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    INTEGRATED FLUORESCENCE SCANNING SYSTEM
    1.
    发明申请
    INTEGRATED FLUORESCENCE SCANNING SYSTEM 有权

    公开(公告)号：US20220291129A1

    公开(公告)日：2022-09-15

    申请号：US17656864

    申请日：2022-03-28

    申请人： Lumencor, Inc.

    发明人： Claudia B. JAFFE ,  Steven M. JAFFE

    IPC分类号： G01N21/64

    摘要： An integrated fluorescence scanning system is provided. The integrated fluorescence scanner combines an embedded computer, light engine, microscope, and motion stage into a compact rack-mountable network appliance that allows for automation of fluorescence microscopy. In an embodiment, the integrated fluorescence scanner includes a solid-state light engine which can provide intense, pure, and stable light across the spectrum required for imaging of all fluorophores of interest. The embedded computer allows for autonomous operation, and network appliance features including synchronous multi-scanner operation and monitoring, multisite operation via a single control terminal, and calibration for inter and intra instrument consistency.

    Solid state light source with hybrid optical and electrical intensity control
    2.
    发明授权
    Solid state light source with hybrid optical and electrical intensity control 有权
    具有混合光电和电强度控制的固态光源

    公开(公告)号：US08998468B2

    公开(公告)日：2015-04-07

    申请号：US13788022

    申请日：2013-03-07

    申请人： Lumencor, Inc.

    发明人： Claudia B. Jaffe ,  Steven M. Jaffe

    IPC分类号： F21V7/04 ,  F21V11/00 ,  A61B1/06 ,  G02B21/16 ,  G02B27/14 ,  F21V8/00

    CPC分类号： F21V11/00 ,  A61B1/0638 ,  A61B1/0669 ,  A61B1/0684 ,  G02B6/0003 ,  G02B6/0006 ,  G02B21/16 ,  G02B27/141

    摘要： A solid state illumination system is provided as a replacement for conventional arc light, metal halide and Xenon light sources for applications in microscopy, fluorescence microscopy, and endoscopy. The illumination system includes hybrid optical and electrical control of output intensity in which the light output of one or more of the light sources is attenuated optically such that it is not necessary to reduce the electrical drive power/current of the LEDs at a level where the spectral power distribution is variable. One or more fixed, selectable, or variable neutral density filters is interposed in the output beam of one or more sources to achieve optical attenuation of the light output. The hybrid optical and electrical control of output intensity allows greater dynamic range of intensity to be achieved than could be achieved with electrical control of the LEDs alone while maintaining the desired spectral power distribution.

    摘要翻译： 提供固态照明系统作为常规电弧光，金属卤化物和氙光源的替代品，用于显微镜，荧光显微镜和内窥镜检查。 照明系统包括输出强度的混合光学和电气控制，其中一个或多个光源的光输出被光学衰减，使得不需要将LED的电驱动功率/电流降低到 光谱功率分布是可变的。 在一个或多个源的输出光束中插入一个或多个固定的，可选择的或可变的中性密度滤光片，以实现光输出的光学衰减。 输出强度的混合光学和电气控制允许在保持所需的光谱功率分布的情况下，仅通过LED的电气控制可实现更大的强度动态范围。

    SYSTEM AND METHOD FOR CONTROLLED INTENSITY ILLUMINATION IN A BIOANALYSIS OR OTHER SYSTEM
    4.
    发明申请
    SYSTEM AND METHOD FOR CONTROLLED INTENSITY ILLUMINATION IN A BIOANALYSIS OR OTHER SYSTEM 审中-公开
    生物分析或其他系统中控制强度照射的系统和方法

    公开(公告)号：US20130234047A1

    公开(公告)日：2013-09-12

    申请号：US13874645

    申请日：2013-05-01

    申请人： LUMENCOR, INC.

    发明人： Claudia B. Jaffe ,  Steven M. Jaffe ,  David Larsen

    IPC分类号： G01N21/64 ,  F21V23/04

    CPC分类号： G01N21/645 ,  F21V23/0457 ,  G01J1/4257 ,  G01N21/64 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2021/6439 ,  G01N2201/061 ,  H05B33/0869

    摘要： A system and method for controlled illumination in a bioanalysis or other system where excitation of fluorescent molecules is desirable. In an embodiment, an illumination system is described which can provide excitation light at a controlled intensity to provide quantitative results. In an embodiment, a solid state light engine is described which includes a plurality of color channels each providing light output suitable for exciting a fluorescent molecule, a light to frequency converter which receives a portion of the light output, a counter which maintains a count of a signal from the light to frequency converter, and a light intensity circuit, responsive to the counter, which adjusts the color channels to control the intensity of the light output.

