公开(公告)号：US20250057727A1

公开(公告)日：2025-02-20

申请号：US18725922

申请日：2022-09-26

Applicant: Paolo Gobbi Frattini s.r.l.

Inventor： Dario CASPANI ,  Paolo Giuseppe GOBBI FRATTINI

IPC: A61J1/20

Abstract: A pressure compensation device (1) for an apparatus for the reconstitution, withdrawal and transfer of a drug from a vial or other vacuum container with a hermetic closure plug being pierceable by axial pressure comprises a three-dimensional compensation bag (2) with distinct flexible walls (3) and internal space (4) containing sterile air, which is interposed between a device (5) for hooking and piercing the closure plug of the vial (16) and a terminal connector (6) with an hermetic closure valve being openable by axial pressure applied with the luer (25) of a needless syringe (27) or with other extraction means and automatically hermetically reclosable upon ceasing pressure. The hooking and piercing device (5) comprises a hooking and retaining cowling (7), a piercing stem (11) with axial internal passage (49), and a sealing element (12).

公开(公告)号：US20220151872A1

公开(公告)日：2022-05-19

申请号：US17529330

申请日：2021-11-18

Applicant: Paolo Gobbi Frattini S.R.L.

Inventor： Paolo Giuseppe Gobbi Frattini

IPC: A61J1/20 ,  A61J1/14 ,  A61J1/10

Abstract: Assembly with connectable and disconnectable elements comprises a flexible bag containing liquid solution with a first valve connector, at least one vial with active substance and provided with a hermetic closing cap, a coupling and piercing device couplable to the cap of the vial and an adapter between the first connector and the coupling and piercing device. The adapter has a hollow external body with a first end fixable by screwing to the first connector, an axially bored, coaxial internal stem, the screwing causes the opening of the first connector and a second end including a second valve connector fixable to the coupling and piercing device and is screwable in the external body so that internal stem causes the opening of the second valve connector.

公开(公告)号：US10010481B2

公开(公告)日：2018-07-03

申请号：US14790175

申请日：2015-07-02

Applicant: Paolo Gobbi Frattini S.R.L.

Inventor： Paolo Guiseppe Gobbi Frattini

IPC: A61B19/00 ,  A61J1/14 ,  A61J1/10 ,  A61J1/20 ,  B65D81/32

CPC classification number: A61J1/1468 ,  A61J1/10 ,  A61J1/1406 ,  A61J1/1412 ,  A61J1/1443 ,  A61J1/1475 ,  A61J1/201 ,  A61J1/2027 ,  A61J1/2055 ,  A61J1/2065 ,  A61J1/2089 ,  A61J1/2093 ,  B65D81/3216 ,  B65D81/3266

Abstract: A package for infusion or instillation of medicinal or nutritional products into the body of a patient comprises a bag of liquid diluent equipped with at least one drain tube and a mixing tube equipped with a coupling and perforation device for a bottle of a pharmacological or nutritional substance in powder, gel or other material, provided with a perforatable cap. The package comprises a flexible airtight sterile casing, containing said bottle of the substance in powder or other and the coupling and perforation device. The bottle is housed in the casing in a coupling position with the coupling and perforation device and is manually manoeuvrable from the outside of the casing up to a perforating position of the cap of the bottle.

公开(公告)号：US20160251620A1

公开(公告)日：2016-09-01

申请号：US15027709

申请日：2014-10-06

Applicant: PAOLO GOBBI FRATTINI S.R.L.

Inventor： Paolo Giuseppe GOBBI FRATTINI

IPC: C12N5/078 ,  B01D21/26

CPC classification number: C12N5/0634 ,  B01D21/26 ,  G01N33/5002

Abstract: The present invention relates to a method for retrieving more numerous, viable and efficient stem cells from the blood of a patient. The method comprises a preliminary step of pre-treating blood cells using an oxygen-ozone mixture and a subsequent step of separating the stem cells from said pre-treated blood cells.

Abstract translation: 本发明涉及一种用于从患者的血液中检索更多的，可行且有效的干细胞的方法。 该方法包括使用氧 - 臭氧混合物预处理血液细胞的预备步骤，以及从所述预处理的血细胞中分离干细胞的后续步骤。

公开(公告)号：US20220151873A1

公开(公告)日：2022-05-19

申请号：US17528221

申请日：2021-11-17

Applicant: Paolo Gobbi Frattini S.R.L.

Inventor： Paolo Giuseppe GOBBI FRATTINI

IPC: A61J1/20 ,  B65D51/00

Abstract: A hooking and piercing device (1) for vials and tubes provided with a closing cap openable by pressure, comprising a hooking hood (2) with circumferentially distributed hooking toothed sectors (3) and an axial perforated stem (4) which extends axially and centrally out of the hooking hood (2) to be engaged by pressure inside a tube. The axial perforated stem (4) has an axially perforated appendix (6) which extends inside the hooking hood (2) and is shaped like a syringe luer. A frangible closing element (17) on the axial perforated stem (4) may be provided at the end of the axial perforated stem (4) opposite to the one with the luer-shaped appendix (6).

