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    Arenavirus growth inhibitor comprising polycyclic carbamoyl pyridone derivative
    1.
    发明授权
    Arenavirus growth inhibitor comprising polycyclic carbamoyl pyridone derivative 有权

    公开(公告)号：US12098151B2

    公开(公告)日：2024-09-24

    申请号：US17957103

    申请日：2022-09-30

    申请人： NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY ,  Shionogi & Co., Ltd.

    发明人： Akihiro Ishii ,  Akihiko Sato ,  Makoto Kawai ,  Yoshiyuki Taoda

    IPC分类号： C07D471/04 ,  A61K31/53 ,  A61P31/14 ,  C07D471/14 ,  C07D498/14

    CPC分类号： C07D471/04 ,  A61P31/14 ,  C07D471/14 ,  C07D498/14

    摘要： The present invention provides a compound having antiviral activity, especially having arenavirus proliferation inhibitory activity, and/or a medicament comprising the compound. More preferably, the present invention provides a compound having proliferation inhibitory activity on the Old World arenaviruses such as Luna virus, Lassa virus, and lymphocytic choriomeningitis virus and/or the New World arenaviruses such as Junin virus, and/or a medicament comprising the compound.
    An arenavirus proliferation inhibitor comprising a compound represented by Formula (I) or a prodrug thereof or a pharmaceutically acceptable salt thereof:




    (wherein R1 is carboxy, or the like: A3 is CR2 or N; R2 is a hydrogen atom, halogen, hydroxy, or the like; R3 is a hydrogen atom, hydroxy, carboxy, cyano, formyl, alkyl optionally substituted with Substituent group F, or the like; either A1 or A2 is CR5R6, and the other is NR7, or A1 is CR8R9, and A2 is CR10OR11; and R5, R6, R7, R8, R9, R10, and R11 are each independently a hydrogen atom, carboxy, cyano, alkyl optionally substituted with Substituent group F, or the like).

    PHARMACEUTICAL COMPOSITION FOR TREATING FATTY LIVER DISEASE
    8.
    发明公开
    PHARMACEUTICAL COMPOSITION FOR TREATING FATTY LIVER DISEASE 审中-公开

    公开(公告)号：US20230210822A1

    公开(公告)日：2023-07-06

    申请号：US17926273

    申请日：2021-05-20

    申请人： Shionogi & Co., Ltd.

    发明人： Hideo YUKIOKA ,  Atsuyuki SHIMAZAKI ,  Tadateru HAMADA ,  Naoki OHYABU

    IPC分类号： A61K31/4184 ,  A61P1/16

    CPC分类号： A61K31/4184 ,  A61P1/16

    摘要： Provided is a pharmaceutical composition for treating and/or preventing fatty liver disease, particularly nonalcoholic fatty liver disease, the pharmaceutical composition having an excellent ACC2-selective inhibitory action and having no side effects such as an increase in plasma triglyceride or a decrease in platelet concentration.
    A pharmaceutical composition for treating and/or preventing fatty liver disease, the pharmaceutical composition comprising a compound represented by Formula (I):






    wherein
    R1 is haloalkyl or non-aromatic carbocyclyl,
    R2 is a hydrogen atom or halogen,
    R3 is halogen,
    ring A is a group represented by the formula:










    -L1- is —O—(CH2)—, —(CH2)2—, or the like,
    R4 is alkyl or haloalkyl, and
    R5 is alkylcarbonyl or carbamoyl,


    or a pharmaceutically acceptable salt thereof.