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    METHODS FOR ASSESSING MUCOSAL HEALING IN CROHN'S DISEASE PATIENTS
    2.
    发明申请
    METHODS FOR ASSESSING MUCOSAL HEALING IN CROHN'S DISEASE PATIENTS 有权

    公开(公告)号：US20220082563A1

    公开(公告)日：2022-03-17

    申请号：US17483462

    申请日：2021-09-23

    申请人： Prometheus Laboratories Inc.

    发明人： Anjali JAIN ,  Venkateswarlu KONDRAGUNTA ,  Michael Hale

    IPC分类号： G01N33/564 ,  G01N33/68

    摘要： The present disclosure provides methods for assessing mucosal healing in a patient with Crohn's Disease. The methods include detecting expression levels of analytes in a serum sample from a patient, and applying a mathematical algorithm to the expression levels, thereby producing a Mucosal Healing Index score for the patient. The present disclosure also provides kits that include two or more binding partners, each or which is capable of binding a different analyte measured in the disclosed mucosal healing assessment methods.

    METHODS FOR DIAGNOSING IRRITABLE BOWEL SYNDROME
    3.
    发明申请
    METHODS FOR DIAGNOSING IRRITABLE BOWEL SYNDROME 有权
    用于诊断可刺激性牙刷综合征的方法

    公开(公告)号：US20110159521A1

    公开(公告)日：2011-06-30

    申请号：US12862707

    申请日：2010-08-24

    申请人： Hua Gong ,  Shui Long Wang ,  Sharat Singh

    发明人： Hua Gong ,  Shui Long Wang ,  Sharat Singh

    IPC分类号： G01N33/573 ,  G01N33/53 ,  G01N33/92

    CPC分类号： G01N33/573 ,  G01N33/6893 ,  G01N33/74 ,  G01N2800/065 ,  G01N2800/56 ,  Y10S436/809 ,  Y10T436/147777

    摘要： The invention provides an ELISA assay for the determination of serum mast cell β-tryptase levels using rabbit anti-tryptase as the capture antibody and alkaline phosphatase conjugated G3 as the detecting antibody. Luminescent substrate CPSD was used to enhance the assay sensitivity. Also provided are methods for aiding in the diagnosis of irritable bowel syndrome by detecting the serum level of β-tryptase, histamine and/or prostaglandin E2.

    摘要翻译： 本发明提供了使用兔抗类胰蛋白酶作为捕获抗体和碱性磷酸酶缀合的G3作为检测抗体的ELISA测定法来测定血清肥大细胞和bgr-酪氨酸酶水平。 使用发光底物CPSD增强测定灵敏度。 还提供了通过检测血清中β-谷氨酸酶，组胺和/或前列腺素E2的水平来帮助诊断肠易激综合征的方法。

    Methods of diagnosing inflammatory bowel disease
    5.
    发明授权
    Methods of diagnosing inflammatory bowel disease 有权
    炎症性肠病诊断方法

    公开(公告)号：US07873479B2

    公开(公告)日：2011-01-18

    申请号：US11565544

    申请日：2006-11-30

    申请人： Augusto Lois ,  Bruce Neri

    发明人： Augusto Lois ,  Bruce Neri

    IPC分类号： G06F7/00

    CPC分类号： G01N33/56972 ,  A61K31/00 ,  A61K31/24 ,  A61K31/4985 ,  A61K31/52 ,  A61K31/56 ,  G01N2469/20 ,  G01N2800/065 ,  G01N2800/52 ,  G16H50/70 ,  Y02A90/26

    摘要： The present invention provides methods, systems, and code for accurately classifying whether a sample from an individual is associated with inflammatory bowel disease (IBD) or a clinical subtype thereof. In particular, the present invention is useful for classifying a sample from an individual as an IBD sample using a statistical algorithm and/or empirical data. The present invention is also useful for differentiating between a clinical subtype of IBD such as Crohn's disease (CD) and ulcerative colitis (UC) using a statistical algorithm and/or empirical data. Thus, the present invention provides an accurate diagnostic prediction of IBD or a clinical subtype thereof and prognostic information useful for guiding treatment decisions.

    摘要翻译： 本发明提供了用于准确地分类来自个体的样品是否与炎症性肠病（IBD）或其临床亚型相关联的方法，系统和代码。 特别地，本发明可用于使用统计学算法和/或经验数据将来自个人的样本作为IBD样本进行分类。 本发明还可用于使用统计学算法和/或经验数据来区分诸如克罗恩病（CD）和溃疡性结肠炎（UC）的IBD的临床亚型。 因此，本发明提供IBD或其临床亚型的准确诊断预测和用于指导治疗决定的预后信息。

    METHODS OF DIAGNOSING TISSUE FIBROSIS
    6.
    发明申请
    METHODS OF DIAGNOSING TISSUE FIBROSIS 审中-公开
    诊断组织纤维化的方法

    公开(公告)号：US20100317022A1

    公开(公告)日：2010-12-16

    申请号：US12695126

    申请日：2010-01-27

    申请人： Esther H. Oh ,  Catherine M. Smith

    发明人： Esther H. Oh ,  Catherine M. Smith

    IPC分类号： G01N33/53

    CPC分类号： C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2800/52

    摘要： The present invention provides a method of diagnosing the presence or severity of tissue fibrosis in an individual by detecting α2-macroglobulin (α2-MG) in a sample from the individual; detecting hyaluronic acid (HA) in a sample from the individual; detecting tissue inhibitor of metalloproteinases-1 (TIMP-1) in a sample from the individual; and diagnosing the presence or severity of tissue fibrosis in the individual based on the presence or level of α2-MG, HA and TIMP-1.

