.发明公开公开(公告)号：US20240274288A1
公开(公告)日：2024-08-15
申请号：US18591539
申请日：2024-02-29
发明人： Michael Donovan , Faisal Khan , Jason Alter , Gerardo Fernandez , Ricardo Mesa-Tejada , Douglas Powell , Valentina Bayer , Stefan Hamann , Carlos Cordon-Cardo , Jose Costa
摘要： Clinical information, molecular information and/or computer-generated morphometric information is used in a predictive model for predicting the occurrence of a medical condition. In an embodiment, a model predicts risk of prostate cancer progression in a patient, where the model is based on features including one or more (e.g., all) of preoperative PSA, dominant Gleason Grade, Gleason Score, at least one of a measurement of expression of AR in epithelial and stromal nuclei and a measurement of expression of Ki67-positive epithelial nuclei, a morphometric measurement of average edge length in the minimum spanning tree (MST) of epithelial nuclei, and a morphometric measurement of area of non-lumen associated epithelial cells relative to total tumor area. In some embodiments, the morphometric information is based on image analysis of tissue subject to multiplex immunofluorescence and may include characteristic(s) of a minimum spanning tree (MST) and/or a fractal dimension observed in the images.
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公开(公告)号：US20240067991A1
公开(公告)日：2024-02-29
申请号：US18142384
申请日：2023-05-02
IPC分类号： C12N15/90 , C12N5/0783 , C12N9/22 , C12N15/11 , C12N15/86
CPC分类号： C12N15/907 , C12N5/0636 , C12N9/22 , C12N15/11 , C12N15/86 , C12N2310/20 , C12N2740/15043 , C12N2830/001
摘要： Certain aspects of the present disclosure provides systems, compositions, and methods for regulating expression or activity of an endogenous cytokine of a cell. In some cases, the present disclosure provides a system comprising an actuator moiety capable of complexing with a target gene encoding the endogenous cytokine to regulate expression or activity of the endogenous cytokine. The actuator moiety can be heterologous to the cell. The actuator moiety can be activatable upon exposing the cell to an external stimulus. Upon the exposure of the cell to the external stimulus, the actuator moiety can be activated to regulate expression or activity of the endogenous cytokine.
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