公开(公告)号：US4351909A

公开(公告)日：1982-09-28

申请号：US265762

申请日：1981-05-21

Applicant: Timothy S. Stevens

Inventor： Timothy S. Stevens

IPC: B01D15/36 ,  B01J39/26 ,  B01J41/20 ,  B01J47/00 ,  G01N30/96 ,  B01J39/06 ,  B01J41/06 ,  B01J47/02

CPC classification number: B01J47/006 ,  B01D15/361 ,  B01J20/3221 ,  B01J39/26 ,  B01J41/20 ,  G01N30/96

Abstract: An ion-exchange composition comprising a substrate of a macroporous synthetic resin having ion-exchanging sites at least on its available surface; and finely divided, synthetic resin particles having a volume average diameter less than 0.1 micron and greater than about 0.005 micron and having, at least on their outer surfaces, ion-exchanging sites which attract the ion-exchanging sites of the substrate, irreversibly attached as a monolayer to the available surface of the substrate. The composition is used for removal and separation of ions, and is especially useful in liquid ion-exchange chromatography.

Abstract translation: 一种离子交换组合物，其包含至少在其可用表面上具有离子交换位点的大孔合成树脂的底物; 和细分的合成树脂颗粒，其体积平均直径小于0.1微米且大于约0.005微米，并且至少在其外表面上具有吸引基底的离子交换位点的离子交换位点，不可逆地连接为 单层到基底的可用表面。 该组合物用于离子的去除和分离，并且在液体离子交换层析中特别有用。

公开(公告)号：US4713362A

公开(公告)日：1987-12-15

申请号：US866531

申请日：1986-05-22

Applicant: Peter J. Maroulis ,  Charles G. Coe ,  Steven M. Kuznicki ,  Patrick J. Clark ,  David A. Roberts

Inventor： Peter J. Maroulis ,  Charles G. Coe ,  Steven M. Kuznicki ,  Patrick J. Clark ,  David A. Roberts

IPC: B01D53/02 ,  B01J20/18 ,  C01B3/56 ,  C01B13/02 ,  C01B23/00 ,  B01J29/06 ,  B01J39/06

CPC classification number: C01B23/00 ,  B01D53/02 ,  B01J20/18 ,  C01B13/027 ,  C01B3/56 ,  C01B2203/042 ,  C01B2203/0465 ,  C01B2203/047 ,  C01B2203/048 ,  C01B2210/0082

Abstract: A selective zeolitic adsorbent is prepared by activating a zeolitic composition having at least a portion, preferably at least 50%, of the exchangeable ion capacity occupied by a cation having a charge density of 2.0 or greater, preferably a divalent cation with a charge density of 2.0 or greater, such as calcium or magnesium by thoroughly dehydrating the exchanged zeolite. Additionally, separation ability of the zeolitic adsorbent can be further increased by reacting the thoroughly dehydrated zeolite in an oxidizing atmosphere.

Abstract translation: 通过活化沸石组合物制备选择性沸石吸附剂，所述沸石组合物具有至少一部分，优选至少50％的电荷密度为2.0或更大的阳离子所占据的可交换离子能力，优选电荷密度为 2.0或更大，例如通过使交换的沸石彻底脱水来脱离钙或镁。 此外，通过在氧化气氛中使完全脱水的沸石反应，可以进一步提高沸石吸附剂的分离能力。

公开(公告)号：US5728553A

公开(公告)日：1998-03-17

申请号：US378859

申请日：1995-05-25

Applicant: Andrew R. Goodey ,  Darrell Sleep ,  Hendrik van Urk ,  Stephen Berezenko ,  John R. Woodrow ,  Richard A. Johnson ,  Patricia C. Wood ,  Steven J. Burton ,  Alan V. Quirk ,  David St. J. Coghlan ,  Mark J. Wilson

Inventor： Andrew R. Goodey ,  Darrell Sleep ,  Hendrik van Urk ,  Stephen Berezenko ,  John R. Woodrow ,  Richard A. Johnson ,  Patricia C. Wood ,  Steven J. Burton ,  Alan V. Quirk ,  David St. J. Coghlan ,  Mark J. Wilson

IPC: C12P21/02 ,  A61K9/08 ,  A61K47/42 ,  A61P7/08 ,  A61P17/02 ,  C07K14/76 ,  C07K14/765 ,  C12N1/19 ,  C12N15/14 ,  B01J39/06 ,  B01J41/06

CPC classification number: C07K14/70571 ,  C07K14/765 ,  C07K2319/10

Abstract: A process for the preparation of albumin which has extremely low levels of or is essentially free of colorants, metal ions, human proteins, fragments of albumin, polymers or aggregates of albumin, and viruses, and which is relatively non-glycated, relatively high in free thiol and with an intact C-terminus. The process comprises passing albumin (preferably expressed and secreted by transformed yeast) through two chromatography purifications, ultrafiltering the product, passing through two further chromatography steps and again ultrafiltering the product.

Abstract translation: 一种制备白蛋白的方法，其具有极低的水平或基本上不含着色剂，金属离子，人类蛋白质，白蛋白片段，白蛋白聚合物或聚集体和病毒，并且相对非糖化，相对较高 游离硫醇和完整的C-末端。 该方法包括使白蛋白（优选由转化酵母表达和分泌）通过两次色谱纯化，超滤产物，通过另外两个色谱步骤，并再次超滤产物。

公开(公告)号：US4525459A

公开(公告)日：1985-06-25

申请号：US343235

申请日：1982-01-27

Applicant: Mary A. Fletcher

Inventor： Mary A. Fletcher

IPC: A61K35/18 ,  C07K14/705 ,  G01N33/569 ,  G01N33/68 ,  G01N33/50 ,  B01J39/06 ,  B01J41/06 ,  B01D9/02

CPC classification number: C07K14/705 ,  A61K35/18 ,  G01N33/56983 ,  G01N33/6854 ,  Y10S436/804 ,  Y10S436/812 ,  Y10T436/10

Abstract: Preparations useful in the diagnosis of infectious mononucleosis are disclosed. Horse and sheep erythrocytes are purified and essentially homogenous glycoproteins are extracted. The purified glycoproteins are useful as antigens in testing for the presence of the heterophile antibodies of infectious mononucleosis and in the preparation of reagents for the enumeration of rosetting lymphocytes without having to have available fresh sheep blood.

Abstract translation: 公开了用于诊断感染性单核细胞增多症的制剂。 纯化马和羊红细胞，提取基本均匀的糖蛋白。 纯化的糖蛋白在测试感染性单核细胞增多症的嗜异性抗体的存在和制备用于计数淋巴细胞的试剂而不必具有新鲜的绵羊血液的情况下可用作抗原。

公开(公告)号：US4511677A

公开(公告)日：1985-04-16

申请号：US548051

申请日：1983-11-02

Applicant: Robert L. Horton ,  G. Allan Stahl

Inventor： Robert L. Horton ,  G. Allan Stahl

IPC: B01J39/16 ,  B01J47/00 ,  C01G3/00 ,  C01G49/00 ,  C22B60/02 ,  B01J39/06 ,  C01G56/00 ,  C01G57/00

CPC classification number: C01G3/003 ,  B01J39/165 ,  B01J47/006 ,  C01G49/0009 ,  C22B3/42 ,  C22B60/0265 ,  Y02P10/234

Abstract: A new class of ion exchange agents comprises water soluble polymers called polyelectrolytes sorbed onto ion exchange functional substrates.

Abstract translation: 一类新的离子交换剂包括吸附在离子交换功能底物上的称为聚电解质的水溶性聚合物。