公开(公告)号：US12121586B2

公开(公告)日：2024-10-22

申请号：US17129251

申请日：2020-12-21

申请人： Genentech, Inc.

发明人： Patrick Koenig ,  Chingwei Vivian Lee ,  Karthikan Rajagopal ,  Amin Famili ,  Germaine Fuh

IPC分类号： C40B30/04 ,  A61K39/395 ,  A61K47/34 ,  A61K47/60 ,  A61K47/61 ,  C07K14/475 ,  C07K16/22 ,  C07K16/44 ,  C07K16/46 ,  C12N15/10 ,  C12N15/115 ,  A61K39/00

CPC分类号： A61K47/61 ,  A61K39/3955 ,  A61K47/34 ,  A61K47/60 ,  C07K14/475 ,  C07K16/22 ,  C07K16/44 ,  C07K16/468 ,  C12N15/1037 ,  C12N15/115 ,  C40B30/04 ,  A61K2039/505 ,  A61K2039/54 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2318/20 ,  C07K2319/30 ,  C07K2319/31 ,  C12N2310/16

摘要： The present invention provides anti-VEGF antibodies and compositions that include anti-VEGF antibodies (e.g., antibody conjugates, fusion proteins, and polymeric formulations), and uses thereof, for example for treatment of disorders associated with pathological angiogenesis. The present invention also provides methods of identifying antibody variants with improved properties, for example, enhanced binding affinity, stability, pharmacokinetics, and/or expression.

公开(公告)号：US20240344013A1

公开(公告)日：2024-10-17

申请号：US18604429

申请日：2024-03-13

申请人： Genentech, Inc.

发明人： Zijuan LAI ,  Shahram MISAGHI ,  Dewakar SANGARAJU ,  Danming TANG

IPC分类号： C12M1/34 ,  C12M1/36 ,  G01N30/72

CPC分类号： C12M41/38 ,  C12M41/48 ,  G01N30/72

摘要： Provided herein are methods for quantifying the concentration of multiple metabolites in a sample. Also provided are methods for relative quantification of multiple metabolites in a sample, methods for monitoring the course of a cell culture, and methods for optimising a cell culture.

公开(公告)号：US20240327536A1

公开(公告)日：2024-10-03

申请号：US18590267

申请日：2024-02-28

申请人： Genentech, Inc.

发明人： David LEPPERT ,  Anne-Marie LI-KWAI-CHEUNG ,  Michele LIBONATI ,  Donna MASTERMAN ,  Jean-Paul PFEFEN ,  Craig SMITH ,  Algirdas Jonas Kakarieka WEISSKOPF ,  Jiameng ZHANG ,  Peter S. CHIN ,  Hideki GARREN

IPC分类号： C07K16/28 ,  A61K38/00 ,  A61K39/00 ,  A61P37/06

CPC分类号： C07K16/2887 ,  A61P37/06 ,  A61K38/00 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76

摘要： The present invention concerns methods for treating multiple sclerosis (MS) in a patient, and an article of manufac-ture with instructions for such use.

公开(公告)号：US20240325559A1

公开(公告)日：2024-10-03

申请号：US18297553

申请日：2023-04-07

申请人： Genentech, Inc.

发明人： Ankit R. PATEL ,  Jun LIU

IPC分类号： A61K47/68 ,  A61J1/10 ,  A61K38/08 ,  A61K47/02 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/26 ,  A61K47/34 ,  A61K47/54 ,  C07K16/28

CPC分类号： A61K47/6811 ,  A61J1/10 ,  A61K38/08 ,  A61K47/02 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/26 ,  A61K47/34 ,  A61K47/542 ,  A61K47/6873 ,  C07K16/2803 ,  C07K2317/24 ,  C07K2317/56

摘要： The disclosure provides stable pharmaceutical compositions comprising an anti-CD79b immunoconjugate and a surfactant. The disclosure also provides methods for using such compositions for the treatment of cancer.

公开(公告)号：USD1044440S1

公开(公告)日：2024-10-01

申请号：US29839673

申请日：2022-05-23

申请人： GENENTECH, INC.

设计人： Nick Rummel ,  Patrick Daniel Ahyow ,  Joseph Perez

摘要： FIG. 1 is a perspective view of the filter insert/removal tool;
FIG. 2 is a front view of the filter insert/removal tool;
FIG. 3 is a back view of the filter insert/removal tool;
FIG. 4 is a left-side view of the filter insert/removal tool;
FIG. 5 is a right-side view of the filter insert/removal tool;
FIG. 6 is a top side view of the filter insert/removal tool;
FIG. 7 is a bottom side view of the filter insert/removal tool; and,
FIG. 8 is a cross-sectional view of FIG. 6 of the filter insert/removal tool.
Surface shading in the figures is provided solely to indicate contour. All other portions of my filter insert/removal tool not shown in the figures or otherwise described in the specification form no part of the claimed design.

