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公开(公告)号：US07699801B2
公开(公告)日：2010-04-20
申请号：US11752173
申请日：2007-05-22
Applicant: Joel R. Haynes , Georg Widera , James T. Fuller , Timothy Shipley , Deborah Fuller , Mary Wu
Inventor： Joel R. Haynes , Georg Widera , James T. Fuller , Timothy Shipley , Deborah Fuller , Mary Wu
CPC classification number: A61K33/24 , A61K39/0011 , A61K39/015 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/292 , A61K45/06 , A61K2039/53 , A61K2039/545 , A61K2039/55572 , A61K2039/55577 , A61K2039/57 , C07K14/005 , C12N15/895 , C12N2730/10122 , C12N2740/16122 , C12N2740/16134 , C12N2760/16122 , C12N2760/16134 , Y02A50/412
Abstract: Reagents useful in nucleic acid immunization techniques are described. More particularly, adjuvanted genetic vaccine compositions are described, as are methods of using those compositions for inducing an enhanced immune response against a selected antigen.
Abstract translation: 描述了可用于核酸免疫技术的试剂。 更具体地，描述了佐剂化的遗传疫苗组合物，以及使用这些组合物诱导针对所选抗原的增强的免疫应答的方法。
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公开(公告)号：US07196066B1
公开(公告)日：2007-03-27
申请号：US09705149
申请日：2000-11-01
Applicant: William F. Swain , Lee K. Roberts , Lendon G. Payne , Ralph P. Braun
Inventor： William F. Swain , Lee K. Roberts , Lendon G. Payne , Ralph P. Braun
IPC: A61K31/711 , C12N15/86 , C12N15/63 , C07H21/04
CPC classification number: A61K39/245 , A61K39/12 , A61K2039/53 , A61K2039/545 , C12N2710/16634
Abstract: Methods of eliciting an immune response in a subject by administering one or more large genomic DNA fragments are provided. Also provided are methods of identifying sequences encoding antigenic polypeptides. Also provided are vaccine compositions comprising one or more large genomic DNA fragments.
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公开(公告)号：US20080160048A1
公开(公告)日：2008-07-03
申请号：US10575087
申请日：2004-10-11
Applicant: James Fuller
Inventor： James Fuller
CPC classification number: C07K14/005 , A61K48/00 , A61K2039/53 , C07K14/4716 , C07K14/4741 , C07K14/62 , C12N15/85 , C12N2710/16622 , C12N2710/16722 , C12N2730/10122 , C12N2830/00 , C12N2830/15 , C12N2830/42 , C12N2830/60
Abstract: A nucleic acid construct comprising a chimeric promoter sequence and a cloning site for insertion of a coding sequence in operable linkage with the chimeric promoter, wherein the chimeric promoter sequence comprises: (a) a hCMV immediate early promoter sequence; (b) exon 1 and at least a part of exon 2 of the hCMV major immediate early gene; and (c) a heterologous intron provided in place of the intron A region of the hCMV major immediate early gene.
Abstract translation: 一种核酸构建体，其包含嵌合启动子序列和用于插入与嵌合启动子可操作连接的编码序列的克隆位点，其中所述嵌合启动子序列包含：（a）hCMV立即早期启动子序列; （b）外显子1和hCMV主要即时早期基因的外显子2的至少一部分; 提供代替hCMV主要立即早期基因的内含子A区域的异源内含子。
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公开(公告)号：US06881723B1
公开(公告)日：2005-04-19
申请号：US09434830
申请日：1999-11-05
Applicant: Deborah L. Fuller , James T. Fuller
Inventor： Deborah L. Fuller , James T. Fuller
IPC: A61K39/385 , A61K48/00 , C07H21/04 , C12N15/74
CPC classification number: A61K39/385 , A61K2039/53 , A61K2039/57 , A61K2039/6075
Abstract: Recombinant nucleic acid molecules are described. The molecules have a first sequence encoding a Hepatitis B virus core antigen and a second sequence encoding at least one T cell epitope inserted within the first sequence. Vectors and compositions containing these molecules are also described. Methods of eliciting an immune response using these molecules are also described.
