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    Apoptotic entities for use in treatment of neurodegenerative and other neurological disorders
    3.
    发明申请
    Apoptotic entities for use in treatment of neurodegenerative and other neurological disorders 审中-公开
    用于治疗神经变性和其他神经障碍的凋亡实体

    公开(公告)号：US20070087010A1

    公开(公告)日：2007-04-19

    申请号：US11583986

    申请日：2006-10-17

    申请人： Anthony Bolton ,  Arkady Mandel ,  Daniel Sauder

    发明人： Anthony Bolton ,  Arkady Mandel ,  Daniel Sauder

    IPC分类号： A61K39/00 ,  C12N5/08

    CPC分类号： A61K35/17

    摘要： Treatment and/or prophylaxis, in mammalian patients, of neurodegenerative and other neurological medical disorders is effected by administering to the patient effective amounts of apoptotic bodies and/or apoptotic cells, preferably those derived from the patient's own white blood cells, e.g. by extracorporeal treatment of the patient's blood cells to induce apoptosis and administration of the apoptotic bodies and/or cells so formed to the patient.

    摘要翻译： 通过向患者施用有效量的凋亡小体和/或凋亡细胞，优选来源于患者自己的白细胞的那些细胞，例如，在哺乳动物患者中治疗和/或预防神经退行性疾病和其它神经病学疾病。 通过体外治疗患者的血液细胞以诱导凋亡和向患者形成的凋亡小体和/或细胞的施用。

    Method for treating mammals with modified mammalian blood
    4.
    发明申请
    Method for treating mammals with modified mammalian blood 失效
    用修饰的哺乳动物血液处理哺乳动物的方法

    公开(公告)号：US20050238623A1

    公开(公告)日：2005-10-27

    申请号：US11150084

    申请日：2005-06-10

    申请人： Anthony Bolton

    发明人： Anthony Bolton

    IPC分类号： A61K35/14 ,  A61K41/00 ,  A61M1/36 ,  A61P9/10 ,  A61P19/02 ,  A61P41/00 ,  A61K45/00 ,  A61N1/30

    CPC分类号： A61M1/3681 ,  A61K35/14 ,  A61K41/0014 ,  A61M1/3683 ,  A61M1/3687 ,  A61M1/369 ,  A61M2205/053

    摘要： An improved method for treating or preventing a pathological condition in a mammalian subject in which modified mammalian blood is administered to the subject. The method comprises administering to the subject from two to four aliquots of modified mammalian blood, with the administration of any pair of consecutive treatments either being on consecutive days or being separated by a rest period of 1 to 21 days. The treatment is useful for treating or preventing a wide range of pathological conditions in which modified mammalian blood is effective, including preconditioning a mammalian subject to better withstand the adverse effects of ischemic stress, atherosclerosis and rheumatoid arthritis.

    摘要翻译： 一种用于治疗或预防哺乳动物受试者的病理状况的改进方法，其中向受试者施用修饰的哺乳动物血液。 该方法包括向受试者施用二至四等份的修饰的哺乳动物血液，施用任何一对连续的处理或连续数天或分开1至21天的休息期。 该治疗可用于治疗或预防修饰的哺乳动物血液有效的广泛病理状况，包括预处理哺乳动物受试者以更好地抵御缺血性应激，动脉粥样硬化和类风湿性关节炎的不良作用。

    Apoptosis-mimicking synthetic entities and use thereof in medical treatment
    5.
    发明申请
    Apoptosis-mimicking synthetic entities and use thereof in medical treatment 审中-公开
    细胞凋亡模拟合成实体及其在医疗中的应用

    公开(公告)号：US20050123598A1

    公开(公告)日：2005-06-09

    申请号：US11039469

    申请日：2005-01-19

    申请人： Anthony Bolton ,  Arkayd Mandel

    发明人： Anthony Bolton ,  Arkayd Mandel

    IPC分类号： A61K9/127 ,  A61K9/16 ,  A61K47/48 ,  A61K31/74

    CPC分类号： A61K31/685 ,  A61K9/0019 ,  A61K9/127 ,  A61K9/141 ,  A61K9/1676 ,  A61K47/61 ,  Y10S514/885

    摘要： Synthetic and semisynthetic bodies having a three-dimensional structure, sized and shaped to resemble apoptotic cells and apoptotic bodies, and having phosphatidyl serine (PS) molecules on the surface thereof, are administered to a patient, to alleviate a variety of disorders such as T-cell mediated disorders (autoimmune conditions). The bodies are believed to trigger an apoptosis-like mechanism in the patient.

    摘要翻译： 向患者施用具有尺寸和形状以类似凋亡细胞和凋亡小体以及在其表面上具有磷脂酰丝氨酸（PS））分子的具有三维结构的合成和半合成体，以减轻多种病症，例如T 细胞介导的疾病（自身免疫病症）。 这些尸体被认为会引发患者的细胞凋亡样机制。

    Treatment of stress and preconditioning against stress
    6.
    发明授权
    Treatment of stress and preconditioning against stress 失效
    治疗压力和预处理压力

    公开(公告)号：US6136308A

    公开(公告)日：2000-10-24

    申请号：US151653

    申请日：1998-09-11

    申请人： Johanne Tremblay ,  Pavel Hamet

    发明人： Johanne Tremblay ,  Pavel Hamet

    IPC分类号： A61K41/00 ,  C12N5/06

    CPC分类号： A61K41/0004

    摘要： Symptoms of stress such as elevated blood pressure in mammals are treated, and mammalian bodies are preconditioned to manifest reduced adverse reactions to subsequently encountered stresses, by injecting into the mammalian patient a small quantity of the patient's own blood which has been previously extracted and subjected extracorporeally to at least one stressor, such as ultraviolet radiation, an oxidative environment, ozone-oxygen and mild heating, especially infra-red radiation causing mild heating. Particularly beneficial combinations of stressors are simultaneous applications of UV radiation and an ozone-oxygen gas mixture bubbled through the blood sample to provide the oxidative environment, or simultaneous application of UV radiation, ozone-oxygen gas mixtures and mild heating. One specific use of the invention is in preconditioning against ischemic-reperfusion injury, e.g. prior to surgery.

    摘要翻译： 治疗哺乳动物压力升高的症状，哺乳动物身体预处理，以便对随后遇到的压力表现出减少的不良反应，通过向哺乳动物患者注入少量患者自己的血液，这些血液先前已被提取并经受体外 至少一种应激源，例如紫外线辐射，氧化环境，臭氧 - 氧气和温和加热，特别是导致温和加热的红外辐射。 压力源的特别有益的组合是同时应用UV辐射和鼓泡通过血液样品的臭氧 - 氧气混合物以提供氧化环境，或同时施加UV辐射，臭氧 - 氧气混合物和温和加热。 本发明的一个具体用途是预防局部缺血再灌注损伤，例如， 手术前。