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公开(公告)号：US06413769B1
公开(公告)日：2002-07-02
申请号：US08929940
申请日：1997-09-15
IPC分类号： C12N500
CPC分类号： C12N15/113 , A01K67/0275 , A01K67/0276 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2227/108 , A01K2267/02 , A01K2267/025 , A61K2035/122 , C12N9/1051 , C12N15/1137 , C12N15/8509 , C12N2310/111 , C12N2310/121 , C12N2310/315 , C12N2517/02 , C12N2830/52 , C12N2840/203 , C12Y204/01228
摘要： Transgenic swine in which the normal expression of &agr;(1, 3) galactosyltransferase is prevented in at least one organ of tissue type. The absence or inactivation of this enzyme prevents the production of carbohydrate moieties having the distinctive terminal Gal&agr;1-3Gal&bgr;1-4GlcNAc epitope that is a significant factor in xenogeneic, particularly human, transplant rejection of swine grafts.
摘要翻译： 转基因猪，其中α（1,3）半乳糖基转移酶的正常表达在至少一种组织型器官中被预防。 该酶的缺失或失活阻止了具有特征性末端Galalpha1-3Galbeta1-4GlcNAc表位的碳水化合物部分的产生，其是异种移植物，特别是人类移植排斥反应中重要因素。
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公开(公告)号：US6153428A
公开(公告)日：2000-11-28
申请号：US621700
申请日：1996-03-26
IPC分类号： A01K67/027 , A61K35/12 , C07H21/04 , C12N9/10 , C12N15/09 , C12N15/113 , C12N15/85 , C12N5/00 , C12N15/00 , A61K48/00
CPC分类号： C12N15/113 , A01K67/0275 , A01K67/0276 , C12N15/1137 , C12N15/8509 , C12N9/1051 , C12Y204/01228 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2227/108 , A01K2267/02 , A01K2267/025 , A61K2035/122 , C12N2310/111 , C12N2310/121 , C12N2310/315 , C12N2517/02 , C12N2830/52 , C12N2840/203
摘要： Transgenic swine in which the normal expression of .alpha.(1,3) galactosyltransferase is prevented in at least one organ of tissue type. The absence or inactivation of this enzyme prevents the production of carbohydrate moieties having the distinctive terminal Gal.alpha.1-3Gal.beta.1-4GlcNAc epitope that is a significant factor in xenogeneic, particularly human, transplant rejection of swine grafts.
摘要翻译： 转基因猪，其中在至少一种组织型器官中预防α（1,3）半乳糖基转移酶的正常表达。 这种酶的缺失或失活阻止了具有特征性末端Galα1-3Galβ1〜4GlcNAc表位的碳水化合物部分的产生，这是异种移植物，特别是人类移植排斥反应中重要因素。
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公开(公告)号：US20030014770A1
公开(公告)日：2003-01-16
申请号：US10098276
申请日：2002-03-15
IPC分类号： A01K067/027
CPC分类号： C12N15/113 , A01K67/0275 , A01K67/0276 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2227/108 , A01K2267/02 , A01K2267/025 , A61K2035/122 , C12N9/1051 , C12N15/1137 , C12N15/8509 , C12N2310/111 , C12N2310/121 , C12N2310/315 , C12N2517/02 , C12N2830/52 , C12N2840/203 , C12Y204/01228
摘要： Transgenic swine in which the normal expression of null(1,3) galactosyltransferase is prevented in at least one organ of tissue type. The absence or inactivation of this enzyme prevents the production of carbohydrate moieties having the distinctive terminal Galnull1-3Galnull1-4GlcNAc epitope that is a significant factor in xenogeneic, particularly human, transplant rejection of swine grafts.
摘要翻译： 转基因猪，其中在至少一种组织型器官中预防α（1,3）半乳糖基转移酶的正常表达。 该酶的缺失或失活阻止了具有特征性末端Galalpha1-3Galbeta1-4GlcNAc表位的碳水化合物部分的产生，其是异种移植物，特别是人类移植排斥反应中重要因素。
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公开(公告)号：US5869035A
公开(公告)日：1999-02-09
申请号：US748344
申请日：1996-11-13
申请人： Charles J. Link, Jr. , John P. Levy
发明人： Charles J. Link, Jr. , John P. Levy
IPC分类号： A61K38/00 , A61K48/00 , A61P35/00 , C12N9/10 , A01N43/04 , A01N63/00 , A61K39/00 , C12N15/00
CPC分类号： C12N9/1051 , C12Y204/01228 , A61K38/00 , A61K48/00 , C12N2799/028
摘要： The invention discloses methods and compositions for killing tumor cells in animals. Through transfer techniques, cancer cells are engineered to express an epitope which is targeted by natural antibodies causing complement destruction of transformed tumor cells that is typically associated with hyperacute xenograft rejection.
摘要翻译： 本发明公开了杀死动物肿瘤细胞的方法和组合物。 通过转移技术，癌细胞被工程化以表达由天然抗体靶向的表位，导致通常与超急性异种移植排斥相关的转化的肿瘤细胞的补体破坏。
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