公开(公告)号：US20140234919A1

公开(公告)日：2014-08-21

申请号：US14130986

申请日：2012-07-06

申请人： Xiaochen Yu ,  Jijiao Zeng ,  Yubin Zheng ,  Mahesh Bule ,  Shulin Chen

发明人： Xiaochen Yu ,  Jijiao Zeng ,  Yubin Zheng ,  Mahesh Bule ,  Shulin Chen

IPC分类号： C12P7/64

CPC分类号： C12P7/6409 ,  C12P7/6463 ,  C12P2203/00 ,  Y02E50/343

摘要： Methods and systems for producing lipids which may be used as biofuel are provided. Sugars produced by pretreatment of lignocellulosic biomass are utilized by heterotrophic oleaginous fungi or yeast to increase their biomass and to produce lipids without prior detoxification of the pretreated biomass. After the fungi/yeast are cultured with the sugars, solid residues from the pretreated biomass are combined with the fungi/yeast under conditions which allow simultaneous 1) enzymatic degradation of cellulose and/or hemicellulose to produce sugars and 2) fermentation of the sugars for further increases in biomass and lipid production.

摘要翻译： 提供了可用作生物燃料的生产脂质的方法和系统。 由异养油性真菌或酵母通过预处理木质纤维素生物质产生的糖增加其生物量并产生脂质，而不预先处理的生物质的解毒。 在将真菌/酵母与糖一起培养后，来自预处理的生物质的固体残余物与真菌/酵母在允许同时进行1）酶促降解纤维素和/或半纤维素以产生糖的条件下进行组合，以及2）发酵糖 生物量和脂质生产进一步增加。

公开(公告)号：US20140116960A1

公开(公告)日：2014-05-01

申请号：US14128311

申请日：2012-06-17

申请人： Richard J. Watts ,  Mushtaque Ahmad

发明人： Richard J. Watts ,  Mushtaque Ahmad

IPC分类号： B09C1/08 ,  C02F1/66 ,  C02F1/72

CPC分类号： C02F1/722 ,  B09C1/00 ,  B09C1/002 ,  B09C1/08 ,  B09C2101/00 ,  C02F1/66 ,  C02F1/72 ,  C02F2101/322 ,  C02F2101/36 ,  C02F2101/363 ,  C02F2103/06 ,  C02F2305/02

摘要： Various embodiments of contaminant removal systems, compositions, and methods are described herein. In one embodiment, a method for oxidizing a contaminant includes contacting the contaminant with a peroxygen compound and initializing, maintaining, or propagating degradation of the peroxygen compound with an oxygenated organic compound, thereby releasing oxidizing radicals. The method also includes oxidizing the contaminant with the released oxidizing radicals.

摘要翻译： 本文描述了污染物去除系统，组合物和方法的各种实施方案。 在一个实施方案中，用于氧化污染物的方法包括使污染物与过氧化合物接触，并用含氧有机化合物初始化，维持或增殖过氧化合物的降解，从而释放氧化基团。 该方法还包括用释放的氧化基团氧化污染物。

公开(公告)号：US20130309740A1

公开(公告)日：2013-11-21

申请号：US13673273

申请日：2012-11-09

申请人： Washington State University Research Foundatio

发明人： Liang Yu ,  Jingwei Ma ,  Craig Frear ,  Usama Zaher ,  Shulin Chen

IPC分类号： C12P5/02

CPC分类号： C12P5/023 ,  C12M21/04 ,  C12M23/58 ,  C12M29/18 ,  C12M41/26 ,  Y02E50/343

摘要： Low cost, efficient two-stage anaerobic digestion systems for the production of biogas (e.g. methane) are provided. During the first stage, biogas is produced in a first reactor by anaerobic microbes cultured in two phases: a high solids phase and a low solids phase. During the second stage, biogas is produced in a second reactor by a methanogen-rich anaerobic culture cultured in low solids medium. Removal of effluent comprising pH lowering reaction products assists in maintaining a suitable pH in the high solids phase. The transfer of effluent from the second reactor to the first reactor assists in maintaining a suitable pH in the high solids phase, in mixing of the high solids phase, and in reseeding the high solids phase with methanogens. Methane is produced in and recovered from both reactors.