Abstract translation: 描述重组核酸分子。 分子具有编码乙型肝炎病毒核心抗原的第一序列和编码插入第一序列内的至少一个T细胞表位的第二序列。 还描述了含有这些分子的载体和组合物。 还描述了使用这些分子引发免疫应答的方法。
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公开(公告)号：US5922685A
公开(公告)日：1999-07-13
申请号：US659206
申请日：1996-06-05
Applicant: Alexander L. Rakhmilevich , Ning-Sun Yang
Inventor： Alexander L. Rakhmilevich , Ning-Sun Yang
CPC classification number: A61K38/208 , A61K48/00
Abstract: In an approach to genetic therapy for treating tumors, a genetic construction encoding the p35 and p40 subunits of the cytokine IL-12 is delivered into cells of individuals in need of therapy so as to express IL-12 in cells and to cause regression of established tumors.
Abstract translation: 在用于治疗肿瘤的遗传疗法的方法中，将编码细胞因子IL-12的p35和p40亚基的遗传构建递送到需要治疗的个体的细胞中，以在细胞中表达IL-12并引起已建立的 肿瘤。
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Patent Agency Ranking
公开(公告)号：US20100221349A1
公开(公告)日：2010-09-02
申请号：US11815278
申请日：2006-02-01
Applicant: James Fuller
Inventor： James Fuller
IPC: A61K39/145 , C12N15/44 , C12N15/52 , C12N15/63 , A61K9/14 , A61K31/7052 , C12N15/00 , A61P31/16 , A61M5/30
CPC classification number: C07K14/005 , A61K48/00 , A61K2039/53 , A61K2039/55544 , C12N15/85 , C12N2710/16622 , C12N2710/16722 , C12N2730/10122 , C12N2760/16122 , C12N2830/00 , C12N2830/15 , C12N2830/42 , C12N2830/60
Abstract: A nucleic acid construct comprising a chimeric promoter sequence and a cloning site for insertion of a coding sequence in operable linkage with the chimeric promoter, wherein the chimeric promoter sequence comprises: (a) a Hcmv immediate early promoter sequence; (b) exon 1 and at least a part of exon 2 of the hCMV major immediate early gene; and (c) a heterologous intron provided in place of the intron A region of the hCMV major immediate early gene.
Abstract translation: 一种核酸构建体，其包含嵌合启动子序列和用于插入与嵌合启动子可操作连接的编码序列的克隆位点，其中所述嵌合启动子序列包含：（a）Hcmv立即早期启动子序列; （b）外显子1和hCMV主要即时早期基因的外显子2的至少一部分; 提供代替hCMV主要立即早期基因的内含子A区域的异源内含子。
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公开(公告)号：US20050025777A1
公开(公告)日：2005-02-03
申请号：US10787880
申请日：2004-02-27
Applicant: Edward Pohlmann , Michael Sheehy , Kenneth Barton
Inventor： Edward Pohlmann , Michael Sheehy , Kenneth Barton
CPC classification number: A61K9/0021 , A61K9/1676 , A61K39/12 , A61K39/145 , A61K39/21 , A61K2039/54 , A61K2039/545 , A61K2039/55566 , A61K2039/60 , C12N2740/16134 , C12N2760/16134
Abstract: A method for inducing an immune response in a mammalian animal includes the steps of coating an immunogenic peptide onto small, dense particles, and delivering the coated particles into target skin cells of the animal. The method is useful as a strategy for obtaining large quantities of specific diagnostic antibodies from laboratory animals and as a method for vaccinating animals or humans against foreign biological agents.
