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公开(公告)号:US20190105342A1
公开(公告)日:2019-04-11
申请号:US15760861
申请日:2016-09-16
申请人: TOHOKU UNIVERSITY
发明人: Tetsuya YAMADA , Hideki KATAGIRI , Sohei TSUKITA
IPC分类号: A61K31/7105 , A61P3/10 , A61K31/711 , G01N33/15 , A61K48/00
摘要: The present invention is directed to provide nucleic acid molecules that promote proliferation of pancreatic islet β-cells. A proliferation promoting agent for promoting proliferation of pancreatic islet β-cells according to the present invention contains at least one of a nucleic acid molecule having SEQ ID NO: 1 or a nucleic acid molecule having SEQ ID NO: 2: (SEQ ID NO: 1) UAAAGUGCUGACAGUGCAGAU (SEQ ID NO: 2) AGCUACAUCUGGCUACUGGGUCUC.
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公开(公告)号:US20230139960A1
公开(公告)日:2023-05-04
申请号:US17907635
申请日:2021-03-05
申请人: TOHOKU UNIVERSITY
发明人: Nobuhiro MARUOKA , Toshimitsu Ono , Satoshi Endo , Tadanobu AIZAWA , Kaoru KONNO
IPC分类号: F28D19/04
摘要: A rotary heat exchanger includes: a tubular-shaped heat transfer tubular body (3) which is rotatable with a central axis (C) as a rotation center, which allows a first medium (11) to flow therein, and outside of which a second medium (12) having a temperature different from a temperature of the first medium (11) flows; a central member (2) which is provided on an inner side of the heat transfer tubular body (3) in a radial direction and which is fixed coaxially with the heat transfer tubular body (3); and an outer sliding contact member (6) which is in sliding contact with an outer circumferential surface of the heat transfer tubular body (3), and the heat transfer tubular body (3) is rotatably supported with respect to the central member (2) via bearings (17, 18) disposed at two end portions of the central member (2) in an axial direction.
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公开(公告)号:US20230134976A1
公开(公告)日:2023-05-04
申请号:US17917934
申请日:2020-11-06
发明人: Koji Kobayashi , Koichi ITO , Takafumi AOKI
摘要: The present invention provides an image processing method capable of intuitively recognizing the three-dimensional shape of an organ by limiting the inspection range to the vicinity of the diagnostic target organ in image diagnosis. Given binary three-dimensional data representing an object in three-dimensional space, the image processing method partitions the object into individual segments with boundaries on narrow parts of the object's shape. A series of organs with no numerical differences in the boundaries on the image data can be segmented into individual organs at geometrically constricted locations because the connected organs can be identified by their shape. As a result, it is possible to examine a limited area specific to the target organ during image diagnosis, and to perform the examination while viewing the intuitive 3D shape of the organ during image interpretation.
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公开(公告)号:USRE49518E1
公开(公告)日:2023-05-02
申请号:US17327001
申请日:2021-05-21
发明人: Yasuteru Urano , Yuri Nagayo , Mako Kamiya , Toru Nakazawa
IPC分类号: C07D493/10 , A61K49/00 , C12Q1/37 , G01N21/78 , G01N33/58
摘要: [Problem] To provide a fluorescent probe that detects calpain activity in cells at high sensitivity.
[Solution] A compound represented by the following general formula (I) or a salt thereof.-
公开(公告)号:US20230101477A1
公开(公告)日:2023-03-30
申请号:US18076657
申请日:2022-12-07
摘要: Provided is a stripping method capable of stripping a resist while suppressing the time and cost of processing required for stripping, while giving sufficient consideration to the load on the environment. The resist stripping method is a method for stripping a resist film-formed on a substrate, including: a pretreatment step of exposing the resist to a heated steam in a predetermined temperature range for a predetermined time; and a stripping step of stripping the resist exposed to the heated steam in the pretreatment step by using a resist stripping liquid, wherein the predetermined temperature range and the predetermined time are set according to the resist.