公开(公告)号：US08563313B2

公开(公告)日：2013-10-22

申请号：US12526778

申请日：2008-02-13

申请人： Subramaniam Srikumaran ,  Weiguo Liu ,  Sudarvili Shanthalingam

发明人： Subramaniam Srikumaran ,  Weiguo Liu ,  Sudarvili Shanthalingam

IPC分类号： C12N15/00 ,  C12N5/00 ,  C12N5/02 ,  A01N63/00 ,  A61K48/00

CPC分类号： A61K39/12 ,  A01K2217/00 ,  A61K2039/525 ,  C07K14/70596 ,  C12N5/0645 ,  C12N2510/00 ,  C12N2510/02 ,  C12N2770/10034

摘要： Particular aspects provide novel recombinant cells and cell lines (e.g., macrophage cell lines) that are permissive for propagation of porcine reproductive and respiratory syndrome virus (PRRSV) propagation in vitro or in vivo. In certain aspects, novel nucleic acid sequences encoding porcine sialoadhesin were transfected into existing macrophage cell-lines from other species, rendering them permissive to PRRSV infection, and suitable for propagation of PRRSV. Particular aspects provide exemplary recombinant cloned cell lines that support the replication of PRRSV, with an obtainable PRRSV titre of between 2×105/ml and 2×106/ml. Additional aspects provide novel nucleic acid sequences and polymorphisms thereof that encode for porcine sialoadhesin. Further aspects provide PRRSV propagation and preparation methods using the novel recombinant cell lines, and methods for PRRSV antigen and vaccine production using same. Yet further aspect provide transgenic, chimerical or engrafted animals having cell comprising nucleic acid sequences encoding porcine sialoadhesin.

摘要翻译： 特定方面提供新的重组细胞和细胞系（例如，巨噬细胞细胞系），其允许在体外或体内繁殖猪繁殖和呼吸综合征病毒（PRRSV）繁殖。 在某些方面，将编码猪唾液酸粘附素的新型核酸序列转染到来自其他物种的现有巨噬细胞细胞系中，使其允许PRRSV感染，并适用于PRRSV的繁殖。 具体方面提供支持PRRSV复制的示例性重组克隆细胞系，其可获得的2RS10 / 2至10×106 / ml的PRRSV滴度。 另外的方面提供编码猪唾液酸粘附素的新型核酸序列及其多态性。 其他方面提供使用新型重组细胞系的PRRSV繁殖和制备方法，以及使用其的PRRSV抗原和疫苗生产的方法。 另外的方面提供具有包含编码猪唾液酸粘附素的核酸序列的细胞的转基因，嵌合或植入的动物。

公开(公告)号：US20130260259A1

公开(公告)日：2013-10-03

申请号：US13636027

申请日：2012-05-09

申请人： Wei-Hong Zhong ,  Jianying Ji ,  Bin Li

发明人： Wei-Hong Zhong ,  Jianying Ji ,  Bin Li

IPC分类号： H01M6/16 ,  H01M10/0565

CPC分类号： H01M10/0525 ,  H01M6/162 ,  H01M8/1025 ,  H01M8/1041 ,  H01M8/1044 ,  H01M8/1067 ,  H01M8/1069 ,  H01M10/052 ,  H01M10/0565 ,  H01M2300/0082 ,  H01M2300/0088 ,  Y02E60/521 ,  Y02P70/56

摘要： Various embodiments of solid-state conductors containing solid polymer electrolytes, electronic devices incorporating the solid-sate conductors, and associated methods of manufacturing are described herein. In one embodiment, a solid-state conductor includes poly(ethylene oxide) having molecules with a molecular weight of about 200 to about 8×106 gram/mol, and a soy protein product mixed with the poly oxide), the soy protein product containing glycinin and β-conglycinin and having a fine-stranded network structure. Individual molecules of the poly(ethylene oxide) are entangled in the fine-stranded network structure of die soy protein product, and the poly(ethylene oxide) is at least amorphous.

摘要翻译： 本文描述了包含固体聚合物电解质的固体导体，结合固体导体的电子器件和相关联的制造方法的各种实施例。 在一个实施方案中，固体导体包括具有分子量为约200至约8×10 6克/摩尔的分子的聚（环氧乙烷）和与聚（环氧乙烷），大豆蛋白 含有大豆球蛋白和β-伴大豆球蛋白并具有细链网络结构的产品。 聚（环氧乙烷）的单个分子缠结在大豆蛋白产物的细链网络结构中，聚（环氧乙烷）至少是无定形的。

