公开(公告)号：US20170166872A1

公开(公告)日：2017-06-15

申请号：US15325650

申请日：2015-07-21

申请人： Janssen Vaccines & Prevention B.V.

发明人： Mariken Segers ,  Beckley Kungah Nfor ,  Feras Nachmi Alazi ,  Marcel Leo De Vocht

IPC分类号： C12N7/00

CPC分类号： C12N7/00 ,  C12N2770/32611 ,  C12N2770/32651

摘要： The disclosure provides methods for poliovirus purification from crude cell culture harvests using a detergent followed by a clarification step.

公开(公告)号：US06821741B1

公开(公告)日：2004-11-23

申请号：US09844311

申请日：2001-04-27

申请人： Yung T. Huang

发明人： Yung T. Huang

IPC分类号： G01N33567

CPC分类号： C12N5/0686 ,  C07K14/70596 ,  C12N7/00 ,  C12N2503/00 ,  C12N2510/02 ,  C12N2770/32311 ,  C12N2770/32611 ,  G01N33/56983

摘要： The invention provides cell lines which are useful for the rapid detection of enteroviruses. In particular, the invention provides transgenic African green monkey kidney cell lines and buffalo green monkey kidney cell lines. The invention provides cell lines which have increased sensitivity to infection by enteroviruses in single-cell type and mixed-cell type cultures compared to other cell types which are currently used for enterovirus detection. The cells of the invention also are permissive to infection by a larger number of enteroviruses as compared to the cell type from which they were derived.

摘要翻译： 本发明提供可用于快速检测肠道病毒的细胞系。 特别地，本发明提供转基因非洲绿猴肾细胞系和水牛绿猴肾细胞系。 本发明提供了与目前用于肠道病毒检测的其它细胞类型相比，对单细胞型和混合细胞型培养物中肠道病毒感染具有增加的敏感性的细胞系。 与其衍生的细胞类型相比，本发明的细胞也可以容忍更多数量的肠道病毒的感染。

公开(公告)号：US20100111873A1

公开(公告)日：2010-05-06

申请号：US12528047

申请日：2008-02-20

申请人： Stephen J. Russell ,  Elizabeth J. Kelly ,  Elizabeth M. Hadac

发明人： Stephen J. Russell ,  Elizabeth J. Kelly ,  Elizabeth M. Hadac

IPC分类号： A61K49/00 ,  A61K31/7052 ,  C07H21/00 ,  A61P35/00

CPC分类号： C07K14/005 ,  A61K35/768 ,  C12N7/00 ,  C12N2770/32311 ,  C12N2770/32332 ,  C12N2770/32611 ,  C12N2770/32632 ,  C12N2840/102 ,  Y02A50/465

摘要： This document provides methods and materials related to the use of nucleic acid coding for viruses to reduce the number of viable cancer cells within a mammal. For example, methods for using infectious nucleic acid to treat cancer, engineered viral nucleic acid, methods for making engineered viral nucleic acid, methods for identifying infectious nucleic acid for treating cancer, methods and materials for controlling virus-mediated cell lysis, and methods and materials for assessing the control of virus-mediated cell lysis are provided.

摘要翻译： 本文件提供了与使用编码病毒的核酸相关的方法和材料，以减少哺乳动物内活细胞的数量。 例如，使用感染性核酸治疗癌症的方法，工程化病毒核酸，制备工程化病毒核酸的方法，用于鉴定用于治疗癌症的感染性核酸的方法，用于控制病毒介导的细胞裂解的方法和材料，以及方法和 提供了评估病毒介导的细胞裂解控制的材料。

公开(公告)号：US07628987B2

公开(公告)日：2009-12-08

申请号：US10460471

申请日：2003-06-13

申请人： Therese Ternynck ,  Alexandre Avrameas ,  Gerard Buttin ,  Stratis Avrameas ,  Marie-Francoise Saron ,  Bruno Blondel ,  Therese Couderc ,  Susan Michelson ,  Donato Zipeto

发明人： Therese Ternynck ,  Alexandre Avrameas ,  Gerard Buttin ,  Stratis Avrameas ,  Marie-Francoise Saron ,  Bruno Blondel ,  Therese Couderc ,  Susan Michelson ,  Donato Zipeto

IPC分类号： A61K39/00

CPC分类号： C07K16/1072 ,  A61K38/00 ,  A61K47/62 ,  A61K47/6883 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/28 ,  C07K16/44 ,  C07K2317/565 ,  C07K2317/80 ,  C07K2319/00 ,  C12N2710/16111 ,  C12N2710/16611 ,  C12N2770/32611 ,  Y02A50/466

摘要： The present invention provides novel polypeptides which can effectively penetrate into cells thereby transporting a substance of interest into the cells.

