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公开(公告)号：US20210355451A1
公开(公告)日：2021-11-18
申请号：US17319760
申请日：2021-05-13
Applicant: Stratatech Corporation
Inventor： B. Lynn Allen-Hoffmann , Allen R. Comer , Kenneth R. Gratz , Barry M. Steiglitz
Abstract: The present disclosure is directed to viable bioengineered skin constructs.
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公开(公告)号：US09526811B2
公开(公告)日：2016-12-27
申请号：US14669095
申请日：2015-03-26
Applicant: STRATATECH CORPORATION
Inventor： Allen R. Comer , B. Lynn Allen-Hoffmann , Barry Steiglitz
CPC classification number: A61L27/3691 , A61F2/105 , A61L27/3813 , A61L27/54 , A61L27/60 , A61L2430/40
Abstract: The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for producing, transporting, storing and using skin equivalents produced by organotypic culture at reduced temperatures, preferably from 2-8 degrees Celsius to ambient temperature. The methods include sterile packaging of the grafts so that the sterility and integrity of the package is maintained until the time of use for grafting purposes.
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公开(公告)号：US20100119495A1
公开(公告)日：2010-05-13
申请号：US12690160
申请日：2010-01-20
Applicant: John M. Centanni , Lynn Allen-Hoffmann
Inventor： John M. Centanni , Lynn Allen-Hoffmann
CPC classification number: A61L27/60 , A61K35/12 , A61K35/36 , A61K38/1709 , A61K38/1825 , A61K2035/122 , A61L27/227 , A61L27/3813 , A61L27/3895 , A61L27/54 , A61L2300/252 , A61L2300/404 , C07H21/04 , C07K14/50 , C12N5/0629 , C12N5/0698 , C12N15/63 , C12N15/79 , C12N2501/117 , C12N2501/998 , C12N2502/094 , C12N2502/1323 , C12N2510/00
Abstract: The present invention relates generally to compositions for wound closure. More specifically, the present invention provides human skin equivalents engineered to express exogenous polypeptides (e.g., antimicrobial polypeptides and keratinocyte growth factor 2) and compositions and methods for making human skin equivalents engineered to express exogenous polypeptides. In addition, the present invention provides methods for treatment of wounds with human skin equivalents engineered to express exogenous polypeptides.
Abstract translation: 本发明一般涉及用于伤口闭合的组合物。 更具体地，本发明提供了用于表达外源多肽（例如抗微生物多肽和角质形成细胞生长因子2）的人皮肤当量以及用于制造人皮肤等同物的工程化以表达外源多肽的组合物和方法。 此外，本发明提供了用于表达外源多肽的用于治疗具有人皮肤当量的伤口的伤口的方法。
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公开(公告)号：US20060141627A1
公开(公告)日：2006-06-29
申请号：US11282283
申请日：2005-11-18
Applicant: Allen Comer
Inventor： Allen Comer
IPC: C12N15/74
CPC classification number: C12N15/85 , C12N15/90 , C12N2800/106 , C12N2800/30 , C12N2830/008 , C12N2830/40
Abstract: The present invention relates to expression vectors capable of promoting transgene expression. The expression vectors include site specific recombination elements, insulator elements, and recombinase elements. In particular, the present invention provides methods for obtaining specific and stable integration of nucleic acids into eukaryotic cells through site specific recombination.
Abstract translation: 本发明涉及能促进转基因表达的表达载体。 表达载体包括位点特异性重组元件，绝缘体元件和重组酶元件。 特别地，本发明提供了通过位点特异性重组获得核酸进入真核细胞的特异性和稳定整合的方法。
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公开(公告)号：US11911444B2
公开(公告)日：2024-02-27
申请号：US16150048
申请日：2018-10-02
Applicant: Stratatech Corporation
Inventor： Allen R. Comer , B. Lynn Allen-Hoffmann
CPC classification number: A61K38/208 , C07K14/5434 , C12N5/0629 , A61K35/12 , A61K48/00 , C12N2501/23 , C12N2510/00
Abstract: The present invention relates generally to compositions for treating patients that have skin cancer or have recently had skin cancers removed. More specifically, the present invention provides human skin substitutes engineered to express exogenous IL-12 and compositions and methods for making human skin substitutes engineered to express exogenous IL-12. In addition, the present invention provides methods for treatment of sites on a patient where skin cancers have been removed with human skin substitutes engineered to express exogenous IL-12.
