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    Avian cell lines useful for the production of substances of interest
    4.
    发明申请
    Avian cell lines useful for the production of substances of interest 审中-公开
    用于生产感兴趣物质的禽类细胞系

    公开(公告)号：US20040058441A1

    公开(公告)日：2004-03-25

    申请号：US10625847

    申请日：2003-07-24

    申请人： VIVALIS

    发明人： Bertrand Pain ,  Fabienne Guehenneux

    IPC分类号： C12N005/06

    CPC分类号： C12N5/0606 ,  C12N2500/90 ,  C12N2500/92 ,  C12N2500/95 ,  C12N2510/02

    摘要： The present invention relates to a method for producing avian cell lines, comprising gradual or complete withdrawal of growth factors, serum and/or feeder layer so that the established lines are adherent or nonadherent cells capable of proliferating indefinitely in a basic culture medium. The invention also relates to the cells derived from such lines which are particularly useful for the production of substances of interest.

    摘要翻译： 本发明涉及一种生产禽类细胞系的方法，包括逐渐或完全撤出生长因子，血清和/或饲养层，使得建立的系是能够在碱性培养基中无限增殖的粘附或非粘附细胞。 本发明还涉及特别可用于生产感兴趣物质的来自这些品系的细胞。

    METHODS FOR PRODUCING NONADHERENT AVIAN CELL LINES
    6.
    发明申请
    METHODS FOR PRODUCING NONADHERENT AVIAN CELL LINES 审中-公开
    生产非空气细胞细胞系的方法

    公开(公告)号：US20110294209A1

    公开(公告)日：2011-12-01

    申请号：US13206056

    申请日：2011-08-09

    申请人： Bertrand Pain ,  Fabienne Guehenneux

    发明人： Bertrand Pain ,  Fabienne Guehenneux

    IPC分类号： C12N5/0735

    CPC分类号： C12N5/0606 ,  C12N2500/90 ,  C12N2500/92 ,  C12N2500/95 ,  C12N2510/02

    摘要： The present invention relates to a method for producing avian cell lines, comprising gradual or complete withdrawal of growth factors, serum and/or feeder layer so that the established lines are adherent or nonadherent cells capable of proliferating indefinitely in a basic culture medium. The invention also relates to the cells derived from such lines which are particularly useful for the production of substances of interest.

    摘要翻译： 本发明涉及一种生产禽类细胞系的方法，包括逐渐或完全撤出生长因子，血清和/或饲养层，使得建立的系是能够在碱性培养基中无限增殖的粘附或非粘附细胞。 本发明还涉及特别可用于生产感兴趣物质的来自这些品系的细胞。

    RECOMBINANT PROTEIN PRODUCTION IN AVIAN EBx® CELLS
    7.
    发明申请
    RECOMBINANT PROTEIN PRODUCTION IN AVIAN EBx® CELLS 审中-公开
    AVIANEBx®细胞中重组蛋白的生产

    公开(公告)号：US20100226912A1

    公开(公告)日：2010-09-09

    申请号：US12601178

    申请日：2008-05-21

    申请人： Majid Mehtali

    发明人： Majid Mehtali

    IPC分类号： A61K39/395 ,  C12N5/10 ,  C12P21/00 ,  C07K16/00 ,  A61P37/04

    CPC分类号： C07K16/00 ,  C07K2317/23 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/732

    摘要： The invention generally relates to the field of recombinant protein production. More particularly, the invention relates to the use of avian embryonic derived stem cell lines, named EBx®, for the production of proteins and more specifically glycoproteins such as antibodies. The invention is useful for the production of monoclonal IgG1 antibody subtype having high cell-mediated cytotoxic activity. The invention relates to the use of such antibodies as a drug to treat cancers and inflammatory diseases.

    摘要翻译： 本发明一般涉及重组蛋白质生产领域。 更具体地，本发明涉及用于生产蛋白质，更具体地说是糖蛋白如抗体的禽胚胎来源的干细胞系（命名为EBx）的用途。 本发明可用于生产具有高细胞介导的细胞毒活性的单克隆IgG1抗体亚型。 本发明涉及这样的抗体作为药物治疗癌症和炎性疾病的用途。

    IN VITRO METHOD TO DETERMINE WHETHER A DRUG CANDIDATE ACTIVE AGAINST A TARGET PROTEIN IS ACTIVE AGAINST A VARIANT OF SAID PROTEIN
    8.
    发明申请
    IN VITRO METHOD TO DETERMINE WHETHER A DRUG CANDIDATE ACTIVE AGAINST A TARGET PROTEIN IS ACTIVE AGAINST A VARIANT OF SAID PROTEIN 审中-公开
    用于确定与目标蛋白有关的药物候选药物的体外方法是否对一种不同的蛋白质有效

