公开(公告)号：US06794423B1

公开(公告)日：2004-09-21

申请号：US09625713

申请日：2000-07-26

申请人： Stephen Li

发明人： Stephen Li

IPC分类号： A61L2716

CPC分类号： A61L27/16 ,  C08L2207/068 ,  C08L2312/06 ,  C08L23/06

摘要： The present invention relates to a tough, wear resistant Ultra High Molecular Weight Polyethylene (UHMWPE) prepared by the cross linking of a UHMWPE shaped article with irradiation doses higher than 4 Mrads, preferably higher than 5 Mrads, and most preferably less than 10 Mrads. The invention particularly provides total joint replacement devices and methods of making them for the hip, knee, elbow and shoulder.

摘要翻译： 本发明涉及通过UHMWPE成形制品与高于4Mrad，优选高于5Mrad，最优选小于10Mrad的照射剂量的交联制备的耐磨，耐磨的超高分子量聚乙烯（UHMWPE）。 本发明特别提供全关节置换装置及其制造用于髋，膝，肘和肩的方法。

公开(公告)号：US06387379B1

公开(公告)日：2002-05-14

申请号：US08202647

申请日：1994-02-28

申请人： Eugene P. Goldberg ,  Ali Yahiaoui ,  Khalid Mentak ,  Theresa Rivero Erickson ,  James Seeger

发明人： Eugene P. Goldberg ,  Ali Yahiaoui ,  Khalid Mentak ,  Theresa Rivero Erickson ,  James Seeger

IPC分类号： A61L2716

CPC分类号： G02B1/041 ,  A61F2/0077 ,  A61F2/16 ,  A61F2002/0086 ,  A61F2002/009 ,  A61K31/727 ,  A61K31/728 ,  A61K31/79 ,  A61L27/16 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  A61L33/0088 ,  A61L2400/18 ,  A61L2430/16 ,  B05D3/068 ,  B05D3/142 ,  B05D7/02 ,  C03C17/32 ,  C03C23/0035 ,  C03C23/004 ,  C03C23/006 ,  C03C2218/31 ,  C04B41/48 ,  C08J7/18 ,  C08L39/06 ,  C23C8/36 ,  C23C26/00 ,  G02B1/043 ,  C08L51/00 ,  C08L51/06 ,  C08L33/14 ,  C08L5/08 ,  C08L1/28

摘要： A method for modifying the surface of a material adapted for contact with tissue of a human or non-human animal to impart biofunctional, bioactive or biomimetic properties to the surface comprising: (a) exposing the surface to a solution comprising (1) an ethylenically unsaturated monomer or mixture thereof capable, via the ethylenic unsaturation, of gamma irradiation or electron beam induced polymerization, and (2) at least one biofunctional agent; and (b) irradiating the surface with gamma or electron beam irradiation in the presence of the solution to thereby form on the surface a graft polymerized coating, the coating having physically entrapped therein or chemically bonded thereto molecules of the at least one biofunctional agent which imparts biofunctional or biomimetic properties to the surface; wherein the gamma or electron beam irradiation induced polymerization is conducted under one of the following conditions: A. (i) monomer concentration in the solution in the range of from about 0.1% to about 50%, by weight; (ii) total gamma or electron beam dose in the range of from about 0.001 to less than about 0.50 Mrad; and (iii) gamma dose rate in the range of from about 10 to about 2,500 rads/min., or electron beam dose rate in the range of from about 10 to about 108 rads/min.; B. (i) hydrophilic monomer(s) graft under conditions which may include monomer pre-soak or plasma gamma surface modification (especially for metal or glass substrates in latter case); and (ii) graft polymerization of monomer(s) with bioactive/biofunctional molecules using (i) as substrate; C. (i) Hydrograft™ as in A or B above followed by dehydration and adsorption of bioactive/biofunctional molecules into the hydrophilic polymer graft; wherein the biological properties of the biofunctional agent are substantially maintained.