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    Assays
    3.
    发明申请
    Assays 审中-公开
    测定

    公开(公告)号：US20100291611A1

    公开(公告)日：2010-11-18

    申请号：US12278883

    申请日：2007-02-15

    申请人： John Anthony Bolbot ,  John William Dilleen ,  Christopher John Slevin

    发明人： John Anthony Bolbot ,  John William Dilleen ,  Christopher John Slevin

    IPC分类号： C12Q1/02 ,  C12M1/00 ,  G01N33/48 ,  G01N33/20

    CPC分类号： G01N33/6803 ,  G01N33/02 ,  G01N33/18 ,  G01N33/48707 ,  G01N33/49 ,  G01N33/54386 ,  G01N33/683 ,  G01N2333/765 ,  G01N2800/325

    摘要： A device includes a substrate that defines, at least in part, a microfluidic network including an inlet in communication with a first detection zone and with a second detection zone. A cobalt reagent and a nickel reagent are disposed within the microfluidic network. First electrodes are in communication with the first detection zone and second electrodes arc in communication with the second detection zone. The device is configured to receive a blood derived sample introduced to the inlet, partition the blood sample into first and second blood sample portions, form a first mixture including at least some of the first blood sample portion and at least some of the cobalt reagent, and form a second mixture including at least some of the second blood sample portion, at least some of the cobalt reagent and at least some of the nickel reagent.

    摘要翻译： 一种装置包括至少部分地限定微流体网络的基底，该微流体网络包括与第一检测区域和第二检测区域连通的入口。 钴试剂和镍试剂置于微流体网络内。 第一电极与第一检测区域连通，第二电极与第二检测区域连通。 该装置被配置为接收引入到入口的血液衍生的样品，将血液样品分隔成​​第一和第二血液样本部分，形成包括第一血液样本部分和至少一些钴试剂中的至少一些的第一混合物， 并形成第二混合物，其包括至少一些第二血液样品部分，至少一些钴试剂和至少一些镍试剂。

    Colloidal Metal Conjugates
    4.
    发明申请
    Colloidal Metal Conjugates 有权
    胶体金属结合物

    公开(公告)号：US20100015636A1

    公开(公告)日：2010-01-21

    申请号：US11887145

    申请日：2006-03-28

    申请人： David E. Charlton

    发明人： David E. Charlton

    IPC分类号： G01N33/53

    CPC分类号： G01N33/553 ,  A61K47/6905 ,  A61K47/6923 ,  A61K47/6929

    摘要： Colloidal metal conjugates can be produced in high concentrations suitable for direct use, for example, in immunoassays. The colloidal metal conjugates can be used in devices for qualitative, semi-quantitative, or quantitative determination of the presence of compounds in samples, including biological samples.

    摘要翻译： 胶体金属共轭物可以以适于直接使用的高浓度制备，例如在免疫测定中。 胶体金属共轭物可用于定性，半定量或定量测定样品（包括生物样品）中化合物的存在的装置。

    Assays
    5.
    发明授权
    Assays 失效
    测定

    公开(公告)号：US07629178B2

    公开(公告)日：2009-12-08

    申请号：US11923930

    申请日：2007-10-25

    申请人： Paul James Davis ,  Michael Evans Prior ,  Keith May

    发明人： Paul James Davis ,  Michael Evans Prior ,  Keith May

    IPC分类号： G01N33/558 ,  C12Q1/00 ,  G01N33/53 ,  C12M1/34 ,  C12M3/00 ,  G01N21/00 ,  G01N15/06 ,  C12Q1/68 ,  B32B5/02

    CPC分类号： G01N33/54386 ,  G01N33/558 ,  G01N33/76 ,  Y10S435/805 ,  Y10S435/806 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/81 ,  Y10S436/814 ,  Y10S436/818

    摘要： An analytical test device incorporating a dry porous carrier to which a liquid sample, eg. urine, suspected of containing an analyte such as HCG or LH can be applied indirectly, the device also incorporating a labelled specific binding reagent which is freely mobile in the porous carrier when in the moist state, and an unlabelled specific binding reagent which is permanently immobilized in a detection zone on the carrier material, the labelled and unlabelled specific binding reagents being capable of participating in either a sandwich reaction or a competition reacts on in the presence of the analyte, in which prior to the application to the device of a liquid sample suspected of containing the analyte, the labelled specific binding reagent is retained in the dry state in a macroporous body, eg. of plastics material having a pore size of 10 microns or greater, through which the applied liquid sample must pass en route to the porous carrier material, the labelled specific binding reagent being freely soluble or dispersible in any liquid sample which enters the macroporous body.

