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公开(公告)号：US20100111873A1
公开(公告)日：2010-05-06
申请号：US12528047
申请日：2008-02-20
IPC分类号： A61K49/00 , A61K31/7052 , C07H21/00 , A61P35/00
CPC分类号： C07K14/005 , A61K35/768 , C12N7/00 , C12N2770/32311 , C12N2770/32332 , C12N2770/32611 , C12N2770/32632 , C12N2840/102 , Y02A50/465
摘要： This document provides methods and materials related to the use of nucleic acid coding for viruses to reduce the number of viable cancer cells within a mammal. For example, methods for using infectious nucleic acid to treat cancer, engineered viral nucleic acid, methods for making engineered viral nucleic acid, methods for identifying infectious nucleic acid for treating cancer, methods and materials for controlling virus-mediated cell lysis, and methods and materials for assessing the control of virus-mediated cell lysis are provided.
摘要翻译： 本文件提供了与使用编码病毒的核酸相关的方法和材料，以减少哺乳动物内活细胞的数量。 例如，使用感染性核酸治疗癌症的方法，工程化病毒核酸，制备工程化病毒核酸的方法，用于鉴定用于治疗癌症的感染性核酸的方法，用于控制病毒介导的细胞裂解的方法和材料，以及方法和 提供了评估病毒介导的细胞裂解控制的材料。
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公开(公告)号：US06464972B1
公开(公告)日：2002-10-15
申请号：US09566581
申请日：2000-05-08
申请人： Matthias Gromeier , Eckard Wimmer
发明人： Matthias Gromeier , Eckard Wimmer
IPC分类号： A01N6300
CPC分类号： C12N15/86 , A61K35/768 , A61K48/00 , C12N2770/32632 , C12N2770/32643 , C12N2840/203 , Y02A50/465
摘要： The present invention is directed to non-pathogenic, oncolytic, recombinant polioviruses for the treatment of various forms of malignant tumors. The recombinant polioviruses of the invention are those in which the internal ribosomal entry site (IRES) of the wild type poliovirus was exchanged with the IRES of other picornaviruses, and optionally P1, P3 or the 3′NTR thereof was exchanged with that of poliovirus Sabin type. More particularly, the present invention is directed to the administration of the non-pathogenic, oncolytic, recombinant poliovirus to the tumor directly, intrathecally or intravenously to cause tumor necrosis. The method of the present invention is particularly useful for the treatment of malignant tumors in various organs, such as: breast, colon, bronchial passage, epithelial lining of the gastrointestinal, upper respiratory and genito-urinary tracts, liver, prostate and the brain. Astounding remissions in experimental animals have been demonstrated for the treatment of malignant glioblastoma multiforme, an almost universally fatal neoplasm of the central nervous system.
摘要翻译： 本发明涉及用于治疗各种形式的恶性肿瘤的非致病性，溶瘤性重组脊髓灰质炎病毒。 本发明的重组体脊髓灰质炎病毒是其中野生型脊髓灰质炎病毒的内部核糖体进入位点（IRES）与其他微小核糖核酸病毒的IRES交换的，并且任选的P1，P3或其3'NTR与脊髓灰质炎病毒Sabin 类型。 更具体地，本发明涉及直接，鞘内或静脉内给予肿瘤非致病性，溶瘤性重组体脊髓灰质炎病毒以引起肿瘤坏死。 本发明的方法特别可用于治疗各种器官中的恶性肿瘤，例如：乳腺，结肠，支气管传代，胃肠道，上呼吸道和生殖泌尿道，肝脏，前列腺和脑部的上皮层。 实验动物的惊人缓解已被证明用于治疗多形性恶性胶质母细胞瘤，这是几乎普遍致命的中枢神经系统肿瘤。
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公开(公告)号：US20180296614A1
公开(公告)日：2018-10-18
申请号：US15768147
申请日：2016-10-14
申请人： Duke University
IPC分类号： A61K35/768 , A61K39/13 , A61K9/127 , A61K39/395 , C07K16/28 , A61P35/00 , C12N15/85
CPC分类号： A61K35/768 , A61K9/127 , A61K39/13 , A61K39/39 , A61K39/39541 , A61K2039/505 , A61K2300/00 , A61P35/00 , C07K16/2818 , C07K2317/76 , C12N7/00 , C12N15/85 , C12N2770/32621 , C12N2770/32632 , C12N2840/203 , Y02A50/466
摘要： Human clinical use of a chimeric poliovirus construct has demonstrated excellent anti-tumor effect. Combination with immune checkpoint inhibitors increases the anti-tumor effect. Tumors of different types are susceptible to the combination treatment, including but not limited to melanoma, glioglastoma, renal cell carcinoma, prostate cancer, breast cancer, lung cancer, medulloblastoma, and colorectal cancer.