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公开(公告)号:US11610615B2
公开(公告)日:2023-03-21
申请号:US17274099
申请日:2018-09-07
申请人: TOHOKU UNIVERSITY
发明人: Takahiro Hanyu , Daisuke Suzuki , Tetsuo Endoh
IPC分类号: G11C11/16
摘要: A lookup table circuit constituting a programmable logic device includes: a memory cell array including a plurality of memory cells, each having a resistive memory element; a selection circuit connected to the memory cell array and configured to output, to the memory cell array, a single cell-select signal or two or more cell-select signals for selecting a single memory cell or two or more memory cells among the plurality of memory cells, based on input of a plurality of logic signals; and a read circuit connected to the memory cell array and configured to read data from the single memory cell or the two or more memory cells selected by the single cell-select signal or the two or more cell-select signals, among the plurality of memory cells. The selection circuit is separated from a path along which the read circuit is configured to read data from the memory cell array.
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公开(公告)号:US11610614B2
公开(公告)日:2023-03-21
申请号:US17047316
申请日:2019-04-11
申请人: TOHOKU UNIVERSITY
发明人: Yoshiaki Saito , Shoji Ikeda , Hideo Sato , Tetsuo Endoh
IPC分类号: G11C11/16 , G11C11/15 , G11C11/18 , H01L43/04 , H01L43/08 , H01L43/10 , H01L27/22 , H01F10/32
摘要: Provided are a magnetoresistive element, a magnetic memory device, and a writing and reading method for a magnetic memory device, in which an aspect ratio of a junction portion can be decreased. A magnetoresistive element 1 of the invention, includes: a heavy metal layer 2 that is an epitaxial layer; and a junction portion 3 including a recording layer 31 that is provided on the heavy metal layer 2 and includes a ferromagnetic layer of an epitaxial layer magnetized in an in-plane direction, which is an epitaxial layer, a barrier layer 32 that is provided on the recording layer 31 and includes an insulating body, and a reference layer 33 that is provided on the barrier layer 32 and has magnetization fixed in the in-plane direction, in which the recording layer 31 is subjected to magnetization reversal by applying a write current to the heavy metal layer 2.
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8.
公开(公告)号:US11602327B2
公开(公告)日:2023-03-14
申请号:US16326294
申请日:2017-08-28
申请人: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , CENTRE LEON BERARD , UNIVERSITE CLAUDE BERNARD LYON 1 , TOHOKU UNIVERSITY
摘要: Method and system for localizing a region of interest in a medium in which cavitation occurs. Method for localizing a region of interest (R) in a medium (M) in which cavitation occurs, the method comprising the steps consisting in: producing cavitation in the region of interest (R), the cavitation generating an acoustic signal, at each of at least three separate positions, detecting a cavitation signal representative of the acoustic signal of the cavitation, for at least two pairs of cavitation signals, determining a delay between the cavitation signals of each pair of cavitation signals, calculating a localization of the region of interest (R) based on the delays and the positions.
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公开(公告)号:US20230070463A1
公开(公告)日:2023-03-09
申请号:US17797241
申请日:2021-02-03
摘要: The present invention provides a novel angiogenesis device. The angiogenesis device comprises an angiogenic component and a polymer, and is used to induce angiogenesis at a site for implantation of a cell- or tissue-containing device. The polymer may comprise, for example, at least one or more polyvinyl alcohol resins (A) selected from a modified polyvinyl alcohol resin having an active carbonyl group (A1), a polyvinyl alcohol resin having a triad syndiotacticity of 32 to 40% (A2), and a polyvinyl alcohol resin having a degree of saponification of 97 mol % or more (A3).
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10.
公开(公告)号:US20230051810A1
公开(公告)日:2023-02-16
申请号:US17962061
申请日:2022-10-07
IPC分类号: H01L23/00 , H01L23/10 , H01L23/20 , H01L21/50 , C23C14/35 , C23C14/58 , C23C14/08 , C23C14/10 , C23C14/16
摘要: Substrates that are bonding targets are bonded in ambient atmosphere via bonding films, including oxides, formed on bonding faces of the substrates. The bonding films, which are metal or semiconductor thin films formed by vacuum film deposition and at least the surfaces of which are oxidized, are formed into the respective smooth faces of two substrates having the smooth faces that serve as the bonding faces. The bonding films are exposed to a space that contains moisture, and the two substrates are overlapped in the ambient atmosphere such that the surfaces of the bonding films are made to be hydrophilic and the surfaces of the bonding films contact one another. Through this, a chemical bond is generated at the bonded interface, and thereby the two substrates are bonded together in the ambient atmosphere. The bonding strength γ can be improved by heating the bonded substrates at a temperature.
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