公开(公告)号：US20240309314A1

公开(公告)日：2024-09-19

申请号：US18508109

申请日：2023-11-13

申请人： Genentech, Inc.

发明人： Masaru Ken SHIRATORI ,  Robert David KISS ,  Hardayal PRASHAD ,  Raquel IVERSON ,  Justin BOURRET ,  Michael KIM ,  Salim CHARANIYA

IPC分类号： C12N1/36 ,  C12N7/00

CPC分类号： C12N1/36 ,  C12N7/00 ,  C12N2750/14061 ,  C12N2760/12061 ,  C12N2760/16061 ,  C12N2760/18061 ,  C12N2760/20061 ,  C12N2770/16061 ,  C12N2770/32061 ,  C12N2770/36061

摘要： The invention provides for methods of viral inactivation using high temperature short time (HTST) treatment and adjustment of various parameters such that generation of precipitate and depositions of precipitate are reduced and/or minimized.

公开(公告)号：US20240299392A1

公开(公告)日：2024-09-12

申请号：US18663549

申请日：2024-05-14

申请人： Genentech, Inc.

发明人： Marie EVANGELISTA ,  Mark Andrew MERCHANT ,  Jennifer Lee SCHUTZMAN ,  Ting-Kun Mark LIN ,  Stephanie Royer JOO ,  Sandhya Vinayak MANDLEKAR ,  Stuart G. LUTZKER

IPC分类号： A61K31/517 ,  A61P35/00 ,  C07K16/22

CPC分类号： A61K31/517 ,  A61P35/00 ,  C07K16/22

摘要： Provided herein are combination therapies comprising a KRasG12C inhibitor (e.g. Compound 1 or a pharmaceutically acceptable salt thereof) and a VEGF antagonist (e.g., bevacizumab) and methods of using such combination therapies.

公开(公告)号：US12084429B2

公开(公告)日：2024-09-10

申请号：US17644993

申请日：2021-12-17

申请人： Genentech, Inc.

发明人： Sushant Malhotra ,  Jianfeng Xin ,  Steven Do ,  Jack Terrett

IPC分类号： C07D401/04 ,  A61K9/00 ,  A61K31/517 ,  A61P35/00 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D471/14

CPC分类号： C07D401/14 ,  A61K9/0019 ,  A61K9/0053 ,  A61P35/00 ,  C07D405/14

摘要： This invention pertains to fused ring compounds of Formula (I), as further detailed herein, which are used for the inhibition of Ras proteins, as well as compositions comprising these compounds and methods of treatment by their administration.

公开(公告)号：US12071422B2

公开(公告)日：2024-08-27

申请号：US18164302

申请日：2023-02-03

申请人： Genentech, Inc. ,  Hoffmann-La Roche Inc.

发明人： Rene Lebl ,  Ngiap Kie Lim ,  Roland Christoph Meier ,  Ugo Jonathan Orcel ,  Joerg Sedelmeier ,  Jeff Shen ,  Lauren Elizabeth Sirois ,  Jacob C. Timmerman ,  Etienne Trachsel ,  Nicholas Andrew White ,  Jie Xu ,  Haiming Zhang ,  Stephan Bachmann ,  Thomas Michael Bass ,  Raphael Bigler ,  Johannes Adrian Burkhard ,  Kyle Bradley Pascual Clagg ,  Francis Gosselin ,  Chong Han ,  Dainis Kaldre ,  Sean M. Kelly ,  Sebastian Herold ,  Christian Leitner

IPC分类号： C07D401/04 ,  B01J23/44 ,  B01J23/755

CPC分类号： C07D401/04 ,  B01J23/44 ,  B01J23/755

摘要： Provided herein are methods to synthesize compounds useful in the treatment of cancer where such compounds comprise a quinazolinyl core moiety and at least one stereoisomeric or atropisomeric moiety.

公开(公告)号：US20240280586A1

公开(公告)日：2024-08-22

申请号：US18636947

申请日：2024-04-16

申请人： Genentech, Inc.

发明人： Kendall CAREY

IPC分类号： G01N33/68 ,  C07K16/28 ,  G01N33/50

CPC分类号： G01N33/6854 ,  C07K16/2809 ,  C07K16/2887 ,  G01N33/505 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/92 ,  G01N33/6845

摘要： The present invention provides a cell-based assay for identifying and/or quantifying anti-CD3 homodimers in a composition comprising a T cell-dependent Bispecific antibody (TDB). In some aspects, the invention T cells comprising a T cell activation responsive reporter are contacted with the TDB to detect the presence of anti-CD3 homodimers. Compositions of reporter T cells and kits are also contemplated.