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Patent Agency Ranking
公开(公告)号：US20220347353A1
公开(公告)日：2022-11-03
申请号：US17763552
申请日：2020-09-28
Applicant: Stratatech Corporation
Inventor： Janice Smiell , Allen Comer , Mary Lokuta , B. Lynn Allen-Hoffmann
Abstract: The present disclosure provides methods for treating acute wounds and improving outcomes by applying to an acute wound a skin substitute that is an organotypic human skin equivalent comprising NIKS cells. In certain embodiments, the closed wound has improved vascularity, improved pigmentation, decreased thickness, decreased pain, increased pliability, increased surface area, decreased stiffness, decreased itching, improved color, or any combination thereof, as assessed by an observer or by the subject, as compared to an autograft or another skin substitute.
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公开(公告)号：US20220287298A1
公开(公告)日：2022-09-15
申请号：US17827270
申请日：2022-05-27
Applicant: Stratatech Corporation
Inventor： Justin Koepsel , Kenneth Gratz
Abstract: The present disclosure relates generally to tissue container systems and kits that find use in the transport of tissues and methods of using the tissue container systems. In particular, systems and kits that support the transport, thawing and use of cryopreserved human skin equivalents, and methods of their use by a health care provider are provided.
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公开(公告)号：US10918768B2
公开(公告)日：2021-02-16
申请号：US16036619
申请日：2018-07-16
Applicant: Stratatech Corporation
Inventor： John M. Centanni , B. Lynn Allen-Hoffman
IPC: C12N15/63 , C12N15/79 , A61K48/00 , C07H21/04 , A61L27/60 , A61K38/18 , A61L27/38 , C07K14/50 , C12N5/071 , A61K35/36 , A61K38/17 , A61L27/22 , A61L27/54 , A61K35/12
Abstract: The present invention relates generally to compositions for wound closure. More specifically, the present invention provides human skin equivalents engineered to express exogenous polypeptides (e.g., antimicrobial polypeptides and keratinocyte growth factor 2) and compositions and methods for making human skin equivalents engineered to express exogenous polypeptides. In addition, the present invention provides methods for treatment of wounds with human skin equivalents engineered to express exogenous polypeptides.
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公开(公告)号：US10091983B2
公开(公告)日：2018-10-09
申请号：US14208439
申请日：2014-03-13
Applicant: STRATATECH CORPORATION
Inventor： B. Lynn Allen-Hoffmann , John C. Pirnstill , Kenneth R. Gratz , Allen R. Comer
IPC: A01N1/02
Abstract: The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for cryopreserving viable skin substitutes.
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公开(公告)号：US09216202B2
公开(公告)日：2015-12-22
申请号：US11297916
申请日：2005-12-09
Applicant: John M. Centanni , Lynn Allen-Hoffmann
Inventor： John M. Centanni , Lynn Allen-Hoffmann
IPC: C12N5/00 , A61K35/36 , A61K38/18 , A61L27/38 , A61L27/60 , C07K14/50 , C12N5/071 , A61K38/17 , A61K35/12
CPC classification number: A61L27/60 , A61K35/12 , A61K35/36 , A61K38/1709 , A61K38/1825 , A61K2035/122 , A61L27/227 , A61L27/3813 , A61L27/3895 , A61L27/54 , A61L2300/252 , A61L2300/404 , C07H21/04 , C07K14/50 , C12N5/0629 , C12N5/0698 , C12N15/63 , C12N15/79 , C12N2501/117 , C12N2501/998 , C12N2502/094 , C12N2502/1323 , C12N2510/00
Abstract: The present invention relates generally to compositions for wound closure. More specifically, the present invention provides human skin equivalents engineered to express exogenous polypeptides (e.g., antimicrobial polypeptides and keratinocyte growth factor 2) and compositions and methods for making human skin equivalents engineered to express exogenous polypeptides. In addition, the present invention provides methods for treatment of wounds with human skin equivalents engineered to express exogenous polypeptides.
Abstract translation: 本发明一般涉及用于伤口闭合的组合物。 更具体地，本发明提供了用于表达外源多肽（例如抗微生物多肽和角质形成细胞生长因子2）的人皮肤当量以及用于制造人皮肤等同物的工程化以表达外源多肽的组合物和方法。 此外，本发明提供了用于表达外源多肽的用于治疗具有人皮肤当量的伤口的伤口的方法。
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