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公开(公告)号：US06264940B1
公开(公告)日：2001-07-24
申请号：US09129686
申请日：1998-08-05
申请人： Matthias Gromeier , Eckard Wimmer
发明人： Matthias Gromeier , Eckard Wimmer
IPC分类号： A01N6300
CPC分类号： C12N15/86 , A61K35/768 , A61K48/00 , C12N2770/32632 , C12N2770/32643 , C12N2840/203 , Y02A50/465
摘要： The present invention is directed to non-pathogenic, oncolytic, recombinant polioviruses for the treatment of various forms of malignant tumors. The recombinant polioviruses of the invention are those in which the internal ribosomal entry site (IRES) of the wild type poliovirus was exchanged with the IRES of other picornaviruses, and optionally P1, P3 or the 3′NTR thereof was exchanged with that of poliovirus Sabin type. More particularly, the present invention is directed to the administration of the non-pathogenic, oncolytic, recombinant poliovirus to the tumor directly, intrathecally or intravenously to cause tumor necrosis. The method of the present invention is particularly useful for the treatment of malignant tumors in various organs, such as: breast, colon, bronchial passage, epithelial lining of the gastrointestinal, upper respiratory and genito-urinary tracts, liver, prostate and the brain. Astounding remissions in experimental animals have been demonstrated for the treatment of malignant glioblastoma multiforme, an almost universally fatal neoplasm of the central nervous system.
摘要翻译： 本发明涉及用于治疗各种形式的恶性肿瘤的非致病性，溶瘤性重组脊髓灰质炎病毒。 本发明的重组体脊髓灰质炎病毒是其中野生型脊髓灰质炎病毒的内部核糖体进入位点（IRES）与其他微小核糖核酸病毒的IRES交换的，并且任选的P1，P3或其3'NTR与脊髓灰质炎病毒Sabin 类型。 更具体地，本发明涉及直接，鞘内或静脉内给予肿瘤非致病性，溶瘤性重组体脊髓灰质炎病毒以引起肿瘤坏死。 本发明的方法特别可用于治疗各种器官中的恶性肿瘤，例如：乳腺，结肠，支气管传代，胃肠道，上呼吸道和生殖泌尿道，肝脏，前列腺和脑部的上皮层。 实验动物的惊人缓解已被证明用于治疗多形性恶性胶质母细胞瘤，这是几乎普遍致命的中枢神经系统肿瘤。
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公开(公告)号：US09957302B2
公开(公告)日：2018-05-01
申请号：US14792178
申请日：2015-07-06
IPC分类号： C07K14/005 , C12N7/00 , A61K35/768
CPC分类号： C07K14/005 , A61K35/768 , C12N7/00 , C12N2770/32311 , C12N2770/32332 , C12N2770/32611 , C12N2770/32632 , C12N2840/102 , Y02A50/465
摘要： This document provides methods and materials related to the use of nucleic acid coding for viruses to reduce the number of viable cancer cells within a mammal. For example, methods for using infectious nucleic acid to treat cancer, engineered viral nucleic acid, methods for making engineered viral nucleic acid, methods for identifying infectious nucleic acid for treating cancer, methods and materials for controlling virus-mediated cell lysis, and methods and materials for assessing the control of virus-mediated cell lysis are provided.
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公开(公告)号：US20170216382A1
公开(公告)日：2017-08-03
申请号：US15428510
申请日：2017-02-09
申请人： Duke University
IPC分类号： A61K35/768 , A61K9/00 , A61K45/06 , C12N7/00
CPC分类号： A61K35/768 , A61K9/0085 , A61K41/00 , A61K45/06 , A61K51/081 , A61N5/10 , C12N7/00 , C12N2770/32611 , C12N2770/32632 , C12N2770/32671 , C12N2770/32733 , Y02A50/465
摘要： Human clinical use of a chimeric poliovirus construct has demonstrated excellent anti-tumor effect. The mechanism of action is believed to involve both viral oncolysis as well as immune recruitment, both of which lead to necrosis in the area of the tumor. No adverse effects have been observed.
