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    Selection Method and Recombinant Microorganisms and uses Therefor
    2.
    发明申请
    Selection Method and Recombinant Microorganisms and uses Therefor 审中-公开
    选择方法和重组微生物及其用途

    公开(公告)号：US20130316364A1

    公开(公告)日：2013-11-28

    申请号：US13900172

    申请日：2013-05-22

    Applicant: LanzaTech New Zealand Limited

    Inventor： Michael Koepke ,  Bakir Al-Sinawi

    IPC: C12N15/74

    CPC classification number: C12N15/65 ,  C12N1/20 ,  C12N9/1014 ,  C12N9/88 ,  C12N9/93 ,  C12N15/52 ,  C12N15/74 ,  C12Y201/02011 ,  C12Y202/01011 ,  C12Y401/01011 ,  C12Y401/99017 ,  C12Y603/02001

    Abstract: One or more genes in a biosynthesis pathway for a vitamin or other essential nutrient which is needed for the survival of a microorganism can be used as an effective selective marker to identify cells transformed with an exogenous nucleic acid. The microorganism does not naturally contain or express the one or more gene. This permits genetic manipulations to be performed. It permits lower cost fermentations to be performed. It permits production of the essential nutrient for subsequent commodity use.

    Abstract translation: 用于维生素或其它必需营养物质的生物合成途径中的一个或多个基因可用作微生物存活所需的有效选择性标记，以鉴定用外源核酸转化的细胞。 微生物不天然含有或表达一个或多个基因。 这允许执行遗传操作。 它允许执行较低成本的发酵。 它允许生产用于随后商品使用的必需营养物质。

    Microorganisms and processes for enhanced production of pantothenate
    3.
    发明授权
    Microorganisms and processes for enhanced production of pantothenate 有权
    用于增加泛酸盐生产的微生物和方法

    公开(公告)号：US07244593B2

    公开(公告)日：2007-07-17

    申请号：US10466641

    申请日：2002-01-18

    Applicant: R. Roger Yocum ,  Thomas A. Patterson ,  Janice G. Pero ,  Theron Hermann

    Inventor： R. Roger Yocum ,  Thomas A. Patterson ,  Janice G. Pero ,  Theron Hermann

    IPC: C12P13/04

    CPC classification number: C12N9/0006 ,  C12N9/1014 ,  C12N9/1022 ,  C12N9/88 ,  C12N9/93 ,  C12P13/02 ,  C12Y201/02011 ,  C12Y401/01011 ,  C12Y603/02001

    Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate by enzymes that contribute to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.

    Abstract translation: 本发明的特征在于利用具有改良的泛酸生物合成酶活性并具有改性的亚甲基四氢叶酸（MTF）生物合成酶活性的微生物增强生产泛酸盐和泛酸盐的改进方法。 特别地，本发明的特征在于通过增加关键中间体水平，通过有助于其合成的酶的酮托品来提高所需产物的生产的方法。 还具有重组微生物和培养条件。 还有这些微生物产生的组合物。

    VITAMIN PROTOTROPHY AS A SELECTABLE MARKER
    4.
    发明申请
    VITAMIN PROTOTROPHY AS A SELECTABLE MARKER 有权
    VITAMIN PROTOTROPHY作为可选标记

    公开(公告)号：US20170016007A1

    公开(公告)日：2017-01-19

    申请号：US15285179

    申请日：2016-10-04

    Applicant: LanzaTech New Zealand Limited

    Inventor： Michael Koepke ,  Bakir Al-Sinawi

    IPC: C12N15/65 ,  C12N9/88 ,  C12N9/10 ,  C12N15/74

    CPC classification number: C12N15/65 ,  C12N1/20 ,  C12N9/1014 ,  C12N9/88 ,  C12N9/93 ,  C12N15/52 ,  C12N15/74 ,  C12Y201/02011 ,  C12Y202/01011 ,  C12Y401/01011 ,  C12Y401/99017 ,  C12Y603/02001

    Abstract: One or more genes in a biosynthesis pathway for a vitamin or other essential nutrient which is needed for the survival of a microorganism can be used as an effective selective marker to identify cells transformed with an exogenous nucleic acid. The microorganism does not naturally contain or express the one or more gene. This permits genetic manipulations to be performed. It permits lower cost fermentations to be performed. It permits production of the essential nutrient for subsequent commodity use.

    Abstract translation: 用于维生素或其它必需营养物质的生物合成途径中的一个或多个基因可用作微生物存活所需的有效选择性标记，以鉴定用外源核酸转化的细胞。 微生物不天然含有或表达一个或多个基因。 这允许执行遗传操作。 它允许执行较低成本的发酵。 它允许生产用于随后商品使用的必需营养物质。

    MUTANT MICROORGANISM HAVING IMPROVED PRODUCTION ABILITY OF BRANCHED AMINO ACID AND METHOD FOR PREPARING BRANCHED AMINO ACID USING THE SAME
    5.
    发明申请
    MUTANT MICROORGANISM HAVING IMPROVED PRODUCTION ABILITY OF BRANCHED AMINO ACID AND METHOD FOR PREPARING BRANCHED AMINO ACID USING THE SAME 有权
    具有改进的分支氨基酸生产能力的突变微生物及使用其制备分支氨基酸的方法

    公开(公告)号：US20090053779A1

    公开(公告)日：2009-02-26

    申请号：US12097099

    申请日：2007-03-14

    Applicant: Sang Yup Lee ,  Jin Hwan Park ,  Kwang Ho Lee ,  Tae Yong Kim

    Inventor： Sang Yup Lee ,  Jin Hwan Park ,  Kwang Ho Lee ,  Tae Yong Kim

    IPC: C12P13/08 ,  C12N15/01 ,  C12N15/80 ,  C12N15/81 ,  C12N15/74 ,  C12N1/14 ,  C12N1/15 ,  C12N1/16 ,  C12N1/19 ,  C12N1/20 ,  C12N1/21