    摘要翻译： 在生物分析或其它系统中控制照明的系统和方法，其中期望荧光分子的激发。 在一个实施例中，描述了可以以受控强度提供激发光以提供定量结果的照明系统。 在一个实施例中，描述了一种固态光引擎，其包括多个颜色通道，每个颜色通道各自提供适于激发荧光分子的光输出，接收光输出的一部分的光频变换器，保持计数 来自光到频率转换器的信号，以及响应于计数器的光强度电路，其调节颜色通道以控制光输出的强度。

    BIOANALYTICAL INSTRUMENTATION USING A LIGHT SOURCE SUBSYSTEM
    7.
    发明申请
    BIOANALYTICAL INSTRUMENTATION USING A LIGHT SOURCE SUBSYSTEM 有权
    使用光源子系统的生物仪器

    公开(公告)号：US20110044858A1

    公开(公告)日：2011-02-24

    申请号：US12938224

    申请日：2010-11-02

    申请人： Claudia B. Jaffe ,  Steven M. Jaffe ,  Michieal L. Jones

    发明人： Claudia B. Jaffe ,  Steven M. Jaffe ,  Michieal L. Jones

    IPC分类号： G01N21/64 ,  C40B60/12 ,  G01J1/58

    CPC分类号： G01J3/10 ,  G01N21/253 ,  G01N21/255 ,  G01N21/4788 ,  G01N21/51 ,  G01N21/53 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6469 ,  G01N2021/6484 ,  G01N2201/06193

    摘要： The invention relates to a light source for irradiating molecules present in a detection volume with one or more selected wavelengths of light and directing the fluorescence, absorbance, transmittance, scattering onto one or more detectors. Molecular interactions with the light allow for the identification and quantitation of participating chemical moieties in reactions utilizing physical or chemical tags, most typically fluorescent and chromophore labels. The invention can also use the light source to separately and simultaneously irradiate a plurality of capillaries or other flow confining structures with one or more selected wavelengths of light and separately and simultaneously detect fluorescence produced within the capillaries or other flow confining structures. In various embodiments, the flow confining structures can allow separation or transportation of molecules and include capillary, micro bore and milli bore flow systems. The capillaries are used to separate molecules that are chemically tagged with appropriate fluorescent or chromophore groups.

    摘要翻译： 本发明涉及用于用存在于检测体积中的分子照射一种或多种所选波长的光并将荧光，吸光度，透射率，散射引导到一个或多个检测器上的光源。 与光的分子相互作用允许使用物理或化学标签（最常见的荧光和发色团标记）在反应中鉴定和定量参与的化学部分。 本发明还可以使用光源单独地并且同时用一个或多个选择的波长的光照射多个毛细管或其它流动约束结构，并且分别并且同时检测在毛细管或其它流动限制结构内产生的荧光。 在各种实施方案中，流动限制结构可以允许分子的分离或运输，并且包括毛细管，微孔和毫里流系统。 毛细血管用于分离用适当荧光或发色团组化学标记的分子。

    LIGHTING DESIGN OF HIGH QUALITY BIOMEDICAL DEVICES
    8.
    发明申请
    LIGHTING DESIGN OF HIGH QUALITY BIOMEDICAL DEVICES 有权
    高品质生物医学设备的照明设计

    公开(公告)号：US20100187440A1

    公开(公告)日：2010-07-29

    申请号：US12691601

    申请日：2010-01-21

    申请人： Claudia B. Jaffe ,  Steven M. Jaffe ,  Arlie R. Conner

    发明人： Claudia B. Jaffe ,  Steven M. Jaffe ,  Arlie R. Conner

    IPC分类号： G01J1/58

    CPC分类号： G01N21/64 ,  G01J1/58 ,  G01J3/10 ,  G02B6/0003

    摘要： The invention relates to a plurality of light sources to power a variety of applications including microarray readers, microplate scanners, microfluidic analyzers, sensors, sequencers, Q-PCR and a host of other bioanalytical tools that drive today's commercial, academic and clinical biotech labs.

    摘要翻译： 本发明涉及多种光源，用于驱动各种应用，包括微阵列阅读器，微孔板扫描仪，微流控分析仪，传感器，定序器，Q-PCR以及驱动当今商业，学术和临床生物技术实验室的许多其他生物分析工具。