公开(公告)号：US20130226468A1

公开(公告)日：2013-08-29

申请号：US13729175

申请日：2012-12-28

申请人： WASHINGTON STATE UNIVERSITY RESEARCH FOUNDATION

发明人： Michael K. Skinner ,  Carlos M. Guerrero-Bosagna

IPC分类号： G06F19/22

CPC分类号： G06F19/22 ,  C12Q1/68 ,  C12Q1/6827 ,  C12Q1/6869 ,  G06F19/18

摘要： CpG densities and sequence motifs that are characteristic of regions of DNA associated with epimutations and control of epimutations are provided. Such regions include, within approximately 400 (or fewer) base pairs, at least one, usually two, and preferably all three of the following features: i) a CpG density of 15% or less; ii) the presence of the sequence motif ATTTGTTTTTTCTTTTnT (SEQ ID NO: 1) where n is A, T, C or G, and statistically relevant variants thereof; and iii) the presence of the sequence motif GGGGGnGGGG (SEQ ID NO: 2), where n is A, T, C or G, and statistically relevant variants thereof.

摘要翻译： 提供了与突变相关的DNA区域和突变的控制特征的CpG密度和序列基序。 这样的区域包括在约400个（或更少）碱基对内，至少一个，通常两个，优选全部三个以下特征：i）CpG密度为15％或更小; ii）序列基序ATTTGTTTTTTCTTTTnT（SEQ ID NO：1）的存在，其中n是A，T，C或G，以及其统计学上相关的变体; 和iii）序列基序GGGGGnGGGG（SEQ ID NO：2）的存在，其中n是A，T，C或G，以及其统计学上相关的变体。

公开(公告)号：US08236761B2

公开(公告)日：2012-08-07

申请号：US11972487

申请日：2008-01-10

申请人： Joseph W. Harding ,  John W. Wright ,  Patrick D. Elias ,  Brent J. Yamamoto

发明人： Joseph W. Harding ,  John W. Wright ,  Patrick D. Elias ,  Brent J. Yamamoto

IPC分类号： A61K38/18 ,  A61K38/08 ,  A61K38/10

CPC分类号： A61K38/085 ,  A61K38/1833 ,  C07K5/06034 ,  C07K5/06078 ,  C07K5/06086 ,  C07K5/06095 ,  C07K5/06113 ,  C07K5/0808 ,  C07K5/0812 ,  C07K5/0815 ,  C07K5/0817 ,  C07K5/0819 ,  C07K5/101 ,  C07K5/1016 ,  C07K5/1019 ,  C07K5/1021 ,  C07K14/705 ,  G01N33/502 ,  G01N33/5023 ,  G01N33/6893 ,  G01N2800/044

摘要： The cell surface c-Met receptor, through which hepatocyte growth factor (HGF) signals are mediated, has now been identified as the Angiotensin-IV receptor (AT(4)R) in processes that include HGF-regulated cell motility, angiogenesis, cancer metastasis, adipogenesis and others. Disclosed are angiotensin-like factor compositions and methods for using them to diagnose, prevent and/or treat conditions associated with c-Met dysregulation, including cancer, obesity and conditions associated with obesity, and other disorders, for example, by altering hepatocyte growth factor activity or c-Met receptor activity by administering an angiotensin-like factor that specifically binds to a cell surface c-Met receptor.

摘要翻译： 肝细胞生长因子（HGF）信号介导的细胞表面c-Met受体已被鉴定为血管紧张素-IV受体（AT（4）R），其包括HGF调节的细胞运动，血管生成，癌症 转移，脂肪形成等。 公开了血管紧张素样因子组合物和使用它们来诊断，预防和/或治疗与c-Met失调相关的病症的方法，包括癌症，肥胖症和与肥胖相关的病症以及其他病症，例如通过改变肝细胞生长因子 活性或c-Met受体活性，通过施用特异性结合细胞表面c-Met受体的血管紧张素样因子。

公开(公告)号：US20110281730A1

公开(公告)日：2011-11-17

申请号：US13107658

申请日：2011-05-13

申请人： Caixi Zhang ,  Matthew D. Whiting

发明人： Caixi Zhang ,  Matthew D. Whiting

IPC分类号： A01N43/08 ,  A01N39/02 ,  A01P21/00 ,  A01N37/02

CPC分类号： A01N37/42 ,  A01N37/38 ,  A01N37/44 ,  A01N39/04 ,  A01N43/90 ,  C05F11/10 ,  A01N25/00 ,  A01N43/12 ,  A01N45/00