摘要翻译： 本发明提供可以有效地渗入细胞中的新型多肽，从而将感兴趣的物质运送到细胞中。

公开(公告)号：US20040259243A1

公开(公告)日：2004-12-23

申请号：US10861724

申请日：2004-06-03

发明人： Yung T. Huang

IPC分类号： C12N005/06

CPC分类号： C12N5/0686 ,  C07K14/70596 ,  C12N7/00 ,  C12N2503/00 ,  C12N2510/02 ,  C12N2770/32311 ,  C12N2770/32611 ,  G01N33/56983

摘要： The invention provides cell lines which are useful for the rapid detection of enteroviruses. In particular, the invention provides transgenic African green monkey kidney cell lines and buffalo green monkey kidney cell lines. The invention provides cell lines which have increased sensitivity to infection by enteroviruses in single-cell type and mixed-cell type cultures compared to other cell types which are currently used for enterovirus detection. The cells of the invention also are permissive to infection by a larger number of enteroviruses as compared to the cell type from which they were derived.

公开(公告)号：US20180215794A1

公开(公告)日：2018-08-02

申请号：US15937567

申请日：2018-03-27

申请人： Mayo Foundation for Medical Education and Research

发明人： Stephen James Russell ,  Elizabeth J. Kelly ,  Elizabeth M. Hadac

IPC分类号： C07K14/005 ,  C12N7/00 ,  A61K35/768

CPC分类号： C07K14/005 ,  A61K35/768 ,  C12N7/00 ,  C12N2770/32311 ,  C12N2770/32332 ,  C12N2770/32611 ,  C12N2770/32632 ,  C12N2840/102 ,  Y02A50/465

摘要： This document provides methods and materials related to the use of nucleic acid coding for viruses to reduce the number of viable cancer cells within a mammal. For example, methods for using infectious nucleic acid to treat cancer, engineered viral nucleic acid, methods for making engineered viral nucleic acid, methods for identifying infectious nucleic acid for treating cancer, methods and materials for controlling virus-mediated cell lysis, and methods and materials for assessing the control of virus-mediated cell lysis are provided.

公开(公告)号：US09474759B2

公开(公告)日：2016-10-25

申请号：US14347756

申请日：2012-09-27

申请人： Kansas State University Research Foundation ,  The Ohio State University ,  Wichita State University

发明人： Kyeong-Ok Chang ,  Yunjeong Kim ,  William C. Groutas ,  Duy Hua ,  Linda J. Saif

IPC分类号： A61K38/06 ,  A61K31/5377 ,  A61K31/4015 ,  A61K31/422 ,  A61K31/427 ,  A61K45/06 ,  C07D207/27

CPC分类号： A61K31/5377 ,  A61K31/4015 ,  A61K31/422 ,  A61K31/427 ,  A61K38/06 ,  A61K45/06 ,  C07D207/27 ,  C12N2770/16011 ,  C12N2770/20011 ,  C12N2770/32111 ,  C12N2770/32311 ,  C12N2770/32411 ,  C12N2770/32611 ,  Y02A50/463

摘要： Antiviral protease inhibitors, including peptidyl aldehydes, peptidyl α-ketoamides, peptidyl bisulfate salts, and peptidyl heterocycles, are disclosed, along with related antiviral compounds, and methods of using the same to treat or prevent viral infection and disease. The compounds possess broad-spectrum activity against viruses that belong to the picornavirus-like supercluster, which include important human and animal pathogens including noroviruses, enteroviruses, poliovirus, foot-and-mouth disease virus, hepatitis A virus, human rhinovirus (cause of common cold), human coronavirus (another cause of common cold), transmissible gastroenteritis virus, murine hepatitis virus, feline infectious peritonitis virus, and severe acute respiratory syndrome coronavirus.