    公开(公告)号：US20110251085A1

    公开(公告)日：2011-10-13

    申请号：US12922409

    申请日：2009-03-16

    申请人： Mehdi Lahmar ,  Isabelle Valarche ,  Majid Mehtali

    发明人： Mehdi Lahmar ,  Isabelle Valarche ,  Majid Mehtali

    IPC分类号： C40B30/04

    CPC分类号： G01N33/5008 ,  G01N33/5767 ,  G01N33/6845 ,  G01N2333/16 ,  G01N2333/70567

    摘要： The present invention relates to the field of virology. More precisely, the invention provides a method of determining the ability of a test compound to modulate the biological activity of a variant of a target protein, wherein said test compound is previously known to modulate the biological activity of said protein. This invention is useful to determine whether a drug candidate, such as anti-viral compounds (eg. against hepatitis C virus: NS5B, NS3), active against a target protein is active against a variant of said protein (eg. polymorphisms, genotypes or mutants).

    摘要翻译： 本发明涉及病毒学领域。 更准确地说，本发明提供了测定化合物调节靶蛋白变体的生物学活性的能力的方法，其中所述测试化合物以前已知可以调节所述蛋白质的生物活性。 本发明可用于确定针对靶蛋白的抗病毒化合物（例如针对丙型肝炎病毒：NS5B，NS3）的药物候选物是否对所述蛋白质的变体（例如多态性，基因型或 突变体）。

    AVIAN CELL LINES USEFUL FOR THE PRODUCTION OF SUBSTANCES OF INTEREST
    9.
    发明申请
    AVIAN CELL LINES USEFUL FOR THE PRODUCTION OF SUBSTANCES OF INTEREST 有权
    用于生产物质的AVIAN细胞系

    公开(公告)号：US20100221825A1

    公开(公告)日：2010-09-02

    申请号：US12717096

    申请日：2010-03-03

    申请人： Bertrand PAIN ,  Fabienne Guehenneux

    发明人： Bertrand PAIN ,  Fabienne Guehenneux

    IPC分类号： C12N5/071

    CPC分类号： C12N5/0606 ,  C12N2500/90 ,  C12N2500/92 ,  C12N2500/95 ,  C12N2510/02

    摘要： The present invention relates to a method for producing avian cell lines, comprising gradual or complete withdrawal of growth factors, serum and/or feeder layer so that the established lines are adherent or nonadherent cells capable of proliferating indefinitely in a basic culture medium. The invention also relates to the cells derived from such lines which are particularly useful for the production of substances of interest.

    摘要翻译： 本发明涉及一种生产禽类细胞系的方法，包括逐渐或完全撤出生长因子，血清和/或饲养层，使得建立的系是能够在碱性培养基中无限增殖的粘附或非粘附细胞。 本发明还涉及特别可用于生产感兴趣物质的来自这些品系的细胞。

    AVIAN CELL LINES USEFUL FOR THE PRODUCTION OF SUBSTRATES OF INTEREST
    10.
    发明申请
    AVIAN CELL LINES USEFUL FOR THE PRODUCTION OF SUBSTRATES OF INTEREST 审中-公开
    用于生产基板的AVIAN细胞线

    公开(公告)号：US20090239297A1

    公开(公告)日：2009-09-24

    申请号：US12350781

    申请日：2009-01-08

    申请人： Bertrand PAIN ,  Fabienne Guehenneux

    发明人： Bertrand PAIN ,  Fabienne Guehenneux

    IPC分类号： C12N5/02 ,  C12N5/06

    CPC分类号： C12N5/0606 ,  C12N2500/90 ,  C12N2500/92 ,  C12N2500/95 ,  C12N2510/02

    摘要： The present invention relates to a method for producing avian cell lines, comprising gradual or complete withdrawal of growth factors, serum and/or feeder layer so that the established lines are adherent or nonadherent cells capable of proliferating indefinitely in a basic culture medium. The invention also relates to the cells derived from such lines which are particularly useful for the production of substances of interest.

    摘要翻译： 本发明涉及一种生产禽类细胞系的方法，包括逐渐或完全撤出生长因子，血清和/或饲养层，使得建立的系是能够在碱性培养基中无限增殖的粘附或非粘附细胞。 本发明还涉及特别可用于生产感兴趣物质的来自这些品系的细胞。