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公开(公告)号：US20030165466A1
公开(公告)日：2003-09-04
申请号：US10175247
申请日：2002-06-19
发明人： Matthias Gromeier , Eckard Wimmer
IPC分类号： C12Q001/70 , C12P021/06 , A61K048/00 , A01N063/00
CPC分类号： C12N15/86 , A61K35/768 , A61K48/00 , C12N2770/32632 , C12N2770/32643 , C12N2840/203 , Y02A50/465
摘要： The present invention is directed to non-pathogenic, oncolytic, recombinant polioviruses for the treatment of various forms of malignant tumors. The recombinant polioviruses of the invention are those in which the internal ribosomal entry site (IRES) of the wild type poliovirus was exchanged with the IRES of other picornaviruses, and optionally P1, P3 or the 3nullNTR thereof was exchanged with that of poliovirus Sabin type. More particularly, the present invention is directed to the administration of the non-pathogenic, oncolytic, recombinant poliovirus to the tumor directly, intrathecally or intravenously to cause tumor necrosis. The method of the present invention is particularly useful for the treatment of malignant tumors in various organs, such as: breast, colon, bronchial passage, epithelial lining of the gastrointestinal, upper respiratory and genito-urinary tracts, liver, prostate and the brain. Astounding remissions in experimental animals have been demonstrated for the treatment of malignant glioblastoma multiforme, an almost universally fatal neoplasm of the central nervous system.
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公开(公告)号：US20160030497A1
公开(公告)日：2016-02-04
申请号：US14646233
申请日：2013-11-21
申请人： DUKE UNIVERSITY
CPC分类号： A61K35/768 , A61K9/0085 , A61K41/00 , A61K45/06 , A61K51/081 , A61N5/10 , C12N7/00 , C12N2770/32611 , C12N2770/32632 , C12N2770/32671 , C12N2770/32733 , Y02A50/465
摘要： Human clinical use of a chimeric poliovirus construct has demonstrated excellent anti-tumor effect. The mechanism of action is believed to involve both viral oncolysis as well as immune recruitment, both of which lead to necrosis in the area of the tumor. No adverse effects have been observed.
摘要翻译： 嵌合脊髓灰质炎病毒构建体的人临床使用已经证明具有优异的抗肿瘤效果。 认为这种作用机制涉及病毒溶瘤以及免疫招募，两者均导致肿瘤区域的坏死。 没有观察到不良反应。
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公开(公告)号：US20150299271A1
公开(公告)日：2015-10-22
申请号：US14792178
申请日：2015-07-06
IPC分类号： C07K14/005 , C12N7/00
CPC分类号： C07K14/005 , A61K35/768 , C12N7/00 , C12N2770/32311 , C12N2770/32332 , C12N2770/32611 , C12N2770/32632 , C12N2840/102 , Y02A50/465
摘要： This document provides methods and materials related to the use of nucleic acid coding for viruses to reduce the number of viable cancer cells within a mammal. For example, methods for using infectious nucleic acid to treat cancer, engineered viral nucleic acid, methods for making engineered viral nucleic acid, methods for identifying infectious nucleic acid for treating cancer, methods and materials for controlling virus-mediated cell lysis, and methods and materials for assessing the control of virus-mediated cell lysis are provided.
摘要翻译： 本文件提供了与使用编码病毒的核酸相关的方法和材料，以减少哺乳动物内活细胞的数量。 例如，使用感染性核酸治疗癌症的方法，工程化病毒核酸，制备工程化病毒核酸的方法，用于鉴定用于治疗癌症的感染性核酸的方法，用于控制病毒介导的细胞裂解的方法和材料，以及方法和 提供了评估病毒介导的细胞裂解控制的材料。
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公开(公告)号：US07147848B2
公开(公告)日：2006-12-12
申请号：US10175247
申请日：2002-06-19
申请人： Matthias Gromeier , Eckard Wimmer
发明人： Matthias Gromeier , Eckard Wimmer
CPC分类号： C12N15/86 , A61K35/768 , A61K48/00 , C12N2770/32632 , C12N2770/32643 , C12N2840/203 , Y02A50/465
摘要： The present invention is directed to non-pathogenic, oncolytic, recombinant polioviruses for the treatment of various forms of malignant tumors. The recombinant polioviruses of the invention are those in which the internal ribosomal entry site (IRES) of the wild type poliovirus was exchanged with the IRES of other picornaviruses, and optionally P1, P3 or the 3′NTR thereof was exchanged with that of poliovirus Sabin type. More particularly, the present invention is directed to the administration of the non-pathogenic, oncolytic, recombinant poliovirus to the tumor directly, intrathecally or intravenously to cause tumor necrosis. The method of the present invention is particularly useful for the treatment of malignant tumors in various organs, such as: breast, colon, bronchial passage, epithelial lining of the gastrointestinal, upper respiratory and genito-urinary tracts, liver, prostate and the brain. Astounding remissions in experimental animals have been demonstrated for the treatment of malignant glioblastoma multiforme, an almost universally fatal neoplasm of the central nervous system.
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