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    METHOD FOR CLEAVING AMIDE BONDS
    4.
    发明申请
    METHOD FOR CLEAVING AMIDE BONDS 审中-公开

    公开(公告)号：US20200002440A1

    公开(公告)日：2020-01-02

    申请号：US16305236

    申请日：2017-05-30

    申请人： GALDERMA S.A.

    发明人： Craig Steven HARRIS ,  Laura JING JING

    IPC分类号： C08B37/00 ,  C08B37/08

    摘要： A method for cleaving amide bonds, including: a) providing a molecule including an amide group; b) reacting the molecule including the amide group with a hydroxylamine salt to cleave the amide bond of the amide group. The method may further include c) recovering a product formed by the reaction of step b).

    PROCESS FOR PREPARING A CROSS-LINKED HYALURONIC ACID PRODUCT
    6.
    发明申请
    PROCESS FOR PREPARING A CROSS-LINKED HYALURONIC ACID PRODUCT 审中-公开

    公开(公告)号：US20190062461A1

    公开(公告)日：2019-02-28

    申请号：US16111493

    申请日：2018-08-24

    申请人： GALDERMA S.A.

    发明人： Morgan KARLSSON ,  Katarina EDSMAN

    IPC分类号： C08B37/08 ,  C08J3/075 ,  A61K9/06 ,  A61K31/728 ,  C08J3/24 ,  A61Q19/00 ,  A61K8/04 ,  A61K8/73

    摘要： Efficient cross-linking of hyaluronic acid (HA) is provided by a manufacturing process. In the process, HA is activated by an initial cross-linking in an aqueous solution. Unreacted cross-linking agent is removed from the activated HA. Cross-linking of the activated HA is finalized, without addition of any additional cross-linking agent, in a suspension of a liquid precipitating medium and the activated HA in precipitated form. The resulting cross-linked HA products exhibit high effective cross-linker ratio and other favorable properties, making the products useful as implants and in medical and cosmetic surgery.

    A SYRINGE
    7.
    发明申请
    A SYRINGE 审中-公开

    公开(公告)号：US20190015597A1

    公开(公告)日：2019-01-17

    申请号：US16066940

    申请日：2016-12-21

    申请人： GALDERMA S.A.

    发明人： Anders Holmqvist ,  Max Blomqvist ,  Jonas Törnsten

    IPC分类号： A61M5/315 ,  A61M5/31

    摘要： A syringe including a barrel, a plunger moveably arranged within said barrel and a plunger rod for driving said plunger is provided. The syringe includes a first engagement member arranged at the plunger rod such that a longitudinal movement of the plunger rod yields a rotational movement of said first engagement member, said first engagement member including a grooved surface, and a second engagement member arranged at the barrel to engage with said grooved surface of the first engagement member such that feedback is given to a user as the plunger rod is moved relative to the barrel for driving said plunger. Wherein, for a given distance D travelled by the plunger rod relative to the barrel, a point of the grooved surface of the first engagement member moves a distance d, wherein d≥D.

    GRAFT COPOLYMER
    10.
    发明申请
    GRAFT COPOLYMER 审中-公开

    公开(公告)号：US20180002454A1

    公开(公告)日：2018-01-04

    申请号：US15540461

    申请日：2015-12-29

    申请人： Galderma S.A.

    发明人： Kristoffer BERGMAN

    IPC分类号： C08B37/08 ,  A61L27/20 ,  C08B37/02 ,  C08B37/00

    摘要： A graft copolymer comprising: a core polymer comprising a crosslinked or non-crosslinked polysaccharide, a plurality of primary graft polymers covalently grafted to the core polymer, a plurality of secondary graft polymers covalently grafted to each primary graft polymer, an injectable dermal aesthetic formulation comprising such a graft copolymer and a method of preparing such a graft copolymer.