    摘要翻译： 本发明提供一种通过检测来自个体的样品中的α2-巨球蛋白（α2-MG）来诊断个体中组织纤维化的存在或严重程度的方法; 检测来自个体的样品中的透明质酸（HA）; 检测来自个体的样品中金属蛋白酶-1（TIMP-1）的组织抑制剂; 并根据α2-MG，HA和TIMP-1的存在或水平诊断个体组织纤维化的存在或严重程度。

    METHODS FOR DIAGNOSING IRRITABLE BOWEL SYNDROME
    7.
    发明申请
    METHODS FOR DIAGNOSING IRRITABLE BOWEL SYNDROME 审中-公开
    用于诊断可刺激性牙刷综合征的方法

    公开(公告)号：US20100094560A1

    公开(公告)日：2010-04-15

    申请号：US12253177

    申请日：2008-10-16

    申请人： AUGUSTO LOIS ,  BRUCE NERI

    发明人： AUGUSTO LOIS ,  BRUCE NERI

    IPC分类号： G06F17/18 ,  C12Q1/37 ,  C12Q1/68 ,  G01N33/53 ,  G06F19/00

    CPC分类号： G01N33/564 ,  G01N33/6893 ,  G01N2800/065 ,  G01N2800/52

    摘要： The present invention provides methods, systems, and code for accurately classifying whether a sample from an individual is associated with irritable bowel syndrome (IBS). In particular, the present invention is useful for classifying a sample from an individual as an IBS sample using a statistical algorithm and/or empirical data. The present invention is also useful for ruling out one or more diseases or disorders that present with IBS-like symptoms and ruling in IBS using a combination of statistical algorithms and/or empirical data. Thus, the present invention provides an accurate diagnostic prediction of IBS and prognostic information useful for guiding treatment decisions.

    摘要翻译： 本发明提供了用于准确分类来自个体的样品是否与肠易激综合征（IBS）相关联的方法，系统和代码。 特别地，本发明可用于使用统计算法和/或经验数据将来自个体的样品作为IBS样品进行分类。 本发明也可用于排除使用统计学算法和/或经验数据的组合在IBS中呈现IBS样症状和统治的一种或多种疾病或障碍。 因此，本发明提供了IBS的准确诊断预测和用于指导治疗决定的预后信息。

    Methods of diagnosing inflammatory bowel disease
    9.
    发明申请
    Methods of diagnosing inflammatory bowel disease 审中-公开
    炎症性肠病诊断方法

    公开(公告)号：US20060154276A1

    公开(公告)日：2006-07-13

    申请号：US11293616

    申请日：2005-12-01

    申请人： Augusto Lois ,  Bruce Neri ,  Esther Oh ,  John Marcelletti ,  Susan Carroll ,  Katie Smith

    发明人： Augusto Lois ,  Bruce Neri ,  Esther Oh ,  John Marcelletti ,  Susan Carroll ,  Katie Smith

    IPC分类号： C12Q1/68 ,  G01N33/569 ,  G01N33/53

    CPC分类号： G01N33/6854 ,  G01N33/6893 ,  G01N2800/065 ,  G01N2800/52

    摘要： The present invention provides methods for diagnosing inflammatory bowel disease (IBD) or for differentiating between Crohn's disease (CD), ulcerative colitis (UC), and indeterminate colitis (IC) in an individual by using a combination of learning statistical classifiers based upon the presence or level of one or more IBD markers in a sample from the individual. The present invention also provides methods for diagnosing the presence or severity of IBD and for stratifying IBD in an individual by determining the level of one or more IBD markers in a sample from the individual and calculating an index value using an algorithm based upon the level of the IBD markers. Methods for monitoring the efficacy of IBD therapy, monitoring the progression or regression of IBD, and optimizing therapy in an individual having IBD are also provided.

    摘要翻译： 本发明提供了通过使用基于存在的学习统计分类器的组合来诊断炎症性肠病（IBD）或用于区分个体中的克罗恩病（CD），溃疡性结肠炎（UC）和不确定性结肠炎（IC） 或来自个体的样品中的一种或多种IBD标记物的水平。 本发明还提供了用于诊断IBD的存在或严重性以及通过确定来自个体的样本中的一种或多种IBD标记的水平来计算个体中IBD的分级的方法，并且使用基于 IBD标记。 还提供了用于监测IBD治疗的功效，监测IBD的进展或消退以及优化IBD个体治疗的方法。

    Methods of diagnosing inflammatory bowel disease
    10.
    发明申请
    Methods of diagnosing inflammatory bowel disease 有权
    炎症性肠病诊断方法

    公开(公告)号：US20060003392A1

    公开(公告)日：2006-01-05

    申请号：US11128011

    申请日：2005-05-11

    申请人： Esther Oh ,  John Marcelletti ,  Susan Carroll ,  Katie Smith

    发明人： Esther Oh ,  John Marcelletti ,  Susan Carroll ,  Katie Smith

    IPC分类号： G01N33/53 ,  G01N33/569

    CPC分类号： G01N33/6893 ,  G01N2800/065 ,  G01N2800/52

    摘要： The present invention provides methods for diagnosing the presence or severity of inflammatory bowel disease (IBD) in an individual and methods for stratifying IBD by determining the level of one or more IBD markers in a sample from the individual and calculating an index value using an algorithm based upon the level of the IBD markers. Methods for monitoring the efficacy of IBD therapy, monitoring the progression or regression of IBD, and optimizing therapy in an individual having IBD are also provided.

    摘要翻译： 本发明提供用于诊断个体中炎症性肠病（IBD）的存在或严重性的方法以及通过确定来自个体的样品中的一种或多种IBD标记物的水平来分级IBD的方法，并使用算法计算指数值 基于IBD标记的水平。 还提供了用于监测IBD治疗的功效，监测IBD的进展或消退以及优化IBD个体治疗的方法。