摘要翻译： 公开了抗病毒蛋白酶抑制剂，包括肽基醛，肽基α-酮酰胺，硫酸氢酯盐和肽基杂环，以及相关的抗病毒化合物，以及使用它们来治疗或预防病毒感染和疾病的方法。 该化合物对属于小核糖核酸病毒超级群集的病毒具有广谱活性，其包括重要的人和动物病原体，包括诺维病毒，肠道病毒，脊髓灰质炎病毒，口蹄疫病毒，甲型肝炎病毒，人类鼻病毒（常见病因 感冒），人类冠状病毒（普通感冒的另一原因），传染性胃肠炎病毒，鼠肝炎病毒，猫感染性腹膜炎病毒和严重急性呼吸综合征冠状病毒。

公开(公告)号：US20140243341A1

公开(公告)日：2014-08-28

申请号：US14347756

申请日：2012-09-27

申请人： Kansas State University Research Foundation ,  Wichita State University ,  The Ohio State University

发明人： Kyeong-Ok Chang ,  Yunjeong Kim ,  William C. Groutas ,  Duy Hua ,  Linda J. Saif

IPC分类号： A61K31/5377 ,  A61K31/4015 ,  A61K45/06 ,  C07D207/27

CPC分类号： A61K31/5377 ,  A61K31/4015 ,  A61K31/422 ,  A61K31/427 ,  A61K38/06 ,  A61K45/06 ,  C07D207/27 ,  C12N2770/16011 ,  C12N2770/20011 ,  C12N2770/32111 ,  C12N2770/32311 ,  C12N2770/32411 ,  C12N2770/32611 ,  Y02A50/463

摘要： Antiviral protease inhibitors, including peptidyl aldehydes, peptidyl α-ketoamides, peptidyl bisulfite salts, and peptidyl heterocycles, are disclosed, along with related antiviral compounds, and methods of using the same to treat or prevent viral infection and disease. The compounds possess broad-spectrum activity against viruses that belong to the picornavirus-like supercluster, which include important human and animal pathogens including noroviruses, enteroviruses, poliovirus, foot-and-mouth disease virus, hepatitis A virus, human rhinovirus (cause of common cold), human coronavirus (another cause of common cold), transmissible gastroenteritis virus, murine hepatitis virus, feline infectious peritonitis virus, and severe acute respiratory syndrome coronavirus.

摘要翻译： 公开了抗病毒蛋白酶抑制剂，包括肽基醛，肽基α-酮酰胺，亚硫酸氢盐和肽基杂环，以及相关的抗病毒化合物，以及使用它们来治疗或预防病毒感染和疾病的方法。 该化合物对属于小核糖核酸病毒超集群的病毒具有广谱活性，其包括重要的人和动物病原体，包括诺维病毒，肠道病毒，脊髓灰质炎病毒，口蹄疫病毒，甲型肝炎病毒，人类鼻病毒（常见病因 感冒），人类冠状病毒（普通感冒的另一原因），传染性胃肠炎病毒，鼠肝炎病毒，猫感染性腹膜炎病毒和严重急性呼吸综合征冠状病毒。

公开(公告)号：US20130345414A1

公开(公告)日：2013-12-26

申请号：US13952343

申请日：2013-07-26

申请人： Mayo Foundation for Medical Education and Research

发明人： Stephen James Russell ,  Elizabeth J. Kelly ,  Elizabeth M. Hadac

IPC分类号： C07K14/005

CPC分类号： C07K14/005 ,  A61K35/768 ,  C12N7/00 ,  C12N2770/32311 ,  C12N2770/32332 ,  C12N2770/32611 ,  C12N2770/32632 ,  C12N2840/102 ,  Y02A50/465

摘要： This document provides methods and materials related to the use of nucleic acid coding for viruses to reduce the number of viable cancer cells within a mammal. For example, methods for using infectious nucleic acid to treat cancer, engineered viral nucleic acid, methods for making engineered viral nucleic acid, methods for identifying infectious nucleic acid for treating cancer, methods and materials for controlling virus-mediated cell lysis, and methods and materials for assessing the control of virus-mediated cell lysis are provided.

公开(公告)号：US20030206900A1

公开(公告)日：2003-11-06

申请号：US10460471

申请日：2003-06-13

申请人： INSTITUT PASTEUR ,  Universite Pierre et Marie Curie

发明人： Therese Ternynck ,  Alexandre Avrameas ,  Gerard Buttin ,  Stratis Avrameas ,  Marie-Francoise Saron ,  Bruno Blondel ,  Therese Couderc ,  Susan Michelson ,  Donato Zipeto

IPC分类号： A61K039/395 ,  C07K016/44 ,  C12P021/02 ,  C12N005/06 ,  C12N015/85

CPC分类号： C07K16/1072 ,  A61K38/00 ,  A61K47/62 ,  A61K47/6883 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/28 ,  C07K16/44 ,  C07K2317/565 ,  C07K2317/80 ,  C07K2319/00 ,  C12N2710/16111 ,  C12N2710/16611 ,  C12N2770/32611 ,  Y02A50/466

摘要： The present invention provides novel polypeptides which can effectively penetrate into cells thereby transporting a substance of interest into the cells.