公开(公告)号：US10391032B2

公开(公告)日：2019-08-27

申请号：US15287235

申请日：2016-10-06

Applicant: PAOLO GOBBI FRATTINI S.R.L.

Inventor： Paolo Giuseppe Gobbi Frattini

IPC: A61J1/20 ,  A61J1/10 ,  A61J1/14 ,  B65D81/32

Abstract: There is described a package for the reconstitution and administration of fluid medicinal or nutritional substances which are infused or instillable within the body of a patient, comprising a flexible casing containing a vial of a medicinal or nutritional substance in a coupling position to a coupling and perforation device inserted into a mixing tube for the connection with a bag of liquid diluent. The casing comprises a connector provided with an openable and hermetically closable cap, adapted to introduce a mixture of sterilizing gas and oxygen into said casing.

公开(公告)号：US09918902B2

公开(公告)日：2018-03-20

申请号：US14407701

申请日：2013-06-21

Applicant: PAOLO GOBBI FRATTINI s.r.l.

Inventor： Paolo Giuseppe Gobbi Frattini

IPC: A61J1/22 ,  B65D51/00 ,  B65D51/20 ,  A61J1/14 ,  A61J1/20

CPC classification number: A61J1/22 ,  A61J1/1406 ,  A61J1/1412 ,  A61J1/1468 ,  A61J1/2003 ,  B65D51/002 ,  B65D51/20

Abstract: A bottle for containing pharmacological and/or nutritional active substances is described. The bottle comprises a closing cap pierceable by the pressure exerted with the luer of a needle-free syringe. The closing cap is made as a single piece including a check valve and closing lips which can be opened by introducing a syringe luer and can be elastically closed back upon the extraction of the luer introduced, and a membrane which is pierceable and elastically resealable to hermetically close the inlet end of the check valve.

公开(公告)号：US11865073B2

公开(公告)日：2024-01-09

申请号：US17529330

申请日：2021-11-18

Applicant: Paolo Gobbi Frattini S.R.L.

Inventor： Paolo Giuseppe Gobbi Frattini

IPC: A61J1/20 ,  A61J1/10 ,  A61J1/14

CPC classification number: A61J1/2037 ,  A61J1/10 ,  A61J1/1412 ,  A61J1/201 ,  A61J1/2027 ,  A61J1/2048 ,  A61J1/2089

Abstract: Assembly with connectable and disconnectable elements comprises a flexible bag containing liquid solution with a first valve connector, at least one vial with active substance and provided with a hermetic closing cap, a coupling and piercing device couplable to the cap of the vial and an adapter between the first connector and the coupling and piercing device. The adapter has a hollow external body with a first end fixable by screwing to the first connector, an axially bored, coaxial internal stem, the screwing causes the opening of the first connector and a second end including a second valve connector fixable to the coupling and piercing device and is screwable in the external body so that internal stem causes the opening of the second valve connector.

公开(公告)号：US11642282B2

公开(公告)日：2023-05-09

申请号：US16592798

申请日：2019-10-04

Applicant: PAOLO GOBBI FRATTINI S.R.L.

Inventor： Paolo Giuseppe Gobbi Frattini

IPC: A61J1/20

CPC classification number: A61J1/2048 ,  A61J1/2027 ,  A61J1/2044 ,  A61J1/2096

Abstract: A male-female adapter (21) can be coupled to a hermetically closable connector (1) with external threading (13) and closing plug (6) which can be bored by pressure of a male fitting so as to form a connector (1)—adapter (21) unit which is suitable for using a female fitting. The adapter (21) comprises an external tubular body (22) with an axial extension (24) which can be hooked to the connector (1) in a rotatable and axially slidable manner, an internal tubular body (26) with terminal tangs (27, 37) axially projecting from the extremities of the external tubular body (22), a middle transversal wall (28) which integrally connects the two tubular bodies (22, 26), and two opposite sense threadings (29, 30) formed in internal portions of the external tubular body (22), which threadings are separated by said middle transversal wall (28).

公开(公告)号：US20220160580A1

公开(公告)日：2022-05-26

申请号：US17531841

申请日：2021-11-22

Applicant: PAOLO GOBBI FRATTINI S.R.L.

Inventor： Paolo Giuseppe GOBBI FRATTINI ,  Dario Caspani

IPC: A61J1/14 ,  A61J1/10

Abstract: A connector (3) which is applicable to a bag (1) for containing liquid solutions for medical or nutritional use comprises a coupling part (11) for coupling to an end of a small tube (2) projecting from the bag (1) and provided with an axial hole (5) closed by a pierceable inner membrane (6). The coupling part (11) includes two coaxial tubes (12, 13) which define an annular space (14) extending axially with a constant cross-section, into which said end of the small tube (2) is forcibly insertable by axial pressure.