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    Broad spectrum anti-viral therapeutics and prophylaxis
    3.
    发明授权
    Broad spectrum anti-viral therapeutics and prophylaxis 有权
    广谱抗病毒治疗和预防

    公开(公告)号：US08084036B2

    公开(公告)日：2011-12-27

    申请号：US10718986

    申请日：2003-11-21

    申请人： Mang Yu ,  Fang Fang ,  Michael Malakhov

    发明人： Mang Yu ,  Fang Fang ,  Michael Malakhov

    IPC分类号： A61K39/00 ,  C12N9/36

    CPC分类号： B82Y5/00 ,  A61K38/47 ,  A61K38/57

    摘要： The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeutic domain that can act extracellularly to prevent infection of the target cell by a pathogen, such as a virus. Preferred target cells are epithelial cells. The invention provides compositions and methods for preventing viral diseases, such as influenza, using compounds having anchoring domains that can bind target cells linked to enzymatic activities that can act extracellularly to interfere with viral infection of target cells. The invention also provides compositions and methods for preventing viral diseases such as influenza using compounds having anchoring domains that can bind target cells linked to protease inhibitors that can act extracellularly to interfere with viral infection of target cells.

    摘要翻译： 本发明提供了用于预防和治疗病原体感染的新的组合物和方法。 特别地，本发明提供具有将化合物锚定在靶细胞表面的锚定结构域的化合物，以及可以在细胞外作用以防止病原体如病毒感染靶细胞的治疗结构域。 优选的靶细胞是上皮细胞。 本发明提供了用于预防病毒性疾病（例如流行性感冒）的组合物和方法，使用具有锚定结构域的化合物，所述化合物具有可结合与细胞外作用以干扰靶细胞的病毒感染的酶活性连接的靶细胞。 本发明还提供了用于使用具有锚定结构域的化合物来预防病毒性疾病例如流感的组合物和方法，所述化合物具有可以结合与蛋白酶抑制剂连接的靶细胞，其可以在细胞外作用以干扰靶细胞的病毒感染。

    Class of therapeutic protein based molecules
    4.
    发明授权
    Class of therapeutic protein based molecules 有权
    基于治疗蛋白质的分子类

    公开(公告)号：US07807174B2

    公开(公告)日：2010-10-05

    申请号：US10939262

    申请日：2004-09-10

    申请人： Fang Fang ,  Michael Malakhov

    发明人： Fang Fang ,  Michael Malakhov

    IPC分类号： A61K39/00 ,  C12N9/36

    CPC分类号： C12N9/2402 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/00 ,  C07K2319/01 ,  C07K2319/33 ,  C12N2760/16111 ,  C12Y302/01018

    摘要： The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeutic domain that can act extracellularly to prevent infection of a target cell by a pathogen, such as a virus. The present invention also comprises therapeutic compositions having sialidase activity, including protein-based compounds having sialidase catalytic domains. Compounds of the invention can be used for treating or preventing pathogen infection, and for treating and reducing allergic and inflammatory responses. The invention also provides compositions and methods for enhancing transduction of target cells by recombinant viruses. Such compositions and methods can be used in gene therapy.

    摘要翻译： 本发明提供了用于预防和治疗病原体感染的新的组合物和方法。 特别地，本发明提供了具有将化合物锚定在靶细胞表面的锚定结构域的化合物，以及可以在细胞外作用以防止病原体如病毒感染靶细胞的治疗结构域。 本发明还包括具有唾液酸酶活性的治疗组合物，包括具有唾液酸酶催化结构域的蛋白质类化合物。 本发明的化合物可用于治疗或预防病原体感染，以及用于治疗和减少变态反应和炎症反应。 本发明还提供了通过重组病毒增强靶细胞转导的组合物和方法。 这些组合物和方法可用于基因治疗。

    Class of therapeutic protein based molecules
    5.
    发明授权
    Class of therapeutic protein based molecules 有权

    公开(公告)号：US07645448B2

    公开(公告)日：2010-01-12

    申请号：US12256230

    申请日：2008-10-22

    申请人： Fang Fang ,  Michael Malakhov

    发明人： Fang Fang ,  Michael Malakhov

    IPC分类号： A61K38/46 ,  C12N9/14

    CPC分类号： C12N9/2402 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/00 ,  C07K2319/01 ,  C07K2319/33 ,  C12N2760/16111 ,  C12Y302/01018

    摘要： The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeutic domain that can act extracellularly to prevent infection of a target cell by a pathogen, such as a virus. The present invention also comprises therapeutic compositions having sialidase activity, including protein-based compounds having sialidase catalytic domains. Compounds of the invention can be used for treating or preventing pathogen infection, and for treating and reducing allergic and inflammatory responses. The invention also provides compositions and methods for enhancing transduction of target cells by recombinant viruses. Such compositions and methods can be used in gene therapy.