    CPC classification number: C12P13/08 ,  C12N9/1014 ,  C12Y201/02011

    Abstract: The present invention relates to mutant microorganisms having improved productivity of branched-chain amino acids, and a method for producing branched-chain amino acids using the mutant microorganisms. More specifically, relates to mutant microorganisms having improved productivity of L-valine, which are produced by attenuating or deleting a gene encoding an enzyme involved in L-isoleucine biosynthesis, a gene encoding an enzyme involved in L-leucine, and a gene encoding an enzyme involved in D-pantothenic acid biosynthesis, and mutating a gene encoding an enzyme involved in L-valine biosynthesis, such that the expression thereof is increased, as well as a method for producing L-valine using the mutant microorganisms. The inventive mutant microorganisms produced by site-specific mutagenesis and metabolic pathway engineering can produce branched-chain amino acids, particularly L-valine, with high efficiency, and thus will be useful as industrial microorganisms for producing L-valine.

    Abstract translation: 本发明涉及具有提高的支链氨基酸生产率的突变微生物，以及使用突变微生物生产支链氨基酸的方法。 更具体地，涉及通过减弱或缺失编码参与L-异亮氨酸生物合成的酶的基因，编码L-亮氨酸的酶的基因和编码L-亮氨酸的基因而产生的L-缬氨酸的生产率提高的突变体微生物 涉及D-泛酸生物合成的酶，以及编码参与L-缬氨酸生物合成的酶的基因的突变，使得其表达增加，以及使用突变微生物产生L-缬氨酸的方法。 通过位点特异性诱变和代谢途径工程产生的本发明的突变体微生物可以高效地产生支链氨基酸，特别是L-缬氨酸，因此可用作生产L-缬氨酸的工业微生物。

    Mutant microorganism having improved production ability of branched amino acid and method for preparing branched amino acid using the same
    8.
    发明授权
    Mutant microorganism having improved production ability of branched amino acid and method for preparing branched amino acid using the same 有权
    具有提高支链氨基酸生产能力的突变体微生物及使用其制备支链氨基酸的方法

    公开(公告)号：US08148137B2

    公开(公告)日：2012-04-03

    申请号：US12097099

    申请日：2007-03-14

    Applicant: Sang Yup Lee ,  Jin Hwan Park ,  Kwang Ho Lee ,  Tae Yong Kim

    Inventor： Sang Yup Lee ,  Jin Hwan Park ,  Kwang Ho Lee ,  Tae Yong Kim

    IPC: C12N1/21 ,  C12P13/08

    CPC classification number: C12P13/08 ,  C12N9/1014 ,  C12Y201/02011

    Abstract: The present invention relates to mutant microorganisms having improved productivity of branched-chain amino acids, and a method for producing branched-chain amino acids using the mutant microorganisms. More specifically, relates to mutant microorganisms having improved productivity of L-valine, which are produced by attenuating or deleting a gene encoding an enzyme involved in L-isoleucine biosynthesis, a gene encoding an enzyme involved in L-leucine, and a gene encoding an enzyme involved in D-pantothenic acid biosynthesis, and mutating a gene encoding an enzyme involved in L-valine biosynthesis, such that the expression thereof is increased, as well as a method for producing L-valine using the mutant microorganisms. The inventive mutant microorganisms produced by site-specific mutagenesis and metabolic pathway engineering can produce branched-chain amino acids, particularly L-valine, with high efficiency, and thus will be useful as industrial microorganisms for producing L-valine.

    Abstract translation: 本发明涉及具有提高的支链氨基酸生产率的突变微生物，以及使用突变微生物生产支链氨基酸的方法。 更具体地，涉及通过减弱或缺失编码参与L-异亮氨酸生物合成的酶的基因，编码L-亮氨酸的酶的基因和编码L-亮氨酸的基因而产生的L-缬氨酸的生产率提高的突变体微生物 涉及D-泛酸生物合成的酶，以及编码参与L-缬氨酸生物合成的酶的基因的突变，使得其表达增加，以及使用突变微生物产生L-缬氨酸的方法。 通过位点特异性诱变和代谢途径工程产生的本发明的突变体微生物可以高效地产生支链氨基酸，特别是L-缬氨酸，因此可用作生产L-缬氨酸的工业微生物。

    Microorganisms and processes for enhanced production of pantothenate
    9.
    发明申请
    Microorganisms and processes for enhanced production of pantothenate 有权
    用于增加泛酸盐生产的微生物和方法

    公开(公告)号：US20040091979A1

    公开(公告)日：2004-05-13

    申请号：US10466641

    申请日：2003-07-18

    Inventor： Rogers R. Yocum ,  Thomas A. Patterson ,  Janice G. Pero ,  Theron Hermann

    IPC: C12P013/04 ,  C12N001/21

    CPC classification number: C12N9/0006 ,  C12N9/1014 ,  C12N9/1022 ,  C12N9/88 ,  C12N9/93 ,  C12P13/02 ,  C12Y201/02011 ,  C12Y401/01011 ,  C12Y603/02001

    Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate by enzymes that contribute to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.

    Abstract translation: 本发明的特征在于利用具有改良的泛酸生物合成酶活性并具有改性的亚甲基四氢叶酸（MTF）生物合成酶活性的微生物增强生产泛酸盐和泛酸盐的改进方法。 特别地，本发明的特征在于通过增加关键中间体水平，通过有助于其合成的酶的酮托品来提高所需产物的生产的方法。 还具有重组微生物和培养条件。 还有这些微生物产生的组合物。

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