公开(公告)号：US12258603B2

公开(公告)日：2025-03-25

申请号：US18550209

申请日：2022-03-11

Applicant: Glycom A/S

Inventor： Getachew S. Molla

IPC: C07H1/06 ,  C07H1/08 ,  C12N9/10 ,  C12P19/04

Abstract: The present invention relates to the isolation and purification of sialylated oligosaccharides from an aqueous medium in which they are produced.

公开(公告)号：US12065462B2

公开(公告)日：2024-08-20

申请号：US16626217

申请日：2018-06-27

Applicant: GLYCOM A/S

Inventor： Nikolay Khanzhin

IPC: C07H1/06 ,  A23L33/00 ,  B01D61/02 ,  B01D61/04 ,  B01D61/14 ,  B01D61/58 ,  B01D69/02 ,  B01D69/12 ,  B01D71/56 ,  B01D71/58 ,  C07H3/06 ,  C08B37/00 ,  C12P19/04 ,  C12P19/12 ,  C12P19/18

CPC classification number: C07H1/06 ,  A23L33/40 ,  B01D61/027 ,  B01D61/04 ,  B01D61/146 ,  B01D61/58 ,  B01D69/02 ,  B01D69/12 ,  B01D71/56 ,  B01D71/58 ,  C07H3/06 ,  C08B37/0003 ,  C12P19/04 ,  C12P19/12 ,  C12P19/18 ,  A23L33/00 ,  A23V2002/00 ,  B01D61/145 ,  B01D2315/16 ,  B01D2325/20

Abstract: The invention relates to a method for separating sialylated oligosaccharides, preferably sialylated human milk oligosaccharides (HMOs), from disaccharides, preferably lactose, produced by a fermentation or enzymatic process.

公开(公告)号：US11998558B2

公开(公告)日：2024-06-04

申请号：US17120881

申请日：2020-12-14

Applicant: GLYCOM A/S

Inventor： Bruce McConnell ,  Louise Kristine Vigsnæs ,  David Paul Kronlage

IPC: A61K31/702 ,  A23L33/125 ,  A61P31/04

CPC classification number: A61K31/702 ,  A23L33/125 ,  A61P31/04 ,  A23V2002/00 ,  Y02A50/30 ,  A61K31/702 ,  A61K2300/00

Abstract: The invention relates to a synthetic composition comprising human milk oligosaccharides for use in at least partially restoring the commensal gastrointestinal microbiota and preventing or mitigating antibiotic associated diarrhoea.

公开(公告)号：US20230338403A1

公开(公告)日：2023-10-26

申请号：US17798270

申请日：2019-12-06

Applicant: Glycom A/S

Inventor： Bruce McConnell ,  Louise Kristine Vigsnæs ,  Gabriela Bergonzelli Degonda ,  Laurent Favre ,  Laurent Ferrier ,  Clara Lucia

IPC: A61K31/702 ,  A61P1/04 ,  A61K9/48

CPC classification number: A61K31/702 ,  A61P1/04 ,  A61K9/4825

Abstract: The application relates to compositions containing 2′-FL and DFL for use in a method of reducing pain and/or the perception of visceral pain in a non-infant human.

公开(公告)号：US20230099060A1

公开(公告)日：2023-03-30

申请号：US18057355

申请日：2022-11-21

Applicant: GLYCOM A/S

Inventor： Benjámin PODÁNYI ,  Pierre CHASSAGNE ,  Martin MATWIEJUK ,  Markus JONDELIUS HEDEROS

IPC: C07H3/06 ,  C07H1/00 ,  C07H3/02

Abstract: It is provided i) an amorphous carbohydrate with improved chemical stability and/or physical features, ii) a method for producing an amorphous carbohydrate with improved chemical stability and/or physical features, and iii) a method for improving the chemical stability and/or the physical features of an amorphous carbohydrate.

公开(公告)号：US20220378809A1

公开(公告)日：2022-12-01

申请号：US17755956

申请日：2020-11-13

Applicant: GLYCOM A/S

Inventor： Louise Kristine VIGSNÆS ,  Bruce MCCONNELL

IPC: A61K31/702 ,  A61K35/745 ,  A61K9/48 ,  A61K9/16 ,  A61P1/12

Abstract: This invention relates to a method and composition for balancing the bile acid profile in the intestine of humans, particularly decreasing primary bile acids and/or increasing production of secondary bile acids.

公开(公告)号：US11505567B2

公开(公告)日：2022-11-22

申请号：US16630372

申请日：2018-07-12

Applicant: GLYCOM A/S

Inventor： Benjámin Podányi ,  Pierre Chassagne ,  Martin Matwiejuk ,  Markus Jondelius Hederos

IPC: C07H3/06 ,  C07H1/00 ,  C07H3/02 ,  A23L33/00

Abstract: It is provided i) an amorphous carbohydrate with improved chemical stability and/or physical features, ii) a method for producing an amorphous carbohydrate with improved chemical stability and/or physical features, and iii) a method for improving the chemical stability and/or the physical features of an amorphous carbohydrate.

公开(公告)号：US20220267782A1

公开(公告)日：2022-08-25

申请号：US17596781

申请日：2020-06-19

Applicant: Glycom A/S

Inventor： Margit PEDERSEN

IPC: C12N15/70 ,  C12N15/113

Abstract: The present invention relates to the field of recombinant production of biological molecules in host cells. The invention provides nucleic acid constructs that allow to modify expression of a desired gene using both in vitro and in vivo gene expression systems with optimized stem-loop structures in the 5′ UTR of said genes. The constructs can advantageously be used to produce a variety of biological molecules recombinantly in industrial scales, e.g. human milk oligosaccharides (HMOs)

公开(公告)号：US11419884B2

公开(公告)日：2022-08-23

申请号：US16312506

申请日：2017-06-23

Applicant: GLYCOM A/S

Inventor： Nikolay Khanzhin ,  Markus Jondelius Hederos ,  Louise Kristine Vigsnæs ,  Bruce McConnell

IPC: A61K31/702 ,  C12P1/04 ,  A61P31/04 ,  A61K31/7016 ,  C07H1/00 ,  C12P19/04 ,  C12N9/10 ,  A61K31/716 ,  A61K31/7032

Abstract: The present disclosure relates to synthetic mixtures of certain human milk oligosaccharides and uses thereof. Particular mixtures provided herein include: lacto-N-triose II, lacto-N-neotetraose, para-lacto-N-neohexaose, and, optionally, lactose; and lacto-N-triose II, lacto-N-tetraose, para-lacto-N-hexaose II, and, optionally, lactose. These mixtures are useful in the prevention and treatment of viral and bacterial infections.

公开(公告)号：US20220119437A1

公开(公告)日：2022-04-21

申请号：US17646093

申请日：2021-12-27

Applicant: GLYCOM A/S

Inventor： Nikolay KHANZHIN ,  Markus JONDELIUS HEDEROS

IPC: C07H1/06 ,  B01D61/02 ,  B01D61/04 ,  B01D61/58 ,  B01D69/02 ,  B01D69/12 ,  B01D71/56 ,  B01D71/58 ,  C07H3/06 ,  C12P19/04 ,  C08B37/00 ,  C12P19/12 ,  A23L33/00 ,  C12P19/18

Abstract: This invention relates to a method for the enzymatic synthesis of oligosaccharides, preferably human milk oligosaccharides (HMOs) The method comprises the enzymatic transfer of a glycosyl moiety and subsequent removal of by-products, such as lactose, by nanofiltration using a membrane comprising an active polyamide layer.