摘要： Disclosed herein are methods for improving fruit production or fruit quality in fruit trees, such as decreasing cold damage, increasing fruit size, increasing fruit quality, and/or increasing fruit set. In some embodiments, the disclosed methods include methods of decreasing cold damage to a fruit tree including applying an effective amount of a composition including DL-β-aminobutyric acid to the fruit tree, thereby decreasing cold damage, for example as compared to a control. In other embodiments, the disclosed methods include methods of increasing fruit size or fruit quality of fruit from a fruit tree, including applying an effective amount of a composition including prohexadione-calcium to the fruit tree after anthesis, thereby increasing fruit size or fruit quality, for example as compared to a control. In further embodiments, the disclosed methods include methods of increasing fruit size of fruit from a fruit tree or increasing fruit set of a fruit tree including applying an effective amount of a composition including 4-chlorophenoxyacetic acid to the fruit tree, thereby increasing fruit size or fruit set, for example as compared to a control.

摘要翻译： 本文公开了用于改善果树中果实生产或果实质量的方法，例如降低冷害，增加果实大小，增加果实质量和/或增加果实。 在一些实施方案中，所公开的方法包括降低对果树的冷害的方法，包括将有效量的包含DL-＆bgr-氨基丁酸的组合物施用于果树，从而降低冷害，例如与对照相比 。 在其他实施方案中，所公开的方法包括从果树增加果实的果实大小或果实质量的方法，包括在开花后向果树施用有效量的包含己酮酮 - 钙的组合物，从而增加果实大小或果实质量， 例如与对照相比。 在另外的实施方案中，所公开的方法包括增加果实果实果实大小的方法，或者增加果树的果实组合，包括将有效量的包含4-氯苯氧基乙酸的组合物施用于果树，从而增加果实的大小或 水果套，例如与对照相比。

公开(公告)号：US08049178B2

公开(公告)日：2011-11-01

申请号：US12202026

申请日：2008-08-29

申请人： Kelvin Lynn ,  Kelly Jones ,  Guido Ciampi

发明人： Kelvin Lynn ,  Kelly Jones ,  Guido Ciampi

IPC分类号： G01T1/26

CPC分类号： G01T1/24

摘要： High rate radiation detectors are disclosed herein. The detectors include a detector material disposed inside the container, the detector material containing cadmium, tellurium, and zinc, a first dopant containing at least one of aluminum, chlorine, and indium, and a second dopant containing a rare earth metal. The first dopant has a concentration of about 500 to about 20,000 atomic parts per billion, and the second dopant has a concentration of about 200 to about 20,000 atomic parts per billion.

摘要翻译： 本文公开了高速辐射探测器。 检测器包括设置在容器内的检测器材料，包含镉，碲和锌的检测器材料，包含铝，氯和铟中的至少一种的第一掺杂物和含有稀土金属的第二掺杂物。 第一掺杂剂具有约500至约20,000原子数十亿的浓度，第二掺杂剂的浓度为约200至约20,000原子数十亿。

公开(公告)号：US07938946B2

公开(公告)日：2011-05-10

申请号：US10544511

申请日：2004-02-06

申请人： Cornelius Ivory ,  Noah Tracy ,  Dan M. Leatzow

发明人： Cornelius Ivory ,  Noah Tracy ,  Dan M. Leatzow

IPC分类号： C02F1/38 ,  G01N27/00

CPC分类号： G01N27/44795 ,  C07K1/26

摘要： A vortex-stabilized electrophoretic processor comprises an annular processing chamber at least partly defined by concentric first and second processing chamber surfaces. At least one of the processing chamber surfaces is rotatable relative to the other processing chamber surface. The electrophoretic processor further comprises an electric field generator operative to be energized to establish a dynamic field gradient within the processing chamber. At least one fluid port is provided, having fluid communication with the processing chamber. The electric field generator may comprise an elongate electrode array positioned within a central bore of a rotor forming the inside surface of the processing chamber. One or both of the processing chamber surfaces can have shaping comprising multiple spaced tines or annular ridges extending toward the other of the processing chamber surfaces.

摘要翻译： 涡流稳定的电泳处理器包括至少部分地由同心的第一和第二处理室表面限定的环形处理室。 处理室表面中的至少一个可相对于另一个处理室表面旋转。 电泳处理器还包括电场发生器，其操作以被激励以在处理室内建立动态场梯度。 提供至少一个流体端口，其具有与处理室的流体连通。 电场发生器可以包括定位在形成处理室的内表面的转子的中心孔内的细长电极阵列。 处理室表面中的一个或两个可以具有包括朝向另一个处理室表面延伸的多个间隔开的齿或环形脊的成形。