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公开(公告)号：US20240124512A1
公开(公告)日：2024-04-18
申请号：US18476763
申请日：2023-09-28
发明人： Xiaohui DU , John EKSTEROWICZ , Valeria R. FANTIN , Daqing SUN , Qiuping YE , Jared MOORE , Tatiana ZAVOROTINSKAYA , Brian R. BLANK , Yosup REW , Kejia WU , Liusheng ZHU , Johnny PHAM , Hiroyuki KAWAI
摘要： Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.
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公开(公告)号：US11377469B2
公开(公告)日：2022-07-05
申请号：US16760380
申请日：2018-11-02
发明人： Xiaohui Du , John Eksterowicz , Valeria R. Fantin , Erica L. Jackson , Daqing Sun , Qiuping Ye , Jared Moore , Tatiana Zavorotinskaya
IPC分类号： C07H19/23 , A61P35/00 , A61K31/706 , C07H19/056 , A61K31/7064 , A61K45/06
摘要： Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.
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公开(公告)号：US11325938B2
公开(公告)日：2022-05-10
申请号：US17078567
申请日：2020-10-23
发明人： Xiaohui Du , John Eksterowicz , Valeria R. Fantin , Daqing Sun , Qiuping Ye , Jared Moore , Tatiana Zavorotinskaya , Brian R. Blank , Yosup Rew , Kejia Wu , Liusheng Zhu , Johnny Pham , Hiroyuki Kawai
摘要： Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.
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公开(公告)号：US20210122730A1
公开(公告)日：2021-04-29
申请号：US16604543
申请日：2018-04-10
发明人： Xiaohui DU , John EKSTEROWICZ , Valeria R. FANTIN , Yosup REW , Daqing SUN , Qiuping YE , Haiying ZHOU , Hiroyuki KAWAI , Jared MOORE , Johnny PHAM , Kejia WU , Liusheng ZHU , Dennis YAMASHITA
IPC分类号： C07D401/12 , C07D417/12 , C07D401/14 , C07D417/14 , C07D405/14 , A61K31/4439 , A61K31/4545 , A61K31/444 , A61K31/427 , A61K31/337 , A61K31/404 , A61K31/58 , A61K31/473 , A61K31/277 , A61K31/567 , A61K31/4164 , A61K31/167 , A61K31/496 , A61K31/18 , A61K31/4166 , A61K45/06 , A61K35/17 , A61K39/00 , A61K39/395
摘要： Described herein are glucocorticoid receptor modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer and hypercortisolism.
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公开(公告)号：US20240124426A1
公开(公告)日：2024-04-18
申请号：US18452278
申请日：2023-08-18
发明人： Chudi NDUBAKU , Jared Thomas MOORE , Paul Anthony GIBBONS , Jae Hyuk CHANG , F. Anthony ROMERO , Xiaohui DU , Hiroyuki KAWAI , Stephane CIBLAT , Hong WANG , Vincent ALBERT , Lea CONSTANTINEAU-FORGET , Hugo de Almeida SILVA , Dilan Emine POLAT , Amit NAYYAR , Daniel Gordon Michael SHORE , Kejia WU , Joanne TAN
IPC分类号： C07D403/14 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14
CPC分类号： C07D403/14 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14
摘要： Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, that are inhibitors of Polo Like Kinase 4 (PLK4). Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
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6.发明公开公开(公告)号：US20230302014A1
公开(公告)日：2023-09-28
申请号：US18007369
申请日：2021-08-03
IPC分类号： A61K31/567 , A61K31/403 , A61K31/513 , A61K31/437 , A61P35/04
CPC分类号： A61K31/567 , A61K31/403 , A61K31/437 , A61K31/513 , A61P35/04
摘要： Disclosed herein are methods of treating prostate cancer in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of (i) a glucocorticoid receptor (GR) antagonist and (ii) an androgen receptor (AR) degrader.
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公开(公告)号：US20230096870A1
公开(公告)日：2023-03-30
申请号：US17887777
申请日：2022-08-15
发明人： Daqing SUN , Lawrence R. McGEE , Xiaohui DU , Liusheng ZHU , Xuelei YAN , Yosup REW , John EKSTEROWICZ , Julio C. MEDINA , Valeria R. FANTIN , Haiying ZHOU , Minna Delarae BALBAS
摘要： The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer.
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公开(公告)号：US20220331343A1
公开(公告)日：2022-10-20
申请号：US17626731
申请日：2020-07-15
发明人： Xiaohui DU , John EKSTEROWICZ , Valeria R. FANTIN , Daqing SUN , Qiuping YE , Jared MOORE , Tatiana ZAVOROTINSKAYA , Brian R. BLANK , Hiroyuki KAWAI , Chien-Hung YEH , Yosup REW , Kejia WU , Johnny PHAM
IPC分类号： A61K31/675 , C07F9/6561 , A61P35/00 , A61K45/06
摘要： Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.
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公开(公告)号：US20210395295A1
公开(公告)日：2021-12-23
申请号：US17404493
申请日：2021-08-17
发明人： Daqing SUN , Lawrence R. McGEE , Xiaohui DU , Liusheng ZHU , Xuelei YAN , Yosup REW , John EKSTEROWICZ , Julio C. MEDINA , Haiying ZHOU , Minna Delarae BALBAS , Valeria R. FANTIN
摘要： The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer and hypercortisolism.
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公开(公告)号：US11124537B2
公开(公告)日：2021-09-21
申请号：US16065626
申请日：2016-12-22
发明人： Daqing Sun , Lawrence R. McGee , Xiaohui Du , Liusheng Zhu , Xuelei Yan , Yosup Rew , John Eksterowicz , Julio C. Medina , Haiying Zhou , Minna Delarae Balbas , Valeria R. Fantin
摘要： The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer and hypercortisolism.
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