Imaging Apparatus for Infrared Rays Nonlinear Molecular Vibrational Microscopy
    3.
    发明申请
    Imaging Apparatus for Infrared Rays Nonlinear Molecular Vibrational Microscopy 失效
    红外线成像仪非线性分子振动显微镜

    公开(公告)号:US20080304046A1

    公开(公告)日:2008-12-11

    申请号:US11861987

    申请日:2007-09-26

    Abstract: The present invention relates to an imaging apparatus for infrared rays nonlinear molecular vibrational microscopy. The imaging apparatus comprises a pump beam source for generating an infrared pump beam; a probe beam source for generating a probe beam; a beam combiner which synchronizes temporally and overlaps spatially the pump beam and probe beam on the same axis; a scanner for two-dimensionally scanning the combined pump beam and probe beam; a first optical focusing system for focusing the scanned pump beam and probe beam on a local point of the sample; a first collecting optical system for collecting the beam of which phase is shifted by interaction with the sample and forming a parallel beam; a first dichroic beam splitter for removing the infrared pump beam out of the parallel beam and splitting the probe beam of which phase is shifted; a reference interferometer for splitting a part of the probe beam out of the beams scanned by the scanner and generating a reference probel beam; an interferometric beam combiner for combining the probe beam having the shifted phase and the reference probe beam; a photodetector for detecting an intensity of a molecular vibrational beam signal from the combined probe beam; and a data analyzer for acquiring the detected signals and extracting a spectrospcopic information corresponding to the strength of molecular vibrational coherence of the sample.

    Abstract translation: 本发明涉及一种用于红外线非线性分子振动显微镜的成像装置。 成像装置包括用于产生红外泵浦光束的泵浦光束源; 用于产生探测光束的探测光束源; 光束组合器在时间上同步并在同一轴线上空间上与泵浦光束和探测光束重叠; 用于二维地扫描组合泵浦光束和探测光束的扫描仪; 用于将扫描的泵浦光束和探测光束聚焦在样品的局部点上的第一光学聚焦系统; 第一采集光学系统,用于收集通过与样本相互作用而移动的相位的波束并形成平行光束; 第一分色器,用于将红外泵浦光束从平行光束中取出并分离出相位移动的探测光束; 参考干涉仪,用于将探测光束的一部分分离出由扫描仪扫描的光束,并产生参考光源; 用于组合具有偏移相位的探测光束和参考探测光束的干涉光束组合器; 用于检测来自组合的探针光束的分子振动束信号的强度的光电检测器; 以及数据分析器,用于获取检测到的信号并提取与样品的分子振动相干强度相对应的光谱信息。

    Color analysis of organic constituents in sedimentary rocks for thermal
maturity
    4.
    发明授权
    Color analysis of organic constituents in sedimentary rocks for thermal maturity 失效
    沉积岩中有机成分的热成熟度的颜色分析

    公开(公告)号:US5233409A

    公开(公告)日:1993-08-03

    申请号:US841063

    申请日:1992-02-25

    Applicant: Karl W. Schwab

    Inventor: Karl W. Schwab

    CPC classification number: E21B49/005 G01N21/255 G01N2201/0492

    Abstract: In accordance with an illustrative embodiment of the present invention, the state of the thermal maturity of organic matter extracted from a sedimentary rock sample is determined by using a microscope in combination with a color video camera to provide an image of the organic matter in transmitted and filtered light, using the output of the camera to compute RGB and HSB values for a selected area of the image on a per-pixel basis, and plotting values integrated over the selected area in the form of a thermal maturation pathway from which a likelihood that oil has been generated in the rock can be determined.

    Abstract translation: 根据本发明的说明性实施例,通过使用显微镜与彩色摄像机组合来确定从沉积岩样品提取的有机物的热成熟度的状态,以提供有机物在透射和 使用相机的输出来以每像素为基础计算图像的选定区域的RGB和HSB值,并以热成熟途径的形式绘制在所选区域上积分的值,从而可能性 石油已经产生在岩石中可以确定。

    Automatic cell sample classifying apparatus
    5.
    发明授权
    Automatic cell sample classifying apparatus 失效
    自动细胞样品分选装置

    公开(公告)号:US4847910A

    公开(公告)日:1989-07-11

    申请号:US67003

    申请日:1987-06-29

    Abstract: A stain discriminating apparatus in which light rays having at least light component having a wavelength in a predetermined range are projected to a cell sample to discriminate the staining method by which the cell sample has been stained on the basis of the light intensity of the light component transmitted through the sample and having the wavelength (530 nm) in the predetermined range. An automatic cell sample classifying apparatus in which a plurality of cell sample slides are sequentially fed to the stain discriminating apparatus is used to determine the staining method by which the cell samples have been stained, respectively. One of the examination/classification programs previously stored in a memory is read out according to the staining method as discriminated and the cell samples are processed in accordance with the program as read out.