    摘要翻译： 包含干多孔载体的分析测试装置，液体样品例如 怀疑含有分析物如HCG或LH的尿液可以间接施用，该装置还包含标记的特异性结合试剂，其在处于潮湿状态时可在多孔载体中自由移动，以及永久固定的未标记的特异性结合试剂 在载体材料上的检测区域中，能够参与夹心反应或竞争性的标记和未标记的特异性结合试剂在分析物存在下反应，其中在施加到液体样品的装置之前 怀疑含有分析物，标记的特异性结合试剂在大孔体内保持干燥状态，例如。 的孔径为10微米或更大的塑料材料，所施加的液体样品通过该材料必须通过多孔载体材料，标记的特异性结合试剂可自由溶解或分散在进入大孔体的任何液体样品中。

    Predicting responses to drugs or drug cadidates
    6.
    发明申请
    Predicting responses to drugs or drug cadidates 审中-公开
    预测对药物或药物队员的反应

    公开(公告)号：US20090240439A1

    公开(公告)日：2009-09-24

    申请号：US11990698

    申请日：2006-08-29

    申请人： Alan George Clark ,  Steven Howell ,  Piet Hugo Christiaan Moerman

    发明人： Alan George Clark ,  Steven Howell ,  Piet Hugo Christiaan Moerman

    IPC分类号： G06F19/00 ,  G01N33/53

    CPC分类号： G01N33/5088 ,  G01N2800/52

    摘要： Patients can be segregated into groups expected to have differential responses to drug treatment based on test results. Patient sub-populations expected to benefit from a particular treatment can thus be identified and directed to that treatment. Similarly, sub-populations expected to suffer a greater risk of side effects from a particular treatment can be identified and steered to other, safer treatments. A patient under treatment can be monitored for safety.

    摘要翻译： 患者可以根据检测结果分为预期对药物治疗有不同反应的组。 因此，预期受益于特定治疗的患者亚群可以被鉴定并针对该治疗。 同样，预期受特定治疗的副作用风险更大的亚种群可以被鉴定并引导至其他更安全的治疗方法。 可以监视正在治疗的患者的安全性。

    Assays
    8.
    发明申请
    Assays 审中-公开
    测定

    公开(公告)号：US20090081714A1

    公开(公告)日：2009-03-26

    申请号：US11988456

    申请日：2006-07-10

    申请人： Leong Ng ,  Sarah Johnson ,  Steve Eida ,  Paul Sheard

    发明人： Leong Ng ,  Sarah Johnson ,  Steve Eida ,  Paul Sheard

    IPC分类号： G01N33/68 ,  C07K7/06 ,  C07K16/18

    CPC分类号： G01N33/6893 ,  G01N2333/5751 ,  G01N2800/32 ,  G01N2800/325

    摘要： Methods and assays for monitoring the cardiac health of a subject are provided. The method involves the detection of a urotensin surrogate in a sample leading to a more accurate and reliable diagnosis of early or late stages of decompensated heart failure, heart failure, risk of a heart failur in a subject than the measurement of the cyclic peptide of urotensin alone.

    摘要翻译： 提供了用于监测受试者的心脏健康的方法和测定。 该方法涉及在样品中检测尿素转运蛋白替代物，导致更准确和可靠地诊断失代偿性心力衰竭，心力衰竭，受试者心脏衰竭的风险，而不是尿路生理素环肽的测量的早期或晚期 单独。

    Method and Apparatus for Patterning a Bibulous Substrate
    9.
    发明申请
    Method and Apparatus for Patterning a Bibulous Substrate 审中-公开
    用于图案化吸收性基材的方法和装置

    公开(公告)号：US20080241953A1

    公开(公告)日：2008-10-02

    申请号：US12065780

    申请日：2006-09-06

    申请人： Falk Fish

    发明人： Falk Fish

    IPC分类号： G01N21/78 ,  B01J19/00 ,  B41F1/00

    CPC分类号： B01L3/5023 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2300/0636 ,  B01L2300/0681 ,  B01L2300/0825 ,  B01L2300/126 ,  B01L2300/165 ,  D21H25/005

    摘要： A method of patterning a bibulous substrate is disclosed. The method comprises contacting the bibulous substrate with a first surface being coated by a barrier compound, using a second surface having a predetermined pattern engraved thereon, and applying heat and pressure onto the first surface such as to pattern the bibulous substrate in a predetermined pattern.

    摘要翻译： 公开了一种图案化吸水性衬底的方法。 该方法包括使吸水性衬底与被阻挡化合物涂覆的第一表面接触，使用刻在其上的预定图案的第二表面，并将热和压力施加到第一表面上，以便以预定图案对吸水衬底进行图案化。