Abstract translation: 用于在哺乳动物中诱导免疫应答的方法包括以下步骤：将免疫原性肽涂覆到小的致密颗粒上，并将包被的颗粒递送到动物的靶皮肤细胞中。 该方法作为从实验室动物获得大量特异性诊断抗体的策略是有用的，并且作为针对外来生物试剂接种动物或人的方法是有用的。
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公开(公告)号：US6053889A
公开(公告)日：2000-04-25
申请号：US874784
申请日：1997-06-13
Applicant: Richard J. Heinzen , Dennis E. McCabe
Inventor： Richard J. Heinzen , Dennis E. McCabe
CPC classification number: C12M35/00 , A61M5/3015 , A61M5/2053
Abstract: A sample delivery module for use in conjunction with a particle acceleration apparatus includes a fitting for connecting the sample delivery module to the apparatus. The sample delivery module provides a particle acceleration path which includes a portion adapted to receive a sample of particles coated with a biological material, a particle acceleration chamber coaxial with, and in fluid communication, with the cartridge chamber, and a substantially conical exit nozzle coaxial with and in fluid communication with the particle acceleration chamber. In use, a gas stream causes sample particles to be entrained therein and accelerated through the particle acceleration chamber and the exit nozzle toward a target.
Abstract translation: 与颗粒加速装置结合使用的样品输送模块包括用于将样品输送模块连接到装置的配件。 样品递送模块提供粒子加速路径，其包括适于接收涂覆有生物材料的颗粒样品的部分，与筒室同轴并与流体连通的颗粒加速室，以及基本上圆锥形的出口喷嘴同轴 与颗粒加速室流体连通。 在使用中，气流使得样品颗粒被夹带在其中并通过颗粒加速室和出口喷嘴朝向目标加速。
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公开(公告)号：US5865796A
公开(公告)日：1999-02-02
申请号：US767374
申请日：1996-12-16
Applicant: Dennis E. McCabe
Inventor： Dennis E. McCabe
IPC: C12N15/09 , A61K48/00 , A61M5/20 , A61M5/28 , A61M5/30 , A61M5/307 , A61M5/31 , C12M1/00 , C12M3/00 , C12N15/63
CPC classification number: A61M5/3015 , C12M35/00 , A61M2005/005 , A61M5/2053
Abstract: A gas driven apparatus for accelerating particles coated with a genetic material into a target comprises a reservoir for releasably retaining a gas at a sufficiently high pressure to detach the particles from the surface of a sample cartridge and to carry the particles through the apparatus toward the target. When leaving the apparatus, the particles entrained in the gas stream pass through a substantially conical exit nozzle which causes the pattern of distribution of the particles to greatly expand. Methods for using the apparatus and for preparing the sample cartridges are also described.
Abstract translation: 用于将涂覆有遗传物质的颗粒加速到靶中的气体驱动装置包括用于以足够高的压力可释放地保持气体的储存器，以将颗粒从样品盒的表面分离并将颗粒通过装置运送到目标 。 当离开设备时，夹带在气流中的颗粒通过基本上圆锥形的出口喷嘴，其导致颗粒分布的图案大大地膨胀。 还描述了使用该设备和准备样品盒的方法。
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公开(公告)号：US07223739B1
公开(公告)日：2007-05-29
申请号：US09433777
申请日：1999-11-03
Applicant: Joel R. Haynes , Georg Widera , James T. Fuller , Timothy Shipley , Deborah Fuller , Mary Wu
Inventor： Joel R. Haynes , Georg Widera , James T. Fuller , Timothy Shipley , Deborah Fuller , Mary Wu
CPC classification number: A61K33/24 , A61K39/0011 , A61K39/015 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/292 , A61K45/06 , A61K2039/53 , A61K2039/545 , A61K2039/55572 , A61K2039/55577 , A61K2039/57 , C07K14/005 , C12N15/895 , C12N2730/10122 , C12N2740/16122 , C12N2740/16134 , C12N2760/16122 , C12N2760/16134 , Y02A50/412
Abstract: Reagents useful in nucleic acid immunization techniques are described. More particularly, adjuvanted genetic vaccine compositions are described, as are methods of using those compositions for inducing an enhanced immune response against a selected antigen.
Abstract translation: 描述了可用于核酸免疫技术的试剂。 更具体地，描述了佐剂化的遗传疫苗组合物，以及使用这些组合物诱导针对所选抗原的增强的免疫应答的方法。
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