    Abstract translation: 一种污染鉴别装置,其中具有至少具有预定范围波长的光成分的光线投射到细胞样品,以基于光成分的光强度来鉴别细胞样品已被染色的染色方法 透过样品并具有预定范围的波长(530nm)。 使用其中将多个细胞样品载片依次送入染色鉴别装置的自动细胞样品分选装置来确定细胞样品已被染色的染色方法。 先前存储在存储器中的检查/分类程序之一根据所识别的染色方法读出,并且根据读出的程序按照程序处理单元样本。

    FLUORESCENCE-BASED SCANNING IMAGING DEVICE
    7.
    发明申请
    FLUORESCENCE-BASED SCANNING IMAGING DEVICE 有权
    基于荧光的扫描成像装置

    公开(公告)号:US20090218513A1

    公开(公告)日:2009-09-03

    申请号:US12092767

    申请日:2006-11-07

    Abstract: A device for analysing a specimen by fluorescence includes a confocal microscope, illumination means capable of emitting a light beam that converges, by means of an objective, on a focal spot, means for successively positioning the focal spot at various points on the specimen during analysis. The confocal microscope includes an objective mounted on a movable rapid-scan carriage driven in a reciprocating linear movement along a traverse direction by a rotating motor by means of a device of the connecting rod type. The specimen is placed on a movable support driven in a longitudinal movement and is able to move along the axis of the objective of the microscope in order to position the specimen relative to the focal spot. The excitation light spectrum is spread over the surface of the specimen in such a way that the excitation light reflected by the specimen and corresponding to the wavelengths close to fluorescence converge on points that are sufficiently distant from a diaphragm positioned in front of a device for measuring the fluorescence.

    Abstract translation: 用于通过荧光分析样品的装置包括共聚焦显微镜,能够发射通过物镜会聚在焦点上的光束的照明装置,用于在分析期间将焦斑连续地定位在样品上的各个点处的装置 。 共焦显微镜包括安装在可移动快速扫描托架上的物镜,该移动快速扫描托架借助于连杆型的装置沿着横动方向由旋转马达沿往复线性运动驱动。 样本被放置在以纵向运动驱动的可移动支撑上,并且能够沿着显微镜的物镜的轴线移动,以便使样本相对于焦点定位。 激发光谱以试样的反射并对应于接近荧光的波长的激发光在测量装置前方的光阑上充分远离的位置上分散在试样的表面上, 荧光。

    Apparatus to evaluate objectively the concentration and motility of
particles suspended in a sample of liquid with data processor and
display of the results
    8.
    发明授权
    Apparatus to evaluate objectively the concentration and motility of particles suspended in a sample of liquid with data processor and display of the results 失效
    用数据处理器和结果显示来客观评价悬浮在液体样品中的颗粒的浓度和运动性的装置

    公开(公告)号:US4577963A

    公开(公告)日:1986-03-25

    申请号:US547394

    申请日:1983-10-31

    Inventor: Vincenzo Traina

    Abstract: An apparatus to evaluate objectively the concentration and motility of particles suspended in a sample of liquid, and particularly to an apparatus to solve objectively the problem of evaluating these important characteristics in a very simple manner and in a short time by exploiting the Doppler effect. The sample to be examined is subjected to one of the two sub-beams resulting from the suitable division of a coherent monochromatic light beam emitted by a polarized LASER, while the other sub-beam is considered as a reference light sub-beam. Because of the very little difference between the frequencies of the original and scattered light a beat is originated in the rejoined two sub-beams which is dependent on the characteristics of the examined sample. Electromechanical means are provided to position automatically and sequentially a set of test-pieces to be examined according to a program and a data processor is provided to process the output signal of the rejoined sub-beams, so that the desired evaluations are displayed on a monitor or printed as alpha-numerical results and/or graphic diagrams. All of the mechanical, electromechanical, optical and data processor members are enclosed within a single box-container as component members of the apparatus.

    Abstract translation: 一种客观评价悬浮在液体样品中的颗粒的浓度和运动性的装置,特别是用于通过利用多普勒效应以非常简单的方式和在短时间内客观地解决评估这些重要特征的问题的装置。 要检查的样品经受由偏振激光器发射的相干单色光束的适当划分而产生的两个子光束中的一个,而另一个子光束被认为是参考光子光束。 由于原始和散射光的频率之间的差异很小,所以在重新连接的两个子光束中产生了一个节拍,这取决于所检查样本的特性。 提供机电装置以根据程序自动和顺序地定位要检查的一组测试件,并且提供数据处理器来处理重新连接的子光束的输出信号,使得期望的评估显示在监视器上 或打印为字母数字结果和/或图形图。 所有机械,机电,光学和数据处理器构件被封装在单个箱形容器内作为装置的组件。

    Integrated calibration sample bay for fluorescence readers
    10.
    发明授权
    Integrated calibration sample bay for fluorescence readers 有权
    用于荧光读取器的集成校准样品架

    公开(公告)号:US08860797B2

    公开(公告)日:2014-10-14

    申请号:US13568653

    申请日:2012-08-07

    Abstract: A stage assembly, an imaging system that uses the stage assembly, and methods for using the stage assembly in a high content screening system. The stage assembly includes a stage having a top surface and an opposing bottom surface and an opening extending between the top and bottom surfaces to receive a specimen plate. The stage assembly also includes a calibration sample bay formed in the stage. A calibration sample can also be secured within the calibration sample bay.

    Abstract translation: 舞台组件,使用舞台组件的成像系统,以及在高含量的筛选系统中使用舞台组件的方法。 舞台组件包括具有顶表面和相对的底表面的台阶以及在顶表面和底表面之间延伸以接收标本板的开口。 舞台组件还包括形成在舞台中的校准样品室。 也可以在校准样品室内固定校准样品。

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